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Metabolic reprogramming is one of the hallmarks of cancer. Nrf2 pathway is one of the critical signaling cascades involved in cell defense and survival against oxidative stress. The significance of Nrf2 in cancer metabolism begins to be recognized. In this minireview, we focus on the Nrf2-mediated cancer metabolic reprogramming and intend to highlight the role of Nrf2 in the regulation of malignant transformation, cancer proliferation, and the development of treatment resistance via metabolic adaptations. We hope for the development of noninvasive biomarkers and novel therapeutic approaches for cancer based on Nrf2-directed cancer metabolic reprogramming in the near future.

② (61302 PLA Troops, Beijing 100016, China) Abstract: In this paper, we present the methods of parametrically reconstructing the position of a 3D scattering center model of the targets from SAR images for a target recognition application. First, a framework for reconstructing the 3D position of the targets from the SAR images is proposed. Then, a method that uses the parameters obtained from the scattering center of the targets from the SAR images is used for reconstructing the 3D scattering center model. Finally, the proposed methods are confirmed using the simulated data.

Background Leukemia cutis (LC) represents a skin infiltration by leukemic cells. Clinically, it can mimic a wide variety of dermatoses. Methods We report a case of LC presenting with a Sweet’s syndrome-like eruption and a histiocytoid Sweet’s syndrome histologic manifestation. Results This case may represent distinct and important cutaneous and histopathologic manifestations of LC. Conclusions We believe that peripheral blood or bone marrow cytologic analysis is necessary in cases of LC to rule out the possibility of histiocytoid Sweet’s syndrome. Additional study is needed to further elucidate the relationship between LC and histiocytoid Sweet’s syndrome.

To arrive at the goal of intensifying the trustworthiness and controllability of d istributed systems, the core function of secure algorithms and chips should be fully exerted. Through building the trustworthy model between distributed system and user behaviors, constructing the architecture of trustworthiness distributed systems, intensifying the survivability of services, and strengthening the manageability of distributed systems, the secure problem of distributed systems is to be rad ically solved. By setting up the trustworthy computing circu mstance and supplying the trustworthy validation and the active protection based on identity and behavior for trustworthy distributed system, we will reach the goal of defending the unaware v iruses and inbreak. This research insists that the security, controllability, manageability, and survivability should be basic properties of a trustworthy distributed system. The key ideas and techniques involved in these properties are studied, and recent developments and progresses are surveyed. At the same time, the technical trends and challenges are briefly discussed.

This paper reports a systematic experimental investigation on the dynamics in the low-frequency region in an erbium-doped flbre-ring laser with loss modulation. A rich variety of bifurcation is analyzed through the bifurcation diagram and structured with the concept of the winding numbers. The coexistence of multiple attractors and the crisis that appear in the saddle-node bifurcations, and an interesting structure of bifurcation which is similar to the bifurcations in high-frequency range, have been observed.

By the aid of the international mining software SURPAC, a geologic database for a multi-metal mine was established, 3D models of the surface, geologic fault, ore body, cavity and the underground openings were built, and the volume of the cavity of the mine based on the cavity 3D model was calculated. In order to compute the reserves, a grade block model was built and each metal element grade was estimated using Ordinary Kriging. Then, the reserve of each metal element and every sublevel of the mine was worked out. Finally, the calculated result of each metal reserve to its actual prospecting reserve was compared, and the results show that they are all almost equal to each other. The absolute errors of Sn, Pb, and Zn reserves are only 1.45%, 1.59% and 1.62%, respectively. Obviously, the built models are reliable and the calculated results of reserves are correct. They can be used to assist the geologic and mining engineers of the mine to do research work of reserves estimation, mining design, plan making and so on.

Traditional timing green wave control with predetermined cycle, split, and offset cannot adapt for dynamic real-time traffic flow. This paper proposes a coordinated control method for variable cycle time green wave bandwidth optimization integrated with traffic-actuated control. In the coordinated control, green split is optimized in real time by the measured presence of arriving and/or standing vehicles in each intersection and simultaneously green waves along arterials are guaranteed. Specifically, the dynamic bound of green wave is firstly determined, and then green early-start and green late-start algorithms are presented respectively to accommodate the fluctuations in vehicle arrival rates in each phase. Numerical examples show that the proposed method improves green time, expands green wave bandwidth, and reduces queuing.

