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1. Contents, Vol. 99, 1992

Author

U. Darsow, J L Macpherson, Rob C. Aalberse, William W. Busse, Tadamitsu Kishimoto, A. Neszmelyi, Chigusa Terajima, E. Perez, Yuzo Sugihara, Merideth Kelley, Mindy Tsai, C. Brom, M. Lopez, Thomas J. Schall, J. Moscoso, A. Poggi, Ana E. Sousa, M.C. Mingari, Stephan C. Bischoff, M. Morganroth, Y. Mizushima, M. Pretolani, Susetta Finotto, E. Gambassi, Francesco Balsano, Francesca Levi-Schaffer, Lisa Carter, Lennart Enerbäck, F. Sanchez, Bruce S. Bochner, K.F. Austen, Harold E. Dvorak, Matsunobu Suko, L. Lanza, Gianfranco Del Prete, M. Scudeletti, R. Fritsché, Luis M. Botana, J. Hakimi, Roberta Biagiotti, C. Stellato, Ann M. Dvorak, Sachio Endo, Gert Kunkel, V. Segal, Vincenzo Casolaro, C.M. Bachelet, Otto Scheiner, A. Ishii, Alec H. Sehon, Akira Akasawa, T. Miyamoto, Kenji Matsumoto, Thomas Bieber, P.F. Mannaioni, Y. Borel, E. Ciccone, Alistair Noble, Xiao-Jun Chen, J.C. Kips, C. Juarez, Rudolf Valenta, Manel Jordana, S.B. Lehrer, H. Friedrichs, Michael Gräfe, J. Crane, Philip S. Norman, S. Sampognaro, Maria Grazia Giudizi, F. Moreno, Peter Valent, Christoph Heusser, N. Yamashita, José M. Carballido, R.A. Pauwels, A. Moretta, M. Blanca, Marco De Carli, Fatima Ferreira, Christof Ebner, Jochen Niehus, B. Prior, Maria L. Sanz, V. Hess, Claus R. Baumgarten, Peter J. Barnes, H.R. Katz, K.H. Friedrichs, P.A. Ward, Akira Ishii, G. Marone, Werner J. Pichler, Sabina Rak, Allen P. Kaplan, Robert P. Schleimer, Mike Kenemy, G.F. Joos, H. Wagner, Doreen Rucinski, Monique Capron, Bernhard Przybilla, Mamoru lto, Christian Sillaber, Franklin Adkinson, J. Fernandez, Hirokazu Okudaira, Sesha Reddigari, P. Contini, Nicole Carballido-Perrig, Klaus Hermann, Haruhiko Koseki, F. Indiveri, C.J. Corrigan, F. Nambu, Joost J. Oppenheim, Michael Duchêne, Peter T. Peachell, Jane Warner, Shuichi Matsuda, Tohru Ando, A.F. Walls, Koji Ito, Marie-Pierre Piccinni, Yoshimichi Okayama, Fabio Almerigogna, K. Rother, Eckart Fleck, Stephen J. Galli, B. Ross, B.B. Vargaftig, S. Raspanti, Motohiro Ebisawa, Anna Ciccarelli, Yoshihiro Adachi, N.C. Barnes, Satoshi Fukuse, R. Scheper, Amato de Paulis, T. Nakagawa, Toshihiko Obata, J. Grabbe, Enrico Maggi, M.M. Glovsky, L. Mugnai, Ayami Iwasaki, A. Fischer, R. Biassoni, Jerry Dolovich, H. Behrendt, Alfonso Oriente, N. Pearce, Karl-Christian Bergmann, Takeshi Koshino, Barry K. Wershil, Peter F. Weller, D. Baker, A. Stütz, Dean Befus, A.G. Alexander, Susan M. MacDonald, Bruce H. Devens, R. Beasley, W. König, J. Obispo, A. Pistelli, Martin K. Church, Ute Bleise, Teresa M. Litchfield, Robin N. Poston, B.M. Czarnetzki, J. García, Albert Oehling, E. Masini, V. Casolaro, J. Bujanowski-Weber, Krisztina M. Zsebo, Sonja Werner, Y. Yui, Kristof Graf, Margit Tejkl, M.G. Buckley, A.L. de Weck, L.M. Lichtenstein, F. Carswell, Ekkehard Haen, Raffaele Cirillo, Steven A. Krilis, P. Welker, H. Ostmeier, C. Mayorga, Taro Tabana, Jean S. Marshall, Kenichi Tomioka, Jose Fernando Chavarria, M. G. Di Bello, Heinrich Matthys, Tak H. Lee, Shyam S. Mohapatra, Wlodzimierz Ptak, M.R. Holliday, J.H. Tavernier, Kurt Blaser, Giuseppe Spadaro, K. Ito, Gianni Marone, Sandra E. Lavens, Koji Hashimoto, Niroku Koya, W.M. Becker, Andrea Koontz, J.R. Lapa e Silva, G.M. Hänsch, Arnon Nagler, Franco Dammacco, J.G. Meingassner, B. Hitzfeld, M. Castells, A. Genovese, Shu Uno, Jacqueline M. Langdon, Donatella Macchia, Robert G. Hamilton, J. del Prado, Piotr Kuna, W. Dorsch, S Gillis, Nao Kanai, J.W. Coleman, Donald W. MacGlashan, Marco Baggiolini, Tatsuro Koshibu, Elliot C. Dick, Yoji Iikura, Matthew P. Hallsworth, Yasuhiko Makino, Toshikazu Tsubaki, Larry M. Lichtenstein, S. Terrados, Gennaro de Crescenzo, M.J. Torres, Mark A. Giembycz, Mario Ricci, Maria L. Baeza, Angel F. Lopez, Christine De Vos, Go Matsuzaki, F. Gambassi, H. Stuppner, Philip W. Askenase, Angelo Vacca, Ronald Mathison, A. Helbling, Cecilia Soh, C. Burgess, T. Shida, Isao Ohno, F. Puppo, Hirohisa Saito, David R. Webb, Masaru Taniguchi, Clemens A. Dahinden, Joseph S. Davison, Paola Parronchi, Tony Wyss-Coray, Massimo Triggiani, N. Farrow, Dietrich Kraft, M. Motoishi, Susanne Vrtala, A.B. Kay, Michele Columbo, R. Tomingas, William J. Calhoun, L. Moretta, Jonathan P. Arm, Roberto Manetti, Teiichi Matsunaga, J. Brom, Sergio Bonini, J.M. Vega, Susanne Seiberler, David Diaz-Sanchez, I. Wörner, Dontcho Z. Staynov, Judah A. Denburg, Johannes Ring, Sergio Romagnani, M. Lupini, Claus Kroegel, R.A. Peleman, Luciano Adorini, Yuko Katakai, Peter S. Creticos, A. Renda, W.A. Massey, E. Horowitz, Lawrence M. Lichtenstein, Uno Shu, Stefano Bonini, Stephen J. Lane, James Kaiser, Blanca E. García, Reinhold Hirschwehr, M. Tomassini, and Elyse Bissonnette

