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2. Joining or Exiting the Defined Benefit Division Superannuation Scheme of UniSuper

Author

John Christie

Subjects
superannuation, pension, universities, defined benefit, indexed pension, retirement, australia, Business, HF5001-6182
Abstract

The Defined Benefit Division of UniSuper is a large defined benefit superannuation scheme in Australia for public universities. Unlike public service superannuation schemes in Australia, it is not guaranteed by the employers. This has previously led to a reduction in benefits of the scheme due to expected funding shortfalls. This paper examines longstanding and more recent issues with the funding of the Defined Benefit Division. Recent changes to superannuation laws in Australia may result in further benefit reductions for the scheme in the future. Should new eligible employees join the Defined Benefit Division? What form of retirement benefit should be taken by retiring Defined Benefit Division members? The paper examines these two key questions. Employees who are contemplating joining the Defined Benefit Division, or those Defined Benefit Division members about to retire, have some very important decisions to make.

Published
2023
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3. Stock Market Crashes in Australia: A Brief Technical Note

Author

John Christie

Subjects
stock market crashes, australia, Business, HF5001-6182
Abstract

This paper analyses the three stock market crashes in Australia which have occurred since the All Ordinaries Index was established in 1980. The index behaves in an approximately exponential manner leading up to each market crash and this behaviour can be interpreted as a sign of a looming market crash.

Published
2021
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5. An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs

