1. Connect MM Registry as a national reference for United States multiple myeloma patients
- Author
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Sikander Ailawadhi, Sundar Jagannath, Mohit Narang, Robert M. Rifkin, Howard R. Terebelo, Kathleen Toomey, Brian G. M. Durie, James W. Hardin, Cristina J. Gasparetto, Lynne Wagner, James L. Omel, Vivek Kumar, Lihua Yue, Amani Kitali, Amit Agarwal, Rafat Abonour, and on behalf of Connect MM Registry Investigators
- Subjects
Adult ,Male ,0301 basic medicine ,Cancer Research ,medicine.medical_specialty ,Younger age ,Databases, Factual ,Population ,survival ,lcsh:RC254-282 ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Epidemiology ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,In patient ,education ,Multiple myeloma ,Aged ,Proportional Hazards Models ,Original Research ,Aged, 80 and over ,education.field_of_study ,Proportional hazards model ,business.industry ,Puerto Rico ,Reproducibility of Results ,Clinical Cancer Research ,registries ,Middle Aged ,medicine.disease ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,United States ,Confidence interval ,Survival Rate ,multiple myeloma ,030104 developmental biology ,Oncology ,030220 oncology & carcinogenesis ,Baseline characteristics ,Female ,business ,Follow-Up Studies ,SEER Program - Abstract
Background The Surveillance, Epidemiology, and End Results (SEER) database and National Cancer Database (NCDB) show improved overall survival (OS) in patients with multiple myeloma (MM) over the last 15 years. This analysis evaluated the validity of the largely community‐based Connect MM Registry as a national reference for MM. Methods Baseline disease characteristics and survival in US newly diagnosed MM patients were examined using the Connect MM Registry as well as SEER and NCDB databases. Baseline characteristics predictive of longer survival in Connect MM were also identified. Results As of February 2017, 3011 patients were enrolled in the Connect MM Registry; 2912 were treated. Median age at time of MM diagnosis and age range were numerically similar from 2010 to 2015 across all 3 registries; SEER had a higher representation of nonwhite racial groups than that in the other 2 registries. OS rates suggest proportionate improvement with year of diagnosis among the 3 registries. A Cox proportional hazards model suggests that younger age (, Survival data from the Connect MM Registry, which is representative of the national MM population, reflect national trends of improvement. This establishes the Connect MM Registry as a reference for MM survival in the US.
- Published
- 2020