Subjects
business.industry, Immunology, Immunology and Allergy, Medicine, General Medicine, business
Published
1992
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2. Contents, Vol. 94, 1991

Author

Graham S. LeGros, Hiroshi Yamakawa, K. Takatsu, Ratko Djukanovic, P.G. Holt, J. Bujanowski-Weber, P. Oehme, S. Bianchj, William Roche, I. Knöller, G. Delespesse, Toru Ando, Reinhold Penner, D. Macchia, R. Djukanovic, George W. Ward, Thomas Bieber, T. Furitsu, Makoto Dohi, Susan M. MacDonald, Martin D. Chapman, F. Chavarria, R. Robert Schellenberg, Michiko Haida, Makoto Nogami, John R. Brashler, J. Brom, Pascal Chanez, A. Ciccarelli, T.D. Whalley, M.J. Carmona, E. Saito, Mamoru Ito, H. Behrendt, W. Zachgo, Gabriele Zwadlo-Klarwasser, Philip J. Thompson, Sylvia Miescher, N.P. Siemensma, A. de Paulis, G. Schultze-Werninghaus, J.-P. Kinet, B.D. Gomperts, Takeo Juji, Ikuo Akutsu, Richard J. Simpson, S. Wilson, T.H. Lee, Suhad El-Lati, Bernhard Przybilla, J. Oliver, Sesha Reddigari, Monique Vogel, Koki Takahashi, Thomas Iff, L. Mugnai, E. Neher, Nathalie Paul-Eugène, Ph. Lassalle, Takeshi Fukuda, Dean D. Metcalfe, V. Lagente, C.E. O’Neil, Go Matsuzaki, C. McMenamin, Jordan N. Fink, G. Burow, Ch. Lemmermann, Ch. Schweiger, H. Wagner, K. Kurihara, D.R. Springall, Karin Pettenburger, A. Capron, H.Y.A. Lau, R. Wahl, G.J. Gleich, K. Rother, Shigeru Takafuji, W.R. Roche, Kurt Blaser, F. Gambassi, A. Pistelli, M. Bubak, Andrew F. Walls, Jeffrey M. Drazen, S.J. Lane, Johann-Christian Virchow, Akio Mori, J.M. Polak, Dietrich Kraft, Hans L. Spiegelberg, L. Lipponer, Friederike von zur Mühlen, R. zur Strassen, Rihoux Jean-Pierre, Susanne Spitzauer, Werner J. Pichler, Karen Britten, M. Schon-Hegrad, Barbara K. Stout, John Wilson, Hirokazu Okudaira, Otto Scheiner, Mitsuko Kondo, Akira Ishii, Richard Sporik, Daniel Weinreich, M. Keating, W. Dorsch, Manel Jordana, Ch.H. Heusser, Ingrid Enander, Massimo Triggiani, T. Ishizaka, Colin J. Sanderson, Dieter Vieluf, Stephanie A. Shore, J. Anrather, S. Terrados, Claus Bachert, Rosa M. Ten, E.W. Rauterberg, E. Masini, H. Rumpold, Jean Yves Lacoste, T.H.W. Lillie, K. Ohno, Alison M. Campbell, E. Gutierrez, F.L. Pearce, Stephan C. Bischoff, R. Suau, Miguel Blanca, P.H. Howarth, P.K. Jeffery, Robert L. Barker, E. Perez, M. Pfenning, Marshall Plaut, Piotr Kuna, T. Abe, H. Rotermund, Michael A. Lett-Brown, Herbert G. Johnson, Thomas Brunner, C. Ra, U. Ganzer, N. Hyslop, Kazuhiko Akiyoshi, Alain L. de Weck, J. Bews, A. Hartnell, J. Dry, K. Nosbüsch, Rafeul Alam, G. Le Gros, V. Brinkmann, Jacqueline M. Langdon, B. Thomas, P. Heap, Corinne Petit-Frère, A.G. Fernández, Wolfgang Schmutzler, Gianni Marone, Matsunobu Suko, R.W. Gristwood, D. Kraft, G.M. Walsh, A.G. Palma-Carlos, B. Bradley, N.S. Sakaguchi, J.M. Vega, O.