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A compact and simple double F-P interference optical fiber optic gas pressure sensor based on suspended core structure is proposed and demonstrated. The sensor is formed by splicing a section of thin-walled grapefruit photonic crystal fiber (G-PCF) with single-mode fiber (SMF). By adjusting the special fusion parameters, a short air-cavity region is formed in the G-PCF next to the splicing point with the SMF segment, and the other end of the G-PCF segment is open to the atmosphere. The output interference spectrum of the sensor comprises of two spectral parameters that have different sensitivities to temperature and gas pressure. One of them is the wideband envelope that is associated with the air-cavity and it is only sensitive to the gas pressure but insensitive to the change of ambient temperature. This property is particularly useful for addressing the complex temperature-pressure cross sensitivity of both spectral parameters. The research findings indicate that the sensor can perform an accurate measurement for gas pressure in dynamic range of 0-1.0 MPa under the high temperature condition up to 500 °C.

Warpage deformation is a common defect in the glass fiber-reinforced plastic (GFRP) injection molding process. In this study, a case study of the GFRP product is proposed. Firstly, with the minimum warpage deformation as the optimization objective, three significant factors affecting product quality (the first stage packing pressure, injection time, and melt temperature) are selected from nine process parameters by using Plackett Burman. Then, the three selected significant factors are considered as design variables, and Box-Behnken design (BBD) is used to design the experiment. Warpage analysis is performed based on Moldflow simulation software. Secondly, on the basis of the BBD experimental samples and results, a regression model by compound optimization, back-propagation neural network based on adaptive boosting and genetic algorithm (AdaBoost-GA-BP) model is established. To further illustrate the prediction accuracy of the model, response surface methodology model, back propagation neural network (BPNN) model, back-propagation neural network based on genetic algorithm (GA-BPNN) model are taken as comparative algorithms. The results show that the prediction system of the AdaBoost-GA-BP model has good stability and accuracy. Finally, the particle swarm optimization approach is used to search for the minimum warpage. It can be concluded that the quality of the plastic part after optimization has been improved.

The traditional dance training process lacks a certain degree of scientificity due to the lack of precise motion capture and analysis system, which directly affects the final training effect. In view of the robust limitations of the type 1 fuzzy reinforcement learning flexible structure control system to the uncertainty of noise interference, based on the reinforcement learning algorithm, this paper proposes a flexible structure controller based on the type 2 fuzzy reinforcement learning algorithm. Moreover, this paper uses fuzzy sets with equidistant fuzzy centers to divide large-scale state or continuous state space into two types of fuzzy divisions, divide the action space uniformly, and build fuzzy rules based on the basic ideas of type 1 fuzzy reinforcement learning. In addition, this paper constructs an evaluation system for factors affecting dance training effects based on reinforcement learning and designs experiments to verify the performance of the system. The research results show that the system constructed in this paper meets the theoretical needs and can be applied to dance training practice later.

Traditional masonry structures have prominent problems, such as high building energy consumption and poor seismic performance. In view of this situation, the research group proposed a structural system of self-insulating inner-framed bearing walls (SIBWs) based on the integration of seismic and energy conservation. In this paper, five SIBWs were designed and manufactured. The influence of openings on the seismic performance of the structures was studied, and the unified calculation formula for the seismic bearing capacity was established by a low cycle cyclic loading test. The results showed that all five specimens had a high seismic bearing capacity; ductility coefficients of 2.95, 3.03, 4.09, 3.55, and 3.67, indicating good ductility and deformation capacity; and that the failure modes were all ductile failure modes. The openings had a significant influence on the hysteretic curve, skeleton curve, stiffness, and energy-dissipation capacity of the SIBWs. The failure process of the test wall was characterized by the interaction, transition, and weak framework stages. In theory, based on the equivalent elastic plate model, the unified calculation method of the wall cracking load was established. Based on the idea of the shear resistance mechanism, the diagonal compression bar model of the rigid frame was proposed, and the unified calculation method of the ultimate load of the wall was also established. A comparison with the measured values shows that the calculation method is accurate and that it helps to promote the integrated development of seismic and energy conservation for masonry structures, especially in rural areas.

The injection molding process of a mold with multiple cavities can reduce the mold space, but the process is complicated and the product is prone to warpage. In order to reduce the transparent parts warpage of such a mold, by optimizing injection molding process parameters, an optimization technique combining orthogonal experiment, Kriging model and an optimization algorithm is proposed. First, the orthogonal experiment is designed, based on Computer Aided Engineering (CAE) simulation results, while the significant factors affecting the warpage are selected. On this basis, the Kriging model is established to map the nonlinear function relationship between the significant factors and the warpage. Specifically in this paper, four types of correlation functions, affecting the model precision accuracy, are used to establish the Kriging model and the high-precision accuracy model is selected. A numerical optimization algorithm, direct search approach and global exploration method are used to optimize the model, so as to obtain the optimal injection molding parameters producing the minimum warpage. Finally, CAE simulation and experimental validation prove the effectiveness and reliability of the proposed optimization method.

