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The aim of this paper is to specify the use of clinically proven probiotics in common pediatric gastrointestinal disorders. The PubMed and Cochrane Library databases were searched in May and June 2018, using the following key words: „probiotics“, „children“, „antibiotic associated diarrhea“, „acute gastroenteritis“, and „functional gastrointestinal disorders“. Only studies published in English and published data were considered. The search included clinical trials, systematic reviews, guidelines and recommendations for clinical practice, and only relevant, high-quality and recent data were taken into account. Probiotics in general are nowadays used for numerous clinical indications and there is also a very large and still growing number of papers addressing this issue. Conclusion – According to current knowledge, two probiotic strains are recommended for antibiotic associated diarrhea prevention and treatment of acute gastroenteritis, LGG and S. boulardii. For the strain L. reuteri DSM 17938 there is a weak recommendation for treatment of acute gastroenteritis. There are still not enough data to recommend the use of probiotics in pediatric functional gastrointestinal disorders, with the exception of L. reuteri DSM 17938 for treatment of infantile colic in breastfed infants.

CAN is communication protocol which is used in automotive industry because of its security and reliability. UDS is a diagnostic communication protocol which enables ECU diagnostics over CAN bus. In this paper, UDS program solution for AURIX platform is proposed. The CAN low level driver is configured for CAN Bus connections upon which UDS program solution is implemented. The implementation of the algorithm is written in ERIKA Enterprise operating system and is run on Infineon Triboard TC297A v1.0 experimental board. The evaluation of the proposed UDS program solution has been done by sending requests by PCAN-USB Pro device and by interpreting the received response.

Introduction: N-terminal prohormone of atrial natriuretic peptide ((proANP(1–98)) has been extensively analyzed in patients with chronic renal failure. It has been found to be closely related to the renal function and to interdialytic hydration status. The clinical relevance of proANP(1–98) and cystatin C, a novel marker of glomerular filtration, has not been investigated in the subgroup of critically ill septic patients with no history of chronic renal impairment. Methods: We measured plasma level ofproANP(1–98) and cystatin C in 29 critically ill septic patients on admittance to the surgical intensive care unit and correlated it with the occurrence of acute renal failure. Results: The proANP(1–98) plasma level was significantly higher in the group of patients who developed renal failure (12,722 ± 12,421 vs. 2,801± 2,023 fmol/ml, p < 0.05). Multiple regression analysis shows that proANP(1–98) on the first day in the intensive care unit has a superior predictive value for the occurrence of renal failure to diuresis, calculated creatinine clearance or cystatin C (r = 0.42, p < 0.039). proANP(1–98) is also higher in non-survivors (9,303.8 ± 11,053 vs. 2,448.5 ± 1,803 fmol/ml, p < 0.018). Conclusion: proANP(1–98) is possibly a better predictor of acute renal failure to calculated creatinine clearance or diuresis among critically ill septic patients. Cystatin C was not correlated with occurrence of acute renal failure in this subgroup of patients.

The aim of this study was to analyze the progression of hand osteoarthritis in rural population and to determine the factors which could influence that progression. Participants of both sexes were 54 - 56 years of age at the first visit. Radiographs of both hands, anthropometry and blood pressure measurement were performed at baseline and than repeated 10 years later. Total number of 286 participants completed the study. Radiographs were red according to Kellgren-Lawrence criteria. Distal interphalangeal (DIP) joints were most frequently affected with osteoarthritis at the baseline and after 10 years. The worst deterioration (three grades) was found in DIP joints in women and in proximal interphalangeal joints in men. Grip strength in men was significantly related with progression of the disease, which allow us to conclude that in our population sample mechanical factors, probably occupational workload, are associated with the more rapid progression of the disease.