Author

Heather J. Cordell, James J. Fryett, Kazuko Ueno, Rebecca Darlay, Yoshihiro Aiba, Yuki Hitomi, Minae Kawashima, Nao Nishida, Seik-Soon Khor, Olivier Gervais, Yosuke Kawai, Masao Nagasaki, Katsushi Tokunaga, Ruqi Tang, Yongyong Shi, Zhiqiang Li, Brian D. Juran, Elizabeth J. Atkinson, Alessio Gerussi, Marco Carbone, Rosanna Asselta, Angela Cheung, Mariza de Andrade, Aris Baras, Julie Horowitz, Manuel A.R. Ferreira, Dylan Sun, David E. Jones, Steven Flack, Ann Spicer, Victoria L. Mulcahy, Jinyoung Byan, Younghun Han, Richard N. Sandford, Konstantinos N. Lazaridis, Christopher I. Amos, Gideon M. Hirschfield, Michael F. Seldin, Pietro Invernizzi, Katherine A. Siminovitch, Xiong Ma, Minoru Nakamura, George F. Mells, Andrew Mason, Catherine Vincent, Gang Xie, Jinyi Zhang, Andrea Affronti, Piero L. Almasio, Domenico Alvaro, Pietro Andreone, Angelo Andriulli, Francesco Azzaroli, Pier Maria Battezzati, Antonio Benedetti, MariaConsiglia Bragazzi, Maurizia Brunetto, Savino Bruno, Vincenza Calvaruso, Vincenzo Cardinale, Giovanni Casella, Nora Cazzagon, Antonio Ciaccio, Barbara Coco, Agostino Colli, Guido Colloredo, Massimo Colombo, Silvia Colombo, Laura Cristoferi, Carmela Cursaro, Lory Saveria Crocè, Andrea Crosignani, Daphne D’Amato, Francesca Donato, Gianfranco Elia, Luca Fabris, Stefano Fagiuoli, Carlo Ferrari, Annarosa Floreani, Andrea Galli, Edoardo Giannini, Ignazio Grattagliano, Pietro Lampertico, Ana Lleo, Federica Malinverno, Clara Mancuso, Fabio Marra, Marco Marzioni, Sara Massironi, Alberto Mattalia, Luca Miele, Chiara Milani, Lorenzo Morini, Filomena Morisco, Luigi Muratori, Paolo Muratori, Grazia A. Niro, Sarah O’Donnell, Antonio Picciotto, Piero Portincasa, Cristina Rigamonti, Vincenzo Ronca, Floriano Rosina, Giancarlo Spinzi, Mario Strazzabosco, Mirko Tarocchi, Claudio Tiribelli, Pierluigi Toniutto, Luca Valenti, Maria Vinci, Massimo Zuin, Hitomi Nakamura, Seigo Abiru, Shinya Nagaoka, Atsumasa Komori, Hiroshi Yatsuhashi, Hiromi Ishibashi, Masahiro Ito, Kiyoshi Migita, Hiromasa Ohira, Shinji Katsushima, Atsushi Naganuma, Kazuhiro Sugi, Tatsuji Komatsu, Tomohiko Mannami, Kouki Matsushita, Kaname Yoshizawa, Fujio Makita, Toshiki Nikami, Hideo Nishimura, Hiroshi Kouno, Hirotaka Kouno, Hajime Ota, Takuya Komura, Yoko Nakamura, Masaaki Shimada, Noboru Hirashima, Toshiki Komeda, Keisuke Ario, Makoto Nakamuta, Tsutomu Yamashita, Kiyoshi Furuta, Masahiro Kikuchi, Noriaki Naeshiro, Hironao Takahashi, Yutaka Mano, Seiji Tsunematsu, Iwao Yabuuchi, Yusuke Shimada, Kazuhiko Yamauchi, Rie Sugimoto, Hironori Sakai, Eiji Mita, Masaharu Koda, Satoru Tsuruta, Hiroshi Kamitsukasa, Takeaki Sato, Naohiko Masaki, Tatsuro Kobata, Nobuyoshi Fukushima, Yukio Ohara, Toyokichi Muro, Eiichi Takesaki, Hitoshi Takaki, Tetsuo Yamamoto, Michio Kato, Yuko Nagaoki, Shigeki Hayashi, Jinya Ishida, Yukio Watanabe, Masakazu Kobayashi, Michiaki Koga, Takeo Saoshiro, Michiyasu Yagura, Keisuke Hirata, Atsushu Tanaka, Hajime Takikawa, Mikio Zeniya, Masanori Abe, Morikazu Onji, Shuichi Kaneko, Masao Honda, Kuniaki Arai, Teruko Arinaga-Hino, Etsuko Hashimoto, Makiko Taniai, Takeji Umemura, Satoru Joshita, Kazuhiko Nakao, Tatsuki Ichikawa, Hidetaka Shibata, Satoshi Yamagiwa, Masataka Seike, Koichi Honda, Shotaro Sakisaka, Yasuaki Takeyama, Masaru Harada, Michio Senju, Osamu Yokosuka, Tatsuo Kanda, Yoshiyuki Ueno, Kentaro Kikuchi, Hirotoshi Ebinuma, Takashi Himoto, Michio Yasunami, Kazumoto Murata, Masashi Mizokami, Kazuhito Kawata, Shinji Shimoda, Yasuhiro Miyake, Akinobu Takaki, Kazuhide Yamamoto, Katsuji Hirano, Takafumi Ichida, Akio Ido, Hirohito Tsubouchi, Kazuaki Chayama, Kenichi Harada, Yasuni Nakanuma, Yoshihiko Maehara, Akinobu Taketomi, Ken Shirabe, Yuji Soejima, Akira Mori, Shintaro Yagi, Shinji Uemoto, Egawa H, Tomohiro Tanaka, Noriyo Yamashiki, Sumito Tamura, Yasuhiro Sugawara, Norihiro Kokudo, Naga Chalasani, Vel Luketic, Joseph Odin, Kapil Chopra, Goncalo Abecasis, Michael Cantor, Giovanni Coppola, Aris Economides, Luca A. Lotta, John D. Overton, Jeffrey G. Reid, Alan Shuldiner, Christina Beechert, Caitlin Forsythe, Erin D. Fuller, Zhenhua Gu, Michael Lattari, Alexander Lopez, Thomas D. Schleicher, Maria Sotiropoulos Padilla, Karina Toledo, Louis Widom, Sarah E. Wolf, Manasi Pradhan, Kia Manoochehri, Ricardo H. Ulloa, Xiaodong Bai, Suganthi Balasubramanian, Leland Barnard, Andrew Blumenfeld, Gisu Eom, Lukas Habegger, Alicia Hawes, Shareef Khalid, Evan K. Maxwell, William Salerno, Jeffrey C. Staples, Marcus B. Jones, Lyndon J. Mitnaul, Richard Sturgess, Christopher Healey, Andrew Yeoman, Anton VJ. Gunasekera, Paul Kooner, Kapil Kapur, V. Sathyanarayana, Yiannis Kallis, Javaid Subhani, Rory Harvey, Roger McCorry, Paul Rooney, David Ramanaden, Richard Evans, Thiriloganathan Mathialahan, Jaber Gasem, Christopher Shorrock, Mahesh Bhalme, Paul Southern, Jeremy A. Tibble, David A. Gorard, Susan Jones, George Mells, Victoria Mulcahy, Brijesh Srivastava, Matthew R. Foxton, Carole E. Collins, David Elphick, Mazn Karmo, Francisco Porras-Perez, Michael Mendall, Tom Yapp, Minesh Patel, Roland Ede, Joanne Sayer, James Jupp, Neil Fisher, Martyn J. Carter, Konrad Koss, Jayshri Shah, Andrzej Piotrowicz, Glyn Scott, Charles Grimley, Ian R. Gooding, Simon Williams, Judith Tidbury, Guan Lim, Kuldeep Cheent, Sass Levi, Dina Mansour, Matilda Beckley, Coral Hollywood, Terry Wong, Richard Marley, John Ramage, Harriet M. Gordon, Jo Ridpath, Theodore Ngatchu, Vijay Paul Bob Grover, Ray G. Shidrawi, George Abouda, L. Corless, Mark Narain, Ian Rees, Ashley Brown, Simon Taylor-Robinson, Joy Wilkins, Leonie Grellier, Paul Banim, Debasish Das, Michael A. Heneghan, Howard Curtis, Helen C. Matthews, Faiyaz Mohammed, Mark Aldersley, Raj Srirajaskanthan, Giles Walker, Alistair McNair, Amar Sharif, Sambit Sen, George Bird, Martin I. Prince, Geeta Prasad, Paul Kitchen, Adrian Barnardo, Chirag Oza, Nurani N. Sivaramakrishnan, Prakash Gupta, Amir Shah, Chris DJ. Evans, Subrata Saha, Katharine Pollock, Peter Bramley, Ashis Mukhopadhya, Stephen T. Barclay, Natasha McDonald, Andrew J. Bathgate, Kelvin Palmer, John F. Dillon, Simon M. Rushbrook, Robert Przemioslo, Chris McDonald, Andrew Millar, Cheh Tai, Stephen Mitchell, Jane Metcalf, Syed Shaukat, Mary Ninkovic, Udi Shmueli, Andrew Davis, Asifabbas Naqvi, Tom JW. Lee, Stephen Ryder, Jane Collier, Howard Klass, Matthew E. Cramp, Nichols Sharer, Richard Aspinall, Deb Ghosh, Andrew C. Douds, Jonathan Booth, Earl Williams, Hyder Hussaini, John Christie, Steven Mann, Douglas Thorburn, Aileen Marshall, Imran Patanwala, Aftab Ala, Julia Maltby, Ray Matthew, Chris Corbett, Sam Vyas, Saket Singhal, Dermot Gleeson, Sharat Misra, Jeff Butterworth, Keith George, Tim Harding, Andrew Douglass, Harriet Mitchison, Simon Panter, Jeremy Shearman, Gary Bray, Michael Roberts, Graham Butcher, Daniel Forton, Zahid Mahmood, Matthew Cowan, Debashis Das, Chin Lye Ch’ng, Mesbah Rahman, Gregory C.A. Whatley, Emma Wesley, Aditya Mandal, Sanjiv Jain, Stephen P. Pereira, Mark Wright, Palak Trivedi, Fiona H. Gordon, Esther Unitt, Altaf Palejwala, Andrew Austin, Vishwaraj Vemala, Allister Grant, Andrew D. Higham, Alison Brind, Ray Mathew, Mark Cox, Subramaniam Ramakrishnan, Alistair King, Simon Whalley, Jocelyn Fraser, S.J. Thomson, Andrew Bell, Voi Shim Wong, Richard Kia, Ian Gee, Richard Keld, Rupert Ransford, James Gotto, Charles Millson, Cordell, H. J., Fryett, J. J., Ueno, K., Darlay, R., Aiba, Y., Hitomi, Y., Kawashima, M., Nishida, N., Khor, S. -S., Gervais, O., Kawai, Y., Nagasaki, M., Tokunaga, K., Tang, R., Shi, Y., Li, Z., Juran, B. D., Atkinson, E. J., Gerussi, A., Carbone, M., Asselta, R., Cheung, A., de