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2. Ultrasound characterization of insulin induced lipohypertrophy in type 1 diabetes mellitus

Author

Livio Luzi, M. Nichelatti, E. Meneghini, E. Bruschi, F. Bertuzzi, and O. Epis

Subjects
Adult, Blood Glucose, Male, medicine.medical_specialty, Adolescent, Lipodystrophy, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Injections, Subcutaneous, 030209 endocrinology & metabolism, Pilot Projects, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Endocrinology, Diabetes mellitus, medicine, Humans, Hypoglycemic Agents, Insulin, 030212 general & internal medicine, Glycemic, Aged, Retrospective Studies, Glycated Hemoglobin, Type 1 diabetes, business.industry, Ultrasound, Lipohypertrophy, Middle Aged, medicine.disease, Prognosis, Surgery, Diabetes Mellitus, Type 1, Basal (medicine), Female, Radiology, business, Biomarkers, Follow-Up Studies
Abstract

Subcutaneous insulin absorption is one of the key factors affecting glycemic control in patients with diabetes mellitus under insulin therapy. Insulin-induced subcutaneous lipohypertrophy has been reported to impair insulin regular absorption and hence glycemic control. So far, lipohypertrophy diagnosis has only been clinical. This study aims at evaluating the possible role of ultrasound scan in the assessment of subcutaneous lipohypertrophy in patients affected by type 1 diabetes mellitus. A pilot observational retrospective study was performed in 20 patients affected by type 1 diabetes mellitus. In these patients the areas with clinical evidence of lipohypertrophy dependent on the insulin injections were characterized by the presence of tissues that at the ultrasound scan resulted similar to fibrotic tissues (hyperechogenic) or to an interstitial edema or to fat tissues (hypoechogenic). It was utilized a multi frequency linear probe (6–18 MHz). The patients were advised to avoid insulin injections on the areas with lipohypertrophy scanned by the ultrasound and the HbA1c changes were evaluated 3 months later. The lipohypertrophic areas presented at least three different aspects upon ultrasound assessment: the iso-hyperechogenic one, with a predominant fibrotic component; the isoechogenic one, with “large tangles” fibrotic elements and the iso-hypoechogenic aspect with no fibrotic elements. When patients were advised to avoid insulin injections on areas with lipohypertrophy defined by ultrasound scan, 3 months after the first evaluation HbA1c had significantly improved (basal HbA1c 7.87 ± 0.56 versus 7.67 ± 0.52 3 months later, p = 0.029). No significant improvements of the HbA1c were found in the control matched group in which lipohypertrophy was only clinically valued through inspection and palpation. Ultrasound scan can help identify and characterize the lipohypertrophic areas and this might be useful to improve glycemic control.

