2,317 results on '"Leduc BE"'
Search Results
2. It's Material
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Froemming, Denise LeDuc
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Business schools ,Banking, finance and accounting industries ,Business - Abstract
Once Upon a Time... There's something about a good story that captures our attention, our imagination and our emotions. Dr. Jennifer Aaker, author, speaker and professor at Stanford Graduate School [...]
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- 2024
3. The Rise of Women Accountants
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Froemming, Denise LeDuc
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Accounting firms ,Business ,Business, regional - Abstract
In the world of finance women have been steadily claiming their place in the accounting profession, challenging stereotypes and reshaping the landscape of finance. Indeed, according to the Bureau of [...]
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- 2024
4. It's Material
- Author
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LeDuc, Denise
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Accountants ,Accounting firms ,Banking, finance and accounting industries ,Business - Abstract
From personalized shopping experiences to your next binge-worthy TV show recommendations to virtual personal assistants like Siri and Alexa, there's really no escaping AI. While many of our interactions with [...]
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- 2024
5. A Transforming Profession
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Froemming, Denise Leduc
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Accountants ,Business ,Business, regional - Abstract
Gone are the days when CPAs were confined to ledgers and balance sheets. The profession has moved from simply tracking debits and credits to sustainability to cloud accounting, data analytics, [...]
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- 2023
6. It's Material
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Froemming, Denise LeDuc
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Accountants ,Banking, finance and accounting industries ,Business - Abstract
Embracing a New Mindset Gone are the days when CPAs were confined to ledgers and balance sheets. As tech advancements reshape the profession and client expectations evolve, CPAs stand at [...]
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- 2023
7. HEALTH AND SAFETY IN POST-PANDEMIC MANUFACTURING: A COMPREHENSIVE APPROACH WILL ENSURE SAFETY AND PRODUCTIVITY
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Leduc, Zoe
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United States. Occupational Safety and Health Administration ,Epidemics ,Occupational health and safety ,Business ,Engineering and manufacturing industries - Abstract
The COVID-19 pandemic has been the largest disruption to the manufacturing in modern history, causing even the largest global manufacturers to stop production. The pandemic forced factories to minimize or [...]
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- 2020
8. HOW TO SPEED UP LEAK TESTING: LEAK TEST MANUFACTURERS OFFER TIPS TO MAKE THE PROCESS MORE EFFICIENT
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Leduc, Zoe
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Business ,Engineering and manufacturing industries - Abstract
Leak testing is an essential part of the manufacturing process for a variety of products, ranging from cardiac pacemakers to automotive radiators. Compared with, say, screwdriving or ultrasonic welding, leak [...]
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- 2020
9. USING UV-CURE ADHESIVES: AVOID THESE COMMON MISTAKES WHEN DISPENSING AND CURING LIGHTCURING ADHESIVES
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Leduc, Zoe
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Business ,Engineering and manufacturing industries - Abstract
LIGHT-CURING ADHESIVES, ALSO REFERRED TO AS UV cure adhesives, offer many advantages for automated assembly. The speed at which the adhesives are cured, the ability to fit into an automated [...]
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- 2020
10. It's Material: A Fresh Look
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Froemming, Denise LeDuc
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Banking, finance and accounting industries ,Business - Abstract
Change. It's not just a word; it's something that pushes us forward, reshapes our world and renews our spirits. Buckle up and hold tight because the future is exciting and [...]
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- 2023
11. It's Material
- Author
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LeDuc, Denise
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Banking, finance and accounting industries ,Business - Abstract
Servant Ledership In today's rapidly evolving world, leadership styles have shifted from authoritative and hierarchical models to more collaborative, empathetic and people-centric approaches. One such leadership philosophy that is gaming [...]
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- 2023
12. Developing a framework for evaluation: a Theory of Change for complex workplace mental health interventions
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Tsantila, Fotini, Coppens, Evelien, De Witte, Hans, Abdulla, Kahar, Amann, Benedikt L, Arensman, Ella, Aust, Birgit, Creswell-Smith, Johanna, D'Alessandro, Luigia, De Winter, Lars, Doukani, Asmae, Fanaj, Naim, Greiner, Birgit, Griffin, Eve, Leduc, Caleb, Maxwell, Margaret, Connor, Cliodhna O', Paterson, Charlotte, Purebl, Gyoergy, Reich, Hanna, Ross, Victoria, Van Weeghel, Jaap, and Van Audenhove, Chantal
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WORK ,Science & Technology ,Intervention development ,DISORDERS ,LITERACY ,Medical Research Council framework ,health interventions ,MENTUPP ,DEPRESSION ,Organizational interventions ,Small and Medium Enterprises (SMEs) ,Complex interventions ,PROMOTION ,BUSINESS ,Workplace-based mental health ,Implementation ,Theory of Change ,Evaluation ,Life Sciences & Biomedicine ,Public, Environmental & Occupational Health - Abstract
BACKGROUND: There is a gap between the necessity of effective mental health interventions in the workplace and the availability of evidence-based information on how to evaluate them. The available evidence outlines that mental health interventions should follow integrated approaches combining multiple components related to different levels of change. However, there is a lack of robust studies on how to evaluate multicomponent workplace interventions which target a variety of outcomes at different levels taking into account the influence of different implementation contexts. METHOD: We use the MENTUPP project as a research context to develop a theory-driven approach to facilitate the evaluation of complex mental health interventions in occupational settings and to provide a comprehensive rationale of how these types of interventions are expected to achieve change. We used a participatory approach to develop a ToC involving a large number of the project team representing multiple academic backgrounds exploiting in tandem the knowledge from six systematic reviews and results from a survey among practitioners and academic experts in the field of mental health in SMEs. RESULTS: The ToC revealed four long-term outcomes that we assume MENTUPP can achieve in the workplace: 1) improved mental wellbeing and reduced burnout, 2) reduced mental illness, 3) reduced mental illness-related stigma, and 4) reduced productivity losses. They are assumed to be reached through six proximate and four intermediate outcomes according to a specific chronological order. The intervention consists of 23 components that were chosen based on specific rationales to achieve change on four levels (employee, team, leader, and organization). CONCLUSIONS: The ToC map provides a theory of how MENTUPP is expected to achieve its anticipated long-term outcomes through intermediate and proximate outcomes assessing alongside contextual factors which will facilitate the testing of hypotheses. Moreover, it allows for a structured approach to informing the future selection of outcomes and related evaluation measures in either subsequent iterations of complex interventions or other similarly structured programs. Hence, the resulting ToC can be employed by future research as an example for the development of a theoretical framework to evaluate complex mental health interventions in the workplace. ispartof: BMC PUBLIC HEALTH vol:23 issue:1 ispartof: location:England status: published
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- 2023
13. Measurement of the effects of rough surfaces on Lamb waves propagation
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Jean-Louis Izbicki, Bruno Morvan, P. Pareige, and Damien Leduc
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Materials science ,Wave propagation ,business.industry ,Mechanical Engineering ,Acoustics ,Attenuation ,Classical Physics (physics.class-ph) ,FOS: Physical sciences ,Surface finish ,Physics - Classical Physics ,Condensed Matter Physics ,symbols.namesake ,Optics ,Lamb waves ,Surface metrology ,Surface wave ,symbols ,General Materials Science ,Phase velocity ,Rayleigh wave ,business ,Physics::Atmospheric and Oceanic Physics - Abstract
This work deals with the sensitivity to the plate roughness of Lamb waves. An experimental study is performed involving an air-coupling transducer system. Signal processing allows us to extract the Lamb waves characteristics: phase velocity and attenuation. Plate surface topographies are obtained by means of an optical surface profiler. The acoustic characteristics and the surface topographies are finally linked.
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- 2023
14. In situ DC electrical resistivity mapping performed in a reinforced concrete wharf using embedded sensors
- Author
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Priou, Johann, Lecieux, Yann, Chevreuil, Mathilde, Gaillard, Virginie, Lupi, Cyril, Leduc, Dominique, Roziere, Emmanuel, Guyard, Romain, and Schoefs, Franck
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Reinforced concrete -- Mechanical properties ,Corrosion (Chemistry) -- Analysis -- Electric properties ,Sensors -- Analysis -- Electric properties ,Information management ,Business ,Construction and materials industries - Abstract
ABSTRACT Installation, calibration protocol and data analysis of multi-electrode sensors embedded in concrete are proposed in this study. Measurements of resistivity are performed in a port wharf and analyzed in [...]
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- 2019
- Full Text
- View/download PDF
15. A New Era for Women in Accounting
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Froemming, Denise Leduc
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Financial analysis ,Working women ,Accounting firms -- Officials and employees ,Business ,Business, regional - Abstract
The accounting profession, like many industries, is evolving, and we must embrace and lean into these changes. Everything from technology to remote work is having an impact on the way [...]
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- 2023
16. Pull-Force Testing Crimped Wires: CONSISTENCY IS KEY IN PULL-FORCE TESTING
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Leduc, Zoe
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Business ,Engineering and manufacturing industries - Abstract
Of the many steps in the process of assembling a wire harness, testing the crimped terminal is a crucial one. If the terminal hasn't been properly attached to the end [...]
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- 2020
17. Sustainable Achievements: FIVE YEARS OF THE YARDI ENERGY EFFICIENCY GRANTS
- Author
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LeDuc-Froemming, Denise
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Energy efficiency ,Real estate management -- Energy use -- Environmental aspects ,Energy management ,Real estate ,Technology ,Energy conservation ,Organizations ,Energy consumption ,Real estate management firms ,Business ,Real estate industry - Abstract
Since 2014, Yardi[R] has leveraged its trusted brand and leadership in the real estate software industry for an exciting giving initiative to improve our shared built environment--the Yardi Energy Efficiency [...]
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- 2019
18. It's Material
- Author
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Froemmmg, Denise LeDuc
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Banking, finance and accounting industries ,Business - Abstract
What's Ahead? Wouldn't it be nice to know the future? Some of you may remember the Magic 8 Ball toy, where you would ask it a yes or no question, [...]
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- 2023
19. Promoting employee wellbeing and preventing non-clinical mental health problems in the workplace: a preparatory consultation survey.