Objective A role of diffusion-weighted imaging (DWI) in the diagnosis of cerebral venous thrombosis (CVT) is not wellunderstood. This study evaluates the effectiveness of DWI in the diagnosis of CVT. Methods Literature search was conducted in electronic databases for the identification of studies which reported the outcomes of patients subjected to DWI for CVT diagnosis. Random-effects meta-analyses were performed to achieve overall estimates of important diagnostic efficiency indices including hyperintense signal rate, the sensitivity and specificity of DWI in diagnosing CVT, and the apparent diffusion coefficient (ADC) of DWI signal areas and surrounding tissue. Results Nineteen studies (443 patients with 856 CVTs; age 40 years [95% confidence interval (CI), 33 to 43]; 28% males [95% CI, 18 to 38]; symptom onset to DWI time 4.6 days [95% CI, 2.3 to 6.9]) were included. Hyperintense signals on DWI were detected in 40% (95% CI, 26 to 55) of the cases. The sensitivity of DWI for detecting CVT was 22% (95% CI, 11 to 34) but specificity was 98% (95% CI, 95 to 100). ADC values were quite heterogenous in DWI signal areas. However, generally the ADC values were lower in DWI signal areas than in surrounding normal areas (mean difference−0.33×10-3 mm2/s [95% CI, −0.44 to −0.23]; p

Although Ti3C2Tx MXene sheets are highly conductive, it is still a challenge to design highly stretchable MXene electrodes for flexible electronic devices. Inspired by the high stretchability of kirigami patterns, we demonstrate a bottom-up methodology to design highly stretchable and conductive polydimethylsiloxane (PDMS)/Ti3C2Tx MXene films for electromagnetic interference (EMI) shielding and pressure sensing applications by constructing wrinkled MXene patterns on a flexible PDMS substrate to create a hierarchical surface with primary and secondary surface wrinkles. The self-controlled microcracks created in the valley domains of the hierarchical film via a nonuniform deformation during prestretching/releasing cycles endow the hierarchical PDMS/MXene film with a high stretchability (100%), strain-invariant conductivity in a strain range of 0%-100%, and stable conductivities over an 1000-cycle fatigue measurement. The stretchable film exhibits a highly stable EMI shielding performance of ≈30 dB at a tensile strain of 50%, and its EMI shielding efficiency increases further to 103 dB by constructing a two-film structure. Furthermore, a highly stretchable and sensitive iontronic sensor array with integrated MXene-based electrodes and circuits is fabricated by a stencil printing process, exhibiting high sensitivity (66.3 nF kPa-1), excellent dynamic cycle stability over 1000 cycles under different frequencies, and sensitive pressure monitoring capability under a tensile strain of 50%.

OBJECTIVE To describe the 10-year prevalence of pressure injury (PI) in a tertiary hospital in China and determine the clinical characteristics of inpatients with PI. METHODS The authors performed a retrospective analysis of PI cases extracted from the electronic health record of a tertiary hospital. The trend of PI prevalence over 10 years was described by estimating the average percent change (EAPC). Comorbidities were described with the Charlson Comorbidity Index (CCI). The clinical characteristics of PI were described using the number of cases and composition ratio. RESULTS The overall prevalence of PI was 0.59% (5,838/986,404). From 2009 to 2018, the rate increased from 0.19% to 1.00% (EAPC = 22.46%). When stage I PIs were excluded, the prevalence of PI ranged from 0.15% to 0.79% (EAPC = 21.90%). The prevalence of hospital-acquired PI was 0.13%. Prevalence increased with age (Ptrend < .001) and was significantly higher in men than women (P < .001). Patients with PI were more widely distributed in the ICU (20.58%), vasculocardiology department (11.73%), gastroenterology department (10.18%), and OR (8.29%). Of patients with PI, 71.3% had a CCI score 4 or higher. CONCLUSIONS The PI prevalence in the study facility increased rapidly over the study period. Pressure injuries among patients in the gastroenterology department and in the community deserve more attention. The CCI may be a good indicator for PI risk assessment.