-H. Wilhelms, R. Wiewrodt, A. Brini, Stephen R. Durham, M. Lupini, M.A. Reed, Thierry Maisonnet, A. Witzel, Peter J. Barnes, Ch. Brander, Lawrence M. Lichtenstein, A. Koffer, Y. Delneste, Laura Palma-Carlos, Jennifer Cairns, T. Brunnee, Elliott Homer, Diana J. Quint, F. Bettens, Monique Capron, Sohei Makino, Luanda Beck, T. Imai, Takayuki Ohtoshi, A. Akasawa, Lore Koller, Yoji Iikura, Naohiro Watanabe, Ahuva Nissim, J.W. Coleman, A. Ohgimi, D. Befus, J.R. Wilkinson, H. Küster, T. Katsunuma, Ch. Ebner, K.J. Turner, M.P. Piccinni, F. Ledermann, Michael Breitenbach, Bradley J. Undem, A.B. Kay, John E. Salvaggio, Carvalho de Sousa, S.T. Holgate, B. Girn, P. Berga, S. Bent, Gerald J. Gleich, Arnold S. Kirshenbaum, P.B. Boulos, Yoshitaka Ino, M. Breitenbach, R. Rathsack, May Azzawi, Sun Ying, Philippe Godard, J.H. Widdicombe, Rudolf Valenta, Christopher Corrigan, S. Romagnani, D.M. Kemeny, Bernard Dugas, Samuel B. Lehrer, Y. Churcher, John Gordon, C. Brom, F. Leynadier, Gert Kunkel, Gerard Cox, B.F. Weber, D. Diaz-Sanchez, Shinji Motojima, J.W. Wilson, Pieter L.B. Bruijnzeel, P.F. Mannaioni, K. Britten, Allen P. Kaplan, Yutaka Morita, K. Ishida, Erika Jensen-Jarolim, Jack Gauldie, Fiona R. Lake, S. Raspanti, Andrew Grant, R. Fadel, S. Dunnette, Jean Bousquet, Ivan Aebischer, Thomas A.E. Platts-Mills, T. Wyss, Richard D. O’Connor, Larry D. Ward, A.G. Morris, Clemens A. Dahinden, Toshifumi Yuuki, P. Parronchi, Hiroyuki Mochizuki, Gail M. McNutt, D.C. Reason, Martin Krieger, Lawrence E. Gelber, Naoki Inagaki, E. Kilchherr, Elisabeth Boichot, Qiu Gang, F. Gabl, Alec H. Sehon, J.V. Collins, Shiro Kasuya, J. Blomgren, Bernadette Pignol, Motohiro Ebisawa, N. Sakaguchi, Jacalyn H. Pierce, U. Blank, Fu-Tong Liu, Robert A. Seder, R. Hilger, Richard P. Bransford, M. Linssen, Jörg Kleine-Tebbe, P.D. Pare, Kazuhiko Yamamoto, Jean Michel Mencia-Huerta, Michael K. Bach, Pierre Braquet, J. Salvaggio, Reuben J.M. Falkoff, R. Merget, J. Hards, B.J. Holt, D. Strickland, P.E.R. Tatham, A.B. Tonnel, H. Saito, François-B. Michel, K. Akimoto, Jerry Dolovich, Brian M. Greenlee, Carl G. A. Persson, Anne Kagey-Sobotka, Tim R. Mosmann, Zelig Eshhar, N. Wallen, Maria Baeza, A.J. Wardlaw, Peter H. Howarth, Robin N. Poston, W. König, R.C. Benyon, M. Lopez, D. Mijic, E. Jarolim, William E. Paul, John P. Caulfield, B. Kunz, Milton A. Martins, Yasushi Okumura, J. Knöller, R. Ciriilo, K. Nieber, Geoffrey A. Stewart, Allen C. Myers, Zami Ben-Sasson, U. Hauser, M. G. Di Bello, Michael Duchêne, C. Baumgarten, C.J. Sanderson, Koji Ito, R. Valenta, M.-H. Jouvin, Menachem Rottem, F. Carswell, A. Miranda, K.R. Tainsh, Kimm J. Hamann, Judah A. Denburg, K. Wagner, Martin K. Church, Qutayba Hamid, O. Mejan, Johannes Ring, J. Fernandez, L. Juhlin, Kiyoshi Takatsu, Martin E. Sanders, Peter W. Heymann, C.E. Reed, P. Wentz-Murtha, Fred D. Finkelman, J. Llupiá, Helmut Rumpold, Stephen T. Holgate, Conceição B. Santos, G.M. Hänsch, W.L. Liu, Christoph Walker, M. Ricci, Ph. Gosset, E. Maggi, J. Wilson, R. Moqbel, and Beda M. Stadler

