12 results on '"Holly Carveth"'
Search Results
2. Improvement in Pulmonary Function After Closure of Atrial Septal Defect in a Patient With Cystic Fibrosis
- Author
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Abdulfattah Saidi, Anwar Tandar, Elisa Rhee, András Bratincsák, William Van Alstine, Lindsay Koren, Kimberly Stoughton, José Negrón-Garcia, Anthony Ragheb, Hannah El-Sabrout, John W. Moore, Howaida el-Said, John P. Breinholt, Jason P. Glotzbach, Frederick G.P. Welt, Vikas Sharma, Kelsee Browning, Craig H. Selzman, David A. Bull, and Holly Carveth
- Subjects
medicine.medical_specialty ,business.industry ,Closure (topology) ,Medicine ,business ,medicine.disease ,Cystic fibrosis ,Pulmonary function testing ,Surgery - Published
- 2017
3. Population Pharmacokinetics of Amikacin in Adult Patients with Cystic Fibrosis
- Author
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Holly Carveth, David C. Young, Catherine M.T. Sherwin, Theodore G. Liou, Hoa Q. Huynh, Xiaoxi Liu, Sílvia M. Illamola, and Zubin N. Bhakta
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Cystic Fibrosis ,Population ,Renal function ,030226 pharmacology & pharmacy ,Cystic fibrosis ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Pharmacokinetics ,Internal medicine ,medicine ,Humans ,Pharmacology (medical) ,education ,Amikacin ,Retrospective Studies ,Pharmacology ,Volume of distribution ,education.field_of_study ,business.industry ,Middle Aged ,medicine.disease ,Aminoglycosides ,Infectious Diseases ,030228 respiratory system ,Creatinine ,Pharmacodynamics ,Female ,business ,Blood sampling ,medicine.drug - Abstract
Practitioners commonly use amikacin in patients with cystic fibrosis. Establishment of the pharmacokinetics of amikacin in adults with cystic fibrosis may increase the efficacy and safety of therapy. This study was aimed to establish the population pharmacokinetics of amikacin in adults with cystic fibrosis. We used serum concentration data obtained during routine therapeutic drug monitoring and explored the influence of patient covariates on drug disposition. We performed a retrospective chart review to collect the amikacin dosing regimens, serum amikacin concentrations, blood sampling times, and patient characteristics for adults with cystic fibrosis admitted for treatment of acute pulmonary exacerbations. Amikacin concentrations were retrospectively collected for 49 adults with cystic fibrosis, and 192 serum concentrations were available for analysis. A population pharmacokinetic model was developed using nonlinear mixed-effects modeling with the first-order conditional estimation method. A two-compartment model with first-order elimination best described amikacin pharmacokinetics. Creatinine clearance and weight were identified as significant covariates for clearance and the volume of distribution, respectively, in the final model. Residual variability was modeled using a proportional error model. Typical estimates for clearance, central and peripheral volumes of distribution, and intercompartmental clearance were 3.06 liters/h, 14.4 liters, 17.1 liters, and 0.925 liters/h, respectively. The pharmacokinetics of amikacin in individuals with cystic fibrosis seems to differ from those in individuals without cystic fibrosis. However, further investigations are needed to confirm these results and, thus, the need for variations in amikacin dosing. Future pharmacodynamic studies will potentially establish the optimal amikacin dosing regimens for the treatment of acute pulmonary exacerbations in adult patients with CF.
- Published
- 2018
4. A Case of Broncholithiasis and Esophagobronchial Fistula
- Author
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Mark R. Elstad, Holly Carveth, Glen Morrell, Howard Mann, and Akram M. Shaaban
- Subjects
Adult ,Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Iohexol ,Contrast Media ,Calculi ,Diagnosis, Differential ,Esophageal Fistula ,Bronchoscopy ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Bronchus ,business.industry ,Ossification ,Bronchial Diseases ,medicine.disease ,Bronchial Fistula ,Esophagobronchial Fistula ,medicine.anatomical_structure ,Mediastinal lymph node ,Radiology ,medicine.symptom ,Tomography, X-Ray Computed ,business ,Calcification - Abstract
Broncholithiasis is the presence of intrabronchial calcification or ossification. We report a case of broncholiths resulting from extrusion of calcified mediastinal lymph node into a bronchus associated with esophagobronchial fistula that became more symptomatic after bronchoscopic removal of the broncholiths.
