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1. Neurodevelopmental Outcome and Treatment Efficacy of Benzoate and Dextromethorphan in Siblings with Attenuated Nonketotic Hyperglycinemia

Author

Michael A. Swanson, Elaine B. Spector, Kendra Bjoraker, Sarah Dyack, M. Antoinette Hodge, Ee S. Tan, Casey Burns, Ayesha Ahmad, Sommer Gaughan, Mark Fergeson, Geralyn Creadon-Swindell, Curtis R. Coughlin, Johan L.K. Van Hove, John Christodoulou, and Marisa W. Friederich

Subjects
Male, 0301 basic medicine, medicine.medical_specialty, Pediatrics, Colorado, Delayed Diagnosis, Hyperglycinemia, Hyperglycinemia, Nonketotic, Neuropsychological Tests, Dextromethorphan, Time-to-Treatment, 03 medical and health sciences, Epilepsy, Child Development, 0302 clinical medicine, Sodium Benzoate, Internal medicine, medicine, Humans, Pediatrics, Perinatology, and Child Health, Dosing, Sibling, Child, Intelligence Tests, Wechsler Preschool and Primary Scale of Intelligence, business.industry, Siblings, Infant, Newborn, Infant, medicine.disease, Child development, Early Diagnosis, 030104 developmental biology, Endocrinology, Child, Preschool, Pediatrics, Perinatology and Child Health, Developmental Milestone, Female, business, Excitatory Amino Acid Antagonists, 030217 neurology & neurosurgery, medicine.drug
Abstract

Objective To evaluate the impact of sodium benzoate and dextromethorphan treatment on patients with the attenuated form of nonketotic hyperglycinemia. Study design Families were recruited with 2 siblings both affected with attenuated nonketotic hyperglycinemia. Genetic mutations were expressed to identify residual activity. The outcome on developmental progress and seizures was compared between the first child diagnosed and treated late with the second child diagnosed at birth and treated aggressively from the newborn period using dextromethorphan and benzoate at dosing sufficient to normalize plasma glycine levels. Both siblings were evaluated with similar standardized neurodevelopmental measures. Results In each sibling set, the second sibling treated from the neonatal period achieved earlier and more developmental milestones, and had a higher developmental quotient. In 3 of the 4 sibling pairs, the younger sibling had no seizures whereas the first child had a seizure disorder. The adaptive behavior subdomains of socialization and daily living skills improved more than motor skills and communication. Conclusions Early treatment with dextromethorphan and sodium benzoate sufficient to normalize plasma glycine levels is effective at improving outcome if used in children with attenuated disease with mutations providing residual activity and when started from the neonatal period.

Published
2016
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2. A double-blind randomized controlled trial of oxytocin nasal spray in Prader Willi syndrome

Author

Naomi L. Rogers, John Raymond Taffe, M. Antoinette Hodge, Ellie E. Smith, Stewart L. Einfeld, Adam J. Guastella, Iain S. McGregor, Lauren J. Rice, Siân K. Horstead, and Kate Steinbeck

Subjects
Adult, Male, Pediatrics, medicine.medical_specialty, Vasopressin, Adolescent, medicine.medical_treatment, Oxytocin, Placebo, law.invention, Young Adult, Double-Blind Method, Randomized controlled trial, law, Internal medicine, Genetics, medicine, Humans, Child, Genetics (clinical), Demography, Behavior, business.industry, Epworth Sleepiness Scale, Nasal Sprays, Crossover study, Endocrinology, Nasal spray, Female, Animal studies, business, Prader-Willi Syndrome, hormones, hormone substitutes, and hormone antagonists, medicine.drug
Abstract