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Coppens, Evelien, Hogg, Bridget, Greiner, Birgit A., Paterson, Charlotte, de Winter, Lars, Mathieu, Sharna, Cresswell-Smith, Johanna, Aust, Birgit, Leduc, Caleb, Van Audenhove, Chantal, Pashoja, Arlinda C., Kim, Dooyoung, Reich, Hanna, Fanaj, Naim, Dushaj, Arilda, Thomson, Katherine, O'Connor, Cliodhna, Moreno-Alcázar, Ana, Amann, Benedikt L., and Arensman, Ella
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MENTAL illness treatment ,EMPLOYEE psychology ,EMPLOYEE education ,MENTAL illness prevention ,PREVENTION of employment discrimination ,WELL-being ,PRIVACY ,MEDICINE information services ,VOCATIONAL guidance ,INDUSTRIAL safety ,SEXISM ,EXECUTIVES ,QUANTITATIVE research ,SOCIAL stigma ,HEALTH information services ,HUMAN services programs ,BUSINESS ,RESEARCH funding ,MEDICAL ethics ,DESCRIPTIVE statistics ,INDUSTRIAL hygiene ,NEEDS assessment ,OCCUPATIONAL health services ,THEMATIC analysis ,MEDICAL needs assessment ,MENTAL health services ,HEALTH promotion - Abstract
Background: Small and medium-sized enterprises (SMEs) face major financial losses due to mental health issues affecting employees at all levels but seldom apply programs to promote wellbeing and prevent mental health issues among employees. To support the development of a multi-country workplace-based mental health intervention for SMEs (MENTUPP), a multinational consultation study was conducted. The study aimed to examine the experiences and needs of SMEs concerning the promotion of employee wellbeing, and the prevention and management of non-clinical mental health problems in workplaces. Methods: A survey consisting of open and closed questions was designed to assess key informants' opinion about the acceptability, the use, and the implementation of interventions to promote wellbeing and prevent mental health issues in the workplace. Academic experts and representatives of SME organisations, specific sector organisations, labour or advocacy groups, and occupational health organisations across the nine MENTUPP intervention countries (eight European countries and Australia) were invited to complete the survey. Data were collected via the online platform Qualtrics. Sixty-five of 146 informants responded, representing a 44.5% response rate. Descriptive statistics were used to analyse the quantitative data and qualitative data were analysed through thematic analysis. Results: Measures to create mentally healthy workplaces were most used in SMEs, while more specific mental health interventions, such as training staff on how to promote wellbeing, were hardly used. Managers lack resources to implement mental health interventions and are concerned about employees spending too much time on these interventions during working hours. Receiving information about the economic benefits of mental health interventions and hearing successful testimonials from other SMEs can persuade managers otherwise. Employees have concerns about confidentiality, discrimination and stigma, and career opportunities when using such interventions. Conclusions: The study identifies a variety of challenges, needs and possibilities related to implementing mental health interventions in SMEs. Employers need to be convinced that investing in mental health in the workplace is worth their time and money. This requires more studies on the (cost-)effectiveness of mental health interventions. Once employers are engaged, their knowledge and competencies about how to implement such interventions should be increased and privacy concerns of employees to participate in them should be addressed. [ABSTRACT FROM AUTHOR]
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- 2023
- Full Text
- View/download PDF
20. Unsupervised Deep Learning for Massive MIMO Hybrid Beamforming
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Hamed Hojatian, Jean-Francois Frigon, Jeremy Nadal, and Francois Leduc-Primeau
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Signal Processing (eess.SP) ,FOS: Computer and information sciences ,Computer Science - Machine Learning ,Optimization problem ,Computer science ,MIMO ,Duplex (telecommunications) ,Data_CODINGANDINFORMATIONTHEORY ,02 engineering and technology ,Machine Learning (cs.LG) ,0203 mechanical engineering ,FOS: Electrical engineering, electronic engineering, information engineering ,0202 electrical engineering, electronic engineering, information engineering ,Wireless ,Electrical Engineering and Systems Science - Signal Processing ,Electrical and Electronic Engineering ,Computer Science::Information Theory ,business.industry ,Applied Mathematics ,Deep learning ,Codebook ,020302 automobile design & engineering ,020206 networking & telecommunications ,Spectral efficiency ,Computer Science Applications ,Computer engineering ,Channel state information ,Artificial intelligence ,business - Abstract
Hybrid beamforming is a promising technique to reduce the complexity and cost of massive multiple-input multiple-output (MIMO) systems while providing high data rate. However, the hybrid precoder design is a challenging task requiring channel state information (CSI) feedback and solving a complex optimization problem. This paper proposes a novel RSSI-based unsupervised deep learning method to design the hybrid beamforming in massive MIMO systems. Furthermore, we propose i) a method to design the synchronization signal (SS) in initial access (IA); and ii) a method to design the codebook for the analog precoder. We also evaluate the system performance through a realistic channel model in various scenarios. We show that the proposed method not only greatly increases the spectral efficiency especially in frequency-division duplex (FDD) communication by using partial CSI feedback, but also has near-optimal sum-rate and outperforms other state-of-the-art full-CSI solutions., Submitted to IEEE Transactions on Wireless Communications
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- 2021
21. Neptune: an environment for the delivery of genomic medicine
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Venner Eric, Victoria Yi, David Murdock, Sara E. Kalla, Tsung-Jung Wu, Aniko Sabo, Shoudong Li, Qingchang Meng, Xia Tian, Mullai Murugan, Michelle Cohen, Christie Kovar, Wei-Qi Wei, Wendy K. Chung, Chunhua Weng, Georgia L. Wiesner, Gail P. Jarvik, Donna Muzny, Richard A. Gibbs, Debra Abrams, Samuel E. Adunyah, Ladia Albertson-Junkans, Berta Almoguera, Darren C. Ames, Paul Appelbaum, Samuel Aronson, Sharon Aufox, Lawrence J. Babb, Adithya Balasubramanian, Hana Bangash, Melissa Basford, Lisa Bastarache, Samantha Baxter, Meckenzie Behr, Barbara Benoit, Elizabeth Bhoj, Suzette J. Bielinski, Sarah T. Bland, Carrie Blout, Kenneth Borthwick, Erwin P. Bottinger, Mark Bowser, Harrison Brand, Murray Brilliant, Wendy Brodeur, Pedro Caraballo, David Carrell, Andrew Carroll, Lisa Castillo, Victor Castro, Gauthami Chandanavelli, Theodore Chiang, Rex L. Chisholm, Kurt D. Christensen, Wendy Chung, Christopher G. Chute, Brittany City, Beth L. Cobb, John J. Connolly, Paul Crane, Katherine Crew, David R. Crosslin, Jyoti Dayal, Mariza De Andrade, Jessica De la Cruz, Josh C. Denny, Shawn Denson, Tim DeSmet, Ozan Dikilitas, Michael J. Dinsmore, Sheila Dodge, Phil Dunlea, Todd L. Edwards, Christine M. Eng, David Fasel, Alex Fedotov, Qiping Feng, Mark Fleharty, Andrea Foster, Robert Freimuth, Christopher Friedrich, Stephanie M. Fullerton, Birgit Funke, Stacey Gabriel, Vivian Gainer, Ali Gharavi, Andrew M. Glazer, Joseph T. Glessner, Jessica Goehringer, Adam S. Gordon, Chet Graham, Robert C. Green, Justin H. Gundelach, Heather S. Hain, Hakon Hakonarson, Maegan V. Harden, John Harley, Margaret Harr, Andrea Hartzler, M. Geoffrey Hayes, Scott Hebbring, Nora Henrikson, Andrew Hershey, Christin Hoell, Ingrid Holm, Kayla M. Howell, George Hripcsak, Jianhong Hu, Elizabeth Duffy Hynes, Joy C. Jayaseelan, Yunyun Jiang, Yoonjung Yoonie Joo, Sheethal Jose, Navya Shilpa Josyula, Anne E. Justice, Divya Kalra, Elizabeth W. Karlson, Brendan J. Keating, Melissa A. Kelly, Eimear E. Kenny, Dustin Key, Krzysztof Kiryluk, Terrie Kitchner, Barbara Klanderman, Eric Klee, David C. Kochan, Viktoriya Korchina, Leah Kottyan, Emily Kudalkar, Alanna Kulchak Rahm, Iftikhar J. Kullo, Philip Lammers, Eric B. Larson, Matthew S. Lebo, Magalie Leduc, Ming Ta (Michael) Lee, Niall J. Lennon, Kathleen A. Leppig, Nancy D. Leslie, Rongling Li, Wayne H. Liang, Chiao-Feng Lin, Jodell E. Linder, Noralane M. Lindor, Todd Lingren, James G. Linneman, Cong Liu, Wen Liu, Xiuping Liu, John Lynch, Hayley Lyon, Alyssa Macbeth, Harshad Mahadeshwar, Lisa Mahanta, Bradley Malin, Teri Manolio, Maddalena Marasa, Keith Marsolo, Michelle L. McGowan, Elizabeth McNally, Jim Meldrim, Frank Mentch, Hila Milo Rasouly, Jonathan Mosley, Shubhabrata Mukherjee, Thomas E. Mullen, Jesse Muniz, David R. Murdock, Shawn Murphy, Melanie F. Myers, Bahram Namjou, Yizhao Ni, Robert C. Onofrio, Aniwaa Owusu Obeng, Thomas N. Person, Josh F. Peterson, Lynn Petukhova, Cassandra J. Pisieczko, Siddharth Pratap, Cynthia A. Prows, Megan J. Puckelwartz, Ritika Raj, James D. Ralston, Arvind Ramaprasan, Andrea Ramirez, Luke Rasmussen, Laura Rasmussen-Torvik, Soumya Raychaudhuri, Heidi L. Rehm, Marylyn D. Ritchie, Catherine Rives, Beenish Riza, Dan M. Roden, Elisabeth A. Rosenthal, Avni Santani, Schaid Dan, Steven Scherer, Stuart Scott, Aaron Scrol, Soumitra Sengupta, Ning Shang, Himanshu Sharma, Richard R. Sharp, Rajbir Singh, Patrick M.A. Sleiman, Kara Slowik, Joshua C. Smith, Maureen E. Smith, Duane T. Smoot, Jordan W. Smoller, Sunghwan Sohn, Ian B. Stanaway, Justin Starren, Mary Stroud, Jessica Su, Casey Overby Taylor, Kasia Tolwinski, Sara L. Van Driest, Sean M. Vargas, Matthew Varugheese, David Veenstra, Eric Venner, Miguel Verbitsky, Gina Vicente, Michael Wagner, Kimberly Walker, Theresa Walunas, Liwen Wang, Qiaoyan Wang, Scott T. Weiss, Quinn S. Wells, Peter S. White, Ken L. Wiley, Janet L. Williams, Marc S. Williams, Michael W. Wilson, Leora Witkowski, Laura Allison Woods, Betty Woolf, Julia Wynn, Yaping Yang, Ge Zhang, Lan Zhang, and Hana Zouk
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Computer science ,business.industry ,Process (engineering) ,MEDLINE ,High-Throughput Nucleotide Sequencing ,Genomics ,Data science ,Article ,Personalization ,Variety (cybernetics) ,Workflow ,Neptune ,Pharmacogenomics ,Health care ,Electronic Health Records ,Humans ,business ,Software ,Genetics (clinical) - Abstract
Genomic medicine holds great promise for improving health care, but integrating searchable and actionable genetic data into electronic health records (EHRs) remains a challenge. Here we describe Neptune, a system for managing the interaction between a clinical laboratory and an EHR system during the clinical reporting process. We developed Neptune and applied it to two clinical sequencing projects that required report customization, variant reanalysis, and EHR integration. Neptune has been applied for the generation and delivery of over 15,000 clinical genomic reports. This work spans two clinical tests based on targeted gene panels that contain 68 and 153 genes respectively. These projects demanded customizable clinical reports that contained a variety of genetic data types including single-nucleotide variants (SNVs), copy-number variants (CNVs), pharmacogenomics, and polygenic risk scores. Two variant reanalysis activities were also supported, highlighting this important workflow. Methods are needed for delivering structured genetic data to EHRs. This need extends beyond developing data formats to providing infrastructure that manages the reporting process itself. Neptune was successfully applied on two high-throughput clinical sequencing projects to build and deliver clinical reports to EHR systems. The software is open source and available at https://gitlab.com/bcm-hgsc/neptune .