Andrade, M., Baras, A., Horowitz, J., Ferreira, M. A. R., Sun, D., Jones, D. E., Flack, S., Spicer, A., Mulcahy, V. L., Byan, J., Han, Y., Sandford, R. N., Lazaridis, K. N., Amos, C. I., Hirschfield, G. M., Seldin, M. F., Invernizzi, P., Siminovitch, K. A., Ma, X., Nakamura, M., Mells, G. F., Mason, A., Vincent, C., Xie, G., Zhang, J., Affronti, A., Almasio, P. L., Alvaro, D., Andreone, P., Andriulli, A., Azzaroli, F., Battezzati, P. M., Benedetti, A., Bragazzi, M., Brunetto, M., Bruno, S., Calvaruso, V., Cardinale, V., Casella, G., Cazzagon, N., Ciaccio, A., Coco, B., Colli, A., Colloredo, G., Colombo, M., Colombo, S., Cristoferi, L., Cursaro, C., Croce, L. S., Crosignani, A., D'Amato, D., Donato, F., Elia, G., Fabris, L., Fagiuoli, S., Ferrari, C., Floreani, A., Galli, A., Giannini, E., Grattagliano, I., Lampertico, P., Lleo, A., Malinverno, F., Mancuso, C., Marra, F., Marzioni, M., Massironi, S., Mattalia, A., Miele, L., Milani, C., Morini, L., Morisco, F., Muratori, L., Muratori, P., Niro, G. A., O'Donnell, S., Picciotto, A., Portincasa, P., Rigamonti, C., Ronca, V., Rosina, F., Spinzi, G., Strazzabosco, M., Tarocchi, M., Tiribelli, C., Toniutto, P., Valenti, L., Vinci, M., Zuin, M., Nakamura, H., Abiru, S., Nagaoka, S., Komori, A., Yatsuhashi, H., Ishibashi, H., Ito, M., Migita, K., Ohira, H., Katsushima, S., Naganuma, A., Sugi, K., Komatsu, T., Mannami, T., Matsushita, K., Yoshizawa, K., Makita, F., Nikami, T., Nishimura, H., Kouno, H., Ota, H., Komura, T., Nakamura, Y., Shimada, M., Hirashima, N., Komeda, T., Ario, K., Nakamuta, M., Yamashita, T., Furuta, K., Kikuchi, M., Naeshiro, N., Takahashi, H., Mano, Y., Tsunematsu, S., Yabuuchi, I., Shimada, Y., Yamauchi, K., Sugimoto, R., Sakai, H., Mita, E., Koda, M., Tsuruta, S., Kamitsukasa, H., Sato, T., Masaki, N., Kobata, T., Fukushima, N., Ohara, Y., Muro, T., Takesaki, E., Takaki, H., Yamamoto, T., Kato, M., Nagaoki, Y., Hayashi, S., Ishida, J., Watanabe, Y., Kobayashi, M., Koga, M., Saoshiro, T., Yagura, M., Hirata, K., Tanaka, A., Takikawa, H., Zeniya, M., Abe, M., Onji, M., Kaneko, S., Honda, M., Arai, K., Arinaga-Hino, T., Hashimoto, E., Taniai, M., Umemura, T., Joshita, S., Nakao, K., Ichikawa, T., Shibata, H., Yamagiwa, S., Seike, M., Honda, K., Sakisaka, S., Takeyama, Y., Harada, M., Senju, M., Yokosuka, O., Kanda, T., Ueno, Y., Kikuchi, K., Ebinuma, H., Himoto, T., Yasunami, M., Murata, K., Mizokami, M., Kawata, K., Shimoda, S., Miyake, Y., Takaki, A., Yamamoto, K., Hirano, K., Ichida, T., Ido, A., Tsubouchi, H., Chayama, K., Harada, K., Nakanuma, Y., Maehara, Y., Taketomi, A., Shirabe, K., Soejima, Y., Mori, A., Yagi, S., Uemoto, S., H, E., Tanaka, T., Yamashiki, N., Tamura, S., Sugawara, Y., Kokudo, N., Chalasani, N., Luketic, V., Odin, J., Chopra, K., Abecasis, G., Cantor, M., Coppola, G., Economides, A., Lotta, L. A., Overton, J. D., Reid, J. G., Shuldiner, A., Beechert, C., Forsythe, C., Fuller, E. D., Gu, Z., Lattari, M., Lopez, A., Schleicher, T. D., Padilla, M. S., Toledo, K., Widom, L., Wolf, S. E., Pradhan, M., Manoochehri, K., Ulloa, R. H., Bai, X., Balasubramanian, S., Barnard, L., Blumenfeld, A., Eom, G., Habegger, L., Hawes, A., Khalid, S., Maxwell, E. K., Salerno, W., Staples, J. C., Jones, M. B., Mitnaul, L. J., Sturgess, R., Healey, C., Yeoman, A., Gunasekera, A. V., Kooner, P., Kapur, K., Sathyanarayana, V., Kallis, Y., Subhani, J., Harvey, R., Mccorry, R., Rooney, P., Ramanaden, D., Evans, R., Mathialahan, T., Gasem, J., Shorrock, C., Bhalme, M., Southern, P., Tibble, J. A., Gorard, D. A., Jones, S., Mells, G., Mulcahy, V., Srivastava, B., Foxton, M. R., Collins, C. E., Elphick, D., Karmo, M., Porras-Perez, F., Mendall, M., Yapp, T., Patel, M., Ede, R., Sayer, J., Jupp, J., Fisher, N., Carter, M. J., Koss, K., Shah, J., Piotrowicz, A., Scott, G., Grimley, C., Gooding, I. R., Williams, S., Tidbury, J., Lim, G., Cheent, K., Levi, S., Mansour, D., Beckley, M., Hollywood, C., Wong, T., Marley, R., Ramage, J., Gordon, H. M., Ridpath, J., Ngatchu, T., Bob Grover, V. P., Shidrawi, R. G., Abouda, G., Corless, L., Narain, M., Rees, I., Brown, A., Taylor-Robinson, S., Wilkins, J., Grellier, L., Banim, P., Das, D., Heneghan, M. A., Curtis, H., Matthews, H. C., Mohammed, F., Aldersley, M., Srirajaskanthan, R., Walker, G., Mcnair, A., Sharif, A., Sen, S., Bird, G., Prince, M. I., Prasad, G., Kitchen, P., Barnardo, A., Oza, C., Sivaramakrishnan, N. N., Gupta, P., Shah, A., Evans, C. D., Saha, S., Pollock, K., Bramley, P., Mukhopadhya, A., Barclay, S. T., Mcdonald, N., Bathgate, A. J., Palmer, K., Dillon, J. F., Rushbrook, S. M., Przemioslo, R., Mcdonald, C., Millar, A., Tai, C., Mitchell, S., Metcalf, J., Shaukat, S., Ninkovic, M., Shmueli, U., Davis, A., Naqvi, A., Lee, T. J., Ryder, S., Collier, J., Klass, H., Cramp, M. E., Sharer, N., Aspinall, R., Ghosh, D., Douds, A. C., Booth, J., Williams, E., Hussaini, H., Christie, J., Mann, S., Thorburn, D., Marshall, A., Patanwala, I., Ala, A., Maltby, J., Matthew, R., Corbett, C., Vyas, S., Singhal, S., Gleeson, D., Misra, S., Butterworth, J., George, K., Harding, T., Douglass, A., Mitchison, H., Panter, S., Shearman, J., Bray, G., Roberts, M., Butcher, G., Forton, D., Mahmood, Z., Cowan, M., Ch'Ng, C. L., Rahman, M., Whatley, G. C. A., Wesley, E., Mandal, A., Jain, S., Pereira, S. P., Wright, M., Trivedi, P., Gordon, F. H., Unitt, E., Palejwala, A., Austin, A., Vemala, V., Grant, A., Higham, A. D., Brind, A., Mathew, R., Cox, M., Ramakrishnan, S., King, A., Whalley, S., Fraser, J., Thomson, S. J., Bell, A., Wong, V. S., Kia, R., Gee, I., Keld, R., Ransford, R., Gotto, J., Millson, C., Cordell H.J., Fryett J.J., Ueno K., Darlay R., Aiba Y., Hitomi Y., Kawashima M., Nishida N., Khor S.-S., Gervais O., Kawai Y., Nagasaki M., Tokunaga K., Tang R., Shi Y., Li Z., Juran B.D., Atkinson E.J., Gerussi A., Carbone M., Asselta R., Cheung A., de Andrade M., Baras A., Horowitz J., Ferreira M.A.R., Sun D., Jones D.E., Flack S., Spicer A., Mulcahy V.L., Byan J., Han Y., Sandford R.N., Lazaridis K.N., Amos C.I., Hirschfield G.M., Seldin M.F., Invernizzi P., Siminovitch K.A., Ma X., Nakamura M., Mells G.F., Mason A., Vincent C., Xie G., Zhang J., Affronti A., Almasio P.L., Alvaro D., Andreone P., Andriulli A., Azzaroli F., Battezzati P.M., Benedetti A., Bragazzi M., Brunetto M., Bruno S., Calvaruso V., Cardinale V., Casella G., Cazzagon N., Ciaccio A., Coco B., Colli A., Colloredo G., Colombo M., Colombo S., Cristoferi L., Cursaro C., Croce L.S., Crosignani A., D'Amato D., Donato F., Elia G., Fabris L., Fagiuoli S., Ferrari C., Floreani A., Galli A., Giannini E., Grattagliano I., Lampertico P., Lleo A., Malinverno F., Mancuso C., Marra F., Marzioni M., Massironi S., Mattalia A., Miele L., Milani C., Morini L., Morisco F., Muratori L., Muratori P., Niro G.A., O'Donnell S., Picciotto A., Portincasa P., Rigamonti C., Ronca V., Rosina F., Spinzi G., Strazzabosco M., Tarocchi M., Tiribelli C., Toniutto P., Valenti L., Vinci M., Zuin M., Nakamura H., Abiru S., Nagaoka S., Komori A., Yatsuhashi H., Ishibashi H., Ito M., Migita K., Ohira H., Katsushima S., Naganuma A., Sugi K., Komatsu T., Mannami T., Matsushita K., Yoshizawa K., Makita F., Nikami T., Nishimura H., Kouno H., Ota H., Komura T., Nakamura Y., Shimada M., Hirashima N., Komeda T., Ario K., Nakamuta M., Yamashita T., Furuta K., Kikuchi M., Naeshiro N., Takahashi H., Mano Y., Tsunematsu S., Yabuuchi I., Shimada Y., Yamauchi K., Sugimoto R., Sakai H., Mita E., Koda M., Tsuruta S., Kamitsukasa H., Sato T., Masaki N., Kobata T., Fukushima N., Ohara Y., Muro T., Takesaki E., Takaki H., Yamamoto T., Kato M., Nagaoki Y., Hayashi S., Ishida J., Watanabe Y., Kobayashi M., Koga M., Saoshiro T., Yagura M., Hirata K., Tanaka A., Takikawa H., Zeniya M., Abe M., Onji M., Kaneko S., Honda M., Arai K., Arinaga-Hino T., Hashimoto E., Taniai M., Umemura T., Joshita S., Nakao K., Ichikawa T., Shibata H., Yamagiwa S., Seike M., Honda K., Sakisaka S., Takeyama Y., Harada M., Senju M., Yokosuka O., Kanda T., Ueno Y., Kikuchi K., Ebinuma H., Himoto T., Yasunami M., Murata K., Mizokami M., Kawata K., Shimoda S., Miyake Y., Takaki A., Yamamoto K., Hirano K., Ichida T., Ido A., Tsubouchi H., Chayama K., Harada K., Nakanuma Y., Maehara Y., Taketomi A., Shirabe K., Soejima Y., Mori A., Yagi S., Uemoto S., H E., Tanaka T., Yamashiki N., Tamura S., Sugawara Y., Kokudo N., Chalasani N., Luketic V., Odin J., Chopra K., Abecasis G., Cantor M., Coppola G., Economides A., Lotta L.A., Overton J.D., Reid J.G., Shuldiner A., Beechert C., Forsythe C., Fuller E.D., Gu Z., Lattari M., Lopez A., Schleicher T.D., Padilla M.S., Toledo K., Widom L., Wolf S.E., Pradhan M., Manoochehri K., Ulloa R.H., Bai X., Balasubramanian S., Barnard