Background: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and has a poor prognosis due to the high incidence of invasion and metastasis-related progression. However, the underlying mechanism remains elusive, and valuable biomarkers for predicting invasion, metastasis, and poor prognosis of HCC patients are still lacking. Methods: Immunohistochemistry (IHC) was performed on HCC tissues (n = 325), and the correlations between MST4 expression of the clinical HCC tissues, the clinicopathologic features, and survival were further evaluated. The effects of MST4 on HCC cell migratory and invasive properties in vitro were evaluated by Transwell and Boyden assays. The intrahepatic metastasis mouse model was established to evaluate the HCC metastasis in vivo. The PI3K inhibitor, LY294002, and a specific siRNA against Snail1 were used to investigate the roles of PI3K/AKT pathway and Snail1 in MST4-regulated EMT, migration, and invasion of HCC cells, respectively. Results: In this study, by comprehensively analyzing our clinical data, we discovered that low MST4 expression is highly associated with the advanced progression of HCC and serves as a prognostic biomarker for HCC patients of clinical-stage III-IV. Functional studies indicate that MST4 inactivation induces epithelial-to-mesenchymal transition (EMT) of HCC cells, promotes their migratory and invasive potential in vitro, and facilitates their intrahepatic metastasis in vivo, whereas MST4 overexpression exhibits the opposite phenotypes. Mechanistically, MST4 inactivation elevates the expression and nuclear translocation of Snail1, a key EMT transcription factor (EMT-TF), through the PI3K/AKT signaling pathway, thus inducing the EMT phenotype of HCC cells, and enhancing their invasive and metastatic potential. Moreover, a negative correlation between MST4 and p-AKT, Snail1, and Ki67 and a positive correlation between MST4 and E-cadherin were determined in clinical HCC samples. Conclusions: Our findings indicate that MST4 suppresses EMT, invasion, and metastasis of HCC cells by modulating the PI3K/AKT/Snail1 axis, suggesting that MST4 may be a potential prognostic biomarker for aggressive and metastatic HCC.

To evaluate the prevalence of Helicobacter pylori infection and risk factors and to serotype the strains in Wuwei, located in north-western China, which has a high incidence of gastric cancer.Helicobacter pylori infection was analysed in 21 291 adults byThe infection rate of H. pylori was 53.0%, and 90.1% of strains were type I strains. The H. pylori infection rate was higher among farmers (OR = 1.34, 95% CI: 1.19-1.50) and individuals who had a junior high school or higher education level (OR = 1.10, 95% CI: 1.06-1.15), and was lower in older individuals (OR = 0.86, 95% CI: 0.83-0.90), individuals with high income (OR = 0.93, 95% CI: 0.90-0.95), individuals with a habit of eating quickly (OR = 0.93, 95% CI: 0.87-0.99) and individuals who consumed more fruit and vegetables (OR = 0.90, 95% CI: 0.85-0.95). Individuals with history of cholecystitis/cholecystolithiasis, hypertension and asthma were negatively correlated with H. pylori infection (P 0.05).The prevalence of H. pylori infection is high in Wuwei. The major prevalent strain is type I strain. Age, education, occupation, household income, consumption of fruit and vegetables, and habit of eating quickly are independent risk factors for H. pylori infection, which is also associated with individuals with a history of extragastric diseases.Evaluer la prévalence de l'infection à Helicobacter pylori et les facteurs de risque et déterminer le sérotype des souches à Wuwei, situé dans le nord-ouest de la Chine, où l'incidence du cancer gastrique est élevée. MÉTHODES: L'infection à H. pylori a été analysée chez 21.291 adultes par un test respiratoire à l'urée auLa prévalence de l'infection à H. pylori est élevée à Wuwei. La principale souche répandue est du type I. L'âge, l'éducation, la profession, le revenu du ménage, la consommation de fruits et de légumes et l'habitude de manger rapidement sont des facteurs de risque indépendants d'infection à H. pylori, qui est également associée à des personnes ayant des antécédents de maladies extra-gastriques.

To observe the time-effect relationship of moxibustion for primary dysmenorrhea (PD) due to stagnation and congelation of cold-damp, thus explore the optimal choice of moxibustion duration, and provide evidence for achieving satisfactory efficacy in moxibustion treatment. A total of 90 patients with PD due to stagnatin and congelation of cold-damp were divided into three groups by the random number table method, with 30 cases in each group. All the patients in the three groups were given moxibustion treatment at Guanyuan (CV 4), 20 min in group A, 40 min in group B and 60 min in group C. The changes in the pain measurement score in the three groups were observed after treatment. After treatment, there were significant differences in the clinical efficacy among the three groups (P