Individuals with Prader-Willi syndrome (PWS) have a significant reduction in the number of oxytocin-producing neurons (42%) in the hypothalamic paraventricular nucleus. A number of animal studies and observations of humans show that lesions in this region can produce PWS-like symptoms. Given the evidence for potential oxytocin deficiency, we tested the effects of a course of intranasal oxytocin on PWS symptoms. Thirty individuals with PWS aged 12-30 years participated in an 18-week randomized double-blind placebo-controlled crossover trial. Participants received 8 weeks of oxytocin and 8 weeks of placebo with a minimum 2-week washout period. The first 11 participants received the following oxytocin doses: 24 IU (twice daily) B.I.D for participants 16 years and over and 18 IU B.I.D for participants 13-15 years. The dose was increased for the remaining 18 participants to 40 IU B.I.D for participants 16 years and over and 32 IU B.I.D for 13-15 years. Measures used to assess changes were standardized well-accepted measures, including the Developmental Behavior Checklist-Monitor, Parent, Teacher, and Adult; The Yale-Brown Obsessive Compulsive Scale; The Dykens Hyperphagia questionnaire; Reading The Mind in the Eyes Test; Epworth Sleepiness Scale and the Movie Stills. Oxytocin had little impact on any measure. The only significant difference found between the baseline, oxytocin, and placebo measures was an increase in temper outbursts (P = 0.023) with higher dose oxytocin. The lack of effect of oxytocin nasal spray may reflect the importance of endogenous release of oxytocin in response to exogenous oxytocin.

Published
2014
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3. Atmospheric point spread function interpolation for weak lensing in short exposure imaging data

Author

Philip J. Marshall, R. R. Gibson, Y. AlSayyad, Andrew J. Connolly, J. Bankert, S. Krughoff, S. M. Kahn, S. L. Marshall, Kirk Gilmore, Z. Ahmad, John R. Peterson, S. F. Gull, N. Sylvestre, Chihway Chang, E. Grace, D. J. Bard, M. Young, A. P. Rasmussen, A. Meert, M. A. Hodge, E. Peng, N. Todd, M. Shmakova, M. Hannel, S. Nagarajan, J. G. Jernigan, S. Lorenz, and Lynne Jones

Subjects
Polynomial regression, Physics, Point spread function, 010308 nuclear & particles physics, business.industry, Astrophysics::Instrumentation and Methods for Astrophysics, Spectral density, Astronomy and Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Large Synoptic Survey Telescope, 01 natural sciences, Shape parameter, Computational physics, Optics, 13. Climate action, Space and Planetary Science, 0103 physical sciences, business, 010303 astronomy & astrophysics, Smoothing, Weak gravitational lensing, Interpolation
Abstract

A main science goal for the Large Synoptic Survey Telescope (LSST) is to measure the cosmic shear signal from weak lensing to extreme accuracy. One difficulty, however, is that with the short exposure time ($\simeq$15 seconds) proposed, the spatial variation of the Point Spread Function (PSF) shapes may be dominated by the atmosphere, in addition to optics errors. While optics errors mainly cause the PSF to vary on angular scales similar or larger than a single CCD sensor, the atmosphere generates stochastic structures on a wide range of angular scales. It thus becomes a challenge to infer the multi-scale, complex atmospheric PSF patterns by interpolating the sparsely sampled stars in the field. In this paper we present a new method, PSFent, for interpolating the PSF shape parameters, based on reconstructing underlying shape parameter maps with a multi-scale maximum entropy algorithm. We demonstrate, using images from the LSST Photon Simulator, the performance of our approach relative to a 5th-order polynomial fit (representing the current standard) and a simple boxcar smoothing technique. Quantitatively, PSFent predicts more accurate PSF models in all scenarios and the residual PSF errors are spatially less correlated. This improvement in PSF interpolation leads to a factor of 3.5 lower systematic errors in the shear power spectrum on scales smaller than $\sim13'$, compared to polynomial fitting. We estimate that with PSFent and for stellar densities greater than $\simeq1/{\rm arcmin}^{2}$, the spurious shear correlation from PSF interpolation, after combining a complete 10-year dataset from LSST, is lower than the corresponding statistical uncertainties on the cosmic shear power spectrum, even under a conservative scenario.