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- 2021
22. Impact of long-term exposure to PM2.5 and temperature on coronavirus disease mortality: observed trends in France
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Hichem Omrani, Gaetan de Lanchy, Anastase Tchicaya, Nathalie Lorentz, and Kristell Leduc
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medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,business.industry ,Cross-sectional study ,Health, Toxicology and Mutagenesis ,Public health ,Mortality rate ,COVID-19 mortality rate ,Public Health, Environmental and Occupational Health ,Air pollution ,Temperature ,Outbreak ,Long-term exposure to PM2.5 ,Environmental exposure ,Spatial disparity ,Industrial medicine. Industrial hygiene ,Persistence (computer science) ,RC963-969 ,Pandemic ,Medicine ,France ,Public aspects of medicine ,RA1-1270 ,business ,Demography - Abstract
Background The outbreak of coronavirus disease (COVID-19) began in Wuhan, China in December 2019 and was declared a global pandemic on 11 March 2020. This study aimed to assess the effects of temperature and long-term exposure to air pollution on the COVID-19 mortality rate at the sub-national level in France. Methods This cross-sectional study considered different periods of the COVID-19 pandemic from May to December 2020. It included 96 departments (or NUTS 3) in mainland France. Data on long-term exposure to particulate matter (PM2.5), annual mean temperature, health services, health risk, and socio-spatial factors were used as covariates in negative binomial regression analysis to assess their influence on the COVID-19 mortality rate. All data were obtained from open-access sources. Results The cumulative COVID-19 mortality rate by department increased during the study period in metropolitan France—from 19.8/100,000 inhabitants (standard deviation (SD): 20.1) on 1 May 2020, to 65.4/100,000 inhabitants (SD: 39.4) on 31 December 2020. The rate was the highest in the departments where the annual average of long-term exposure to PM2.5 was high. The negative binomial regression models showed that a 1 μg/m3 increase in the annual average PM2.5 concentration was associated with a statistically significant increase in the COVID-19 mortality rate, corresponding to 24.4%, 25.8%, 26.4%, 26.7%, 27.1%, 25.8%, and 15.1% in May, June, July, August, September, October, and November, respectively. This association was no longer significant on 1 and 31 December 2020. The association between temperature and the COVID-19 mortality rate was only significant on 1 November, 1 December, and 31 December 2020. An increase of 1 °C in the average temperature was associated with a decrease in the COVID-19-mortality rate, corresponding to 9.7%, 13.3%, and 14.5% on 1 November, 1 December, and 31 December 2020, respectively. Conclusion This study found significant associations between the COVID-19 mortality rate and long-term exposure to air pollution and temperature. However, these associations tended to decrease with the persistence of the pandemic and massive spread of the disease across the entire country.
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- 2021
23. Classically Presenting GCA with an Unusual Evolution
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Sébastien Perron, Simon Guertin, Charles Leduc, and Samuel Doiron
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medicine.medical_specialty ,business.industry ,Medicine ,General Medicine ,business ,Dermatology - Abstract
Giant cell arteritis (GCA) is a primary vasculitis of large and medium-sized arteries. It is the most common vasculitis affecting the elderly. GCA involves the cranial branches of the carotid arteries and classically presents with cranial symptoms such as headache or jaw claudication. Aortitis can occur, and cases of mesenteric ischemia have been reported. Diagnosis can be challenging, and subclinical mesenteric ischemia in GCA may be more prevalent than previously recognized. ResumeL’artérite temporale est une vasculite primaire des artères de gros et de moyen calibre. Il s’agit de la vasculite la plus courante chez les personnes âgées. Elle touche les ramifications crâniennes des carotides, et la forme classique se manifeste par des symptômes crâniens comme la céphalée ou la claudication intermittente de la mâchoire. Une aortite peut survenir, et des cas d’ischémie mésentérique ont été rapportés. Le diagnostic peut être difficile à poser, et l’ischémie mésentérique infraclinique dans les cas d’artérite temporale est peut-être plus fréquente que ce que l’on croyait auparavant. Ce cas met en évidence la nature systémique et l’évolution clinique potentiellement imprévisible de l’artérite temporale. Nous décrivons les caractéristiques histopathologiques de l’atteinte mésentérique et résumons l’état actuel de la documentation scientifique sur le sujet en mettant l’accent sur des stratégies de prise en charge.
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- 2021
24. Effectiveness of nutrition interventions and combined nutrition and physical activity interventions in older adults with frailty or prefrailty: a systematic review and meta-analysis
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Muhammad Usman Ali, Perry Kim, John Muscedere, Milos Jovkovic, Ruth Lewis, Danielle R. Bouchard, Jayna Holroyd-Leduc, Amanda Lorbergs, Megan Racey, Donna Fitzpatrick-Lewis, Heather H. Keller, Diana Sherifali, Jeanette Prorok, Anik Giguère, Ada Tang, and Leah Gramlich
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Gerontology ,Nutrition Interventions ,Physical activity interventions ,business.industry ,Meta-analysis ,Research ,Medicine ,General Medicine ,business - Abstract
Background: Although nutrition interventions may reverse frailty, it is unclear which interventions are optimal. We conducted a systematic review and meta-analysis to identify effective nutrition interventions that improve outcomes related to frailty. Methods: We searched MEDLINE, Embase, the Cochrane Central Register of Controlled Trials and CINAHL (inception to July 2019) for English-language trials of nutrition and combined-approach (nutrition and exercise) interventions (with a control group) involving prefrail or frail adults aged 65 years or more. Outcomes of interest were frailty, mobility, health (body weight, body mass index), physical function (e.g., activities of daily living, muscle strength, appendicular lean mass), use of health care services (e.g., hospital admissions), quality of life, diet quality, mortality, and caregiver and social support. After data extraction, we assessed the risk of bias using the Cochrane Collaboration risk of bias tool for randomized controlled trials, rated the certainty of evidence with the Grading of Recommendation, Assessment, Development and Evaluations (GRADE) approach, and assessed statistical and methodologic heterogeneity. In addition, we conducted subgroup analyses of studies based on the primary intervention of protein supplementation. Results: We identified 15 studies involving 1825 prefrail or frail older participants: 7 were nutrition trials, 7 were combined-approach trials, and 1 trial had both a nutrition arm and a combined-approach arm. Seven studies had low risk of bias, 2 studies had high risk of bias, and for 6 studies the risk of bias was unclear. Nutrition interventions had small but significant effects on measures of physical function (standardized mean difference [SMD] 0.16, 95% confidence interval [CI] 0.02 to 0.29), mobility (SMD 0.15, 95% CI 0.00 to 0.30) and frailty (SMD −0.22, 95% CI −0.44 to −0.01) outcomes. Nutrition interventions combined with physical activity also had small but significant effects on physical function (SMD 0.19, 95% CI 0.06 to 0.32), mobility (SMD 0.25, 95% CI 0.02 to 0.48) and frailty (SMD −0.41, 95% CI −0.68 to −0.14; risk ratio 0.72, 95% CI 0.52 to 1.00) measures. Protein supplementation (5 studies) had small but significant effects on physical function measures (SMD 0.16, 95% CI 0.01 to 0.31) and mobility measures (SMD 0.20, 95% CI 0.02 to 0.39), with moderate certainty of evidence. Interpretation: There is moderate evidence that nutrition (including protein supplementation) and combined interventions are beneficial for prefrail or frail older adults. Trials with clear definitions of frailty and outcomes that reflect frailty identification and diagnosis are needed. PROSPERO registration: CRD42020144819
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- 2021
25. CSNK2B
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Judith Bluvstein, Suneeta Madan-Khetarpal, Daniel Groepper, Theodore Sheehan, Michael J. Lyons, Louise Bier, Julie Fleischer, Annapurna Poduri, Lynn Pais, Pascal Joset, Elena Infante, Evan H. Baugh, David Goldstein, Tristan T. Sands, Katharina Steindl, Pim Suwannarat, Cyril Mignot, Boris Keren, Matthew J. Ferber, Laura Schultz-Rogers, Natalie Lippa, Linda Hasadsri, Vinodh Narayanan, Maureen S. Mulhern, Alejandra Vasquez, Claudia A. L. Ruivenkamp, Marleen Simon, Susan M. White, Vimla Aggarwal, Eric W. Klee, Kristine K. Bachman, Lindsay C. Burrage, Caroline Nava, Nicholas Stong, Neil A. Hanchard, Josephine S.C. Chong, Anita Rauch, Renee Bend, Erin L. Heinzen, Sulagna Kushary, Marije Koopmans, Marissa S. Ellingson, Keri Ramsey, Raymond Yeh, Michelle E. Ernst, Ellen van Binsbergen, Sarah S. Barnett, Amanda Thomas, Kristin G. Monaghan, Eva H. Brilstra, Magalie S. Leduc, Weimin Bi, Jennifer A. Lee, Cigdem I. Akman, Sophie Mathieu, Andrea H. Seeley, Grazia M. S. Mancini, and Clinical Genetics
- Subjects
0301 basic medicine ,Adult ,Male ,Pediatrics ,medicine.medical_specialty ,Adolescent ,CK2 ,Developmental Disabilities ,Epilepsies, Myoclonic ,Status epilepticus ,casein kinase II ,Article ,MSNE ,03 medical and health sciences ,Broad spectrum ,Epilepsy ,Young Adult ,0302 clinical medicine ,Status Epilepticus ,Intellectual Disability ,Intellectual disability ,medicine ,Humans ,Exome ,Generalized epilepsy ,Age of Onset ,generalized epilepsy ,Child ,Exome sequencing ,business.industry ,Genetic Variation ,Infant ,medicine.disease ,Young age ,030104 developmental biology ,myoclonic status epilepticus ,Phenotype ,Neurology ,Child, Preschool ,Mutation ,myoclonic seizures ,Epilepsy, Generalized ,Female ,Neurology (clinical) ,medicine.symptom ,Epilepsy severity ,business ,030217 neurology & neurosurgery - Abstract
CSNK2B has recently been implicated as a disease gene for neurodevelopmental disability (NDD) and epilepsy. Information about developmental outcomes has been limited by the young age and short follow-up for many of the previously reported cases, and further delineation of the spectrum of associated phenotypes is needed. We present 25 new patients with variants in CSNK2B and refine the associated NDD and epilepsy phenotypes. CSNK2B variants were identified by research or clinical exome sequencing, and investigators from different centers were connected via GeneMatcher. Most individuals had developmental delay and generalized epilepsy with onset in the first 2 years. However, we found a broad spectrum of phenotypic severity, ranging from early normal development with pharmacoresponsive seizures to profound intellectual disability with intractable epilepsy and recurrent refractory status epilepticus. These findings suggest that CSNK2B should be considered in the diagnostic evaluation of patients with a broad range of NDD with treatable or intractable seizures.
