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The present report describes a case of Epstein-Barr virus (EBV)-positive mucocutaneous ulcer (EBVMCU) with an ulcerative lesion on the right tongue. A 69-year-old Japanese woman with awareness of pain in the right lingual margin visited our hospital. The patient had rheumatoid arthritis and had been treated with methotrexate (MTX) for 9 years. Vitiligo was found throughout the oral cavity, and ulceration was found on the right tongue. Under a diagnosis of oral candidiasis and suspected right tongue tumor, treatment for candidiasis and biopsy of the right tongue ulcer were performed. Histopathological results were positive for CD20 and CD30 and negative for CD3 and CD5. EBV-encoded small RNA in situ hybridization confirmed positive results in large, atypical cells, suggesting involvement of EBV. EBVMCU was diagnosed based on the history of MTX use associated with rheumatoid arthritis, blood biochemical findings, and histopathological findings. The ulcer on the right tongue margin resolved spontaneously after treatment for oral candidiasis prior to discontinuation of MTX. No recurrence was seen for 18 months.

Burkitt lymphoma (BL) is an aggressive form of non-Hodgkin B-cell lymphoma, with three subtypes: endemic, sporadic, and human immunodeficiency associated subtypes. Endemic BL typically involves the mandible, maxilla, and abdomen, whereas sporadic BL usually presents as an abdominal mass involving the mesenteric lymph nodes or ileocecal region, and jaw involvement is uncommon. In pediatric patients, oral BL commonly presents as facial swelling with an intraoral exophytic mass and is usually accompanied by mobile, displaced, and/or painful teeth. We report sporadic BL initially presented as orofacial manifestations in an 8-year-old boy, and conduct a mini-review. He had left facial and gingival swelling. CT revealed the lesions were located at the left anterior maxilla and the masticator muscle, and PET showed multiple lesions. An incisional biopsy of left anterior maxillary gingiva was performed, and the pathological diagnosis was BL. Oral management has been performed since initial chemotherapy, and tumor remission was achieved by chemotherapy with the B-NHL03 study regimen at our pediatric department. There was no recurrence of the tumor 5 years after chemotherapy. Dentists and oral surgeons should be aware that dental problems including floating teeth and/or alveolar bone resorption might be the first clinical manifestation of BL. Because the success of intensive treatment relies on good supportive care, oral management plays an important role to maintain oral hygiene.

Objective Intra-oral minor salivary gland tumors are relatively rare. This study aimed to clarify the frequency and distribution of intra-oral minor salivary gland tumors in Japanese patients. Methods We retrospectively analyzed the histopathological records of 131 patients with minor salivary gland tumors that were surgically treated between 1967 and 2017 at a single institution. Results Of the 131 minor salivary gland tumors, 61 (47%) were benign and 70 (53%) were malignant. The male:female ratio was 1:1.8 for benign cases and 1:1 for malignant cases. Most of the tumors occurred in the palate, followed by the floor of the mouth. The most frequent minor salivary gland tumor was pleomorphic adenoma among benign tumors and adenoid cystic carcinoma among malignant tumors. The rarest minor salivary gland tumors were Warthin tumors and basal cell adenocarcinoma, accounting for only 0.8% of all cases. Conclusions The present study determined the incidence rates of these rare tumors.

Osteomas are benign, slow-growing osteogenic tumors that consist of compact or cancellous bone. They sometimes arise from the craniomaxillofacial region. Among the peripheral, central, and extraskeletal types, peripheral osteomas arise from the periosteum, usually as unilateral, pedunculated, mushroom-like masses. Here, we report an unusual peripheral osteoma arising from the lateral surface of the mandibular ramus. A 57-year-old woman with a mass at the left mandibular ramus was referred to us. The hard and immobile mass had been growing for 15 years, and she had facial asymmetry. She had no trismus, temporomandibular joint dysfunction, previous facial trauma, or infection. Computed tomography showed a mushroom-like lesion (21.1 × 13.4 × 13.1 mm) arising from the lateral surface of the left mandibular ramus. Clinical diagnosis was peripheral osteoma. The lesion was removed using rotary instruments and a chisel through an intraoral approach under general anesthesia. The lesion had intruded into the masseter muscle. Pathological diagnosis was compact osteoma. The postoperative course was uneventful and there has been no recurrence 1.5 years after surgery.