Published
2012
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4. LOFT: the Large Observatory For X-ray Timing

Author

M. Feroci, JW den Herder, JW Bozzo, E. Barret, D. Brandt, S. Hernanz, M. van der Klis, M. Pohl, M. Santangelo, A. Stella, L. Watts, A. Wilms, J. Zane, S. Ahangarianabhari, M. Alpar, A. Altamirano, D. Alvarez, L. Amati, L. Amoros, C. Andersson, N. Antonelli, A. Argan, A. Artigue R, Azzarello P, Balman, S. Barbera, M. Belloni, T. Bertuccio, G. Bianchi, S. Bianchini, A. Bodin, P. Bidaud, JMB Boutloukos, S. Braga, J. Brown, E. Bucciantini, N. Burderi, L. Bursa, M. Budtz Jorgensen, C. Cackett, E. Cadoux, FR Cais, P. Caliandro, GA Campana, R. Campana, S. Casella, P. Chakrabarty, D. Chenevez, J. Coker, J. Cole, R. Collura, A. Courvoisier, T. Cros, A. Cumming, A. Cusumano, G. D'Ai, A. D'Elia, V. Del Monte, E. De Martino, D. De Rosa, A. Di Cosimo, S. Diebold, S. Di Salvo, T. Donnarumma, I. Drago, A. Durant, M. Emmanoulopoulos, D. Evangelista, Y. Fabian, A. Falanga, M. Favre, Y. Feldman, C. Ferrigno, C. Finger, MH Fraser, GW Fuschino, F. Galloway, DK Sanchez, JLG Garcia Berro, E. Gendre, B. Gezari, S. Giles, AB Gilfanov, M. Giommi, P. Giovannini, G. Giroletti, M. Goldwurm, A. Gotz, D. Gouiffes, C. Grassi, M. Groot, P. Guidorzi, C. Haas, D. Hansen, F. Hartmann, DH Haswell, CA Heger, A. Homan, J. Hornstrup, A. Hudec, R. Huovelin, J. Ingram, A. in't Zand, JJM Isern, J. Israel, G. Izzo, L. Jonker, P. Kaaret, P. Karas, V. Karelin, D. Kataria, D. Keek, L. Kennedy, T. Klochkov, D. Kluzniak, W. Kokkotas, K. Korpela, S. Kouveliotou, C. Kreykenbohm, I. Kuiper, LM Kuvvetli, I. Labanti, C. Lai, D. Lamb, FK Lebrun, F. Lin, D. Linder, D. Lodato, G. Longo, F. Lund, N. Maccarone, TJ Macera, D. Maier, D. Malcovati, P. Mangano, V. Manousakis, A. Marisaldi, M. Markowitz, A. Martindale, A. Matt, G. McHardy, IM Melatos, A. Mendez, M. Migliari, S. Mignani, R. Miller, MC Miller, JM Mineo, T. Miniutti, G. Morsink, S. Motch, C. Motta, S. Mouchet, M. Muleri, F. Norton, AJ Nowak, M. O'Brien, P. Orienti, M. Orio, M. Orlandini, M. Orleanski, P. Osborne, JP Osten, R. Ozel, F. Pacciani, L. Papitto, A. Paul, B. Perinati, E. Petracek, V. Portell, J. Poutanen, J. Psaltis, D. Rambaud, D. Ramsay, G. Rapisarda, M. Rachevski, A. Ray, PS Rea, N. Reddy, S. Reig, P. Aranda, MR Remillard, R. Reynolds, C. Rodriuez Gil, P. Rodriguez, J. Romano, P. Rossi, EMR Ryde, F. Sabau Graziati, L. Sala, G. Salvaterra, R. Sanna, A. Schanne, S. Schee, J. Schmid, C. Schwenk, A. Schwope, AD Seyler, JY Shearer, A. Smith, DM Smith, PJ Sochora, V. Soffitta, P. Soleri, P. Stappers, B. Stelzer, B. Stergioulas, N. Stratta, G. Strohmayer, TE Stuchlik, Z. Suchy, S. Sulemainov, V. Takahashi, T. Tamburini, F. Tenzer, C. Tolos, L. Torok, G. Torrejon, JM Torres, DF Tramacere, A. Trois, A. Turriziani, S. Uter, P. Uttley, P. Vacchi, A. Varniere, P. Vaughan, S. Vercellone, S. Vrba, V. Walton, D. Watanabe, S. Wawrzaszek, R. Webb, N. Weinberg, N. Wende, H. Wheatley, P. Wijers, R. Wijnands, R. Wille, M. Wilson