- Published
- 2021
26. Invasive Mucinous Adenocarcinomas With Spatially Separate Lung Lesions: Analysis of Clonal Relationship by Comparative Molecular Profiling
- Author
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Soo-Ryum Yang, Laetitia Borsu, Michael Offin, Natasha Rekhtman, Snjezana Dogan, Marc Ladanyi, Alexander Drilon, Jason C. Chang, Ryma Benayed, Maria E. Arcila, Charles Leduc, Kay See Tan, and William D. Travis
- Subjects
0301 basic medicine ,Pulmonary and Respiratory Medicine ,Mutation ,Pathology ,medicine.medical_specialty ,Lung ,business.industry ,Cancer ,medicine.disease ,Molecular diagnostics ,medicine.disease_cause ,Article ,03 medical and health sciences ,Clonal relationship ,030104 developmental biology ,0302 clinical medicine ,medicine.anatomical_structure ,Oncology ,030220 oncology & carcinogenesis ,medicine ,Personalized medicine ,KRAS ,business ,Gene - Abstract
Introduction Pulmonary invasive mucinous adenocarcinomas (IMAs) often present with spatially separate lung lesions. Clonal relationship between such lesions, particularly those involving contralateral lobes, is not well established. Here, we used comparative genomic profiling to address this question. Methods Patients with genomic analysis performed on two IMAs located in different lung regions were identified. Molecular assays included DNA-based next-generation sequencing (NGS) for 410 to 468 genes (Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets), RNA-based NGS for 62 genes (Memorial Sloan Kettering-Fusion), or non-NGS assays. Results Comparative genomic profiling was performed on two separate IMAs in 24 patients, of whom 19 had contralateral lesions. Tumors from all but one patient shared matching driver alterations, including KRAS (n = 19), NRG1 (n = 2), ERBB2 (n = 1) or BRAF (n = 1). In addition, in patients with paired tumors profiled by NGS (n = 12), shared driver alterations were accompanied by up to 4 (average 2.6) other identical mutations, further supporting the clonal relationship between the tumors. Only in a single patient separate IMAs harbored entirely nonoverlapping mutation profiles, supporting clonally unrelated, distinct primary tumors. Notably, in a subset of patients (n = 3), molecular testing confirmed a clonal relationship between the original resected IMAs and subsequent contralateral IMA presenting after an extremely long latency (8.1–11.7 y). Conclusions Comparative molecular profiling supports that nearly all separate pulmonary IMA lesions represent intrapulmonary spread arising from a single tumor and documents a subset with a remarkably protracted course of intrapulmonary progression. This study reinforces the unique biology and clinical behavior of IMAs while further highlighting the value of genomic testing for clarifying the clonal relationship between multiple lung carcinomas.
- Published
- 2021
27. Lymphoscintigraphic Investigations for Axillary Web Syndromes
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Mirela Mariana Roman, Nele Adriaenssens, Clarence Karler, Christine Eddy, Isabelle Veys, Assaf Zeltzer, Olivier Leduc, Romain Barbieux, Pierre Bourgeois, Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education and Physical Therapy, Anatomical Research and Clinical Studies, Surgical clinical sciences, Plastic Surgery, Physical Medicine and Rehabilitation, and Rehabilitation Research
- Subjects
medicine.medical_specialty ,business.industry ,Breast Neoplasms ,Axillary web syndrome ,Institutional ethics ,medicine.disease ,Lymphovascular ,Lymphatic System ,Breast cancer ,Lymphatic system ,Axilla ,medicine ,Humans ,In patient ,Female ,Radiology ,Lymphedema ,Cardiology and Cardiovascular Medicine ,Complication ,business ,Collateralization ,Lymphatic Diseases ,Lymphoscintigraphy ,Retrospective Studies - Abstract
Background: Axillary web syndrome (AWS) is a frequent complication after surgery for breast cancer, but its lymphatic involvement is not definitively established. Here we report the results of lymphoscintigraphic investigations in patients with AWS. Methods and Findings: We conducted a retrospective, single-center review of lymphoscintigraphic investigations performed in 46 patients with AWS that was either clinically obvious or suspected. Of this group, 23 patients had two investigations with a mean interval of 19 weeks between them (range, 6-98 weeks). Results of the lymphoscintigraphic investigations, which were performed according to a well-standardized protocol, were classified into four patterns: normal; functional lymphatic insufficiency only (no lymphatic vascular morphologic abnormality); lymphovascular blockade without collateralization; and vascular collateralization and/or dermal backflow. Of the 46 patients, on the first lymphoscintigraphic investigation, four (8.6%) had a normal pattern, seven (15.2%) had functional lymphatic insufficiency only, four (8.6%) had lymphovascular blockade without collateralization, and 31 (67.3%) had vascular collateralization and/or dermal backflow. Among patients who underwent two investigations, four of the five who had only functional lymphatic insufficiency at the first investigation had developed vascular collateralization and/or dermal backflow by the second. The three patients who had lymphovascular blockade without collateralization at the first examination had also progressed to collateralization and/or dermal backflow at the second. None of the 15 patients who initially had vascular collateralization and/or dermal backflow showed any reversal at the second examination. Conclusions: Our analysis confirms the lymphatic nature of AWS and shows the lymphoscintigraphic patterns and evolutions of the lymphatic lesions with potential therapeutic implications. The retrospective review of our database is approved by the institutional ethics committee under number 2048.
- Published
- 2022
28. Calcium sulphate mixed with antibiotics does not decrease efficacy against Cutibacterium acnes (formerly Propionibacterium acnes), in vitro study
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Valery Lavergne, Dominique M. Rouleau, Benoit Benoit, Stéphane Leduc, Anne Couture, Emilie Sandman, and Jean-Michel Leduc
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030222 orthopedics ,Gradient Diffusion Method ,biology ,business.industry ,medicine.drug_class ,Antibiotics ,Clindamycin ,chemistry.chemical_element ,030229 sport sciences ,Calcium ,biology.organism_classification ,Article ,Microbiology ,Penicillin ,03 medical and health sciences ,Propionibacterium acnes ,0302 clinical medicine ,chemistry ,polycyclic compounds ,medicine ,Ceftriaxone ,Vancomycin ,Orthopedics and Sports Medicine ,business ,medicine.drug - Abstract
Background This study explored the in vitro efficacy of antibiotics mixed with calcium sulfate (ACS) against Cutibacterium acnes (C. acnes). Methods C. acnes isolates from orthopaedic infection sites were tested for antimicrobial susceptibility with ACS. Minimal inhibitory concentrations (MIC) were determined with a gradient diffusion method (Etest® strips). Results When tested with Etest®, all 22 isolates were susceptible to penicillin, ceftriaxone, vancomycin, and two were resistant to clindamycin (MICs of 4 and 8 mg/L). Penicillin and rifampin had the largest inhibition zone diameters. Conclusions Antibiotics retained activity against C. acnes when mixed with calcium sulfate.
- Published
- 2020
29. The Power of Giving
- Author
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Froemming, Denise Leduc
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Accountants ,Banking, finance and accounting industries ,Business - Abstract
As we enter the holiday season many are thinking of family gatherings, festive tables full of food--and paying it forward. Whether it's the giving of gifts, time or money, this [...]
- Published
- 2022
30. Association between biochemical control and comorbidities in patients with acromegaly: an Italian longitudinal retrospective chart review study
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Hoi Ching Cheung, Ricardo Maamari, Philippe Thompson-Leduc, Alberto M Pedroncelli, Wendy Y. Cheng, M.S. Duh, A. Colao, Maureen P. Neary, M Di Cera, Ludovica F S Grasso, Rosario Pivonello, Colao, A., Grasso, L. F. S., Di Cera, M., Thompson-Leduc, P., Cheng, W. Y., Cheung, H. C., Duh, M. S., Neary, M. P., Pedroncelli, A. M., Maamari, R., and Pivonello, R.