Published
2016

3. Poster Session 2: Thursday 8 December 2011, 14:00-18:00 * Location: Poster Area

Author

X. Luo, F. Fang, J. Sun, J. Xie, A. Lee, Q. Zhang, C. Yu, O. Breithardt, S. Schiessl, M. Schmid, M. Seltmann, L. Klinghammer, C. Zeissler, M. Kuechle, W. Daniel, M. Ege, U. Guray, Y. Guray, B. Demirkan, H. Kisacik, S.-E. Kim, J.-Y. Hong, J.-H. Lee, D.-G. Park, K.-R. Han, D.-J. Oh, O. Tufekcioglu, D. C. Cozma, C. Mornos, A. Ionac, L. Petrescu, C. Tutuianu, S. I. Dragulescu, L. Guimaraes, G. Tavares, A. Rodrigues, C. Nagamatsu, C. Fischer, M. Vieira, W. Oliveira, T. Wilberg, A. Cordovil, S. Morhy, D. Muraru, M. Peluso, L. Dal Bianco, M. Beraldo, E. Solda', M. Tuveri, U. Cucchini, A. Al Mamary, L. Badano, S. Iliceto, A. Pizzuti, B. Mabritto, C. Derosa, A. Tomasello, M. Rovere, I. Parrini, M. Conte, N. Lareva, A. Govorin, R. Cooper, J. Sharif, J. D. Somauroo, J. D. Hung, V. Porcelli, R. Skevington, A. Shahzad, S. Scott, P. Lindqvist, S. Soderberg, M. Gonzalez, E. Tossavainen, M. Henein, N. Nciri, H. Saad, S. Nawas, A. Ali, A. Youssufzay, A. Safi, S. Faruk, S. Yurdakul, V. Erdemir, Y. Tayyareci, O. Yildirimturk, K. Memic, V. Aytekin, M. Gurel, S. Aytekin, M. Przewlocka-Kosmala, M. Cielecka-Prynda, A. Mysiak, W. Kosmala, S. Pescariu, D. Cozma, A. Mornos, S. Dragulescu, N. Maurea, C. G. Tocchetti, C. Coppola, C. Quintavalle, D. Rea, A. Barbieri, G. Piscopo, C. Arra, G. Condorelli, R. Iaffaioli, H. Dalen, A. Thorstensen, H. Moelmen, H. Torp, A. Stoylen, D. Augustine, C. Basagiannis, J. Suttie, P. Cox, R. Aitzaz, A. Lewandowski, M. Lazdam, C. Holloway, H. Becher, P. Leeson, S. Radovanovic, A. Djokovic, B. Todic, M. Zdravkovic, M. Zaja-Simic, S. Banicevic, D. Lisulov-Popovic, M. Krotin, J. Grapsa, D. O'regan, D. Dawson, G. Durighel, L. Howard, J. Gibbs, P. Nihoyannopoulos, C. Tulunay Kaya, M. Kilickap, H. Kurklu, N. Ozbek, C. Koca, V. Kozluca, K. Esenboga, C. Erol, B. Kusmierczyk-Droszcz, E. Kowalik, J. Niewiadomska, P. Hoffman, M. Satendra, L. Sargento, S. Lopes, S. Longo, N. Lousada, R. Palma Reis, P. Chillo, A. Rieck, J. Lwakatare, J. Lutale, E. Gerdts, S. Bonapace, G. Molon, G. Targher, A. Rossi, L. Lanzoni, G. Canali, E. Campopiano, L. Zenari, L. Bertolini, E. Barbieri, K. Hristova, L. Vladiomirova-Kitova, T. Katova, F. Nikolov, P. Nikolov, S. Georgieva, I. Simova, V. Kostova, V. A. Kuznetsov, D. V. Krinochkin, P. A. Chandraratna, Y. A. Pak, E. H. Zakharova, A. V. Plusnin, M. V. Semukhin, E. A. Gorbatenko, E. I. Yaroslavskaya, G. Bedetti, L. Gargani, M. Scalese, C. Pizzi, R. Sicari, E. Picano, M. Reali, E. Canali, S. Cimino, M. Francone, M. Mancone, R. Scardala, F. Boccalini, Y. Hiramoto, A. Frustaci, L. Agati, K. Savino, A. Lilli, E. Bordoni, C. Riccini, G. Ambrosio, D. Silva, N. Cortez-Dias, P. Carrilho-Ferreira, C. Jorge, J. Silva-Marques, A. Magalhaes, L. Santos, S. Ribeiro, F. Pinto, A. Nunes Diogo, E. Kinova, N. Zlatareva, A. Goudev, C. Bonanad, M. Lopez-Lereu, J. Monmeneu, V. Bodi, J. Sanchis, J. Nunez, F. Chaustre, A. Llacer, D. Ermacora, D. Peluso, M. Di Lazzari, P. Meimoun, F. Elmkies, T. Benali, J. Boulanger, H. Zemir, J. Clerc, A. Luycx-Bore, M. S. Velasco Del Castillo, A. Cacicedo Fernandez De