Hodge, CA Winter, B. Wood, K. Zampa, G. Zampa, N. Zampieri, L. Zdziarski, A. Zhang, BALDAZZI, GIUSEPPE, FORMATION STELLAIRE 2012, Laboratoire d'astrodynamique, d'astrophysique et d'aéronomie de bordeaux (L3AB), Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Observatoire aquitain des sciences de l'univers (OASU), Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire d'Astrophysique de Bordeaux [Pessac] (LAB), Université de Bordeaux (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB), Istituto di Astrofisica e Planetologia Spaziali - INAF (IAPS), Istituto Nazionale di Astrofisica (INAF), Mullard Space Science Laboratory (MSSL), University College of London [London] (UCL), PCAS, APC - Astrophysique des Hautes Energies (APC - AHE), AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Dipartimento di Astronomia, Universita degli Studi di Bologna, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO)-Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Istituto di Fisica dello Spazio Interplanetario (IFSI), Consiglio Nazionale delle Ricerche (CNR), Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Laboratoire Avancé de Spectroscopie pour les Intéractions la Réactivité et l'Environnement - UMR 8516 (LASIRE), Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille Institut (CLIL), Laboratoire d’Optique Atmosphérique - UMR 8518 (LOA), Institut national des sciences de l'Univers (INSU - CNRS)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), NOAA Geophysical Fluid Dynamics Laboratory (GFDL), National Oceanic and Atmospheric Administration (NOAA), Departamento de Biología Animal (Universidad de Granada), Universidad de Granada (UGR), Estación Experimental de Zonas Áridas (CSIC), Universitat Politècnica de Catalunya [Barcelona] (UPC), INAF-IASF Milano, Groupe d'Etudes des Matériaux Hétérogènes (GEMH), Université de Limoges (UNILIM)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Institute of Geology, Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Tadayuki Takahashi, Stephen S. Murray, Jan-Willem A. den Herder, Shiro Ueno, LOFT, Université Sciences et Technologies - Bordeaux 1 (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1 (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Observatoire aquitain des sciences de l'univers (OASU), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire d'Astrophysique de Bordeaux [Pessac] (LAB), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Universidad de Granada = University of Granada (UGR), Feroci, M, den Herder, JW, Bozzo, E, Barret, D, Brandt, S, Hernanz, M, van der Klis, M, Pohl, M, Santangelo, A, Stella, L, Watts, A, Wilms, J, Zane, S, Ahangarianabhari, M, Alpar, A, Altamirano, D, Alvarez, L, Amati, L, Amoros, C, Andersson, N, Antonelli, A, Argan, A, Artigue, R, Azzarello, P, Baldazzi, G, Balman, S, Barbera, M, Belloni, T, Bertuccio, G, Bianchi, S, Bianchini, A, Bodin, P, Bonnet Bidaud, J-M, Boutloukos, S, Braga, J, Brown, E, Bucciantini, N, Burderi, L, Bursa, M, Budtz-Jørgensen, C, Cackett, E, Cadoux, F