L., Blumenfeld A., Eom G., Habegger L., Hawes A., Khalid S., Maxwell E.K., Salerno W., Staples J.C., Jones M.B., Mitnaul L.J., Sturgess R., Healey C., Yeoman A., Gunasekera A.V., Kooner P., Kapur K., Sathyanarayana V., Kallis Y., Subhani J., Harvey R., McCorry R., Rooney P., Ramanaden D., Evans R., Mathialahan T., Gasem J., Shorrock C., Bhalme M., Southern P., Tibble J.A., Gorard D.A., Jones S., Mells G., Mulcahy V., Srivastava B., Foxton M.R., Collins C.E., Elphick D., Karmo M., Porras-Perez F., Mendall M., Yapp T., Patel M., Ede R., Sayer J., Jupp J., Fisher N., Carter M.J., Koss K., Shah J., Piotrowicz A., Scott G., Grimley C., Gooding I.R., Williams S., Tidbury J., Lim G., Cheent K., Levi S., Mansour D., Beckley M., Hollywood C., Wong T., Marley R., Ramage J., Gordon H.M., Ridpath J., Ngatchu T., Bob Grover V.P., Shidrawi R.G., Abouda G., Corless L., Narain M., Rees I., Brown A., Taylor-Robinson S., Wilkins J., Grellier L., Banim P., Das D., Heneghan M.A., Curtis H., Matthews H.C., Mohammed F., Aldersley M., Srirajaskanthan R., Walker G., McNair A., Sharif A., Sen S., Bird G., Prince M.I., Prasad G., Kitchen P., Barnardo A., Oza C., Sivaramakrishnan N.N., Gupta P., Shah A., Evans C.D., Saha S., Pollock K., Bramley P., Mukhopadhya A., Barclay S.T., McDonald N., Bathgate A.J., Palmer K., Dillon J.F., Rushbrook S.M., Przemioslo R., McDonald C., Millar A., Tai C., Mitchell S., Metcalf J., Shaukat S., Ninkovic M., Shmueli U., Davis A., Naqvi A., Lee T.J., Ryder S., Collier J., Klass H., Cramp M.E., Sharer N., Aspinall R., Ghosh D., Douds A.C., Booth J., Williams E., Hussaini H., Christie J., Mann S., Thorburn D., Marshall A., Patanwala I., Ala A., Maltby J., Matthew R., Corbett C., Vyas S., Singhal S., Gleeson D., Misra S., Butterworth J., George K., Harding T., Douglass A., Mitchison H., Panter S., Shearman J., Bray G., Roberts M., Butcher G., Forton D., Mahmood Z., Cowan M., Ch'ng C.L., Rahman M., Whatley G.C.A., Wesley E., Mandal A., Jain S., Pereira S.P., Wright M., Trivedi P., Gordon F.H., Unitt E., Palejwala A., Austin A., Vemala V., Grant A., Higham A.D., Brind A., Mathew R., Cox M., Ramakrishnan S., King A., Whalley S., Fraser J., Thomson S.J., Bell A., Wong V.S., Kia R., Gee I., Keld R., Ransford R., Gotto J., Millson C., Medical Research Council (MRC), LiveR North, Cordell, H, Fryett, J, Ueno, K, Darlay, R, Aiba, Y, Hitomi, Y, Kawashima, M, Nishida, N, Khor, S, Gervais, O, Kawai, Y, Nagasaki, M, Tokunaga, K, Tang, R, Shi, Y, Li, Z, Juran, B, Atkinson, E, Gerussi, A, Carbone, M, Asselta, R, Cheung, A, de Andrade, M, Baras, A, Horowitz, J, Ferreira, M, Sun, D, Jones, D, Flack, S, Spicer, A, Mulcahy, V, Byan, J, Han, Y, Sandford, R, Lazaridis, K, Amos, C, Hirschfield, G, Seldin, M, Invernizzi, P, Siminovitch, K, Ma, X, Nakamura, M, Mells, G, Mason, A, Vincent, C, Xie, G, Zhang, J, Affronti, A, Almasio, P, Alvaro, D, Andreone, P, Andriulli, A, Azzaroli, F, Battezzati, P, Benedetti, A, Bragazzi, M, Brunetto, M, Bruno, S, Calvaruso, V, Cardinale, V, Casella, G, Cazzagon, N, Ciaccio, A, Coco, B, Colli, A, Colloredo, G, Colombo, M, Colombo, S, Cristoferi, L, Cursaro, C, Croce, L, Crosignani, A, D'Amato, D, Donato, F, Elia, G, Fabris, L, Fagiuoli, S, Ferrari, C, Floreani, A, Galli, A, Giannini, E, Grattagliano, I, Lampertico, P, Lleo, A, Malinverno, F, Mancuso, C, Marra, F, Marzioni, M, Massironi, S, Mattalia, A, Miele, L, Milani, C, Morini, L, Morisco, F, Muratori, L, Muratori, P, Niro, G, O'Donnell, S, Picciotto, A, Portincasa, P, Rigamonti, C, Ronca, V, Rosina, F, Spinzi, G, Strazzabosco, M, Tarocchi, M, Tiribelli, C, Toniutto, P, Valenti, L, Vinci, M, Zuin, M, Nakamura, H, Abiru, S, Nagaoka, S, Komori, A, Yatsuhashi, H, Ishibashi, H, Ito, M, Migita, K, Ohira, H, Katsushima, S, Naganuma, A, Sugi, K, Komatsu, T, Mannami, T, Matsushita, K, Yoshizawa, K, Makita, F, Nikami, T, Nishimura, H, Kouno, H, Ota, H, Komura, T, Nakamura, Y, Shimada, M, Hirashima, N, Komeda, T, Ario, K, Nakamuta, M, Yamashita, T, Furuta, K, Kikuchi, M, Naeshiro, N, Takahashi, H, Mano, Y, Tsunematsu, S, Yabuuchi, I, Shimada, Y, Yamauchi, K, Sugimoto, R, Sakai, H, Mita, E, Koda, M, Tsuruta, S, Kamitsukasa, H, Sato, T, Masaki, N, Kobata, T, Fukushima, N, Ohara, Y, Muro, T, Takesaki, E, Takaki, H, Yamamoto, T, Kato, M, Nagaoki, Y, Hayashi, S, Ishida, J, Watanabe, Y, Kobayashi, M, Koga, M, Saoshiro, T, Yagura, M, Hirata, K, Tanaka, A, Takikawa, H, Zeniya, M, Abe, M, Onji, M, Kaneko, S, Honda, M, Arai, K, Arinaga-Hino, T, Hashimoto, E, Taniai, M, Umemura, T, Joshita, S, Nakao, K, Ichikawa, T, Shibata, H, Yamagiwa, S, Seike, M, Honda, K, Sakisaka, S, Takeyama, Y, Harada, M, Senju, M, Yokosuka, O, Kanda, T, Ueno, Y, Kikuchi, K, Ebinuma, H, Himoto, T, Yasunami, M, Murata, K, Mizokami, M, Kawata, K, Shimoda, S, Miyake, Y, Takaki, A, Yamamoto, K, Hirano, K, Ichida, T, Ido, A, Tsubouchi, H, Chayama, K, Harada, K, Nakanuma, Y, Maehara, Y, Taketomi, A, Shirabe, K, Soejima, Y, Mori, A, Yagi, S, Uemoto, S, H, E, Tanaka, T, Yamashiki, N, Tamura, S, Sugawara, Y, Kokudo, N, Chalasani, N, Luketic, V, Odin, J, Chopra, K, Abecasis, G, Cantor, M, Coppola, G, Economides, A, Lotta, L, Overton, J, Reid, J, Shuldiner, A, Beechert, C, Forsythe, C, Fuller, E, Gu, Z, Lattari, M, Lopez, A, Schleicher, T, Padilla, M, Toledo, K, Widom, L, Wolf, S, Pradhan, M, Manoochehri, K, Ulloa, R, Bai, X, Balasubramanian, S, Barnard, L, Blumenfeld, A, Eom, G, Habegger, L, Hawes, A, Khalid, S, Maxwell, E, Salerno, W, Staples, J, Jones, M, Mitnaul, L, Sturgess, R, Healey, C, Yeoman, A, Gunasekera, A, Kooner, P, Kapur, K, Sathyanarayana, V, Kallis, Y, Subhani, J, Harvey, R, Mccorry, R, Rooney, P, Ramanaden, D, Evans, R, Mathialahan, T, Gasem, J, Shorrock, C, Bhalme, M, Southern, P, Tibble, J, Gorard, D, Jones, S, Srivastava, B, Foxton, M, Collins, C, Elphick, D, Karmo, M, Porras-Perez, F, Mendall, M, Yapp, T, Patel, M, Ede, R, Sayer, J, Jupp, J, Fisher, N, Carter, M, Koss, K, Shah, J, Piotrowicz, A, Scott, G, Grimley, C, Gooding, I, Williams, S, Tidbury, J, Lim, G, Cheent, K, Levi, S, Mansour, D, Beckley, M, Hollywood, C, Wong, T, Marley, R, Ramage, J, Gordon, H, Ridpath, J, Ngatchu, T, Bob Grover, V, Shidrawi, R, Abouda, G, Corless, L, Narain, M, Rees, I, Brown, A, Taylor-Robinson, S, Wilkins, J, Grellier, L, Banim, P, Das, D, Heneghan, M, Curtis, H, Matthews, H, Mohammed, F, Aldersley, M, Srirajaskanthan, R, Walker, G, Mcnair, A, Sharif, A, Sen, S, Bird, G, Prince, M, Prasad, G, Kitchen, P, Barnardo, A, Oza, C, Sivaramakrishnan, N, Gupta, P, Shah, A, Evans, C, Saha, S, Pollock, K, Bramley, P, Mukhopadhya, A, Barclay, S, Mcdonald, N, Bathgate, A, Palmer, K, Dillon, J, Rushbrook, S, Przemioslo, R, Mcdonald, C, Millar, A, Tai, C, Mitchell, S, Metcalf, J, Shaukat, S, Ninkovic, M, Shmueli, U, Davis, A, Naqvi, A, Lee, T, Ryder, S, Collier, J, Klass, H, Cramp, M, Sharer, N, Aspinall, R, Ghosh, D, Douds, A, Booth, J, Williams, E, Hussaini, H, Christie, J, Mann, S, Thorburn, D, Marshall, A, Patanwala, I, Ala, A, Maltby, J, Matthew, R, Corbett, C, Vyas, S, Singhal, S, Gleeson, D, Misra, S, Butterworth, J, George, K, Harding, T, Douglass, A, Mitchison, H, Panter, S, Shearman, J, Bray, G, Roberts, M, Butcher, G, Forton, D, Mahmood, Z, Cowan, M, Ch'Ng, C, Rahman, M, Whatley, G, Wesley, E, Mandal, A, Jain, S, Pereira, S, Wright, M, Trivedi, P, Gordon, F, Unitt, E, Palejwala, A, Austin, A, Vemala, V, Grant, A, Higham, A, Brind, A, Mathew, R, Cox, M, Ramakrishnan, S, King, A, Whalley, S, Fraser, J, Thomson, S, Bell, A, Wong, V, Kia, R, Gee, I, Keld, R, Ransford, R, Gotto, J, Millson, C, Cordell HJ, Fryett JJ, Ueno K, Darlay R, Aiba Y, Hitomi Y, Kawashima M, Nishida N, Khor SS, Gervais O, Kawai Y, Nagasaki M, Tokunaga K, Tang R, Shi Y, Li Z, Juran BD, Atkinson EJ, Gerussi A, Carbone M, Asselta R, Cheung A, de Andrade M, Baras A, Horowitz J, Ferreira MAR, Sun D, Jones DE, Flack S, Spicer A, Mulcahy VL, Byan J, Han Y, Sandford RN, Lazaridis KN, Amos CI, Hirschfield GM, Seldin MF, Invernizzi P, Siminovitch KA, Ma X, Nakamura M, Mells GF, PBC Consortia, Canadian PBC Consortium, Chinese PBC Consortium, Italian PBC Study Group, Japan-PBC-GWAS Consortium, US PBC Consortium, UK-PBC Consortium, and Calvaruso V. .