- Published
- 2007
5. Idiopathic congenital central hypoventilation syndrome: the next generation
- Author
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Debra E. Weese-Mayer, Frank J. Cerny, John M. McQuitty, Jean M. Silvestri, Maida Lynn Chen, Dennis W. Nielson, Holly Carveth, and Drucy Borowitz
- Subjects
medicine.medical_specialty ,Pediatrics ,business.industry ,Offspring ,Respiratory disease ,Infant, Newborn ,Hypoventilation ,Syndrome ,Disease ,Hypoxia (medical) ,Congenital central hypoventilation syndrome ,medicine.disease ,Central nervous system disease ,Autonomic nervous system ,Endocrinology ,El Niño ,Internal medicine ,Humans ,Medicine ,Female ,medicine.symptom ,business ,Genetics (clinical) - Abstract
Idiopathic congenital central hypoventilation syndrome (CCHS) is a rare disorder in which affected children have a decreased sensitivity of their respiratory centers to hypercarbia and hypoxia, as well as evidence for generalized autonomic nervous system dysfunction. A genetic origin has long been hypothesized for CCHS. Previous reports of the syndrome among twins, siblings, and half siblings, as well as an established association with Hirschsprung disease and neural crest tumors support this genetic hypothesis. Here, we present the first reported offspring born to four women diagnosed with idiopathic CCHS. Their children display a spectrum of abnormalities with one child being diagnosed with CCHS, one child with recurrent apparent life threatening events, one infant born prematurely with severe chronic lung disease and diminished ventilatory responses to carbon dioxide, and one infant who is apparently healthy with no clinical manifestations suggestive of disordered respiratory control to date. Two and potentially three of these patients illustrate transmission of altered respiratory control by CCHS patients into the next generation, furthering the evidence that CCHS is part of a broadly based inherited syndrome of autonomic nervous system dysfunction.
- Published
- 2002
6. Sputum biomarkers and the prediction of clinical outcomes in patients with cystic fibrosis
- Author
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Theodore G. Liou, William Robert Walsh, Shaunessy L. Rogers, Judy L. Jensen, Jimmy Moore, Kristyn A Packer, Christen Lane, Ruth H. Keogh, Jun Chen, Anne Sturrock, Robert Paine, David Cox, Holly Carveth, Yanping Li, John R. Hoidal, Teresa Clark, and Frederick R. Adler
- Subjects
Oncology ,Pulmonology ,Cystic Fibrosis ,Epidemiology ,medicine.medical_treatment ,lcsh:Medicine ,Biochemistry ,Defense proteins ,Cystic fibrosis ,Pulmonary function testing ,Cohort Studies ,0302 clinical medicine ,Interquartile range ,Clinical Epidemiology ,HMGB1 Protein ,lcsh:Science ,Immune Response ,0303 health sciences ,Multidisciplinary ,Statistics ,Hazard ratio ,Prognosis ,Innate Immunity ,3. Good health ,Treatment Outcome ,Cytokines ,Medicine ,Biomarker (medicine) ,medicine.symptom ,Research Article ,Lung Transplantation ,Adult ,medicine.medical_specialty ,Immunology ,Biostatistics ,Immune system proteins ,03 medical and health sciences ,Internal medicine ,DNA-binding proteins ,medicine ,Humans ,Lung transplantation ,Biology ,030304 developmental biology ,Inflammation ,business.industry ,lcsh:R ,Immunity ,Sputum ,Proteins ,Granulocyte-Macrophage Colony-Stimulating Factor ,medicine.disease ,Transplantation ,Biomarker Epidemiology ,030228 respiratory system ,Immune System ,lcsh:Q ,business ,Mathematics ,Biomarkers - Abstract
Lung function, acute pulmonary exacerbations (APE), and weight are the best clinical predictors of survival in cystic fibrosis (CF); however, underlying mechanisms are incompletely understood. Biomarkers of current disease state predictive of future outcomes might identify mechanisms and provide treatment targets, trial endpoints and objective clinical monitoring tools. Such CF-specific biomarkers have previously been elusive. Using observational and validation cohorts comprising 97 non-transplanted consecutively-recruited adult CF patients at the Intermountain Adult CF Center, University of Utah, we identified biomarkers informative of current disease and predictive of future clinical outcomes. Patients represented the majority of sputum producers. They were recruited March 2004-April 2007 and followed through May 2011. Sputum biomarker concentrations were measured and clinical outcomes meticulously recorded for a median 5.9 (interquartile range 5.0 to 6.6) years to study associations between biomarkers and future APE and time-to-lung transplantation or death. After multivariate modeling, only high mobility group box-1 protein (HMGB-1, mean = 5.84 [log ng/ml], standard deviation [SD] = 1.75) predicted time-to-first APE (hazard ratio [HR] per log-unit HMGB-1 = 1.56, p-value = 0.005), number of future APE within 5 years (0.338 APE per log-unit HMGB-1, p
- Published
- 2012
7. Granulomatous pneumonitis following bone marrow transplantation
- Author
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Krishna M. Sundar, Holly Carveth, Patrick G. Beatty, M. V. Gosselin, T. V. Colby, and John R. Hoidal
- Subjects
Adult ,Male ,Pathology ,medicine.medical_specialty ,Systemic disease ,Granuloma, Respiratory Tract ,Sarcoidosis ,medicine ,Humans ,Pneumonitis ,Bone Marrow Transplantation ,Transplantation ,business.industry ,Respiratory disease ,Hematology ,Pneumonia ,medicine.disease ,Tissue Donors ,Radiography ,medicine.anatomical_structure ,Granuloma ,Female ,Bone marrow ,business ,Complication - Abstract
We describe the rare occurrence of a granulomatous pneumonitis seen in a patient following allogeneic bone marrow transplantation. Interestingly sarcoidosis was diagnosed in the marrow donor less than a year after donating his bone marrow.