Flexible dispersion of photonic crystal fiber (PCF) has been demonstrated with the help of Hermite–Gaussian functions. Parametric fluorescence (PF) based on four wave mixing (FWM) in PCF with zero-dispersion wavelength at 0.85, 1.33 and 1.55 μm have been simulated, respectively. Simulations show that PCF can be used to generate efficient photon-pairs on desired wavelength.

In urban traffic network, the traffic flow within several adjacent intersections is strongly relevant and traffic congestion happened on one road section will probably result in cascade of regional congestion. In this paper, we try to optimize each traffic section state to a desired consensus state in traditional subarea. Because of the difficulty to execute real experiment, we apply ACP computational experiments method to realize the process. Firstly, we establish a regional road network traffic model and set up traffic state equation with traffic density as traffic state and leaving proportions of traffic flow on sections during effective green per cycle as control input. Secondly, we design a state feedback control strategy to regulate the leaving proportions of each section which indirectly reflects the effective green time, according to the difference between real-time traffic states and desired traffic consistency state. Thirdly, we apply computational experiments method to find the right value of leaving proportions indexes which will make section traffic state converge towards the desired consensus states and balance the distribution of traffic in overall regional traffic network. The MATLAB simulation results show the feasibility and efficiency of the proposed method.

Introducing the trust evaluation into the access control for the service requester in a distributed network environment could be helpful for enhancing the precision and security of authorization decisions, special to the strange requesters. The existing researches of the trust evaluation could be divided into the objective means and the subjective means. The subjective evaluations could be used to dynamically measure the user's trust degree according to the reputation based on its past actions. But it cannot work when the interaction experience with the user is absence. Compared with other subjective evaluation models using the probability theory, the fuzzy based model could exactly depict the unsure and fuzzy phenomena in process. But the existing fuzzy method based on the fuzzy synthetic evaluation needs to do complex calculations between trust vectors. And the chosen operators are not enough accurate. In this paper we promote a comprehensive trust evaluation framework was a fusion of objective and subjective means. An initial trust view for user is provided based on the certified trust and a reputation is derived by the fuzzy synthetic evaluation method based on user's past actions. The proposed fuzzy method can avoid complex calculations between trust vectors, and adopts a more accurate operator to avert the information wastage.

This paper briefly introduces the network boundaries can be effectively protected using network defense in depth system and the shortcomings of its technical means. Then introduced the data mining technology applications in the firewall policy optimization, traffic identification, intrusion detection technology areas at different levels of defense in depth, and lists a variety of specific application modes, which can effectively enhance the dynamic adaptation and automated optimization capabilities of defense in depth system to a wide range of network attacks and traffic flow changes.

In order to ensure the security of Web Geographic Information System in network transmission, the vector map data can be encrypted in the way of byte by byte using the chaos system to design encryption arithmetic. In this way of encryption, it should firstly make sure the parameter of Logistic mapping, secondly the logistic mapping should be the key stream generator, which would be design to convert block cipher Data Encryption Standard into sequential cipher, finally the result of encryption should be real-time and key stream longness of plaintext and cipher text would be the same. In this way the impression of encryption would be more secure and efficient. The experiment showed that this arithmetic had less error code diffusibility and efficiency was well.

Division approach of traffic control Sub-area is an important aspect for city traffic control. Aim at this problem, based on analyzing relative factors for traffic sub-area division, a new method with grey relation degree is put forward, this new method is not only easy to realize, but also able to describe the relation between intersection Quantitatively. How to realize this method is given in this paper, and the example proves the effectiveness of the method.

The typical intersection traffic flow control ways play poor role in saturated status, in order to resolve this problem, at first, the intersection control features under saturated status is analyzed, then by the queue length detection by video detection way, a new control way with threshold and rule is put forward, in which three control stages are included. Simulation result shows that this method has more effectiveness than the Webster's method when traffic flow is saturated.