R, Cais, P, Caliandro, G A, Campana, R, Campana, S, Casella, P, Chakrabarty, D, Chenevez, J, Coker, J, Cole, R, Collura, A, Courvoisier, T, Cros, A, Cumming, A, Cusumano, G, D'Ai, A, D'Elia, V, Del Monte, E, de Martino, D, De Rosa, A, Di Cosimo, S, Diebold, S, Di Salvo, T, Donnarumma, I, Drago, A, Durant, M, Emmanoulopoulos, D, Evangelista, Y, Fabian, A, Falanga, M, Favre, Y, Feldman, C, Ferrigno, C, Finger, M H, Fraser, GW, Fuschino, F, Galloway, DK, Galvez Sanchez, JL, Garcia-Berro, E, Gendre, B, Gezari, S, Giles, AB, Gilfanov, M, Giommi, P, Giovannini, G, Giroletti, M, Goldwurm, A, Götz, D, Gouiffes, C, Grassi, M, Groot, P, Guidorzi, C, Haas, D, Hansen, F, Hartmann, D H, Haswell, C A, Heger, A, Homan, J, Hornstrup, A, Hudec, R, Huovelin, J, Ingram, A, In't Zand, J J M, Isern, J, Israel, G, Izzo, L, Jonker, P, Kaaret, P, Karas, V, Karelin, D, Kataria, D, Keek, L, Kennedy, T, Klochkov, D, Kluzniak, W, Kokkotas, K, Korpela, S, Kouveliotou, C, Kreykenbohm, I, Kuiper, L M, Kuvvetli, I, Labanti, C, Lai, D, Lamb, F K, Lebrun, F, Lin, D, Linder, D, Lodato, G, Longo, F, Lund, N, Maccarone, TJ, Macera, D, Maier, D, Malcovati, P, Mangano, V, Manousakis, A, Marisaldi, M, Markowitz, A, Martindale, A, Matt, G, McHardy, IM, Melatos, A, Mendez, M, Migliari, S, Mignani, R, Miller, M C, Miller, J M, Mineo, T, Miniutti, G, Morsink, S, Motch, C, Motta, S, Mouchet, M, Muleri, F, Norton, AJ, Nowak, M, O'Brien, P, Orienti, M, Orio, M, Orlandini, M, Orleanski, P, Osborne, J P, Osten, R, Ozel, F, Pacciani, L, Papitto, A, Paul, B, Perinati, E, Petracek, V, Portell, J, Poutanen, J, Psaltis, D, Rambaud, D, Ramsay, G, Rapisarda, M, Rachevski, A, Ray, P S, Rea, N, Reddy, S, Reig, P, Reina Aranda, M, Remillard, R, Reynolds, C, Rodríguez-Gil, P, Rodriguez, J, Romano, P, Rossi, E M R, Ryde, F, Sabau-Graziati, L, Sala, G, Salvaterra, R, Sanna, A, Schanne, S, Schee, J, Schmid, C, Schwenk, A, Schwope, A D, Seyler, J-Y, Shearer, A, Smith, A, Smith, D M, Smith, P J, Sochora, V, Soffitta, P, Soleri, P, Stappers, B, Steltzer, B, Stergioulas, N, Stratta, G, Strohmayer, T E, Stuchlik, Z, Suchy, S, Sulemainov, V, Takahashi, T, Tamburini, F, Tenzer, C, Tolos, L, Torok, G, Torrejon, J M, Torres, D F, Tramacere, A, Trois, A, Turriziani, S, Uter, P, Uttley, P, Vacchi, A, Varniere, P, Vaughan, S, Vercellone, S, Vrba, V, Walton, D, Watanabe, S, Wawrzaszek, R, Webb, N, Weinberg, N, Wende, H, Wheatley, P, Wijers, R, Wijnands, R, Wille, M, Wilson-Hodge, C A, Winter, B, Wood, K, Zampa, G, Zampa, N, Zampieri, L, Zdziarski, A, Zhang, B, High Energy Astrophys. & Astropart. Phys (API, FNWI), Feroci, M., den Herder, J. W., Bozzo, E., Barret, D., Brandt, S., Hernanz, M., van der Klis, M., Pohl, M., Santangelo, A., Stella, L., Watts, A., Wilms, J., Zane, S., Ahangarianabhari, M., Alpar, A., Altamirano, D., Alvarez, L., Amati, L., Amoros, C., Andersson, N., Antonelli, A., Argan, A., Artigue, R., Azzarello, P., Baldazzi, G., Balman, S., Barbera, M., Belloni, T., Bertuccio, G., Bianchi, S., Bianchini, A., Bodin, P., Bonnet