Subjects
Liver Cirrhosis, ALSPAC, ERN RARE-LIVER, Genomic co-localization, Network-based in silico drug efficacy screening, UK-PBC, 0301 basic medicine, Candidate gene, Genome-Wide Association Study, Humans, Liver Cirrhosis, Biliary, Italian PBC Study Group, LD SCORE REGRESSION, Japan-PBC-GWAS Consortium, Genome-wide association study, Locus (genetics), Disease, SUSCEPTIBILITY, PBC, Chronic liver disease, Bioinformatics, GENETIC ASSOCIATION, 1117 Public Health and Health Services, 03 medical and health sciences, 0302 clinical medicine, UK-PBC Consortium, Genotype, Medicine, Genetic association, Science & Technology, Gastroenterology & Hepatology, Hepatology, business.industry, Biliary, Chinese PBC Consortium, 1103 Clinical Sciences, medicine.disease, PBC Consortia, 030104 developmental biology, Meta-analysis, ERN RARE LIVER, 030211 gastroenterology & hepatology, US PBC Consortium, Canadian PBC Consortium, business, Life Sciences & Biomedicine, Human
Abstract

[BACKGROUND & AIMS] Primary biliary cholangitis (PBC) is a chronic liver disease in which autoimmune destruction of the small intra-hepatic bile ducts eventually leads to cirrhosis. Many patients have inadequate response to licensed medications, motivating the search for novel therapies. Previous genome-wide association studies (GWAS) and meta-analyses (GWMA) of PBC have identified numerous risk loci for this condition, providing insight into its aetiology. We undertook the largest GWMA of PBC to date, aiming to identify additional risk loci and prioritise candidate genes for in silico drug efficacy screening. [METHODS] We combined new and existing genotype data for 10, 516 cases and 20, 772 controls from five European and two East Asian cohorts. [RESULTS] We identified 56 genome-wide significant loci (20 novel) including 46 in European, 13 in Asian, and 41 in combined cohorts; and a 57th genome-wide significant locus (also novel) in conditional analysis of the European cohorts. Candidate genes at newly identified loci include FCRL3, INAVA, PRDM1, IRF7, CCR6, CD226, and IL12RB1, each having key roles in immunity. Pathway analysis reiterated the likely importance of pattern recognition receptor and TNF signalling, Jak-STAT signalling, and differentiation of TH1 and TH17 cells in the pathogenesis of this disease. Drug efficacy screening identified several medications predicted to be therapeutic in PBC, some well-established in the treatment of other autoimmune disorders. [CONCLUSIONS] This study has identified additional risk loci for PBC, provided a hierarchy of agents that could be trialled in this condition, and emphasised the value of genetic and genomic approaches to drug discovery in complex disorders. [Lay summary] Primary biliary cholangitis (PBC) is a chronic liver disease that eventually leads to cirrhosis. In this study, we analysed genetic information from 10, 516 people with PBC and 20, 772 healthy individuals recruited in Canada, China, Italy, Japan, UK, or USA. We identified several genetic regions associated with PBC. Each of these regions contains several genes. For each region, we used diverse sources of evidence to help us choose the gene most likely to be involved in causing PBC. We used these ‘candidate genes’ to help us identify medications that are currently used for treatment of other conditions, which might also be useful for treatment of PBC., 原発性胆汁性胆管炎のゲノムワイド関連解析 --国際メタ解析による新規疾患感受性遺伝子と治療薬候補の同定--. 京都大学プレスリリース. 2021-06-28.

Published
2021

6. On the roles of central and peripheral vision in the extraction of material and form from a scene

Author

John Christie, Bryan Maycock, Mathew Reichertz, Raymond M. Klein, and Jack Wong

Subjects
Adult, Male, Linguistics and Language, genetic structures, Computer science, Experimental and Cognitive Psychology, Central region, 050105 experimental psychology, Language and Linguistics, Square (algebra), Task (project management), 03 medical and health sciences, 0302 clinical medicine, Humans, 0501 psychology and cognitive sciences, Computer vision, business.industry, 05 social sciences, eye diseases, Sensory Systems, Form Perception, Spatial relation, Peripheral vision, Central vision, Visual Perception, Female, Artificial intelligence, Visual Fields, business, Perceptual Masking, 030217 neurology & neurosurgery
Abstract

Conventional wisdom tells us that the appreciation of local (detail) and global (form and spatial relations) information from a scene is preferentially processed by central and peripheral vision, respectively. Using an eye monitor with high spatial and temporal precision, we sought to provide direct evidence for this idea by controlling whether carefully designed hierarchical scenes were viewed only with central vision (the periphery was masked), only with peripheral vision (the central region was masked), or with full vision. The scenes consisted of a neutral form (a D shape) composed of target circles or squares, or a target circle or square composed of neutral material (Ds). The task was for the participant to determine as quickly as possible whether the scene contained circle(s) or square(s). Increasing the size of the masked region had deleterious effects on performance. This deleterious effect was greater for the extraction of form information when the periphery was masked, and greater for the extraction of material information when central vision was masked, thus providing direct evidence for conventional ideas about the processing predilections of central and peripheral vision.

