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Waste management in rural areas poses a major challenge to local governments in developing countries. Municipalities face limited budgets and obstacles with the collection of waste, as well as a lack of proper equipment, infrastructure, and treatment centres. These obstacles lead to further problems, such as littering and illegal dumping, contributing to the knowledge base regarding remote and rural towns in South Africa. This study aims to assess the waste management practices and challenges of households in a Municipality in the Northern Cape, South Africa. The study investigates the household waste management practices, identifies the challenges experienced by households regarding their waste management, and explores their willingness to participate in a separation-at-source program. A cross-sectional research design was used along with a mixed methods research methodology. A sample of 160 interviews was completed over the period 16 to 20 September 2019. Descriptive statistics and a thematic analysis were used in the data analysis. The results indicate that municipalities, and households, will have to collaboratively search for solutions towards effective waste management in rural areas. Financial constraints also necessitate the investigation of alternative ways of managing household waste through cooperation with surrounding towns.

Objectives: The objectives were to determine the pharmacokinetics (PK) of artemisone and artemisone formulated in the Pheroid® drug delivery system in primates and to establish whether the formulation affects the in vitro metabolism of artemisone in human and monkey liver and intestinal microsomes. Methods: For the PK study, a single oral dose of artemisone was administered to vervet monkeys using a crossover design. Plasma samples were analyzed by means of liquid chromatography-tandem mass spectrometry. For the in vitro metabolism study, clearance was determined using microsomes and recombinant CYP3A4 enzymes, and samples were analyzed by means of ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry. Results: Artemisone and M1 plasma levels were unexpectedly low compared to those previously recorded in rodents and humans. The in vitro intrinsic clearance (CLint) of the reference formulation with monkey liver microsomes was much higher (1359.33 ± 103.24 vs 178.86 ± 23.42) than that of human liver microsomes. The in vitro data suggest that microsomal metabolism of artemisone is inhibited by the Pheroid delivery system. Conclusions: The in vivo results obtained in this study indicate that the Pheroid delivery system improves the PK profile of artemisone. The in vitro results indicate that microsomal metabolism of artemisone is inhibited by the Pheroid delivery system http://dx.doi.org/10.1517/17425255.2014.885503 http://www.tandfonline.com/loi/iemt20#.VjiobytpETY South African Technology Innovation Agency (TIA), the Swiss South African Joint Research Project Initiative and the North-West University