Crawler rice combine harvester threshing rack excited by different frequencies of multiple working parts would cause strong vibration response. In this paper, the rack-type rice combine harvester threshing rack was taken as research objective, and then the static analysis of the existing threshing rack was carried out by ANSYS Finite Element software. The topology of the rack structure was optimized according to the stress and strain distribution of the threshing rack. Based on solving the 6 natural frequencies and mode shapes of the threshing rack of combine harvester, the morphological test of threshing rack was carried out and the reliability of the modal analysis was verified. Finally, the multivibration source was assembled on the rack for simulation to test and verify the optimization effectiveness. Results showed that the 1st to 6th natural frequency of threshing rack after modal optimization could avoid the excitation frequency of the working part. Compared with the original design, the optimized threshing rack had a weight reduction of 13.7%. This study can provide a theoretical reference for the structural design and optimization of combine harvester threshing rack.

Ghrelin plays a pivotal role in the regulation of food intake, body weight and energy metabolism. However, these effects of ghrelin in the lateral parabrachial nucleus (LPBN) are unexplored. C57BL/6J mice and GHSR−/− mice were implanted with cannula above the right LPBN and ghrelin was microinjected via the cannula to investigate effect of ghrelin in the LPBN. In vivo electrophysiological technique was used to record LPBN glucose-sensitive neurons to explore potential udnderlying mechanisms. Microinjection of ghrelin in LPBN significantly increased food intake in the first 3 h, while such effect was blocked by [D-Lys3]-GHRP-6 and abolished in GHSR−/− mice. LPBN ghrelin microinjection also significantly increased the firing rate of glucose-excited (GE) neurons and decreased the firing rate of glucose-inhibited (GI) neurons. Additionally, LPBN ghrelin microinjection also significantly increased c-fos expression. Chronic ghrelin administration in the LPBN resulted in significantly increased body weight gain. Meanwhile, no significant changes were observed in both mRNA and protein expression levels of UCP-1 in BAT. These results demonstrated that microinjection of ghrelin in LPBN could increase food intake through the interaction with growth hormone secretagogue receptor (GHSR) in C57BL/6J mice, and its chronic administration could also increase body weight gain. These effects might be associated with altered firing rate in the GE and GI neurons.

Huawei serves as a vehicle for presenting the multiple barriers faced by Multinational Enterprises (MNEs) that happen to be born in China, a non-democratic and non-Western country who now challenges the world’s No.1 superpower, thus requires a multi-disciplinary analytical framework by taking much broader contexts into considerations. This comparative case study of its operations in the US and UK aims to develop the old model of examining Chinese MNEs that is heavily economic factor focused by including more variables, such as ‘bilateral relations’, ‘law’, ‘media influence’ and ‘cultural proximity’ under host country factors, and ‘governance structure’ under home country factors. The new model will show the increasing complexity in the global competitive landscape and inspire more research to further advance understanding of this new international business phenomenon.

This article considers the issue of whether Singapore should amend its trust laws to allow for non-charitable purpose trusts (NCPTs) for the specific purpose of holding company shares in perpetuity. The authors argue that such trusts should be allowed for two reasons. First, NCPTs in general should not be regarded as repugnant to the trust concept. Secondly, the practical advantages of allowing non-charitable trusts in a limited fashion outweigh the disadvantages. The article concludes by proposing possible reforms to the Singapore trust legislation.

Although flexible, transparent, and conductive materials are increasingly required for electromagnetic interference (EMI) shielding applications in foldable and wearable electronics, it remains a g...

The goal of this study was twofold: firstly, to investigate vocational accounting students’ attitudes towards sustainable development; secondly, to explore the influence of students’ professional s...

After the completion of fracturing operation in coalbed methane (CBM), the fracturing fluid needs to flow back to the ground in time to reduce the damage to the coal reservoir. The damage of guar-based fracturing fluid to the coal reservoir has an adverse effect on the fracturing stimulation. A series of flow experiments were carried out with the unconventional natural gas reservoir damage evaluation equipment. This paper investigates the evolution of fracture permeability in coal samples during the process of hydroxypropyl guar (HPG) fracturing fluid flow back. The experimental results show that the fracturing fluid concentration, proppant type, proppant particle size, and proppant concentration all affect fracture permeability. The high concentration of fracturing fluid caused irreversible damage to fracture permeability of coal samples. With the increase of fracturing fluid concentration, the permeability damage rate increased from 65.31% to 84.57%, and the damage degree was strong. KCL brine flushing can only decrease the damage rate of coal sample fracture permeability within a certain range. The proppant embedment and the generation of pulverized coal exacerbated the damage of fracture permeability. The research results can be beneficial for optimizing the type and performance of fracturing fluid for hydraulic fracturing in CBM reservoir.