Bobadilla, J. Onaindia Gandarias, M. Telleria Arrieta, G. Zugazabeitia Irazabal, O. Quintana Raczka, I. Rodriguez Sanchez, A. Romero Pereiro, E. Laraudogoitia Zaldumbide, I. Lekuona Goya, B. Bonello, E. El Louali, V. Fouilloux, I. Kammache, C. Ovaert, B. Kreitmann, A. Fraisse, R. Migliore, M. Adaniya, M. Barranco, G. Miramont, H. Tamagusuku, A. Alassar, R. Sharma, A. Marciniak, O. Valencia, N. Abdulkareem, M. Jahangiri, N. Jander, R. Kienzle, C. Gohlke-Baerwolf, H. Gohlke, F.-J. Neumann, J. Minners, S. Valbuena, F. De Torres, T. Lopez, J. J. Gomez, G. Guzman, F. Dominguez, E. Refoyo, M. Moreno, J. L. Lopez-Sendon, R. Ancona, S. Comenale Pinto, P. Caso, G. Di Salvo, S. Severino, M. Cavallaro, R. Calabro, R. Enache, R. Piazza, A. Roman-Pognuz, B. Popescu, A. Calin, C. Beladan, F. Purcarea, G. Nicolosi, C. Ginghina, O. Savu, M. Rosca, R. Jurcut, M. Serban, L. Dorobantu, E. Donal, S. Mascle, C. Thebault, D. Veillard, H. Hamonic, A. Leguerrier, H. Corbineau, B. A. Popa, M. Diena, A. Bogdan, D. Benea, G. Lanzillo, V. Casati, E. Novelli, A. Popa, G. Cerin, F. Gual Capllonch, A. Teis, J. Lopez Ayerbe, E. Ferrer, N. Vallejo, E. Gomez Denia, A. Bayes Genis, S. Spethmann, S. Schattke, G. Baldenhofer, V. Stangl, M. Laule, G. Baumann, K. Stangl, F. Knebel, C. Labata, C. Garcia Alonso, F. Gual, R. Nunez Aragon, C. Sousa, A. I. Vasile, M. Dorobantu, C. Iorgulescu, S. Bogdan, D. Constantinescu, C. Caldararu, O. Tautu, R. Vatasescu, H. Badran, M. F. Elnoamany, M. Ayad, A. Elshereef, A. Farhan, Y. Nassar, M. Yacoub, J. Costabel, G. Avegliano, P. Elissamburu, J. Thierer, F. Castro, M. Huguet, A. Frangi, R. Ronderos, C. Prinz, F. Van Buuren, L. Faber, T. Bitter, N. Bogunovic, W. Burchert, D. Horstkotte, J. D. Kasprzak, A. Smialowski, T. Rudzinski, P. Lipiec, M. Krzeminska-Pakula, K. Wierzbowska-Drabik, E. Trzos, M. Kurpesa, H. Motoki, M. Hana, T. Marwick, K. Allan, M. Vazquez-Alvarez, C. Medrano Lopez, S. Granja Da Silva, C. Marcos, A. Rodriguez-Ogando, M. Alvarez, M. Camino, M. Centeno, E. Maroto, G. Feltes Guzman, V. Serra Tomas, O. Acevedo, A. Calli, M. Barba, G. Pintos, V. Valverde, J. Zamorano Gomez, M. Marchel, J. Kochanowski, R. Piatkowski, A. Madej, K. Filipiak, I. Hausmanowa-Petrusewicz, G. Opolski, E. Malev, E. Zemtsovsky, S. Reeva, E. Timofeev, A. Pshepiy, S. Mihaila, R. Rimbas, R. Mincu, R. Dulgheru, R. Mihaila, C. Badiu, M. Cinteza, D. Vinereanu, E. Lira, D. Lebihan, C. Monaco, M. Ruiz Ortiz, D. Mesa, M. Delgado, E. Romo, M. Pena, M. Puentes, M. Santisteban, A. Lopez Granados, J. Arizon Del Prado, J. Suarez De Lezo, W.-C. Tsai, J.-Y. Shih, T.-S. Huang, Y.-W. Liu, Y.-Y. Huang, L.-M. Tsai, E. Cho, K. Choi, B. Kwon, D. Kim, S. Jang, C. Park, H. Jung, H. Jeon, H. Youn, J. Kim, A. E. Rieck, D. Cramariuc, M. Lonnebakken, B. Lund, P. Moceri, D. Doyen, P. Cerboni, E. Ferrari, W. Li, S. Goncalves, G. Vinhais De Sousa, A. G. Almeida, C. Hernandez Garcia, A. De La Rosa Hernandez, E. Arroyo Ucar, P. Jorge Perez, A. Barragan Acea, J. Lacalzada Almeida, J. Jimenez Rivera, A. Duque Garcia, I. Laynez Cerdena, O. Arhipov, A. N. Sumin, L. Campens, M. Renard, B. Trachet, P. Segers, A. De Paepe, J. De