- Subjects
Adult ,Male ,medicine.medical_specialty ,Pituitary diseases ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,Comorbidity ,030204 cardiovascular system & hematology ,Growth hormone ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Statistical significance ,Diabetes mellitus ,Internal medicine ,Arthropathy ,Acromegaly ,medicine ,Humans ,In patient ,Longitudinal Studies ,Retrospective Studies ,Human Growth Hormone ,Proportional hazards model ,business.industry ,Insulin-like growth factor I ,Middle Aged ,medicine.disease ,Italy ,Cardiovascular Diseases ,Original Article ,Female ,business - Abstract
PurposeAchieving biochemical control (normalization of insulin-like growth factor-1 [IGF-1] and growth hormone [GH]) is a key goal in acromegaly management. However, IGF-1 and GH fluctuate over time. The true potential impact of time-varying biochemical control status on comorbidities is unclear and relies on multiple, longitudinal IGF-1 and GH measurements. This study assessed the association between time-varying biochemical control status and onset of selected comorbidities in patients with acromegaly.MethodsMedical charts of adults with confirmed acromegaly and ≥ 6 months of follow-up at an Italian endocrinology center were reviewed. Patients were followed from the first diagnosis of acromegaly at the center until loss to follow-up, chart abstraction, or death. Biochemical control status was assessed annually and defined as IGF-1 ≤ the upper limit of normal, or GH ≤ 2.5 µg/L in the few cases where IGF-1 was unavailable. Time-varying Cox models were used to assess the association between biochemical control status and comorbidities.ResultsAmong 150 patients, 47% were female, average age at diagnosis was 43.1, and mean length of follow-up was 10.4 years. Biochemical control was significantly associated with a lower hazard of diabetes (HR = 0.36, 95% CI 0.15; 0.83) and cardiovascular system disorders (HR = 0.54, 95% CI 0.31; 0.93), and a higher hazard of certain types of arthropathy (HR = 1.68, 95% CI 1.04; 2.71); associations for other comorbidities did not reach statistical significance.ConclusionResults further support the importance of achieving biochemical control, as this may reduce the risk of high-burden conditions, including diabetes and cardiovascular system disorders. The association for arthropathy suggests irreversibility of this impairment. Due to limitations, caution is required when interpreting these results.
- Published
- 2019
31. The Relationships between Personal Values, Justifications, and Academic Cheating for Business vs. Non-Business Students
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Leigh Mulligan, Laura Parks-Leduc, and Russell P. Guay
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2019-20 coronavirus outbreak ,Sociology and Political Science ,Coronavirus disease 2019 (COVID-19) ,business.industry ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Cheating ,ComputingMilieux_PERSONALCOMPUTING ,Sample (statistics) ,Values ,Business Students ,Article ,Education ,Power (social and political) ,Philosophy ,Arts and Humanities (miscellaneous) ,ComputerApplications_MISCELLANEOUS ,ComputingMilieux_COMPUTERSANDEDUCATION ,The Internet ,business ,Psychology ,Social psychology ,Un-prescribed Adderall - Abstract
In this study we examine college cheating behaviors of business students compared to non-business students, and investigate possible antecedents to cheating in an effort to better understand why and when students cheat. We specifically examine power values; we found that they were positively related to academic cheating in our sample, and that choice of major (business or non-business) partially mediated the relationship between power values and cheating. We also considered the extent to which students provide justifications for their cheating, and found that business students were more likely to justify (rationalize) their cheating behaviors. Finally, we update the literature in terms of the ways students cheat. We assess newer forms of academic cheating, as increased accessibility to information via the Internet and smartphones may have changed the ways and ease with which students cheat – a particularly relevant topic currently, as many classes have moved online during the COVID-19 pandemic. In our study, cheating was especially prevalent when taking quizzes or tests or completing homework online. We found that only 10% of participants reported never engaging in any of the cheating behaviors we examined.
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- 2021
32. Imaging and leaks in peritoneal dialysis
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Emilie Podevin, Vincent Leduc, and Simon Duquennoy
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pleurodesis ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,leak ,computed tomography ,RC31-1245 ,Atomic and Molecular Physics, and Optics ,dialysate ,Surgery ,Peritoneal dialysis ,peritoneal dialysis ,peritoneography ,medicine ,Electrical and Electronic Engineering ,business ,Internal medicine - Abstract
Dialysate leaks are non-rare mechanical but dreaded complications in peritoneal dialysis (PD). They usually occur at the beginning of PD, with various clinical events depending on their location. Use of imaging tests such as computed tomography (CT) peritoneography, or magnetic resonance imaging (MRI) peritoneography, or scintigraphic peritoneography, can confirm the diagnosis and guide surgical intervention if needed. These simple, non-invasive, and accessible tests can be done in collaboration between the radiological et peritoneal teams. Depending on the leakage site, PD can be pursued with small volumes with a cycler. In other cases, it must be interrupted and the patient transferred to hemodialysis, in order to permit the peritoneal cavity to regain its integrity by cicatrization or with surgical intervention. Imaging can help to make sure peritoneal cavity has regained its integrity after this period of transition. Early leaks can be avoided by delaying PD start with by 14 days. Intraperitoneal pressure does not seem to contribute significantly. Prevention of PD leaks essentially depends on individual risk factors such as obesity or anterior abdominal surgeries. This article reviews the characteristics of dialysate leaks in PD and the imagery tests to limit transfer to hemodialysis.
- Published
- 2021
33. Quality Indicators for Older Persons’ Transitions in Care: A Systematic Review and Delphi Process
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Brian H. Rowe, Kaitlyn Tate, Rowan El-Bialy, Carol Anderson, Sarah Lee, Greta G. Cummings, Jeffrey A. Bakal, Carole A. Estabrooks, Jayna Holroyd-Leduc, Garnet E. Cummings, and R. Colin Reid
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Canada ,medicine.medical_specialty ,Health (social science) ,Delphi Technique ,media_common.quotation_subject ,Delphi method ,Institute of medicine ,03 medical and health sciences ,0302 clinical medicine ,Documentation ,Acute care ,medicine ,Humans ,Relevance (information retrieval) ,Quality (business) ,030212 general & internal medicine ,Aged ,Quality Indicators, Health Care ,media_common ,Aged, 80 and over ,Community and Home Care ,business.industry ,030503 health policy & services ,Emergency department ,Systematic review ,Family medicine ,Geriatrics and Gerontology ,Emergency Service, Hospital ,0305 other medical science ,business ,Gerontology - Abstract
We identified quality indicators (QIs) for care during transitions of older persons (≥ 65 years of age). Through systematic literature review, we catalogued QIs related to older persons’ transitions in care among continuing care settings and between continuing care and acute care settings and back. Through two Delphi survey rounds, experts ranked relevance, feasibility, and scientific soundness of QIs. A steering committee reviewed QIs for their feasible capture in Canadian administrative databases. Our search yielded 326 QIs from 53 sources. A final set of 38 feasible indicators to measure in current practice was included. The highest proportions of indicators were for the emergency department (47%) and the Institute of Medicine (IOM) quality domain of effectiveness (39.5%). Most feasible indicators were outcome indicators. Our work highlights a lack of standardized transition QI development in practice, and the limitations of current free-text documentation systems in capturing relevant and consistent data.
- Published
- 2021
34. Spinal A 3 adenosine receptor activation acutely restores morphine antinociception in opioid tolerant male rats
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Nikita N. Burke, Tuan Trang, Cynthia Xu, Kenneth A. Jacobson, Yuta Kohro, Rebecca Dalgarno, Christophe Altier, Sydney Sparanese, Churmy Y. Fan, Heather Leduc-Pessah, and Daniela Salvemini
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0301 basic medicine ,Agonist ,business.industry ,medicine.drug_class ,Analgesic ,Central nervous system ,Pharmacology ,Adenosine ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,030104 developmental biology ,0302 clinical medicine ,medicine.anatomical_structure ,Nociception ,Opioid ,Morphine ,Medicine ,business ,Nucleoside ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Opioids are potent analgesics, but their pain-relieving effects diminish with repeated use. The reduction in analgesic potency is a hallmark of opioid analgesic tolerance, which hampers opioid pain therapy. In the central nervous system, opioid analgesia is critically modulated by adenosine, a purine nucleoside implicated in the beneficial and detrimental actions of opioid medications. Here, we focus on the A3 adenosine receptor (A3 AR) in opioid analgesic tolerance. Intrathecal administration of the A3 AR agonist MRS5698 with daily systemic morphine in male rats attenuated the reduction in morphine antinociception over 7 days. In rats with established morphine tolerance, intrathecal MRS5698 partially restored the antinociceptive effects of morphine. However, when MRS5698 was discontinued, these animals displayed a reduced antinociceptive response to morphine. Our results suggest that MRS5698 acutely and transiently potentiates morphine antinociception in tolerant rats. By contrast, in morphine-naive rats MRS5698 treatment did not impact thermal nociceptive threshold or affect antinociceptive response to a single injection of morphine. Furthermore, we found that morphine-induced adenosine release in cerebrospinal fluid was blunted in tolerant animals, but total spinal A3 AR expression was not affected. Collectively, our findings indicate that spinal A3 AR activation acutely potentiates morphine antinociception in the opioid tolerant state.