Ground penetrating radar (GPR) is a widely used nondestructive testing tool. This letter presents a modified model for quasi-monostatic configured GPRs. In this model, the antenna effects are represented by a set of linear transfer functions and the GPR responses of the layered media are modelled by 3-D Green’s functions. In order to obtain sufficient accuracy, the proposed model includes a special effect such that a part of the electromagnetic wave, propagating directly from the transmitting antenna to the receiving antenna, is reflected outside as a new transmitting signal. The experimental results of the full-waveform inversion have demonstrated that considering this special effect in the quasi-monostatic model is effective for improving accuracy. Although both monostatic and quasi-monostatic GPRs can be accurately modelled for full-waveform inversion, the results of the experiment performing inversion of a three-layer media with low permittivity contrast, proved that the latter can achieve better performance due to its intrinsic higher signal-to-noise ratio (SNR).

This paper discusses the differences in perceived usability evaluations between crowdsourcing platform and laboratory testing. A retrospective evaluation measurement method was adopted. A SUS quali...

Virtopsy technology is noninvasive, noncontact, and can find potential lesions. For these reasons, it has broad application prospects in forensic pathology and forensic clinical science. The present article reviews the brief history of virtopsy development, introduces the application of virtopsy in various fields of forensic medicine, summarizes the current situation regarding virtopsy in China, and puts forward suggestions for strengthening planning, setting standards, strengthening assistance, and promoting scientific research.

Background: Pancreatic cancer (PC) is one of the most common digestive malignancy, with severe cancer-related death and disease burden. Yes-associated protein 1 (YAP1) has been reported to be involved in the tumorigenesis and progression of several cancers, thus leading to poor prognosis of patients. However, the relationship between YAP1 and immune microenvironment in PC deserve more scrutiny. Methods: GEPIA, OncoLnc, PROGgeneV2 and HPA database were utilized to analyze the expression (transcriptome and protein levels) and overall survival of YAP1 in PC. Then, we evaluated the risk factors associated with overall survival based on public data from TCGA-PAAD via Cox regression. Besides, LinkedOmics was utilized to identify co-expression genes and the potential regulation network of YAP1. Furthermore, we explored the relationship between YAP1 and immune infiltration using CIBERSORT algorithm and GEPIA database. Results: The age, lymph node metastasis status and up-regulated YAP1 expression have been proved to be independent prognostic factors for poor prognosis. The functions of YAP1 and co-expression genes were mainly involved in the angiogenesis, immune response-regulating signaling pathway, regulation of actin cytoskeleton, NOD-like receptor signaling pathway and cytokine-cytokine receptor interaction. Specifically, increased YAP1 expression was significantly correlated with immune infiltrating levels of resting CD4+T cells. Conclusions: Our findings provide evidence of the immune regulatory role of YAP1 in PC and help elucidate the role of YAP1 in carcinogenesis as well.

Tuberculosis (TB) remains a global healthcare crisis, with an estimated 5.8 million new cases and 1.5 million deaths in 2020. TB is caused by infection with the major human pathogen Mycobacterium tuberculosis, which is difficult to rapidly diagnose and treat. There is an urgent need for new methods of diagnosis, sufficient in vitro models that capably mimic all physiological conditions of the infection, and high-throughput drug screening platforms. Microfluidic-based techniques provide single-cell analysis which reduces experimental time and the cost of reagents, and have been extremely useful for gaining insight into monitoring microorganisms. This review outlines the field of microfluidics and discusses the use of this novel technique so far in M. tuberculosis diagnostics, research methods, and drug discovery platforms. The practices of microfluidics have promising future applications for diagnosing and treating TB.

According to the data of the national transmission line icing trip accidents, this paper uses data mining technology to preprocess the trip data, and uses data analysis technology to mine and analyze the main influencing factors of the line icing trip, including meteorological factors, micro terrain factors and the combination of line parameters and meteorological parameters, etc The main reason and mechanism of transmission line icing trip are analyzed.

Tuberculosis (TB) remains a global healthcare crisis with an estimated 10 million new cases and 1.4 million deaths per year TB is caused by infection with the major human pathogen Mycobacte-rium tuberculosis, which is difficult to rapidly diagnose and treat. There is an urgent need for new methods of diagnosis, sufficient in vitro models which capably mimic all physiological condi-tions of the infection, and high-throughput drug screening platforms. Microfluidic-based tech-niques provide single-cell analysis which reduces experimental time, the cost of reagents, and have been extremely useful for gaining insight into monitoring microorganisms. This review out-lines the field of microfluidics and discusses the use of this novel technique so far in M. tuberculo-sis diagnostics, research methods, and drug discovery platforms. The practices of microfluidics have promising future applications for diagnosing and treating TB.