Published
2019

7. Methods for the evaluation of biomarkers in patients with kidney and liver diseases: multicentre research programme including ELUCIDATE RCT

Author

James Neuberger, Sue E. Bell, Michelle Hutchinson, Peter Heudtlass, Paul G. Richardson, Adebanji Adeyoju, Marc Jones, Michael P. Messenger, Anusha Edwards, Matthew Potton, Jacqueline Dinnes, Alice J Sitch, David A Cairns, Tilly Hale, Douglas Thompson, Claire Hulme, Roberta Longo, Stephanie Roberts, Paul D. Baxter, Joan Bedlington, Francesco Del Galdo, Sudeep Tanwar, William Rosenberg, Christopher McCabe, Nick Hornigold, Douglas Thorburn, John Christie, Jonathan J Deeks, Rosamonde E. Banks, Peter Selby, Andrew Lewington, Grant D. Stewart, Neil S. Sheerin, Tobias Livingstone, Sebastian Trainor, Vicky Napp, Paul Gibbs, Janine C Bestall, Jenny Hewison, Maureen Twiddy, Naeem Soomro, Walter M Gregory, Naveen S. Vasudev, Nicola Calder, Douglas G. Altman, Catharine M. Sturgeon, Julie Parkes, Matthew Welberry Smith, Carys Lippiatt, David Hrouda, Sheryl Sim, Neil Corrigan, and William McKane

Subjects
medicine.medical_specialty, business.industry, lcsh:Public aspects of medicine, MEDLINE, Psychological intervention, lcsh:RA1-1270, Disease, Health informatics, law.invention, Transplantation, Randomized controlled trial, law, Health care, medicine, Physical therapy, Biomarker (medicine), Intensive care medicine, business
Abstract

BackgroundProtein biomarkers with associations with the activity and outcomes of diseases are being identified by modern proteomic technologies. They may be simple, accessible, cheap and safe tests that can inform diagnosis, prognosis, treatment selection, monitoring of disease activity and therapy and may substitute for complex, invasive and expensive tests. However, their potential is not yet being realised.Design and methodsThe study consisted of three workstreams to create a framework for research: workstream 1, methodology – to define current practice and explore methodology innovations for biomarkers for monitoring disease; workstream 2, clinical translation – to create a framework of research practice, high-quality samples and related clinical data to evaluate the validity and clinical utility of protein biomarkers; and workstream 3, the ELF to Uncover Cirrhosis as an Indication for Diagnosis and Action for Treatable Event (ELUCIDATE) randomised controlled trial (RCT) – an exemplar RCT of an established test, the ADVIA Centaur® Enhanced Liver Fibrosis (ELF) test (Siemens Healthcare Diagnostics Ltd, Camberley, UK) [consisting of a panel of three markers – (1) serum hyaluronic acid, (2) amino-terminal propeptide of type III procollagen and (3) tissue inhibitor of metalloproteinase 1], for liver cirrhosis to determine its impact on diagnostic timing and the management of cirrhosis and the process of care and improving outcomes.ResultsThe methodology workstream evaluated the quality of recommendations for using prostate-specific antigen to monitor patients, systematically reviewed RCTs of monitoring strategies and reviewed the monitoring biomarker literature and how monitoring can have an impact on outcomes. Simulation studies were conducted to evaluate monitoring and improve the merits of health care. The monitoring biomarker literature is modest and robust conclusions are infrequent. We recommend improvements in research practice. Patients strongly endorsed the need for robust and conclusive research in this area. The clinical translation workstream focused on analytical and clinical validity. Cohorts were established for renal cell carcinoma (RCC) and renal transplantation (RT), with samples and patient data from multiple centres, as a rapid-access resource to evaluate the validity of biomarkers. Candidate biomarkers for RCC and RT were identified from the literature and their quality was evaluated and selected biomarkers were prioritised. The duration of follow-up was a limitation but biomarkers were identified that may be taken forward for clinical utility. In the third workstream, the ELUCIDATE trial registered 1303 patients and randomised 878 patients out of a target of 1000. The trial started late and recruited slowly initially but ultimately recruited with good statistical power to answer the key questions. ELF monitoring altered the patient process of care and may show benefits from the early introduction of interventions with further follow-up. The ELUCIDATE trial was an ‘exemplar’ trial that has demonstrated the challenges of evaluating biomarker strategies in ‘end-to-end’ RCTs and will inform future study designs.ConclusionsThe limitations in the programme were principally that, during the collection and curation of the cohorts of patients with RCC and RT, the pace of discovery of new biomarkers in commercial and non-commercial research was slower than anticipated and so conclusive evaluations using the cohorts are few; however, access to the cohorts will be sustained for future new biomarkers. The ELUCIDATE trial was slow to start and recruit to, with a late surge of recruitment, and so final conclusions about the impact of the ELF test on long-term outcomes await further follow-up. The findings from the three workstreams were used to synthesise a strategy and framework for future biomarker evaluations incorporating innovations in study design, health economics and health informatics.Trial registrationCurrent Controlled Trials ISRCTN74815110, UKCRN ID 9954 and UKCRN ID 11930.FundingThis project was funded by the NIHR Programme Grants for Applied Research programme and will be published in full inProgramme Grants for Applied Research; Vol. 6, No. 3. See the NIHR Journals Library website for further project information.

Published
2018

8. Illusory line motion is not caused by object-differentiating mechanisms or endogenous attention

Author

John Christie

Subjects
genetic structures, Physiology, media_common.quotation_subject, Experimental and Cognitive Psychology, Motion (physics), Discrimination Learning, Spatial Processing, Physiology (medical), Perception, Psychophysics, Humans, Attention, General Psychology, media_common, Communication, Optical Illusions, Optical illusion, business.industry, General Medicine, Object (philosophy), Neuropsychology and Physiological Psychology, Pattern Recognition, Visual, Line (geometry), Cues, Psychology, business, Photic Stimulation, Cognitive psychology
Abstract

Christie and Klein [2005. Does attention cause illusory line motion? Perception & Psychophysics, 67(6), 1032–1043] published line motion ratings consistent with illusory line motion (ILM) after peripheral endogenous cues but not central arrow cues. When attention was directed endogenously on the basis of the shape of one of two peripherally presented objects, participants reported small, but significant motion away from the attended object, and this was attributed to participant bias, or to a peripherally directed object-based attention system endogenously recruited to differentiate the peripheral shapes. By using a unique cueing method with identical peripheral markers, but still allowing them to act as cues, the findings of Christie and Klein Experiment 4 were replicated. This reduces the likelihood that object discrimination or object attention mechanisms are responsible for the reported ILM-like effects.

Published
2014
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9. Placeholders dissociate two forms of inhibition of return

Author

Matthew D. Hilchey, John Christie, and Jay Pratt

Subjects
Male, Visual perception, Formative Feedback, Physiology, media_common.quotation_subject, Experimental and Cognitive Psychology, Object processing, 050105 experimental psychology, Inhibition of return, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Physiology (medical), Perception, Orientation, Reaction Time, Humans, 0501 psychology and cognitive sciences, Attention, General Psychology, media_common, Communication, business.industry, 05 social sciences, Eye movement, General Medicine, Fixation (psychology), Response bias, Inhibition, Psychological, Neuropsychology and Physiological Psychology, Covert, Visual Perception, Female, Cues, Psychology, business, 030217 neurology & neurosurgery, Photic Stimulation, Cognitive psychology
Abstract

Decades of research using Posner’s classic spatial cueing paradigm has uncovered at least two forms of inhibition of return (IOR) in the aftermath of an exogenous, peripheral orienting cue. One prominent dissociation concerns the role of covert and overt orienting in generating IOR effects that relate to perception- and action-oriented processes, respectively. Another prominent dissociation concerns the role of covert and overt orienting in generating IOR effects that depend on object- and space-based representation, respectively. Our objective was to evaluate whether these dichotomies are functionally equivalent by manipulating placeholder object presence in the cueing paradigm. By discouraging eye movements throughout, Experiments 1A and 1B validated a perception-oriented form of IOR that depended critically on placeholders. Experiment 2A demonstrated that IOR was robust without placeholders when eye movements went to the cue and back to fixation before the manual response target. In Experiment 2B, we replicated Experiment 2A’s procedures except we discouraged eye movements. IOR was observed, albeit only weakly and significantly diminished relative to when eye movements were involved. We conclude that action-oriented IOR is robust against placeholders but that the magnitude of perception-oriented IOR is critically sensitive to placeholder presence when unwanted oculomotor activity can be ruled out.

Published
2016

10. Unpacking a Wicked Problem: Enablers/Impediments to Regional Engagement

Author

Michael John Christie, David Pickernell, and Patricia A Rowe

Subjects
Unpacking, Government, Wicked problem, Public Administration, Sociology and Political Science, business.industry, Stakeholder, Context (language use), Public relations, Regional development, Local government, Political science, business, Triple helix
Abstract

A case study approach is applied to review Local Government Authorities (LGA) regional engagement in the Australian context. We address the question 'What are the key LGA enablers/impediments to regional engagement?' by applying Leydesdorff's (2000) proposition that triple helix type network systems exhibit patterns of complex behaviour if the interaction factors that trigger enablers are reflexively declared. The three strands of the LGA triple helix network system are institutions, industry and government. In this case study the LGA's overall management of its regional stakeholder relationships resulted in impediments that limit strong regional engagement. Importantly, the findings inform practitioners, policy-makers and research audiences of the nature of impediments and, by inference, the nature of enablers in LGA triple helix network systems.