Bidaud, J. M., Boutloukos, S., Braga, J., Brown, E., Bucciantini, N., Burderi, L., Bursa, M., Budtz Jørgensen, C., Cackett, E., Cadoux, F. R., Cais, P., Caliandro, G. A., Campana, R., Campana, S., Casella, P., Chakrabarty, D., Chenevez, J., Coker, J., Cole, R., Collura, A., Courvoisier, T., Cros, A., Cumming, A., Cusumano, G., D'Ai, A., D'Elia, V., Del Monte, E., de Martino, D., De Rosa, A., Di Cosimo, S., Diebold, S., Di Salvo, T., Donnarumma, I., Drago, A., Durant, M., Emmanoulopoulos, D., Evangelista, Y., Fabian, A., Falanga, M., Favre, Y., Feldman, C., Ferrigno, C., Finger, M. H., Fraser, G. W., Fuschino, F., Galloway, D. K., Galvez Sanchez, J. L., Garcia Berro, E., Gendre, B., Gezari, S., Giles, A. B., Gilfanov, M., Giommi, P., Giovannini, G., Giroletti, M., Goldwurm, A., Götz, D., Gouiffes, C., Grassi, M., Groot, P., Guidorzi, C., Haas, D., Hansen, F., Hartmann, D. H., Haswell, C. A., Heger, A., Homan, J., Hornstrup, A., Hudec, R., Huovelin, J., Ingram, A., In't Zand, J. J. M., Isern, J., Israel, G., Izzo, L., Jonker, P., Kaaret, P., Karas, V., Karelin, D., Kataria, D., Keek, L., Kennedy, T., Klochkov, D., Kluzniak, W., Kokkotas, K., Korpela, S., Kouveliotou, C., Kreykenbohm, I., Kuiper, L. M., Kuvvetli, I., Labanti, C., Lai, D., Lamb, F. K., Lebrun, F., Lin, D., Linder, D., Lodato, G., Longo, Francesco, Lund, N., Maccarone, T. J., Macera, D., Maier, D., Malcovati, P., Mangano, V., Manousakis, A., Marisaldi, M., Markowitz, A., Martindale, A., Matt, G., Mchardy, I. M., Melatos, A., Mendez, M., Migliari, S., Mignani, R., Miller, M. C., Miller, J. M., Mineo, T., Miniutti, G., Morsink, S., Motch, C., Motta, S., Mouchet, M., Muleri, F., Norton, A. J., Nowak, M., O'Brien, P., Orienti, M., Orio, M., Orlandini, M., Orleanski, P., Osborne, J. P., Osten, R., Ozel, F., Pacciani, L., Papitto, A., Paul, B., Perinati, E., Petracek, V., Portell, J., Poutanen, J., Psaltis, D., Rambaud, D., Ramsay, G., Rapisarda, M., Rachevski, A., Ray, P. S., Rea, N., Reddy, S., Reig, P., Reina Aranda, M., Remillard, R., Reynolds, C., Rodríguez Gil, P., Rodriguez, J., Romano, P., Rossi, E. M. R., Ryde, F., Sabau Graziati, L., Sala, G., Salvaterra, R., Sanna, A., Schanne, S., Schee, J., Schmid, C., Schwenk, A., Schwope, A. D., Seyler, J. Y., Shearer, A., Smith, A., Smith, D. M., Smith, P. J., Sochora, V., Soffitta, P., Soleri, P., Stappers, B., Steltzer, B., Stergioulas, N., Stratta, G., Strohmayer, T. E., Stuchlik, Z., Suchy, S., Sulemainov, V., Takahashi, T., Tamburini, F., Tenzer, C., Tolos, L., Torok, G., Torrejon, J. M., Torres, D. F., Tramacere, A., Trois, A., Turriziani, S., Uter, P., Uttley, P., Vacchi, A., Varniere, P., Vaughan, S., Vercellone, S., Vrba, V., Walton, D., Watanabe, S., Wawrzaszek, R., Webb, N., Weinberg, N., Wende, H., Wheatley, P., Wijers, R., Wijnands, R., Wille, M., Wilson Hodge, C. A., Winter, B., Wood, K., Zampa, G., Zampa, N., Zampieri, L., Zdziarski, A., Zhang, B., Astronomy, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Dipartimento