BACKGROUND The aim of this study was to evaluate the prognostic factors and treatment outcomes of advanced maxillary gingival squamous cell carcinoma (SCC) treated with intra-arterial infusion chemotherapy concurrent with radiotherapy. METHODS A total of 46 patients were reviewed retrospectively in this study. The treatment schedule comprised intra-arterial chemotherapy (total, 60 mg/m2 docetaxel and 150 mg/m2 cisplatin) and three-dimensional computed tomography based, daily conventional radiotherapy (total, 60 Gy/30 fr) for 6 weeks. RESULTS The median follow-up period was 40 months (range, 3-110 months). The 3-year overall survival and locoregional control rates for all patients were 64.3% and 84.3%, respectively. The OS rate of the patients with N0-1 was significantly higher than that of the patients with N ≥ 2 (P

Humanoid robots are typical application of real-time systems and have required timing constraints, low-latency, and parallel/distributed processing to achieve fine-grained real-time execution. Therefore, we have developed Dependable Responsive Multithreaded Processor I (D-RMTP I), which has one Responsive Multithreaded Processing Unit with an 8-way prioritized Simultaneous Multithreading architecture. In addition, D-RMTP I has Responsive Link, which is a communication standard as specified in ISO/IEC 24740:2008 for distributed real-time systems. Our previous work presented Responsive Task, which is a low-latency real-time task with the interrupt wake-up structure on D-RMTP I. Unfortunately, Responsive Task does not support real-time communication. We present Responsive Task for real-time communication by using Responsive Link. Responsive Task for real-time communication can be waked up with low-latency by the external interrupt when packets in Responsive Link are received. Experimental results by using Responsive Link show that Responsive Tasks outperform real-time tasks with respect to the overhead of wake-up, the response time, and the jitter.

Cyber-Physical Systems (CPS) are tight integrations of computational and physical worlds for various kinds of applications. For example, a humanoid robot, which is a typical application of CPS, has required timing constraints, low-latency execution, and parallel processing to achieve fine-grained real-time execution. Therefore low-latency parallel real-time computing is an important factor for CPS. In order to achieve such CPS applications, commercial off-the-shelf systems including processors and operating systems are difficult due to many requirements including such system performance and space constraints, and hence proprietary systems are favored. We had developed Dependable Responsive Multithreaded Processor I (D-RMTP I), which has one Responsive Multithreaded Processing Unit (RMT PU) with an 8-way prioritized Simultaneous Multithreading architecture, for parallel real-time computing. In addition, we have developed a high-end processor of D-RMTP I, called Dependable Responsive Multithreaded Processor II (D-RMTP II). D-RMTP II has two RMT PUs for high throughput and eight Flower cores for I/O processing. Our previous work presented Responsive Task, which is a low-latency real-time task with the interrupt wake-up structure to occupy a hardware thread in D-RMTP I for fine-grained real-time execution. Responsive Task can be executed in dozens of microsecond periods with low-jitter though executing real-time tasks simultaneously. Unfortunately, Responsive Task does not support parallel computing. This paper presents Parallel Responsive Task, which is an extension to Responsive Task for parallel computing on D-RMTP II. Evaluations show that Parallel Responsive Task improves the throughput and achieves fine-grained real-time execution with reasonable overhead.

The robotics field provides with many typical applications of Cyber-Physical Systems (CPS). Robots are expected to be deployed in a wide variety of applications including life supporting work or disaster response and therefore they need to follow strict safety and dependability constraints. In order to create robots with high utility, safety and dependability, research has focused both on creating mechanically safe systems and safe control laws. Throughout the present work, we use the embedded real-time processor D-RMTP as a motor controller to attain high responsiveness on a high power robot. D-RMTP has a hardware mechanism to support hard real-time processing, which enables lower-jitter and lower-overhead processing compared with conventional software based real-time execution (Real-Time Task). Responsive Task, a real-time execution mechanism based on D-RMTP, has also been proposed in recent works. In this paper, we have evaluated the effects of the low-jitter and low-overhead performance of Responsive Task on a distributed robot control system. The result of the experiment showed that Responsive Task resulted in improving the control cycle speed and the responsiveness of the controller.