Published
2009
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11. Improved electric field modelling for TDR

Author

Ian Woodhead, Graeme D. Buchan, John Christie, and Ian Platt

Subjects
Field (physics), Discretization, business.industry, Applied Mathematics, Basis function, Integral equation, Moment (mathematics), Optics, Electric field, Applied mathematics, Limit (mathematics), business, Reflectometry, Instrumentation, Engineering (miscellaneous), Mathematics
Abstract

Integral equation (IE) methods may be used to model the interaction between microwave signals and porous materials and hence lead to improvements in time-domain reflectometry (TDR) or other techniques for measurement of moisture content. Although they may employ pulse basis functions to represent the field in each cell of the discretized region, the inherent approximations limit accuracy. Higher order basis functions provide one alternative, but here we describe a method that retains the geometric and cell density advantages of delta functions, and improves accuracy by correcting for the field integration errors of the conventional moment method. Our approach circumvents errors that arise when assuming that the field of a cell is adequately represented by a source at its centre, and results in close agreement between empirical results and the model.

Published
2007
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12. 'Street' and Prescription Drug Abuse

Author

Sharon S. Kelley, James Godin, and John Christie

Subjects
Substance abuse, medicine.medical_specialty, business.industry, Anesthesia, medicine, Methamphetamine, business, medicine.disease, Psychiatry, Amphetamine, Prescription drug abuse, medicine.drug
Published
2015
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13. Vector averaging of inhibition of return

Author

Eric M. J. Morris, Raymond M. Klein, and John Christie

Subjects
Cued speech, Communication, Angular distance, business.industry, Experimental and Cognitive Psychology, Inhibition of return, Orienting response, Inhibition, Psychological, User-Computer Interface, Eye position, Center of gravity, Arts and Humanities (miscellaneous), Fixation (visual), Reaction Time, Developmental and Educational Psychology, Humans, Computer vision, Artificial intelligence, Cues, Psychology, business, Neural coding
Abstract

Observers detected targets presented 400 msec after a display containing one cue or two to four cues displayed simultaneously in randomly selected locations on a virtual circle around fixation. The cue arrangement was completely uninformative about the upcoming target's location, and eye position was monitored to ensure that the participants maintained fixation between the cue and their manual detection response. Reflecting inhibition of return (IOR), there was a gradient of performance following single cues, with reaction time decreasing monotonically as the target's angular distance from the cued direction increased. An equivalent gradient of IOR was found following multiple cues whose center of gravity fell outside the parafoveal region and, thus, whose net vector would activate an orienting response. Moreover, on these trials, whether or not the targeted location had been stimulated by a cue had little effect on this gradient. Finally, when the array of cues was balanced so that its center of gravity was at fixation, there was no IOR. These findings, which suggest that IOR is an aftermath of orienting elicited by the cue, are compatible with population coding of the entire cue (as a grouped array for multiple cues) as the generator of IOR.

Published
2005
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14. A water content sensor for baked products

Author

John Christie, Richard Fenton, Ian M. Woodhead, and Kenji Irie

Subjects
Ingredient, Moisture, business.industry, Moisture measurement, Food products, Mixing (process engineering), Environmental science, Relative humidity, Experimental work, Process engineering, business, Water content
Abstract

The water content of baked products such as bread, cake and biscuits, affect the texture, colour, keeping qualities and consumer acceptance. Currently, moisture content is controlled by ensuring a uniform set of ingredients, mixing and baking, but inevitably variation arises from, for example, variation in ingredient characteristics, position within ovens and ambient temperature and relative humidity. A water content sensor that can measure on-line moisture after baking and adjust oven temperature distribution or just the mean oven temperature, will lead to more consistent products. This paper outlines requirements of a sensor for on-line measurement of moisture content, describes a sensor concept that meets these requirements, and then presents the results from experimental work that determined typical permittivity values of bread, one of the target baked products.

Published
2014
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15. Inhibition of return is at the midpoint of simultaneous cues

Author

Matthew D. Hilchey, Raymond M. Klein, and John Christie

Subjects
Adult, Male, Linguistics and Language, Adolescent, Computer science, Poison control, Experimental and Cognitive Psychology, Language and Linguistics, Inhibition of return, Young Adult, Reaction Time, Saccades, Humans, Cued speech, Communication, Reactive inhibition, business.industry, Eye movement, Reactive Inhibition, Sensory Systems, Center of gravity, Saccade, Female, Cues, Neural coding, business, Neuroscience, Photic Stimulation
Abstract

When multiple cues are presented simultaneously, Klein, Christie, and Morris (Psychonomic Bulletin & Review 12:295-300, 2005) found a gradient of inhibition (of return, IOR), with the slowest simple manual detection responses occurring to targets in the direction of the center of gravity of the cues. Here, we explored the possibility of extending this finding to the saccade response modality, using methods of data analysis that allowed us to consider the relative contributions of the distance from the target to the center of gravity of the array of cues and the nearest element in the cue array. We discovered that the bulk of the IOR effect with multiple cues, in both the previous and present studies, can be explained by the distance between the target and the center of gravity of the cue array. The present results are consistent with the proposal advanced by Klein et al., (2005) suggesting that this IOR effect is due to population coding in the oculomotor pathways (e.g., the superior colliculus) driving the eye movement system toward the center of gravity of the cued array.

Published
2013

16. Temporal order judgments activate temporal parietal junction

Author

John Christie, Ben Davis, and Chris Rorden

Subjects
Male, Visual perception, Journal Club, media_common.quotation_subject, Lateralization of brain function, Judgment, Perception, Parietal Lobe, Neural Pathways, medicine, Reaction Time, Humans, Attention, Rectangle, media_common, Communication, medicine.diagnostic_test, business.industry, General Neuroscience, Temporal Lobe, Time Perception, Female, business, Functional magnetic resonance imaging, Psychology, Photic Stimulation, Cognitive psychology
Abstract

Perceptual temporal order judgments require an individual to determine the relative timing of two spatially separate events. Here we reveal the brain regions involved with this task. We had participants observe perceptually identical visual stimuli while conducting two different tasks: discriminating temporal order or discriminating spatial properties. By contrasting the functional magnetic resonance imaging signals during these tasks, we were able to isolate regions specifically engaged by each task. Participants observed two briefly presented rectangles. In one task, participants were instructed to report which appeared first, and, in the other, they were requested to report which rectangle was squarer. A potential confound of this study is that the temporal order judgment (TOJ) task required processing of brief events (onsets), whereas the shape task did not require temporal selectivity. To address this, we conducted a second study in which both tasks required discriminating brief events concurrent with the object onsets. The stimuli were similar to the first experiment, except a gray line was briefly superimposed on each rectangle at onset. Participants reported either which rectangle appeared first (TOJ) or which rectangle had a slightly wider gray line (shape). The first study found that the TOJ task resulted in greater bilateral activation of the temporal parietal junction (TPJ). The second revealed TOJ activation in the TPJ of the left hemisphere. This suggests that TPJ activation increases when we need to temporally sequence information. This finding supports the notion that the TPJ may be a crucial component of the “when” pathway.

Published
2009

17. Subconjunctival High Dose Plasminogen Activator in Rabbit Filtration Surgery

Author

John Christie, Gary B. Bodiford, Randall C. Dunn, Glenn H. Strauss, and Esther T. Dunn

Subjects
Pathology, medicine.medical_specialty, genetic structures, medicine.medical_treatment, Statistics as Topic, Glaucoma, Pilot Projects, Trabeculectomy, Placebos, Postoperative Complications, Double-Blind Method, Fibrosis, Ophthalmology, Image Processing, Computer-Assisted, medicine, Animals, Pharmacology (medical), Bleb (cell biology), Intraocular Pressure, Pharmacology, Drug Carriers, Chemotherapy, Lagomorpha, biology, business.industry, medicine.disease, biology.organism_classification, Recombinant Proteins, eye diseases, Filtration surgery, Tissue Plasminogen Activator, Rabbits, sense organs, Complication, business, Gels, Plasminogen activator, Sclera
Abstract

The primary cause of failure in glaucoma filtration surgery is fibroblastic proliferation and subconjunctival fibrosis at the bleb site resulting in decreased aqueous flow. We evaluated New Zealand white rabbits in a masked, placebo controlled pilot study to determine the potential reduction of episcleral fibrosis at the surgical bleb site utilizing 0.3 mls of: balanced salt solution (n = 11); an inert gel delivery vehicle (n = 13); the gel delivery vehicle with incorporated recombinant tissue plasminogen activator (tpa; n = 14), 1 mg/ml. Statistical analysis of computer assisted area measurements from multiple histologic sections demonstrated a significant decrease in episcleral fibrosis in the t-PA group as compared to the two other groups (p less than 0.05). Results from the t-PA group did not demonstrate an effect on intraocular pressure. There was no clinical evidence of toxicity or healing complications in the t-PA group.