The manipulator launched with the TianHe capsule is currently the most complex, intelligent, and integrated space intelligence system in China. It indicates that China has become the world's third country after Canada and Japan who has the ability to independently develop the Space Station Manipulator. When designing the manipulator, we have to concern the space environment of vibration, vacuum, thermal and electromagnetic radiation in aerospace, and the joints must adapt to the space environment. By adopting a series of methods of multi-point compression, solid silicate bonded MoS2 known as PM5, a combining of active thermal control and passive thermal control, the problem of environmental adaptability is solved. The joint successfully passed the verification of mechanical test, thermal cycle test, thermal vacuum test and life test. The environmental adaptability design and verification of the joint can be used as a reference for joints and end effectors of space manipulator.

It is necessary to elucidate the potential risk factors of pulmonary infection to provide references for the management of breast cancer. Our study was a retrospective design, patients who underwent modified radical mastectomy for breast cancer in our department of breast surgery from January 2019 to November 2020 were included. The personal and clinical data of included patients with and without pulmonary infection were compared. A total of 234 patients with radical mastectomy were included, the incidence of pulmonary infection was 15.38% with 95%confidence interval (CI) 11.42% to 18.98%. There were significant differences in the age, body mass index, diabetes, duration of surgery, combined radiotherapy and chemotherapy, and duration of drainage between patients with and without pulmonary infections (all P

Deep neural networks are prone to catastrophic forgetting when incrementally trained on new classes or new tasks as adaptation to the new data leads to a drastic decrease of the performance on the old classes and tasks. By using a small memory for rehearsal and knowledge distillation, recent methods have proven to be effective to mitigate catastrophic forgetting. However due to the limited size of the memory, large imbalance between the amount of data available for the old and new classes still remains which results in a deterioration of the overall accuracy of the model. To address this problem, we propose the use of the Balanced Softmax Cross-Entropy loss and show that it can be combined with exiting methods for incremental learning to improve their performances while also decreasing the computational cost of the training procedure in some cases. Experiments on the competitive ImageNet, subImageNet and CIFAR100 datasets show states-of-the-art results.

In order to develop a new kind low-dimensional and efficient chaff interference mode, a discontinuous super-long chaff made of S-type glass fiber is proposed. In this paper, its kinematics and scattering characteristics in the thin atmosphere are emphatically studied. Simulation results show that long chaffs have stronger shape-maintaining ability and better interference effect than the traditional dipole chaffs under different polarization conditions.

Many scholars have already studied the daybook (rishu 日書) text titled “Stars” (Xing 星), which was included among the excavated Qin manuscripts at Shuihudi 睡虎地. The Corpus of Qin Documents Written On Bamboo and Wood (Qin jiandu heji 秦簡牘合集) can be seen as a consequential culmination of these studies. Based on a collative approach, this article offers a comparative reading by citing ancient theories on astrological divination in order to clarify the provenance of passages found within the “Stars” text. Through such a comparative study, it is possible to provide an enhanced explanation of certain passages, somewhat different from the understandings of other scholars.

Objective: To investigate the ameliorating effect of ginsenoside Rg1 on the depression-like behaviors induced by chronic restraint stress (CRS) in rats and the underlying mechanisms. Methods: Forty male Wistar rats were divided into 4 groups according to their baseline sucrose preference: control group, model group, and Rg1-treated groups (5 and 10 mg/kg). Except for control group, the groups were exposed to CRS (6 h/day) for 28 days. All drugs were intraperitoneally administered once daily to CRS rats after restraint stress for 14 days. The behavioral tests were carried out via the open field test (OFT), sucrose preference test (SPT), forced swim test (FST), and the Morris water maze (MWM) 4 weeks following CRS induction. The levels of serum corticosterone (CORT) and the activities of the antioxidant defense biomarkers (SOD, MDA and GSH-x) in the prefrontal cortex (PFC) were analyzed using commercial ELISA kits. The levels of the neurotransmitter (5-HT, 5-HIAA, Ach, NE, GABA and Glu) in the PFC were measured by ultra-performance liquid chromatography tandem mass spectrometry. The protein expression of BDNF, Trkb, Bax and Bcl-2 in the PFC was detected by western blotting. Results: Owing to increased sucrose consumption in the SPT, decreased immobility time in the FST, and the improved cognitive performance in MWM, chronic treatment with Ginsenoside Rg1 was found to significantly attenuate depression- like behaviors (anhedonia, behavioral despair and poor spatial memory) in rats. Moreover, CRS exposure caused evident alterations in the levels of the neurotransmitters (5-HT, 5-HIAA, Ach, GABA and Glu) and the activities of the antioxidant defense biomarkers (SOD, MDA and GSH-x) in the PFC and the levels of corticosterone in serum. However, Ginsenoside Rg1 treatment could restore these levels to normal values. Additionally, Ginsenoside Rg1 treatment significantly reverted the decreased expression of BDNF, Trkb and Bcl-2 and the increased expression of Bax in the PFC of CRS rats. Conclusions: Ginsenoside Rg1 could attenuate the CRS-induced depression-like behaviors, in part, by regulating neurotransmitter levels and HPA function, antagonizing oxidative stress and apoptosis, and restoring BDNF-TrkB signaling in PFC. Altogether, our results provide a novel basis regarding the potential therapeutic effects of Rg1 on depression. Keywords: Ginsenosides Rg1, Depression, Chronic restraint stress, Neurotransmitter, Oxidative stress, BDNF

