1. Performance Characteristics of a Clinical Decision Support Tool for Disease Complications in Crohn’s Disease
- Author
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Corey A. Siegel, Dermot P B Mc Govern, Stephan R. Targan, Karen Lasch, Janine Bilsborough, Jonathan Braun, Carol J. Landers, Marla Dubinsky, Thierry Dervieux, Fred Princen, Ninfa Candela, and Lori S. Siegel
- Subjects
Crohn's disease ,medicine.medical_specialty ,business.industry ,Gastroenterology ,medicine ,Disease ,medicine.disease ,Intensive care medicine ,business ,Clinical decision support system - Abstract
Background Patients with Crohn’s disease (CD) are at risk of complications. Performance characteristics of a decision support tool assessing the risk of CD complications were evaluated. Methods CDPATH (formerly called the Personalized Risk and Outcome Prediction Tool [PROSPECT]) was calibrated and validated in 2 cohorts. Tool prediction of disease characteristics was assessed using Cox regression and Harrell’s C-statistic. Results All associations of CD complications and CDPATH components were significant except perianal location. There was a significant association between individualized risk assessment scores and CD complications in both cohorts. Conclusion CDPATH is validated as a clinical decision support tool for assessing the risk of CD complications.
- Published
- 2021