Backer, J. A. Purvis, D. Sharma, S. M. Hughes, D. Marek, D. Vindis, E. Kocianova, M. Taborsky, H. Yoon, K. Kim, Y. Ahn, M. Chung, J. Cho, J. Kang, W. Rha, O. Ozcan, D. Sezgin Ozcan, B. Candemir, M. Aras, I. Dincer, R. Atak, L. Gianturco, M. Turiel, F. Atzeni, L. Tomasoni, E. Bruschi, O. Epis, P. Sarzi-Puttini, C. Aggeli, E. Poulidakis, I. Felekos, S. Sideris, P. Dilaveris, K. Gatzoulis, C. Stefanadis, N. Roszczyk, M. Sobczak, J. Peruga, R. Krecki, J. Kasprzak, K. Ishii, T. Suyama, K. Kataoka, A. Furukawa, T. Nagai, M. Maenaka, Y. Seino, F. Musca, B. De Chiara, A. Moreo, S. Cataldo, M. Parolini, O. Parodi, T. Bombardini, F. Faita, S.-J. Park, J.-H. Kil, S.-J. Kim, S.-Y. Jang, S.-A. Chang, J.-O. Choi, S.-C. Lee, S. Park, P. Park, J. Oh, M. Cikes, V. Velagic, B. Biocina, H. Gasparovic, Z. Djuric, B. Bijnens, D. Milicic, A. Huqi, B. Klas, A. He, I. Paterson, M. Irween, J. Ezekovitz, J. Choy, Y. Chen, L. Cheng, R. Yao, H. Yao, H. Chen, C. Pan, X. Shu, B. Sobkowicz, M. Kaminska, W. Musial, R. Buechel, G. Sommer, G. Leibundgut, A. Rohner, J. Bremerich, B. Kaufmann, A. Kessel-Schaefer, M. Handke, A. Kiotsekoglou, S. Saha, R. Toole, S. Sharma, A. Gopal, S. Adhya, W. Tsang, C. Kenny, S. Kapetanakis, R. Lang, M. Monaghan, B. Smith, T. Coulter, A. Rendon, W.-S. Cheung, W. Gorissen, J. A. Ejlersen, O. May, F. J. Van Slochteren, T. Van Der Spoel, H. Hanssen, P. Doevendans, S. Chamuleau, C. De Korte, A. Tarr, S. Stoebe, T. Trache, J.-G. Kluge, A. Varga, A. Hagendorff, A. Nagy, A. Kovacs, A. Apor, B. Sax, D. Becker, B. Merkely, R. Lindquist, A. Miller, C. Reece, B. W. Eidem, W.-G. Choi, S. Kim, S. Oh, Y. Kim, R. Iacobelli, M. Chinali, M. D' Asaro, A. Toscano, A. Del Pasqua, C. Esposito, G. Seghetti, F. Parisi, G. Pongiglione, G. Rinelli, O. Omaygenc, R. Bakal, C. Dogan, K. Teber, S. Akpinar, G. Sahin, N. Ozdemir, A. Penhall, M. Joseph, F. Chong, C. De Pasquale, J. Selvanayagam, D. Leong, E. G. Nyktari, A. P. Patrianakos, C. Goudis, G. Solidakis, F. Parthenakis, P. Vardas, E. Nestaas, D. Fugelseth, A. Vitarelli, L. Capotosto, M. Bernardi, Y. Conde, F. Caranci, G. Placanica, O. Dettori, M. Vitarelli, S. De Chiara, V. De Cicco, M. Ferro', R. Calabro', S. Apostolakis, G. Chalikias, D. Tziakas, D. Stakos, A. Thomaidi, S. Konstantinides, G. Iorio, R. Rucos, G. Continanza, M. D Ascanio, L. Alessandroni, M. Saponara, M. Berry, J. Nahum, O. Zaghden, J. Monin, J. Couetil, O. Lairez, L. Macron, J. Dubois Rande, P. Gueret, P. Lim, M. Cameli, E. Giacomin, M. Lisi, S. Benincasa, F. Righini, D. Menci, M. Focardi, S. Mondillo, E. Philip, G. Gorincour, H. Bellsham-Revell, A. J. Bell, O. I. Miller, P. Beerbaum, R. Razavi, G. Greil, J. M. Simpson, S. Ann, T. Kim, J. Lee, J. Chin, P. Cabeza Lainez, V. Escolar Camas, L. Gheorghe, P. Fernandez Garcia, R. Vazquez Garcia, V. Caiulo, S. Caiulo, A. Fisicaro, F. Moramarco, G. Latini, A. Seale, J. Carvalho, H. Gardiner, M. Roughton, J. Simpson, A. Tometzki, O. Uzun, S. Webber, P. Daubeney, A. Dawood, G. Dwivedi, G. Mahadevan, D. Jiminez, R. Steeds, M. Frenneaux, C. H. Attenhofer Jost, B. Knechtle, A. Bernheim, M. Pfyffer, A. Linka, A. Faeh-Gunz, B. Seifert, G. De Pasquale, M. Zuber, A. Tomaszewski, A. Kutarski, and M. Tomaszewski