Subjects
business.industry, Immunology, Immunology and Allergy, Medicine, General Medicine, business
Published
1991
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3. Cell mobilisation and cytokine gene expression in a rat model of non-antigen-induced lung inflammation

Author

C.M.M. Williams and J.W. Coleman

Subjects
Male, Neutrophils, Immunology, Rat model, Cell, Inflammation, Antigen, Cell Movement, Interleukin 25, medicine, Immunology and Allergy, Animals, Cytokine genes, RNA, Messenger, Rats, Wistar, Lung, business.industry, General Medicine, Pneumonia, Rats, Eosinophils, medicine.anatomical_structure, Cytokines, medicine.symptom, business
Published
1997

4. Identification of a spleen cell-derived factor that inhibits sensitization of murine peritoneal mast cells as interferon-gamma

Author

J.W. Coleman and A.G. Morris

Subjects
medicine.medical_treatment, Immunology, Spleen, In Vitro Techniques, Interferon-gamma, Mice, medicine, Splenocyte, Immunology and Allergy, Animals, Interferon gamma, Mast Cells, Peritoneal Cavity, Sensitization, biology, business.industry, General Medicine, Mast cell, Cytokine, medicine.anatomical_structure, Monoclonal, biology.protein, Antibody, business, medicine.drug
Abstract

We present evidence that a spleen cell-derived factor that inhibits the sensitization of mouse peritoneal mast cells is IFN gamma. Conditioned medium (CM) from Con A-activated mouse spleen cells and recombinant MuIFN gamma both inhibited antigen-induced 5-HT release from peritoneal mast cells when added at the sensitization stage, but were without effect on presensitized cells. Both preparations were active at dilutions corresponding to similar levels of IFN activity (1-10 units/ml). The inhibitory activity of CM was blocked by a rat monoclonal MuIFN gamma-neutralizing antibody, thus confirming that IFN gamma was the active molecule.

