1. Effect of Acupuncture in Patients With Irritable Bowel Syndrome: A Randomized Controlled Trial
- Author
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Xiaoliang Wu, Lu Jin, Lian Liu, Shuyu Xia, Jing Li, Jing Guo, Hao Geng, Lin Wang, Guo-Hui Yang, Shengjie Weng, Lu Ju, Xiao Chen, Min Ding, Rong-Rong Shen, Xiaoxiao Wang, Yan-Ye Shu, Hua Feng, Hong Shen, Li-Xia Pei, Xiang-Dong Fang, and Jian-Hua Sun
- Subjects
Male ,medicine.medical_specialty ,Morpholines ,Acupuncture Therapy ,Severity of Illness Index ,Polyethylene Glycols ,law.invention ,Irritable Bowel Syndrome ,Randomized controlled trial ,law ,Internal medicine ,PEG ratio ,Severity of illness ,medicine ,Acupuncture ,Humans ,Adverse effect ,Irritable bowel syndrome ,Aged ,business.industry ,General Medicine ,medicine.disease ,Clinical trial ,Treatment Outcome ,Pinaverium Bromide ,Quality of Life ,Drug Therapy, Combination ,Female ,business - Abstract
Objective To evaluate the effect and safety of acupuncture for the treatment of irritable bowel syndrome (IBS) through comparisons with those of polyethylene glycol (PEG) 4000 and pinaverium bromide. Patients and Methods This multicenter randomized controlled trial was conducted at 7 hospitals in China and enrolled participants who met the Rome III diagnostic criteria for IBS between May 3, 2015, and June 29, 2018. Participants were first stratified into constipation-predominant or diarrhea-predominant IBS group. Participants in each group were randomly assigned in a 2:1 ratio to receive acupuncture (18 sessions) or PEG 4000 (20 g/d, for IBS-C)/pinaverium bromide (150 mg/d, for IBS-D) over a 6-week period, followed by a 12-week follow-up. The primary outcome was change in total IBS-Symptom Severity Score from baseline to week 6. Results Of 531 patients with IBS who were randomized, 519 (344 in the acupuncture group and 175 in the PEG 4000/ pinaverium bromide group) were included in the full analysis set. From baseline to 6 weeks, the total IBS-Symptom Severity Score decreased by 123.51 (95% CI, 116.61 to 130.42) in the acupuncture group and 94.73 (95% CI, 85.03 to 104.43) in the PEG 4000/pinaverium bromide group. The between-group difference was 28.78 (95% CI, 16.84 to 40.72; P Conclusion Acupuncture may be more effective than PEG 4000 or pinaverium bromide for the treatment of IBS, with effects lasting up to 12 weeks. Trial Registration Chinese Clinical Trials Register, ChiCTR-IOR-15006259.
- Published
- 2020
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