Subjects
Computer science, Plane (geometry), business.industry, Echo (computing), Left atrium, General Medicine, Biplane, medicine.anatomical_structure, Software, Left atrial, medicine, Radiology, Nuclear Medicine and imaging, Cardiology and Cardiovascular Medicine, business, Nuclear medicine
Published
2011
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4. S.9.1 Lung ultrasound for the screening of interstitial lung disease in SSc

Author

T. Barskova, L. Gargani, M. L. Conforti, S. Guiducci, C. Bruni, A. Moggi Pignone, E. Picano, M. Matucci Cerinic, M. Doveri, G. Agoston, A. Moreo, F. Musca, E. Bruschi, O. Epis, S. Bellando Randone, L. Bazzichi, S. Bombardieri, A. Varga, R. Sicari, E. Akbayrak, I. H. Tarner, U. Muller-Ladner, R. Dinser, B. Stamenkovic, A. Stankovic, A. Dimic, N. Damjanov, J. Nedovic, D. Menkovic, S. Stojanovic, and S. Milenkovic

Subjects
medicine.medical_specialty, Pathology, Lung, business.industry, Interstitial lung disease, medicine.disease, Systemic scleroderma, Stretch shortening cycle, Lung ultrasound, medicine.anatomical_structure, Rheumatology, medicine, Pharmacology (medical), Radiology, business
Published
2012
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5. S.5.1 Clinical and echocardiographic correlations of exercise-induced pulmonary hypertension in SSc: a multicentre study

Author

L. Gargani, A. Moggi Pignone, G. Agoston, A. Moreo, A. Pavellini, M. Doveri, L. Bazzichi, O. Epis, E. Bruschi, F. Musca, L. Badano, A. Varga, S. Bombardieri, R. Sicari, E. Picano, M. Matucci Cerinic, E. Capati, M. L. Caputo, S. Mondillo, J. Eicher, S. Berthier, B. Lorcerie, B. Bonnotte, J.- L. Philip, J.- E. Wolf, V. Codullo, G. Cuomo, C. Fusetti, E. Borgogno, S. Breda, M. D'Alto, S. Ghio, C. Montecucco, G. Valentini, R. Caporali, M. D'alto, M. Mical-Strak, M. Sobieszczanska, K. Laszki-Szczachor, E. Morgiel, and P. Wiland

Subjects
medicine.medical_specialty, Rheumatology, business.industry, Internal medicine, medicine, Cardiology, Pharmacology (medical), Systemic scleroderma, medicine.disease, business, Pulmonary hypertension
Published
2012
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6. Ultrasonographic analysis in vitro of parietal thickness of lower limb varicose veins

Author

Massimo Bazzocchi, E. Segatto, Chiara Zuiani, M. Rocco, Giuseppe Como, E. Bruschi, and G. Biasi

Subjects
Adult, Male, medicine.medical_treatment, In Vitro Techniques, Lower limb, Veins, Varicose Veins, Varicose veins, Humans, Medicine, Radiology, Nuclear Medicine and imaging, Aged, Ultrasonography, Neuroradiology, medicine.diagnostic_test, business.industry, Ultrasound, Endovenous laser treatment, Interventional radiology, Hypertrophy, General Medicine, Anatomy, Middle Aged, Female, medicine.symptom, business, Lower limbs venous ultrasonography
Abstract

The aim of this study was to evaluate the ability of ultrasound (US) to measure the parietal thickness of varicose veins.In a blind in vitro analysis, 28 great saphenous veins, obtained after stripping surgery from 28 patients with chronic venous insufficiency, were examined with a digital US scanner ATL-HDI5000, linear 5-1 to 2-MHz broadband probe, compound imaging technique and analogic-digital zooming. We obtained one to three progressive measurements for each vein wall (total 67 parietal thicknesses). The samples, fixed in formalin, were sent to the pathology laboratory: sections were obtained at the same level of the sonographic planes, and images were obtained by digital camera mounted on an optical microscope. Measurements obtained at histology were considered as the gold standard. K-statistic was applied to compare sonographic and histologic measurements.Considering only the hypoechoic wall portion, 29/29 (100%) diagnoses of hypotrophy (K=0.91), 19/22 (86%) diagnoses of normotrophy (K=0,47) and 12/16 (75%) diagnoses of hypertrophy (K=0.7) were obtained by sonography.In our preliminary experience, the in vitro study of varicose veins allows precise, at least morphological, detection of hypotrophic walls. If these preliminary data are confirmed in vivo, sonography could be used to discriminate patients eligible for conservative treatment instead of surgery.