- Published
- 2021
35. Real-World Evidence of the Clinical and Economic Impact of Long-Acting Injectable Versus Oral Antipsychotics Among Patients with Schizophrenia in the United States: A Systematic Review and Meta-Analysis
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Isabelle Ghelerter, Panagiotis Mavros, Marie-Hélène Lafeuille, Patrick Lefebvre, Dee Lin, Philippe Thompson-Leduc, Carmela Benson, and Ha Nguyen
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medicine.medical_specialty ,business.industry ,Context (language use) ,Pharmacy ,Odds ratio ,Rate ratio ,Confidence interval ,030227 psychiatry ,Clinical trial ,03 medical and health sciences ,Psychiatry and Mental health ,0302 clinical medicine ,Pharmacotherapy ,Meta-analysis ,Internal medicine ,Medicine ,Pharmacology (medical) ,Systematic Review ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
Background Long-acting injectable (LAI) antipsychotics, compared with oral antipsychotics (OA), have been found to significantly improve patient outcomes, including reduced hospitalizations and emergency room (ER) admissions and increased medication adherence among adult patients with schizophrenia. In turn, the clinical benefits achieved may translate into lower economic burden. Real-world evidence of the comparative effectiveness of LAI is needed to understand the potential benefits of LAI outside of the context of clinical trials. This study aimed to provide a comprehensive synthesis of recent published real-world studies comparing healthcare utilization, costs, and adherence between patients with schizophrenia treated with LAI versus OA in the United States. Methods In this systematic literature review, MEDLINE® was searched for peer-reviewed, real-world studies (i.e., retrospective or pragmatic designs) published in English between January 1, 2010 and February 10, 2020. Comparative studies reporting hospitalizations, ER admissions, healthcare costs, or medication adherence (measured by proportion of days covered [PDC]) in adults with schizophrenia treated with LAI versus OA (or pre- vs post-LAI initiation) in the United States were retained. Random effects meta-analyses were conducted among eligible studies to evaluate the association of LAI versus OA use on hospitalizations, ER admissions, healthcare costs, and treatment adherence. A sensitivity analysis among the subset of studies that compared OA with paliperidone palmitate once monthly (PP1M), specifically, was conducted. Results A total of 1083 articles were identified by the electronic literature search, and two publications were manually added subsequently. Among the 57 publications meeting the inclusion criteria, 25 provided sufficient information for inclusion in the meta-analyses. Compared with patients treated with OA, patients initiated on LAI had lower odds of hospitalization (odds ratio [OR] 0.62, 95% confidence interval [CI] 0.54–0.71, n = 7), fewer hospitalizations (incidence rate ratio [IRR] [95% CI] 0.75 [0.65–0.88], n = 9), and fewer ER admissions (IRR [95% CI] 0.86 [0.77–0.97], n = 6). The initiation of LAI was associated with higher per-patient-per-year (PPPY) pharmacy costs (mean difference [MD] [95% CI] $5603 [3799–7407], n = 6), which was offset by lower PPPY medical costs (MD [95% CI] − $5404 [− 7745 to − 3064], n = 6), resulting in no significant net difference in PPPY total all-cause healthcare costs between patients treated with LAI and those treated with OA (MD [95% CI] $327 [− 1565 to 2219], n = 7). Patients initiated on LAI also had higher odds of being adherent to their medication (PDC ≥ 80%; OR [95% CI] 1.89 [1.52–2.35], n = 9). A sensitivity analysis on a subset of publications evaluating PP1M found results similar to those of the main analysis conducted at the LAI class level. Conclusions Based on multiple studies with varying sub-types of patient populations with schizophrenia in the United States published in the last decade, this meta-analysis demonstrated that LAI antipsychotics were associated with improved medication adherence and significant clinical benefit such as reduced hospitalizations and ER admissions compared with OA. The lower medical costs offset the higher pharmacy costs, resulting in a non-significant difference in total healthcare costs. Taken together, these findings provide strong evidence on the clinical and economic benefits of LAI compared with OA for the treatment of schizophrenia in the real world. Supplementary Information The online version contains supplementary material available at 10.1007/s40263-021-00815-y.
- Published
- 2021
36. Frequency and characterization of mutations in genes in a large cohort of patients referred to MODY registry
- Author
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Xiao Fan, Wendy K. Chung, Emily Breidbart, Rudolph L. Leibel, Jiancheng Guo, Patricia Lanzano, Charles A. LeDuc, and Liyong Deng
- Subjects
Adult ,Male ,0301 basic medicine ,Proband ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,New York ,030209 endocrinology & metabolism ,Article ,Maturity onset diabetes of the young ,Germinal Center Kinases ,Cohort Studies ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Molecular genetics ,Exome Sequencing ,Humans ,Medicine ,Genetic Testing ,Hepatocyte Nuclear Factor 1-alpha ,Registries ,Exome sequencing ,Genetic testing ,Genetics ,medicine.diagnostic_test ,business.industry ,Prognosis ,medicine.disease ,HNF1B ,HNF1A ,Phenotype ,030104 developmental biology ,Diabetes Mellitus, Type 2 ,Mutation ,Pediatrics, Perinatology and Child Health ,Female ,Age of onset ,business ,Biomarkers ,Follow-Up Studies - Abstract
Objectives There have been few large-scale studies utilizing exome sequencing for genetically undiagnosed maturity onset diabetes of the young (MODY), a monogenic form of diabetes that is under-recognized. We describe a cohort of 160 individuals with suspected monogenic diabetes who were genetically assessed for mutations in genes known to cause MODY. Methods We used a tiered testing approach focusing initially on GCK and HNF1A and then expanding to exome sequencing for those individuals without identified mutations in GCK or HNF1A. The average age of onset of hyperglycemia or diabetes diagnosis was 19 years (median 14 years) with an average HbA1C of 7.1%. Results Sixty (37.5%) probands had heterozygous likely pathogenic/pathogenic variants in one of the MODY genes, 90% of which were in GCK or HNF1A. Less frequently, mutations were identified in PDX1, HNF4A, HNF1B, and KCNJ11. For those probands with available family members, 100% of the variants segregated with diabetes in the family. Cascade genetic testing in families identified 75 additional family members with a familial MODY mutation. Conclusions Our study is one of the largest and most ethnically diverse studies using exome sequencing to assess MODY genes. Tiered testing is an effective strategy to genetically diagnose atypical diabetes, and familial cascade genetic testing identified on average one additional family member with monogenic diabetes for each mutation identified in a proband.
- Published
- 2021
37. Flex's Multi-Industry Success is by Design
- Author
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Leduc, Zoe
- Subjects
Electronic components industry -- Officials and employees -- Innovations ,Business ,Engineering and manufacturing industries - Abstract
For Flex, there isn't a question of what can't they do, but what they will do next. The 50-year-old company began manufacturing electronic products, something it still does today, but [...]
- Published
- 2019
38. THE FUTURE OF WORK: Industry 4.0 will change how we define manufacturing work
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Leduc, Zoe
- Subjects
Business ,Engineering and manufacturing industries - Abstract
The fourth industrial revolution has begun and with it, comes changes to the way manufacturing work is done. New technology, such as collaborative robots, the Industrial Internet of Things (IIoT) [...]
- Published
- 2019
39. TAPE FOR WIRE HARNESSES: Tapes are a cost-effective method for protecting and bundling wire harnesses
- Author
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LeDuc, Zoe
- Subjects
Tesa Tape Inc. ,Business ,Engineering and manufacturing industries - Abstract
In a single year, millions of cars are manufactured worldwide. While the styles, parts and features may vary, every vehicle requires a wire harness. The harness connects the wiring throughout [...]
- Published
- 2019
40. Estimating mill residue surplus in Canada: A spatial forest fiber cascade modeling approach
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Ghafghazi, Saeed, Lochhead, Kyle, Mathey, Anne-Helen, Forsell, Nicklas, Leduc, Sylvain, Mabee, Warren, and Bull, Gary
- Subjects
Canada. Canadian Forest Service -- Economic policy ,Biomass -- Environmental aspects ,Bioeconomics -- Analysis ,Business ,Forest products industry - Abstract
Abstract The potential development of a Canadian forest-based bioeconomy requires an assessment of both fiber availability and associated marginal supply costs. To a large extent, the bioeconomy is expected to [...]
- Published
- 2017
- Full Text
- View/download PDF
41. Multi-centre implementation of an Educational program to improve the Cardiac Arrest diagnostic accuracy of ambulance Telecommunicators and survival outcomes for sudden cardiac arrest victims: the EduCATe study design and methodology
- Author
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Ian E. Blanchard, John M. Tallon, Jamie C. Brehaut, Sarika Naidoo, Monica Taljaard, Matthew Spidel, Kathryn Cyr, Judah Goldstein, Jim Garland, Manya Charette, Colette Lacroix, Jennie Helmer, Sheldon Cheskes, Sandra Zambon, Aaron Sibley, Michael Feldman, Paul Dorian, Katie N. Dainty, Shannon Leduc, Matthew Church, Jim Christenson, Stephanie Hodges, Christian Vaillancourt, and Venkatesh Thiruganasambandamoorthy
- Subjects
medicine.medical_specialty ,Canada ,Agonal breathing ,medicine.medical_treatment ,Resuscitation ,Population ,Ambulances ,lcsh:Special situations and conditions ,Sudden cardiac death ,Study Protocol ,Quality of life ,Emergency medical services ,Medicine ,Humans ,Cardiopulmonary resuscitation ,Prospective Studies ,education ,Telecommunicators ,education.field_of_study ,business.industry ,Medical record ,lcsh:RC952-1245 ,lcsh:Medical emergencies. Critical care. Intensive care. First aid ,Sudden cardiac arrest ,lcsh:RC86-88.9 ,medicine.disease ,Cardiac arrest ,Survival Analysis ,Death, Sudden, Cardiac ,Emergency medicine ,Emergency Medicine ,Quality of Life ,Telecommunications ,medicine.symptom ,business ,Educational program ,Out-of-Hospital Cardiac Arrest - Abstract
Background Sudden cardiac death remains a leading cause of mortality in Canada, resulting in more than 35,000 deaths annually. Most cardiac arrest victims collapse in their own home (85% of the time) and 50% are witnessed by a family member or bystander. Survivors have a quality of life similar to the general population, but the overall survival rate for out-of-hospital cardiac arrest (OHCA) rarely exceeds 8%. Victims are almost four times more likely to survive when receiving bystander CPR, but bystander CPR rates have remained low in Canada over the past decade, not exceeding 15–25% until recently. Telecommunication-assisted CPR instructions have been shown to significantly increase bystander CPR rates, but agonal breathing may be misinterpreted as a sign of life by 9–1-1 callers and telecommunicators, and is responsible for as much as 50% of missed OHCA diagnoses. We sought to improve the ability and speed with which ambulance telecommunicators can recognize OHCA over the phone, initiate timely CPR instructions, and improve survival. Methods In this multi-center national study, we will implement and evaluate an educational program developed for ambulance telecommunicators using a multiple baseline interrupted time-series design. We will compare outcomes 12 months before and after the implementation of a 20-min theory-based educational video addressing barriers to recognition of OHCA while in the presence of agonal breathing. Participating Canadian sites demonstrated prior ability to collect standardized data on OHCA. Data will be collected from eligible 9–1-1 recordings, paramedic documentation and hospital medical records. Eligible cases will include suspected or confirmed OHCA of presumed cardiac origin in patients of any age with attempted resuscitation. Discussion The ability of telecommunication-assisted CPR instructions to improve bystander CPR and survival rates for OHCA victims is undeniable. The ability of telecommunicators to recognize OHCA over the phone is unequivocally impeded by relative lack of training on agonal breathing, and reluctance to initiate CPR instructions when in doubt. Our pilot data suggests the potential impact of this project will be to increase absolute OHCA recognition and bystander CPR rates by at least 10%, and absolute out-of-hospital cardiac arrest survival by 5% or more. Trial registration Prospectively registered on March 28, 2019 at ClinicalTrials.gov identifier: NCT03894059.
