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Summary and Conclusions1. Six out of 12 Rhesus monkeys failed to secrete free acid in their gastric juice 45 to 60 minutes after subcutaneous injections of 0.5 mg. histamine while 5 out of 12 failed to respond to 1.0 cc. of a preparation of “gastrin”. 2. Three out of 12 monkeys were refractory to 1.0 mg. of histamine and to 2.0 cc. of the “gastrin”preparation. 3. The “gastrin extracts”of hog's pyloric mucosa did not contain a substance capable of stimu-lating acid gastric secretion other than histamine, both in the normal and anacid monkeys. 4. None of the 12 monkeys secreted free acid in the gastric juice in response to 7% alcohol or to a meal of farina gruel and boiled potatoes.

"Anoxemia not only stops the machine but wrecks the machinery." Only a great pioneer in the study of respiration like Haldane 1 could have spoken such truth. His words should be foremost in the mind of every surgeon dealing with a patient in shock. They should be foremost in the mind of every anesthetist dealing with a narcotized patient, because asphyxia is one of the dangers present in all forms of anesthesia. The health and the very life of the patient depend on the surgeon's knowledge and skill in preventing and averting anoxia. The number of deaths under anesthesia is appalling. Jarman 2 collected statistics from the hospitals of all the English-speaking countries. He received detailed reports of nearly 1,300 deaths under anesthesia between 1921 and 1939. Of this series of approximately 1,300 detailed cases the following classifications were made: When the anesthetic was specified the number of deaths under

Since Tainter and Stockton's 1 original report on the effectiveness of neo-synephrin as a systemic vasoconstrictor stimulant, its use as a vasopressor drug for spinal anesthesia has been reported by numerous investigators. 2 These workers have reported its effect in elevating and sustaining the blood pressure during spinal anesthesia. The associated bradycardia has also been discussed thoroughly. The action of neo-synephrin on the respiration has been briefly commented on by Tainter and Throndson 3 and by Tainter, Throndson and Moose 4 in conjunction with its use in solutions of procaine hydrochloride as a local anesthetic for dental nerve blocking. Their results indicated that the action of neo-synephrin on the respiration is not of great clinical significance. Data relative to the effects of neo-synephrin on urinary excretion are meager. Boyd 5 reported that 0.5 cc. of a 0.01 per cent solution of neosynephrin hydrochloride caused a marked antidiuretic action analogous to