Published
2006

7. AB0304 Clinical and serological response to tocilizumab in patients with rheumatoid arthritis

Author

Oscar Massimiliano Epis, Cinzia Casu, Sara Marceglia, Claudia Alpini, L. Giacomelli, and E. Bruschi

Subjects
musculoskeletal diseases, medicine.medical_specialty, Immunology, Arthritis, Gastroenterology, General Biochemistry, Genetics and Molecular Biology, Serology, chemistry.chemical_compound, Tocilizumab, Rheumatology, Internal medicine, Immunology and Allergy, Medicine, Rheumatoid factor, skin and connective tissue diseases, biology, business.industry, Autoantibody, medicine.disease, chemistry, Rheumatoid arthritis, biology.protein, Antibody, business
Abstract

Background The role of rheumatoid factor (RF) and anti-cyclic citrullinated peptide antibodies (anti-CCP) in the response to treatment for rheumatoid arthritis (RA) is not fully understood. Studies investigating changes in the levels of RF in response to synthetic and biological DMARDs have not been able to confirm a definitive relationship between decreased RF subtypes and clinical response, while studies investigating changes in anti-CCP levels have yielded conflicting results. In addition, to our knowledge the correlation between autoantibodies and tocilizumab treatment has been poorly investigated. Objectives This study investigates the relationship between the presence and levels of RF and anti-CCP and clinical response to tocilizumab in patients with RA. Methods This was an observational longitudinal study in 27 patients with active, long-standing RA despite previous treatment with >2 DMARDs and/or steroids. Patients were treated with tocilizumab 8 mg/kg every 4 weeks. All patients were assessed using approved clinical scales (VES, PCR, HAQ, DAS28-VES, DAS28-PCR, CDAI, and SDAI). IgM-, IgA- and IgG-RFs and anti-CCP antibodies were assessed using ELISA at baseline, 3 months (T1), 6 months (T2), and 12 months (T3). Results All patients showed significant and sustained clinical response to tocilizmuab treatment. All clinical scales with the exception of HAQ significantly decreased. There was a significant correlation (p=0.03) between anti-CCP and SDAI changes from baseline at T1 and T2. Likewise there were no significant correlations between antibody count at T0 and changes in the DAS-28 VES at T1 and at T2. No significant relationship between clinical scales and antibody levels RF-IgG, IgA, IgM and anti-CCP levels were observed. Conclusions Tocilizumab is effective in treating the clinical symptoms of RA, and the efficacy of this molecule was not correlated with either RF or anti-CCP levels. There is now a growing body of evidence suggesting that markers associated with clinical response may not be the same biomarkers that predict risk of further joint damage References MIKULS TR, O’DELL JR, STONER JA, ET AL: Association of rheumatoid arthritis treatment response and disease duration with declines in serum levels of IgM rheumatoid factor and anti-cyclic citrullinated peptide antibody. Arthritis Rheum 2004; 50: 3776–82. KARSDAL MA, WOODWORTH T, HENRIKSEN K, ET AL: Biochemical markers of ongoing joint damage in rheumatoid arthritis--current and future applications, limitations and opportunities. Arthritis Res Ther 2011; 13: 215 TAKEUCHI T, TANAKA Y, AMANO K, ET AL: Clinical, radiographic and functional effectiveness of tocilizumab for rheumatoid arthritis patients-REACTION 52-week study. Rheumatology 2011; 50: 1908–15. Disclosure of Interest None Declared

Published
2013
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8. Altered Cellular Calcium Control in Blood Cells in Primary Hypertension

Author

Maria E. Bruschi, Alberico Borghetti, Giacomo Bruschi, and Cavatorta A

Subjects
medicine.medical_specialty, Erythrocytes, Primary (chemistry), business.industry, Rats, Cell calcium, Text mining, Endocrinology, Nephrology, Rats, Inbred SHR, Internal medicine, Hypertension, Animals, Humans, Medicine, Calcium, business, Cytosolic calcium
Published
1986
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9. Increased sensitivity to protein kinase C activation in aortas of spontaneously hypertensive rats

Author

Patrizio Capelli, Alberico Borghetti, Giuseppe Regolisti, Giacomo Bruschi, and Maria E. Bruschi

Subjects
medicine.medical_specialty, Time Factors, Vascular smooth muscle, Physiology, chemistry.chemical_element, In Vitro Techniques, Calcium, Calcium in biology, Contractility, chemistry.chemical_compound, Rats, Inbred SHR, Internal medicine, Internal Medicine, Extracellular, Animals, Medicine, Protein kinase A, Protein Kinase C, Protein kinase C, business.industry, Rats, Inbred Strains, Rats, Enzyme Activation, Endocrinology, chemistry, Vasoconstriction, Hypertension, Phorbol, Tetradecanoylphorbol Acetate, Cardiology and Cardiovascular Medicine, business, Muscle Contraction
Abstract