- Published
- 2021
42. Adapting the Wheelchair Skills Program for pediatric rehabilitation: recommendations from key stakeholders
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Geneviève Daoust, Najoua Assila, Louise Demers, Marissa Racine, Paula W. Rushton, and Karolann Leduc
- Subjects
Occupational therapy ,Adult ,030506 rehabilitation ,medicine.medical_specialty ,Canada ,Context (language use) ,Wheelchair skills program ,03 medical and health sciences ,Consolidated framework for implementation research, qualitative studies ,0302 clinical medicine ,Wheelchair ,Intervention (counseling) ,Knowledge translation ,medicine ,Humans ,Disabled Persons ,030212 general & internal medicine ,Adaptation (computer science) ,Child ,Qualitative Research ,Medical education ,business.industry ,lcsh:RJ1-570 ,Knowledge-to-action ,lcsh:Pediatrics ,Focus Groups ,Focus group ,Wheelchairs ,Pediatric rehabilitation ,Pediatrics, Perinatology and Child Health ,Implementation research ,0305 other medical science ,business ,Research Article - Abstract
Background Backed by over 20 years of research development, the Wheelchair Skills Program (WSP) has proven to be a safe and effective program to improving wheelchair skills for adult wheelchair users. However, evidence is lacking for the pediatric population, which may help to explain the limited use of the WSP in pediatric settings. While additional evidence specific to the pediatric population is needed, concurrent implementation of the WSP into pediatric clinical practice is equally prudent to allow those users to benefit from the years of accumulated WSP evidence. To facilitate implementation of evidence-based programs into practice, adaptation is also often required to improve the fit between the program and the local context. Therefore, the objective of this study was to understand what adaptations, if any, are required for the WSP to be implementable in a pediatric setting. Methods A deductive qualitative descriptive study design was used, guided by the Knowledge to Action Framework and Consolidated Framework for Implementation Research (CFIR). Occupational Therapists (OTs) from a pediatric rehabilitation center and two specialized schools in Montreal, Canada were invited to participate in a 90-min focus group. The Framework Method was followed for the data analysis. Results One focus group in each site (n = 3) was conducted with a total of 19 participants. From the OTs’ perspectives, our analysis revealed benefits of WSP use and various issues (e.g. some skills seem unrealistic) affecting its uptake in relation to the constructs of the CFIR Intervention Characteristics domain. The results provided guidance for the recommendations of adaptations (e.g. addition of a caregiver assistance score) to enhance implementation of the WSP in pediatric rehabilitation settings and helped to identify the need for the production of new knowledge and knowledge translation (KT) tools. Conclusions Implementation of the WSP with the adaptations and KT tools proposed could allow pediatric manual wheelchair users to improve their wheelchair skills.
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- 2021
43. Evaluation of the polyp-based resect and discard strategy: a retrospective study
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Raymond Leduc, Roupen Djinbachian, Daniel von Renteln, Alan N. Barkun, Andres Aguilera-Fish, Mickael Bouin, Annie Deshêtres, Antoine Duong, Eric Deslandres, Heiko Pohl, and P Marques
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,General surgery ,Gastroenterology ,MEDLINE ,Colonoscopy ,Retrospective cohort study ,Confidence interval ,Clinical trial ,03 medical and health sciences ,0302 clinical medicine ,Chart ,030220 oncology & carcinogenesis ,Post-hoc analysis ,medicine ,030211 gastroenterology & hepatology ,Prospective cohort study ,business - Abstract
Background Standard colonoscopy practice requires removal and histological characterization of almost all detected small ( Methods A post hoc analysis was performed on patients enrolled in a prospective study. The primary outcome was surveillance interval agreement of the PBRD strategy with pathology-based management according to 2020 US Multi-Society Task Force guidelines. Chart analysis also evaluated clinician adherence to pathology-based recommendations. One-sided testing was performed with a null-hypothesis of 90 % agreement with pathology-based surveillance intervals and a two-sided 96.7 % confidence interval (CI) using correction for multiple testing. Results 452 patients were included in the study. Surveillance intervals assigned using the PBRD strategy were correct in 97.8 % (96.7 %CI 96.3–99.3 %) of patients compared with pathology-based management. The PBRD strategy reduced pathology examinations by 58.7 % while providing 87.8 % of patients with immediate surveillance interval recommendations on the day of colonoscopy, compared with 47.1 % when using pathology-based management. Chart analysis of surveillance interval assignments showed 63.3 % adherence to pathology-based guidelines. Conclusion The PBRD strategy surpassed the 90 % agreement with the pathology-based standard for determining surveillance interval, reduced the need for pathology examinations, and increased the proportion of patients receiving immediate surveillance interval recommendations. The PBRD strategy does not require expertise in optical diagnosis and may replace histological characterization of small and diminutive colorectal polyps.
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- 2021
44. Survival Impact of Aggressive Treatment and PD-L1 Expression in Oligometastatic NSCLC
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Roula Albadine, Danh Tran-Thanh, Charles Leduc, Mustapha Tehfe, Vimal Krishnan, Normand Blais, Bertrand Routy, Louis Gaboury, Imane Kaci, Karine Bédard, Marie Florescu, and Camille Gauvin
- Subjects
PD-L1 ,Oncology ,medicine.medical_specialty ,Lung Neoplasms ,oligometastatic ,overall survival ,medicine.medical_treatment ,Subgroup analysis ,Article ,B7-H1 Antigen ,Group B ,law.invention ,immune checkpoint inhibitors ,Randomized controlled trial ,law ,Carcinoma, Non-Small-Cell Lung ,Internal medicine ,medicine ,Humans ,Stage (cooking) ,prognostic factor ,Lung cancer ,non-small cell lung cancer ,RC254-282 ,Neoplasm Staging ,business.industry ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Immunotherapy ,Prognosis ,medicine.disease ,Primary tumor ,respiratory tract diseases ,aggressive treatment ,Cohort ,immunotherapy ,business - Abstract
Background: Studies have shown that aggressive treatment of non-small cell lung cancer (NSCLC) with oligometastatic disease improves the overall survival (OS) compared to a palliative approach and some immunotherapy checkpoint inhibitors, such as anti-programmed cell death ligand 1 (PD-L1), anti-programmed cell death protein 1 (PD-1), and T-Lymphocyte-associated antigen 4 (CTLA-4) inhibitors are now part of the standard of care for advanced NSCLC. However, the prognostic impact of PD-L1 expression in the oligometastatic setting remains unknown. Methods: Patients with oligometastatic NSCLC were identified from the patient database of the Centre hospitalier de l&rsquo, Université, de Montré, al (CHUM). &ldquo, Oligometastatic disease&rdquo, definition chosen is one synchronous metastasis based on the M1b staging of the eight IASLC (The International Association for the Study of Lung Cancer) Classification (within sixth months of diagnosis) or up to three cerebral metastasis based on the methodology of the previous major phase II randomized study of Gomez et al. We compared the OS between patients receiving aggressive treatment at both metastatic and primary sites (Group A) and patients receiving non-aggressive treatment (Group B). Subgroup analysis was performed using tumor PD-L1 expression. Results: Among 643 metastatic NSCLC patients, we identified 67 patients with oligometastasis (10%). Median follow-up was 13.3 months. Twenty-nine patients (43%) received radical treatment at metastatic and primary sites (Group A), and 38 patients (57%) received non-aggressive treatment (Group B). The median OS (mOS) of Group A was significantly longer than for Group B (26 months vs. 5 months, p = 0.0001). Median progression-free survival (mPFS) of Group A was superior than Group B (17.5 months vs. 3.4 months, p = 0.0001). This difference was still significant when controlled for primary tumor staging: stage I (p = 0.316), stage II (p = 0.024), and stage III (p = 0.001). In the cohort of patients who were not treated with PD-L1 inhibitors, PD-L1 expression negatively correlated with mOS. Conclusions: Aggressive treatments of oligometastatic NSCLC significantly improve mOS and mPFS compared to a more palliative approach. PD-L1 expression is a negative prognostic factor which suggests a possible role for immunotherapy in this setting.
- Published
- 2021
45. Weight‐loss response to naltrexone/bupropion is modulated by the <scp>Taq1A</scp> genetic variant near <scp> DRD2 </scp> ( <scp>rs1800497</scp> ): A pilot study
- Author
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Jamie A. Mullally, Rajasekhar Ramakrishnan, Steven Holleran, Tirissa J. Reid, Charles A. LeDuc, Gerardo Febres, Wendy K. Chung, and Judith Korner
- Subjects
Bupropion ,Dopamine binding ,ANKK1 ,medicine.medical_specialty ,business.industry ,Endocrinology, Diabetes and Metabolism ,media_common.quotation_subject ,Appetite ,Naltrexone ,Endocrinology ,Weight loss ,Internal medicine ,Genotype ,Internal Medicine ,medicine ,medicine.symptom ,business ,Pharmacogenetics ,medicine.drug ,media_common - Abstract
Naltrexone/bupropion (NB) is a US Food and Drug Administration-approved antiobesity medication. Clinical trials have shown variable weight loss, with responders and non-responders. NB is believed to act on central dopaminergic pathways to suppress appetite. The Taq1A polymorphism near DRD2 (rs1800497) is associated with the density of striatal dopamine D2 receptors, with individuals carrying the A allele (AA or AG; termed A1+) having 30%-40% fewer dopamine binding sites than those who do not carry the A allele (GG; termed A1-). We performed a pilot study to assess the association of the rs1800497 ANKK1 c.2137G > A (p.Glu713Lys) variant with weight loss with NB treatment in 33 subjects. Mean (SD) weight loss was 5.9% (3.2%) for the A1+ genotype group (n = 15) and 4.2% (4.2%) for the A1- genotype group (n = 18). The mean weight loss for the A1+ genotype group was significantly greater than the predefined clinically significant 4% weight-loss target (one-sample t-test, P = .035), whereas the mean weight loss for the A1- genotype group was not (P = .85). Individuals with the A1+ genotype appear to respond better to NB than A1- individuals.