A Wi-Fi scatter communication method based on microcontroller unit (MCU) is proposed, and an ultra-low power micro Wi-Fi scatter communication device μWi-Fi is designed and implemented. First, according to the characteristics of the microcontroller, the software virtual modulation method and the serial communication port direct memory access (DMA) transmission method is proposed to realise Wi-Fi scattering communication. Then the MCU + exclusive OR (XOR) baseband architecture is proposed to further reduce the main frequency of the microcontroller and the system power consumption. The communication test and power consumption measurement results show that μWi-Fi can generate signals conforming to the IEEE802.11b standard, which can be received and forwarded by universal Wi-Fi routers. Its effective communication distance reaches 15 m, its communication peak current reaches 720 μA, and its standby current reaches 390 nA. Compared with traditional internet of things (IOTs) Wi-Fi devices, μWi-Fi can not only reduce the power consumption of Wi-Fi communication by 2–3 orders but also has a simple composition and low cost, which is very helpful for the rapid development of Wi-Fi IoT products.

Current therapeutic approaches have a limited effect on cardiac remodeling, which is characteristic of cardiac fibrosis and myocardial hypertrophy. In this study, we examined whether Danshenol A (DA), an active ingredient extracted from the traditional Chinese medicine Radix Salviae, can attenuate cardiac remodeling and clarified the underlying mechanisms. Using the spontaneously hypertensive rat (SHR) as a cardiac remodeling model, DA ameliorated blood pressure, cardiac injury, and myocardial collagen volume and improved cardiac function. Bioinformatics analysis revealed that DA might attenuate cardiac remodeling through modulating mitochondrial dysfunction and reactive oxygen species. DA repaired the structure/function of the mitochondria, alleviated oxidative stress in the myocardium, and restored apoptosis of cardiomyocytes induced by angiotensin II. Besides, DA inhibited mitochondrial redox signaling pathways in both the myocardium and cardiomyocytes. Thus, our study suggested that DA attenuates cardiac remodeling induced by hypertension through modulating mitochondrial dysfunction and reactive oxygen species.

This paper investigates the pressure-relief response of the floor in top slice mining, taking No. 2 coal seam in Jinta coal mine as its engineering background. The failure laws of the lower slice along strike and with depth during the top slice mining process are analyzed with comprehensive methods including theoretical calculation, similar simulation, and numerical simulation. It is found that physical experiments on similar materials and numerical simulation with FLAC3D software using a Mohr–Coulomb model give comparable results, both indicating that floor destruction in the top slice reaches a depth of about 20 m. The empirical formula is found to be non-applicable for predicting the depth of damage in the top slice when mining an extra-thick seam. It is further shown that the lower slice is able to restrict floor failure. In the mining direction, the distribution and change characteristics of stress are highly correlated with the periodic weighting: the range over which stress recovery occurs in the floor after periodic weighting is about 0.6 times that before periodic weighting. The conclusions are of engineering significance for the accurate arrangement of gas drainage boreholes and the avoidance of mine gas disasters. On the basis of all the rules, the practical application of gas drainage of the lower slice was carried out, which is beneficial for coal mining and economic achievements at the same time.