The aortic muscle of spontaneously hypertensive (SHR) and normotensive control (WKY) rats was stimulated with phorbol esters and the contractile response was measured as isometric tension. Phorbol esters are known activators of protein kinase C. The aortas of SHR were characterized by the following distinct alterations in the response to phorbol myristate acetate: (1) increased sensitivity: half-maximal force was achieved at 62 +/- 6 nmol/l phorbol myristate acetate in SHR and 105 +/- 8 nmol/l in WKY; (2) increased contractility: the maximal force developed by phorbol myristate acetate was greater in SHR aortas (1.9 +/- 0.3 versus 1.6 +/- 0.2 g in WKY) compared with the decreased contractility generated with noradrenaline and high levels of potassium; (3) decreased dependency on extracellular calcium for half-maximal tension: in the presence of 3 mumol/l phorbol myristate acetate 50% of maximal force was attained at 21 +/- 8 mumol/l extracellular calcium compared with 49 +/- 9 mumol/l in WKY; (4) diminished relaxation in response to excess extracellular calcium: phorbol myristate acetate-precontracted WKY aortas began to relax when calcium was raised above 4 mmol/l in the bath and relaxation reached 51% at 8-10 mmol/l. Relaxation was almost absent in SHR (3-7%). Hence, there is an abnormality in the response to protein kinase C activation by phorbol esters in SHR vascular smooth muscle. Intracellular calcium appears to be involved. Studies of protein kinase C will prove important in understanding vascular smooth muscle function in normal and abnormal states.

Published
1988
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10. Similarities of essential and spontaneous hypertension. Volume and number of blood cells

Author

Tacinelli L, Giacomo Bruschi, B Milani, M Minari, Cavatorta A, Maria E. Bruschi, and Alberico Borghetti

Subjects
Male, medicine.medical_specialty, Essential hypertension, Rats, Inbred WKY, Blood cell, Erythrocyte volume, Internal medicine, Internal Medicine, medicine, Animals, Humans, Platelet, Mean platelet volume, Erythrocyte Volume, Platelet Count, business.industry, Healthy subjects, Rats, Inbred Strains, medicine.disease, Rats, Disease Models, Animal, Red blood cell, Endocrinology, medicine.anatomical_structure, Volume (thermodynamics), Hypertension, Erythrocyte Count, Female, business
Abstract

Spontaneously hypertensive rats have long been used as an animal counterpart of human essential hypertension. The validation of this strain as a model rests mainly on the "clinical" similarity of the two syndromes, but it has scarcely been founded on numerical comparison of measurable parameters. We investigated three hematological indexes previously recognized to be altered in spontaneously hypertensive rats: the single-cell volume of erythrocytes, the single-cell volume of platelets, and the erythrocyte number. Erythrocyte volume was lower by 7%, platelet volume was higher by 12%, and erythrocyte count was higher by 22% in spontaneously hypertensive rats in comparison with Wistar-Kyoto controls. More unexpectedly, it was found that erythrocyte volume is lower by 2%, platelet volume is higher by 3%, and erythrocyte number is higher by 6% in essential hypertensive subjects when compared with normotensive healthy subjects. These results, combined with previously reported blood cell alterations in subjects and rats, reinforce the evidence of a biological similarity between essential and spontaneous hypertension.

Published
1986
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11. The vasodilator effect of human atrial natriuretic factor (99–126) on human omental arteries

Author

Ennio Banchini, Maria E. Bruschi, Giacomo Bruschi, Alberico Borghetti, and Guido Orlandini

Subjects
Adult, Male, medicine.medical_specialty, Relaxation (psychology), Physiology, business.industry, Vasodilation, Arteries, In Vitro Techniques, Middle Aged, Rats, Endocrinology, Human plasma, Internal medicine, Internal Medicine, medicine, Animals, Humans, Cardiology and Cardiovascular Medicine, business, Atrial Natriuretic Factor
Abstract

The effect of synthetic human atrial natriuretic factor [ANF-(99-126)] on human omental arteries was investigated. The compound produced concentration-dependent relaxation, 10, 50 and 90% of maximum effect being observed at about 1, 10 and 100 nmol/l, respectively. These concentrations are considerably higher than those measured by radio-immunoassay in human plasma, even under extreme conditions (0.001-0.3 nmol/l). Therefore, ANF can dilate human resistance-size arteries, but whether it does so under physiological conditions has not been established.