Published
1991

5. A comparison of the effects of chlorpromazine and more selective histamine and 5-hydroxytryptamine antagonists on human IgG synthesis in vitro

Author

J.W. Coleman and Francisca Martinez

Subjects
Serotonin, Chlorpromazine, medicine.medical_treatment, Immunology, Mepyramine, Methysergide, Histamine Antagonists, Pharmacology, H2 antagonist, chemistry.chemical_compound, medicine, Humans, Histamine H4 receptor, Cimetidine, Cells, Cultured, business.industry, Mechanism of action, chemistry, Immunoglobulin G, Receptors, Serotonin, Leukocytes, Mononuclear, Receptors, Histamine, Serotonin Antagonists, medicine.symptom, business, Histamine, medicine.drug
Abstract

We have shown previously that chlorpromazine, a drug associated with immunological abnormalities in vivo, significantly potentiates pokeweed mitogen (PWM)-stimulated IgG synthesis by human peripheral blood mononuclear cells (PBMC) in culture. Chlorpromazine is a pharmacological antagonist of histamine and 5-hydroxytryptamine (5-HT) and thus may exert its immune-enhancing effects by competing with these amines for their respective receptors, which are known to be present on lymphocytes. In this report we show that histamine and 5-HT are present at micromolar concentrations in PBMC cultures. To examine the role of histamine and 5-HT in chlorpromazine-induced enhancement of IgG synthesis we incubated PWM-treated cells with a range of selective histamine and 5-HT antagonists, and with the amines added to cultures either alone or in combination with chlorpromazine. The H1 antagonists mepyramine and promethazine and the H2 antagonist cimetidine had no significant effect on IgG synthesis. The combined 5-HT1/5-HT2 antagonists methysergide and methiothepin also failed to modulate synthesis. Neither histamine nor 5-HT at concentrations up to 100 microM modulated IgG synthesis, nor did they abrogate the enhancement of IgG synthesis induced by chlorpromazine. We conclude that the modulation of IgG synthesis in vitro by chlorpromazine cannot be attributed to an interaction of this drug with lymphocyte receptors for histamine and 5-HT. Other possibilities for the mechanism of action of this drug on immune function are discussed.

Published
1990

6. Contents, Vol. 66, 1981

Author

Pam Drysdale, Jerzy Wasserman, Lucy A. Gallinger, Kazuo Ohuchi, Anne-Marie Ros, Masamichi Ishiguro, B. Huitfeldt, Nils Thyresson, Satoko Kiso, Patrick G. Holt, M.G. Baines, S. Leivers, Atsushi Kurihara, T. F. Huff, N.R. Ling, B. Skoogh, E.C. Olson, Susumu Tsurufuji, B.S. Wostmann, R.C. Godfrey, J.W. Coleman, Robbert Benner, Lars-Victor von Stedingk, Teruko Ishizaka, J J Haaijman, P. Rubin, T. Månsson, Shin Yoshino, Roger Henriksson, W. Hijmans, Shao-Qiu Gu, H. Ginsburg, A. Van Oudenaren, Corey Weiner, Te Piao King, Hiromitsu Yoshimura, S. Ahlstedt, Hirokazu Okudaira, J. Sjövall, J Slingerland-Teunissen, F. Maesen, Per E. Alm, Gunnar D. Bloom, H.F. Pross, and Janet E. Batty

Subjects
business.industry, Immunology, Immunology and Allergy, Medicine, General Medicine, business
Published
1981
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7. Inhibition of Human Lung Mast Cell Sensitization by IgE in Allergic Sera

Author

J.W. Coleman and R.C. Godfrey

Subjects
Immunosuppression Therapy, biology, business.industry, Immunology, General Medicine, Immunoglobulin E, Mast cell, Binding, Competitive, Histamine Release, Human lung, Myeloma Proteins, medicine.anatomical_structure, Antibody Specificity, Passive sensitization, medicine, biology.protein, Humans, Immunology and Allergy, Binding Sites, Antibody, Mast Cells, business, Lung, Sensitization
Abstract

Passive sensitization of mast cells in human lung tissue by antigen-specific IgE was inhibited by allergic sera containing IgE of other specificities. IgE-free sera and heat-treated sera failed to inhibit. Inhibition by purified myeloma IgE was quantitatively similar to that produced by serum IgE. It is concluded that IgE antibodies of different antigen specificity at concentrations found in allergic sera compete for cell surface receptors on human mast cells.

Published
1981
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