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Malignant mesothelioma (MM) is a rare, aggressive, and highly lethal cancer that is substantially induced by exposure to asbestos fibers. High-mobility group box 1 (HMGB1) is an intriguing proinflammatory molecule involved in MM. In this review, we describe the possible crucial roles of HMGB1 in carcinogenic mechanisms based on in vivo and in vitro experimental evidence and outline the clinical findings of epidemiological investigations regarding the possible roles of HMGB1 as a biomarker for MM. We conclude that novel strategies targeting HMGB1 may suppress MM cells and interfere with asbestos-induced inflammation.

Aircraft center of gravity control is an important technology to gain potential performance benefits. In-flight center of gravity control is usually based on a fuel transfer system which enables fuel to be transferred among fuselage fuel tanks and then adjust aircraft center of gravity. The aim of this article is to systematically investigate the influences of partial fuel pump failures on the CG control performance for the high-speed aircraft. As the basis, modeling process of center of gravity varying with fuel transfer is put forward and the sliding model based control law for center of gravity is presented in detail. Then the detailed simulation analysis of possible failures effects on center of gravity tracking performance for the high-speed aircraft is carried out, including different one or two fuel pump failures. Finally, the corresponding emergency strategies for the aircraft center of gravity control system are proposed.

Active center of gravity control can transfer fuel among many fuselage fuel tanks to effectively optimize aircraft center of gravity and gain the potential economic performance benefits. In-flight possible failures in the fuel system may generate direct influences on aircraft center of gravity control. The aim of this article is to investigate the influence of partial fuel transfer line leak on the active center of gravity control system. First, modeling of center of gravity variation due to fuel transfer is presented and then aircraft center of gravity control law based on sliding mode is put forward. Then, detailed simulation analyses of the influence of possible fuel transfer line leak on center of gravity tracking performance are carried out, including different one or two fuel lines leak conditions. Finally, the emergency strategies for the aircraft center of gravity control system to cope with possible failures are concluded and proposed.

A sliding mode based active center of gravity control law is designed for the aircraft with center of gravity varying during flight. As the basis, the general scheme of the active center of gravity control system is proposed, and the mathematic model of aircraft center of gravity varying with fuel transfer is established. Then, the center of gravity control law based on sliding mode control theory is designed, which can guarantee the control error converges to zero in finite time. Finally, simulations are carried out to verify the proposed method. Simulation results show that the sliding mode based center of gravity control law can accurately and rapidly track the given command for various different fuel transfer conditions.