Published
1991
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18. The effect of gaze on gaze direction while looking at art

Author

John Christie, Kristie R. Dukewich, and Raymond M. Klein

Subjects
Generality, Communication, Direction detection, Social communication, business.industry, media_common.quotation_subject, Eye movement, Experimental and Cognitive Psychology, Observer (special relativity), Fixation, Ocular, Gaze, Arts and Humanities (miscellaneous), Pattern Recognition, Visual, Perception, Orientation, Fixation (visual), Developmental and Educational Psychology, Saccades, Humans, Paintings, Cues, Nonverbal Communication, business, Psychology, media_common
Abstract

In highly controlled cuing experiments, conspecific gaze direction has powerful effects on an observer’s attention. We explored the generality of this effect by using paintings in which the gaze direction of a key character had been carefully manipulated. Our observers looked at these paintings in one of three instructional states (neutral, social, or spatial) while we monitored their eye movements. Overt orienting was much less influenced by the critical gaze direction than what the cuing literature might suggest: An analysis of the direction of saccades following the first fixation of the critical gaze showed that observers were weakly biased to orient in the direction of the gaze. Over longer periods of viewing, however, this effect disappeared for all but the social condition. This restriction of gaze as an attentional cue to a social context is consistent with the idea that the evolution of gaze direction detection is rooted in social communication. The picture stimuli from this experiment can be downloaded from the Psychonomic Society’s Archive of Norms, Stimuli, and Data, www.psychonomic.org/archive.

Published
2008

19. Does attention cause illusory line motion?

Author

Raymond M. Klein and John Christie

Subjects
Cued speech, Communication, genetic structures, Property (programming), business.industry, Optical Illusions, Perceptual illusion, Motion Perception, Experimental and Cognitive Psychology, Sensory Systems, Motion (physics), Small magnitude, Visual attention, Humans, Attention, sense organs, Line (text file), business, Psychology, Neuroscience, General Psychology
Abstract

Illusory line motion (ILM) has been shown to occur when a line is presented with one end next to a previously stimulated location. The line appears to be drawn away from the site of stimulation. It has been suggested that this is because of the allocation of attention to the stimulated site. Using an endogenous attentional manipulation (a central arrow cue) with no differences in the display between the two ends of the line at the time of line presentation or immediately prior, no ILM was detected, though there was a small effect in the opposite direction. Those who have found endogenously induced ILM have used an endogenous cue based on a property of a location marker that indicated the cued location. Changing the method of cuing to one based on a property of a peripheral marker instead of a central arrow produced a small but significant report of ILM. The small magnitude of the effect, participant self-reports, and the absence of the effect in the purely endogenous condition, suggest that this was merely a bias. ILM is not generated by endogenous attention shifts.

Published
2006

21. Educating children about heart disease

Author

John Christie, Grace M. Lindsay, Allan Gaw, Christopher J. Packard, and James Shepherd

Subjects
Male, medicine.medical_specialty, Educational measurement, Heart disease, business.industry, Coronary Disease, General Medicine, Disease, Coronary disease, medicine.disease, Coronary heart disease, Basic knowledge, Risk Factors, Family medicine, Surveys and Questionnaires, medicine, Physical therapy, Humans, Health education, Female, Educational Measurement, business, Child, Health Education, Computer-Assisted Instruction
Abstract

The authors have designed a computer-based health education programme introducing coronary heart disease (CHD) prevention to primary school children using the novel authoring system, Course Builder. To aid design of the programme, the basic knowledge of a randomly selected group of 90 children aged 8-11 years old from three city schools was assessed, using a questionnaire in storyline format. This surveyed children's understanding of the heart's basic function, the importance and prevalence of CHD, and perception of CHD as a preventable disease. The children's response after using the programme and their increased knowledge and awareness were evaluated, and the programme was deemed an overwhelming success.

Published
1994

22. Micro-finance agencies and SMEs: model of explication of tacit knowledge

Author

Frank Hoy, Michael John Christie, and Patricia A Rowe

Subjects
Economics and Econometrics, Entrepreneurship, Microfinance, Knowledge management, business.industry, Public relations, Small business, law.invention, Micro finance, Explication, Tacit knowledge, law, Preparedness, Business and International Management, business, Set (psychology)
Abstract

This paper contributes to a new area of research, namely: institutional preparedness of economic development agencies for developing small and medium-sized enterprises (SMEs). The cases presented illustrate variations in the micro-finance lender agency-enterprise development of processes for sharing vision and interdependence. In clarifying the nature of the agency-enterprise relationship along these two dimensions, we develop a set of propositions. Our model contends: 1) that effective processes for sharing vision and good cooperation maximise the likelihood of explication of tacit knowledge; 2) that ineffective processes for sharing vision and good cooperation lead to ad hoc explication of tacit knowledge; 3) ineffective processes for sharing vision and poor cooperation minimise the likelihood of explication of tacit knowledge; 4) effective processes for sharing vision and poor cooperation maximise the likelihood of explication of tacit knowledge.

Published
2010
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23. Discussion on 'Notes on surface condensing plants, with special reference to the requirements of large power stations'

Author

J.C. Wigham, P.R. Boulton, R.A. Chattock, W.M. Selvey, S.B. Donkin, G.W. Partridge, C.C. Paterson, John Christie, F. Bailey, W.B. Woodhouse, E.R. Briggs, I.V. Robinson, G.R.J. Parkinson, S.F. Walker, F.F.P. Bisacre, R.J. Kaula, F. Forrest, and E.H. Cockshott

Subjects
Surface (mathematics), Engineering, Power station, business.industry, Electrical engineering, Mechanical engineering, business
Published
1919
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25. Discussion on 'Stand-by charges and motor load development' before the Birmingham Local Section

Author

S.E.F Fedden, R.A. Dawbarn, Andrew Wright, W.R. Cooper, G. Wilkinson, W. Fennell, P.J. Pringle, J.C. Vaudrey, J.S. Highfield, W.A. Vignoles, H.L.P. Boot, Rosemary Wilson, L. Gaster, J.A. Jeckell, K.A. Chattock, R.K. Morcom, Alexander Siemens, W.E. Sumpner, John Christie, A.M. Taylor, W.H. Patchell, C.E.C. Shawfield, W.C.P. Tapper, and C.P. Sparks

Subjects
Engineering, business.industry, Section (archaeology), Forensic engineering, Mechanical engineering, Motor load, business
Published
1905
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26. 2. Theory of Construction of the Great Pyramid

Author

John Christie

Subjects
business.industry, Computer science, Pyramid, General Engineering, Computer vision, Artificial intelligence, business
Abstract

In his early investigations on the principles of construction of the Great Pyramid, the author was forcibly struck with the following fact—viz., that if a perpendicular be drawn through the apex of the Pyramid to its base, and the unit angle with the horizontal thrown up from the base on each side of this perpendicular, the angle comes out on the faces of the Pyramid at the openings of the north and south ventilating air-channels; at the same time he was led to the conclusion that one-tenth of the base line, and the same tenths also applied to the faces of the Pyramid, ruled the entire structure.

Published
1871
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28. Idiopathic Presinusoidal Portal Hypertension (Banti's Syndrome)

Author

Benjamin Sullivan, Arthur H. Cohen, Edwin Polish, and John Christie

Subjects
Liver Cirrhosis, medicine.medical_specialty, Banti's syndrome, Cirrhosis, Pancytopenia, Anemia, Portal venous pressure, Gastroenterology, Hypersplenism, Medical Records, Internal medicine, Hypertension, Portal, Internal Medicine, medicine, Humans, Stage (cooking), business.industry, Medical record, Idiopathic Noncirrhotic Portal Hypertension, General Medicine, medicine.disease, Hypertension, Splenomegaly, Portal hypertension, business
Abstract

Excerpt In 1894 Banti (1) reported a disease characterized by splenomegaly and "cirrhosis" of the liver. He described three stages: the anemic stage in which hypersplenism was the only finding; the...

Published
1962
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