Roux-en-Y gastric bypass (RYGB) is considered effective for weight loss and for treatment of many obesity-related metabolic diseases. Ghrelin is an essential orexigenic peptide that plays an indispensable role in controlling body weight and energy homeostasis of post-operative patients. This systematic review and meta-analysis aimed to investigate changes in the level of fasting total ghrelin following RYGB. A systematic literature search of PubMed, EMBASE, and the Cochrane Library until April 2018 with keywords “ghrelin” and “gastric bypass” was performed in accordance with the MOOSE guidelines and PRISMA statement. Three reviewers independently selected the studies and extracted data. Quality assessment of the included studies was undergone. A random effects model was employed to calculate overall effect sizes. Subgroup analyses and meta-regression were subsequently performed. Sixteen studies with 325 patients were included. We found ghrelin levels had an increasing tendency (SMD = 0.30; 95% CI = 0.04 to 0.57) despite moderate heterogeneity (I2 = 58%). Subsequent subgroup analysis indicated that ghrelin levels decreased (SMD = − 0.49; 95% CI = − 0.98 to 0.00) in the short term (≤ 3 months) and increased (SMD = 0.46; 95% CI = 0.22 to 0.69) in the long term (> 3 months) after RYGB. Meta-regression showed that gastric pouch volume, alimentary limb length and biliopancreatic limb length were not associated with changes in ghrelin levels. Fasting total ghrelin levels decreased in the short term (≤ 3 months) and increased in the long term (> 3 months) after RYGB.

Fulfilling users' needs and increasing the retention rate of recommendation systems are challenging. Most users have consumed a few items in most systems. Translation-based model performs well on sparse datasets. However, a user and only single previous item are considered for the user suggestion of next items. Alternatively, recurrent neural network utilizes sequential dependency but performs poorly on sparse datasets. We unify both and propose Recurrent Translation-based Network (RTN). RTN utilizes sequences of users' consumed items without limiting interactions between items to the most recent one. The results of conducting experiments on real-world datasets show that RTN outperforms other state-of-the-art approaches on sparse datasets.

Background: Hodgkin lymphoma (HL) is one of the most frequent cancers occurring at a young age. Although diagnosis of HL is not difficult, a minimally invasive method to diagnose HL, and a radiation-free method to confirm the remission status are highly desired. Methods: In this study, we employed cutting-edge Luminex technology to evaluate 67 soluble plasma proteins for their suitability for diagnosis and for confirming remission of classical HL (cHL). Results: Soluble cluster of differentiation (CD)30 and CC motif chemokine ligand (CCL)22 were identified to be capable of differentiating cHL patients from healthy donors and from patients with diffuse large B cell lymphoma (DLBCL), a disease that shares many characteristics with cHL. Soluble tumor necrosis factor receptor (TNFR)2 was found to be lower in the remission than in the initial diagnosis cohort of cHL patients, and also to be lower in plasmas at remission than in plasmas at initial diagnosis from the same patients. In DLBCL plasmas, concentrations of interleukin (IL)-2, soluble IL-2 receptor and IL-31 changed in patients upon entering remission. Conclusions: Measurement of these factors may: 1) provide a minimally-invasive method to diagnose and differentiate HL and DLBCL, and 2) make it possible to monitor the remission status of these patients without use of radiation-based imaging. J Hematol. 2019;8(2):47-54 doi: https://doi.org/10.14740/jh499

A compact high-amplitude electromagnetic field pulse generator with tunable parameters, such a pulse wide, rising time, amplitude, is developed between a transmission stripline. The rising time can be tuned down to 8.2 ns, and the half pulse width up to 1730.8 ns, and the peak electromagnetic field up to 270 kV/m. By using a step motorina gas-fill vessel to move the electrodes, the discharge process can be controlled automatically by using a computer. The stability of the electromagnetic field between the impedance-matched transmission stripline then is characterized systematically in this paper.

In this paper, the simulation model of millimeter wave reflected, absorbed and transmitted characteristics in underdense uniform plasma is established. The calculation of reflection energy, transmission energy and absorption energy of millimeter wave is completed. The frequency of millimeter wave is 50-100GHz, and other parameters such as polarization, incident angle, plasma length are different. The results are shown that the propagation characteristics of millimeter wave in plasma are the same although polarization is different. Thin plasma can hardly absorb millimeter wave energy; when the plasma has centimeter scale, the millimeter wave energy can be absorbed more than 95% by optimizing the plasma parameters. The propagation characteristics of millimeter wave at different incident angles are obviously different.

This paper investigates the key technology of a K-band linearized channel amplifier (LCAMP) which can be used on a satellite. The LCAMP is placed in front of a traveling wave tube amplifier (TWTA) to improve nonlinearity of the TWTA, it consists of three modules: a channel amplifier, a linearizer, and a DC control circuit, which enables control of channel gain and output power. It also has a certain temperature compensation effect. The actual frequency range covers from 17.7GHz to 19.7GHz.