Published
1988
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12. Adrenoceptor Alterations in Different Tissues in Human and Animal Genetic Hypertension

Author

Cavatorta A, Alberico Borghetti, Giacomo Bruschi, and Maria E. Bruschi

Subjects
medicine.medical_specialty, Adrenergic receptor, business.industry, Adrenergic, Alpha (ethology), Disease, Pharmacology, Antiadrenergic Drugs, Endocrinology, Genetic hypertension, Internal medicine, medicine, business, Beta (finance)
Abstract

It is scarcely necessary to stress the importance of adrenoceptor regulation in arterial hypertension. In this disease an altered response to adrenergic agonists has been described in different organs, and particularly in the blood vessels [1–6]. Moreover, antiadrenergic drugs, and particularly alpha and beta blockers, are effective antihypertensive agents.

Published
1986
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13. Subject Index, Vol. 6, 1986

Author

R.-D. Hesch, Hermann Haller, Luigi Minetti, P. Madeddu, Andreas Hvarfner, Helmut Geiger, Leif Wide, Michael A. Kirschenbaum, Grazia Covi, Filippo Quarto di Palo, Marco Boscaro, Louis V. Avioli, Barbara Lucani, M.J. Atkinson, N. Glorioso, Lorenzo Malatino, Enrico Valvo, F.M. Pala, Carmelo Erio Fiore, Michael Thiede, Emilio Nardi, Vito M. Campese, Enrico Arosio, Peter Weidmann, Sverker Ljunghall, A. Elli, Giorgio Bazzato, Roberto Pedrinelli, Silvana Favaro, Luigi Corea, R. Ziegler, Franco Mantero, Agostino Fracasso, Carlo Gennari, Maurizio Giuseppe Abrignani, M.A. Spanu, Mihaela Lüdersdorf, Antonio Dal Canton, Armando Magagna, Giacomo Bruschi, Salvatore Cantaro, Alessandro Lechi, A. Rappelli, Hans Vetter, D. Scherling, Rosangela Genchi, Armin Distler, Lenz T, Maurizio Bentivoglio, D. D'Agostino, Bernward Garthoff, Uwe Heckmann, Paolo Verdecchia, Patrizia Veniero, Adele Nardecchia, Anna Filomena Perrone, K.-H. Graefe, R. Foti, Michele Stornello, Giacomo Tamburino, Flavio Scanferla, Gerhard Schmid, Werner Schmidt, August Heidland, Giulio Romano, Aurelio Rapado, Anshumali Chaudhari, Giuseppe Maschio, David A. McCarron, Alberto Vianello, E. Benazzi, G. Greco, Pablo Cosci, Luigi Scapellato, Salvatore Novo, Gerard A. Charbon, Ketty Savino, S. Rubattu, Thomas Philipp, Wolfgang Haecker, Udo Bahner, Mario Passeri, Heinz Losse, A.D. Perris, Antonio Salvetti, C. Mörlin, Paolo Bonino, S. Rocco, Antonia Fabris, Roberto Polignano, Maria E. Bruschi, Giovanni Bonadonna, Shaul G. Massry, Heinrich Ohnmeiss, Vittorio E. Andreucci, Hugo Kesteloot, Rosario Modica, E. Niutta, Giuseppe Bianchi, Ugo Coli, G. Herrmann, Gaetano Crepaldi, Maresa Altomonte, Paola Corradini, Anna Pirrelli, Concetta Fargetta, Alberico Borghetti, Ernesto Carafoli, Paolo Morachiello, Marco Nazzari, Maurizio Surian, Miklos Palkovits, Domenico Galati, Giuseppe Donia, Clara Lechi, B. Corradi, Giovanni Pavese, Massimo Sabbatini, Antonio Pinto, Silvano Landini, Kunitoshi Iseki, Palummeri E, Vittorio Nicita-Mauro, Ciro Esposito, J. Sommer, Peter Baumgart, Flavio Righetto, Arturo Borsatti, Fabio Malberti, Gianfranco Cervellin, P. Dessi-Fulgheri, F. Fallo, Stanislav Kazda, Claudio Bianchini, Giuseppe Vezzoli, Cynthia D. Morris, Giacomo Colussi, Marina Del Turco, Renato Nami, Angelo Cavatorta, Lorenzo A. Calò, Claudio Marone, Riccardo Pieri, Francesco Uccello, Georg Luckhaus, Angela D'Angelo, Walter Zidek, Giuseppe Opocher, Antonio Strano, and K.-D. Rämsch

Subjects
Gerontology, Index (economics), Nephrology, business.industry, Medicine, Subject (documents), business
Published
1986
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