- Published
- 2001
8. Endothelial activation in ARDS
- Author
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John R. Michael, T. Imaizumi, Guy A. Zimmerman, Colin K. Grissom, Thomas M. McIntyre, Holly Carveth, Stephen M. Prescott, Matthew S. Topham, John R. Hoidal, Kurt H. Albertine, James F. Orme, Edward A. Gill, and Christopher G. Maloney
- Subjects
Pulmonary and Respiratory Medicine ,ARDS ,Respiratory Distress Syndrome ,Endothelium ,business.industry ,Neutrophils ,MEDLINE ,Cell Communication ,Critical Care and Intensive Care Medicine ,Bioinformatics ,medicine.disease ,Endothelial activation ,Text mining ,medicine.anatomical_structure ,Medicine ,RESPIRATORY DISTRESS SYNDROME ADULT ,Animals ,Humans ,Endothelium, Vascular ,Cardiology and Cardiovascular Medicine ,business ,Cell Adhesion Molecules ,Lung - Published
- 1999
9. Inhaled nitric oxide versus conventional therapy: effect on oxygenation in ARDS
- Author
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John R. Michael, Karen Hillier, Wayne M. Samuelson, Mary C. Mone, Stephen E. Morris, Holly Carveth, Mark R. Elstad, Ralph E. Whatley, Richard Barton, Ronald W. Day, Brett E. Troyer, Theodore G. Liou, Edward J. Campbell, Boaz A. Markewitz, Doug M. Hinson, Jeffrey R. Saffle, and Byron L. Davis
- Subjects
Pulmonary and Respiratory Medicine ,Artificial ventilation ,Adult ,Male ,ARDS ,Randomization ,Adolescent ,medicine.medical_treatment ,Critical Care and Intensive Care Medicine ,Nitric Oxide ,law.invention ,Randomized controlled trial ,law ,Administration, Inhalation ,medicine ,Humans ,Aged ,Respiratory Distress Syndrome ,Respiratory distress ,Inhalation ,business.industry ,Respiratory disease ,Oxygenation ,Middle Aged ,medicine.disease ,Respiration, Artificial ,Oxygen ,Treatment Outcome ,Anesthesia ,Child, Preschool ,Female ,business - Abstract
A randomized, controlled clinical trial was performed with patients with acute respiratory distress syndrome (ARDS) to compare the effect of conventional therapy or inhaled nitric oxide (iNO) on oxygenation. Patients were randomized to either conventional therapy or conventional therapy plus iNO for 72 h. We tested the following hypotheses: (1) that iNO would improve oxygenation during the 72 h after randomization, as compared with conventional therapy; and (2) that iNO would increase the likelihood that patients would improve to the extent that the FI(O2) could be decreased by > or = 0.15 within 72 h after randomization. There were two major findings. First, That iNO as compared with conventional therapy increased Pa(O2)/FI(O2) at 1 h, 12 h, and possibly 24 h. Beyond 24 h, the two groups had an equivalent improvement in Pa(O2)/FI(O2). Second, that patients treated with iNO therapy were no more likely to improve so that they could be managed with a persistent decrease in FI(O2) > or = 0.15 during the 72 h following randomization (11 of 20 patients with iNO versus 9 of 20 patients with conventional therapy, p = 0.55). In patients with severe ARDS, our results indicate that iNO does not lead to a sustained improvement in oxygenation as compared with conventional therapy.
- Published
- 1998
10. BRONCHOESOPHAGEAL FISTULA SECONDARY TO BRONCHOLITHIASIS
- Author
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Mark R. Elstad, Wei Peng, Holly Carveth, and Scott C. Woller
- Subjects
Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,business.industry ,Medicine ,Bronchoesophageal fistula ,Cardiology and Cardiovascular Medicine ,Critical Care and Intensive Care Medicine ,business ,Surgery - Published
- 2005
11. The Role of Ultraviolet Radiation-Induced Cross-Reactive Tumor Antigens in Tumor Immunity
- Author
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Kay H. Seilstad, Steven Hong, Holly Carveth, and Lee K. Roberts
- Subjects
Skin Neoplasms ,Ultraviolet Rays ,business.industry ,Cross reactions ,General Medicine ,Tumor immunity ,Cross Reactions ,Disease Models, Animal ,Antigen ,Antigens, Neoplasm ,Neoplasms ,Immunology ,Animals ,Humans ,Medicine ,Antigens neoplasm ,business ,Ultraviolet radiation ,Skin - Published
- 1987
12. Treatment of Condyloma Acuminatum with Three Different Interferons Administered Intralesionallv
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Richard C. Reichman, Gerald G. Krueger, Carol Greisberger, Lori Yorkley, Lisa Miller, Steven Turing, Norbert J. Roberts, Raphael Dolln, David Oakes, Melissa Weidner, William Bonnez, Holly Carveth, and Richard J. Whitley
- Subjects
Double blind ,medicine.medical_specialty ,business.industry ,Internal medicine ,Placebo-controlled study ,Obstetrics and Gynecology ,Medicine ,General Medicine ,Condyloma Acuminatum ,business ,Gastroenterology - Published
- 1988
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