- Published
- 2021
46. Mobile-Optimized Facial Expression Recognition Techniques
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Nizar El Zarif, Leila Montazeri, Francois Leduc-Primeau, and Mohamad Sawan
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General Computer Science ,Computer science ,020209 energy ,Feature extraction ,pose-invariant ,ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION ,active shape model ,02 engineering and technology ,Facial recognition system ,Convolutional neural network ,Software portability ,0202 electrical engineering, electronic engineering, information engineering ,General Materials Science ,multithreaded ,Facial expression ,Artificial neural network ,business.industry ,General Engineering ,Pattern recognition ,Frame rate ,TK1-9971 ,machine learning ,ComputingMethodologies_PATTERNRECOGNITION ,Memory management ,020201 artificial intelligence & image processing ,Electrical engineering. Electronics. Nuclear engineering ,Artificial intelligence ,Facial expression recognition ,business - Abstract
This paper presents two novel facial expression recognition techniques: the real-time ensemble for facial expression recognition (REFER) and the facial expression recognition network (FERNet). Both approaches can detect facial expressions from various poses, distances, angles, and resolutions, and both techniques exhibit high computational efficiency and portability. REFER outperforms the existing approaches in terms of cross-dataset accuracy, making it an ideal network to use on fresh data. FERNet is a compact convolutional neural network that uses both geometric and texture features to achieve up to 98% accuracy on the MUG dataset. Both approaches can process 14 frames per second (FPS) from a live video capture on a battery-powered Raspberry Pi 4.
- Published
- 2021
47. The Mini-Med School and Its Impact on Future Health Care Professionals' Attitudes toward Indigenous People
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Éric Drouin, Anne-Sophie Thommeret-Carrière, Jean-Michel Leduc, Richard Rioux, Christophe Moderie, and Sébastien Béland
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Medical education ,Schools ,Adolescent ,Social work ,Attitude of Health Personnel ,business.industry ,Health Personnel ,Public Health, Environmental and Occupational Health ,Indigenous ,Health care ,Humans ,Indigenous Peoples ,Students ,Psychology ,Baseline (configuration management) ,business - Abstract
Mini-Med Schools (MiMS) are an opportunity for health sciences and social work undergraduates to discuss health-related topics with Innu and Atikamekw youth in Canada. More than 500 undergraduates and 1,000 students have taken part in the project since its beginning in 2011. This study aims to assess the impact of both 1) MiMS's predeparture training and 2) the MiMS themselves on undergraduates' prejudices toward Indigenous peoples. Satisfaction of the undergraduates taking part in the activity was also assessed. Seventy-eight undergraduates were recruited and completed the Old-fashioned and Modern Prejudiced Attitudes Toward Aboriginals Scales (O-PATAS and M-PATAS) at baseline, after the pre-departure training, and after the MiMS. They also completed satisfaction surveys. This study shows a reduction of prejudices after participating to a MiMS, but no effect of a pre-departure training. The activities were overall appreciated by undergraduates and most of them would like to take part again in the MiMS.
- Published
- 2021
48. Continuous Pneumatic Regulation of Tracheal Cuff Pressure to Decrease Ventilator-associated Pneumonia in Trauma Patients Who Were Mechanically Ventilated
- Author
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Olivier Mimoz, Benoit Veber, Matthieu Boisson, Dominique Falcon, Carole Ichai, Claire-Marie Drevet, Lilit Kelesyan, Thiên-Nga Chamaraux-Tran, Laurent Muler, Julien Pottecher, Marc Leone, Abdelouaid Nadji, Hervé Quintard, Claire Dahyot-Fizelier, Belaid Bouhemad, Nicolas Marjanovic, Sigismond Lasocki, Claire Roger, Thomas Kerforne, Jean-Yves Lefrant, Catherine Paugam-Burtz, Marc Ginet, Antoine Roquilly, Elodie Caumon, Emmanuelle Hammad, Florian Grimaldi, Pierre-Olivier Ludes, Jérémy Guenezan, Arnaud Foucrier, Sébastien Leduc, Guillaume Besch, Sabrina Seguin, Russell Chabanne, Karim Asehnoune, Philippe Gouin, Pierre-Gildas Guitard, Denis Frasca, Maxime Léger, Sebastien Pili-Floury, Raphaël Cinotti, Marie-Héléne Po, Joe de Keizer, Soizic Gergaud, Thomas Gaillard, Centre hospitalier universitaire de Poitiers (CHU Poitiers), Université de Poitiers - Faculté de Médecine et de Pharmacie, Université de Poitiers, CIC - Poitiers, Université de Poitiers-Centre hospitalier universitaire de Poitiers (CHU Poitiers)-Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Pharmacologie des anti-infectieux (PHAR), Université de Poitiers-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre hospitalier universitaire de Nantes (CHU Nantes), Département d'Anesthésie et Réanimation [Hôpital Beaujon], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Département d'Anesthésie-Réanimation [CHU Angers], Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Centre Hospitalier Universitaire de Nice (CHU Nice), Aix Marseille Université (AMU), Service Anesthésie et Réanimation [Hôpital Nord - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital Nord [CHU - APHM], Hôpital de Hautepierre [Strasbourg], Université de Strasbourg - Faculté de Médecine [Strabourg] (FMTS), Initial MAnagement and prevention of acute orGan failures IN critically ill patiEnts (IMAGINE), Université de Montpellier (UM), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Centre Hospitalier Universitaire [Grenoble] (CHU), Service de soins intensifs [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), CHU Clermont-Ferrand, Service d'anesthésie - réanimation chirurgicale [CHU de Dijon], Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Marqueurs pronostiques et facteurs de régulations des pathologies cardiaques et vasculaires - UFC ( EA 3920) (PCVP / CARDIO), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), MethodS in Patients-centered outcomes and HEalth ResEarch (SPHERE), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques, Université de Nantes (UN)-Université de Nantes (UN), AGATE Study Group: Guillaume Besch, Bélaid Bouhemad, Elodie Caumon, Thien-Nga Chamaraux-Tran, Raphael Cinotti, Thomas Gaillard, Soizic Gergaud, Marc Ginet, Philippe Gouin, Florian Grimaldi, Pierre-Gildas Guitard, Emmanuelle Hammad, Lilit Kelesyan, Sébastien Leduc, Maxime Leger, Pierre-Olivier Ludes, Laurent Muler, Abdelouaid Nadji, Catherine Paugam-Burtz, Marie-Héléne Po, Hervé Quintard, Claire Roger, Antoine Roquilly, Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Marqueurs pronostiques et facteurs de régulations des pathologies cardiaques et vasculaires - UFC ( UR 3920) (PCVP / CARDIO), Chauzy, Alexia, Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), and Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques
- Subjects
Pulmonary and Respiratory Medicine ,medicine.medical_treatment ,[SDV]Life Sciences [q-bio] ,Population ,Critical Care and Intensive Care Medicine ,Tracheal tube ,03 medical and health sciences ,0302 clinical medicine ,Intensive care ,ventilator-associated ,medicine ,pneumonia ,030212 general & internal medicine ,education ,intensive care ,Mechanical ventilation ,education.field_of_study ,business.industry ,Tracheal intubation ,Ventilator-associated pneumonia ,[SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences ,medicine.disease ,infection ,3. Good health ,[SDV] Life Sciences [q-bio] ,[SDV.SP] Life Sciences [q-bio]/Pharmaceutical sciences ,030228 respiratory system ,Anesthesia ,Cuff ,tracheal cuff pressure ,Injury Severity Score ,Cardiology and Cardiovascular Medicine ,business - Abstract
International audience; Background: Ventilator-associated pneumonia (VAP) is the most frequent health care-associated infection in severely ill patients, and aspiration of contaminated oropharyngeal content around the cuff of the tracheal tube is the main route of contamination.Research question: Is continuous regulation of tracheal cuff pressure using a pneumatic device superior to manual assessment three times daily using a portable manometer (routine care) in preventing VAP in patients with severe trauma?Study design and methods: In this open-label, randomized controlled superiority trial conducted in 13 French ICUs, adults (age ≥ 18 years) with severe trauma (Injury Severity Score > 15) and requiring invasive mechanical ventilation for ≥ 48 h were enrolled. Patients were randomly assigned (1:1) via a secure Web-based random number generator in permuted blocks of variable sizes to one of two groups according to the method of tracheal cuff pressure control. The primary outcome was the proportion of patients developing VAP within 28 days following the tracheal intubation, as determined by two assessors masked to group assignment, in the modified intention-to-treat population. This study is closed to new participants.Results: A total of 434 patients were recruited between July 31, 2015, and February 15, 2018, of whom 216 were assigned to the intervention group and 218 to the control group. Seventy-three patients (33.8%) developed at least one episode of VAP within 28 days following the tracheal intubation in the intervention group compared with 64 patients (29.4%) in the control group (adjusted subdistribution hazard ratio, 0.96; 95% CI, 0.76-1.20; P = .71). No serious adverse events related to the use of the pneumatic device were noted.Interpretation: Continuous regulation of cuff pressure of the tracheal tube using a pneumatic device was not superior to routine care in preventing VAP in patients with severe trauma.Clinical trial registration: ClinicalTrials.gov; No.: NCT02534974; URL: www.clinicaltrials.gov.
- Published
- 2021
49. It's Material: Riding the Pipeline
- Author
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Froemming, Denise LeDuc
- Subjects
Pipe lines ,Banking, finance and accounting industries ,Business - Abstract
Fall is here and it's back to school for many. Including CalCPA, in a way. The application period recently closed on our Industry Influencer campaign--our retooled Campus Ambassador program--and we're [...]
- Published
- 2022
50. It's Material
- Author
-
Froemming, Denise LeDuc
- Subjects
Banking, finance and accounting industries ,Business - Abstract
Lead On Leadership. It's one of those things we all recognize, but sometimes have a hard time explaining. Varied thoughts have been --and will continue to be--discussed for years because [...]
- Published
- 2022
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