On the basis of relation between driver's decision when vehicle-cross action is done in the unsignalized intersection, the driver's decision on minor time and space scale is analyzed, and the expression for safety factors and speed factors for traffic conflict vehicles in the unsignalized intersection is put up, then the utility function for vehicle-cross action is put up too. With these work, the model of driver vehicle-cross action in the unsignalized intersection is built up with dynamic game theory, and the Nash equilibrium for dynamic game process is analyzed. At last, the game model is verified by simulation, result shows that the game model is able to reflect the development result of traffic conflict under different condition, and it is logical to study driver action using dynamic game theory.

Aiming at the intelligent control for reheating furnace combustion, a kind of genetic algorithm-based intelligent control method is presented. The performance index of the controller is a function that consists of error, output, rising tune and overshooting of the system. A group of optimum intelligent control parameters are acquired with the aid of global search ability on line based on real time error. Application results show that the combustion control system has good dynamic and static performances, adaptive capability and robustness.

Driver fatigue is one of the main causes of traffic accidents. Many researchers believe that electroencephalography is very accurate and promising to detect driving fatigue, but so far, the research results have been variable. Through simulation experiments, this paper found when driving at night, delta band varies significantly with the degree of fatigue. The results have implications for real-time automatic detecting driver fatigue at night and are helpful for future development of driver fatigue countermeasures.

Vehicle navigation system (VNS) is an important system in intelligent transportation system (ITS). Floating vehicle data detection system is an important part of VNS. The paper introduces the VNS project in Beijing and discusses selection of floating car used in data detection system of Beijing. Also the paper gives basic structure of floating vehicle data detection system and the functions of the system. At last, a test system is built to testify the practicality of the floating vehicle data detection system. The results show that the system works well and has good potential market in Beijing

In this paper we present an approach based on multi-agent technology to realize optimal intersection control. First description and function of intersection agent and phase agent are given, then with an example, the whole structure of the intersection control approach and its intensive learning process are showed. Simulation test fully indicates its effectiveness and reliability.

On the basis of agent technology, this paper focuses on a study of area traffic flow coordination control. The composition and structure of agents for area traffic flow control is discussed and the coordination strategy of the intersection agent is described. On the basis of this study, some simulations on a sample road net are preformed by analyzing the simulation results. The feasibility of using agent technology to study area traffic coordination control is asserted.

By carefully controlling the shape of single-mode fiber taper, an acousto-optic switch with 24 dB extinction ratio, 0.1 dB insertion loss and 20 /spl mu/s switching time is achieved for the first time.

Null coupler with very high splitting ratio of 100,000:1 and low excess loss of 0.1 dB is reported. The control of the splitting ratio and loss is studied. The switching function is demonstrated by an acoustooptic modulation experiment.

A dynamically tunable fiber filter realizing complex spectra of phase-shifted long period fiber gratings (LPFGs) is proposed and demonstrated experimentally. The principle of the filter is based on two acousto-optic coupling processes occurring simultaneously. The first coupling process acts as a normal LPFG, while the second makes the coupling direction of the first process change continuously, leading to a similar transmission spectrum with the phase-shifted LPFGs, in which the changing of coupling direction is realized by the discrete phase shifts of the index modulation. By adjusting the acoustic drive signals, its transmission spectrum can be dynamically tuned to realize the phase-shifted LPFGs' spectra under different phase shift numbers and locations.

Chaotic behaviors in loss-modulated erbium-doped fiber-ring lasers are reported. In a single-frequency loss-modulated erbium-doped fiber-ring laser, the coexistence of period-doubling bifurcation and intermittency routes to chaos is observed by changing the modulation frequency or the modulation voltage. The results are in agreement with those in an erbium-doped fiber-ring laser subjected to pump modulation. Dual-frequency loss-modulated erbium-doped fiber-ring lasers are proposed. When the value of the frequency ratio is approximately equal to the gold mean and the silver mean, respectively, the transition to chaos via quasiperiodicity is found when the modulation voltage is increased. The modulation voltages for the transition are different for the varied values of the frequency ratio.