di Astronomia, Universita degli Studi di Bologna, Università di Bologna [Bologna] (UNIBO)-Università di Bologna [Bologna] (UNIBO), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Spectrochimie Infrarouge et Raman - UMR 8516 (LASIR), Centre National de la Recherche Scientifique (CNRS)-Université de Lille, Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Lille, Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology in Zürich [Zürich] (ETH Zürich), SPIE-INT SOC OPTICAL ENGINEERING, 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA, M Feroci, JW den Herder, JW Bozzo, E Barret, D Brandt, S Hernanz, M van der Kli, M Pohl, M Santangelo, A Stella, L Watt, A Wilm, J Zane, S Ahangarianabhari, M Alpar, A Altamirano, D Alvarez, L Amati, L Amoro, C Andersson, N Antonelli, A Argan, A Artigue R, Azzarello P, G Baldazzi, Balman, S Barbera, M Belloni, T Bertuccio, G Bianchi, S Bianchini, A Bodin, P Bidaud, JMB Boutlouko, S Braga, J Brown, E Bucciantini, N Burderi, L Bursa, M Budtz-Jorgensen, C Cackett, E Cadoux, FR Cai, P Caliandro, GA Campana, R Campana, S Casella, P Chakrabarty, D Chenevez, J Coker, J Cole, R Collura, A Courvoisier, T Cro, A Cumming, A Cusumano, G D'Ai, A D'Elia, V Del Monte, E De Martino, D De Rosa, A Di Cosimo, S Diebold, S Di Salvo, T Donnarumma, I Drago, A Durant, M Emmanoulopoulo, D Evangelista, Y Fabian, A Falanga, M Favre, Y Feldman, C Ferrigno, C Finger, MH Fraser, GW Fuschino, F Galloway, DK Sanchez, JLG Garcia-Berro, E Gendre, B Gezari, S Gile, AB Gilfanov, M Giommi, P Giovannini, G Giroletti, M Goldwurm, A Gotz, D Gouiffe, C Grassi, M Groot, P Guidorzi, C Haa, D Hansen, F Hartmann, DH Haswell, CA Heger, A Homan, J Hornstrup, A Hudec, R Huovelin, J Ingram, A in't Zand, JJM Isern, J Israel, G Izzo, L Jonker, P Kaaret, P Kara, V Karelin, D Kataria, D Keek, L Kennedy, T Klochkov, D Kluzniak, W Kokkota, K Korpela, S Kouveliotou, C Kreykenbohm, I Kuiper, LM Kuvvetli, I Labanti, C Lai, D Lamb, FK Lebrun, F Lin, D Linder, D Lodato, G Longo, F Lund, N Maccarone, TJ Macera, D Maier, D Malcovati, P Mangano, V Manousaki, A Marisaldi, M Markowitz, A Martindale, A Matt, G McHardy, IM Melato, A Mendez, M Migliari, S Mignani, R Miller, MC Miller, JM Mineo, T Miniutti, G Morsink, S Motch, C Motta, S Mouchet, M Muleri, F Norton, AJ Nowak, M O'Brien, P Orienti, M Orio, M Orlandini, M Orleanski, P Osborne, JP Osten, R Ozel, F Pacciani, L Papitto, A Paul, B Perinati, E Petracek, V Portell, J Poutanen, J Psalti, D Rambaud, D Ramsay, G Rapisarda, M Rachevski, A Ray, PS Rea, N Reddy, S Reig, P Aranda, MR Remillard, R Reynold, C Rodriuez-Gil, P Rodriguez, J Romano, P Rossi, EMR Ryde, F Sabau-Graziati, L Sala, G Salvaterra, R Sanna, A Schanne, S Schee, J Schmid, C Schwenk, A Schwope, AD Seyler, JY Shearer, A Smith, DM Smith, PJ Sochora, V Soffitta, P Soleri, P Stapper, B Stelzer, B Stergioula, N Stratta, G Strohmayer, TE Stuchlik, Z Suchy, S Sulemainov, V Takahashi, T Tamburini, F Tenzer, C Tolo, L Torok, G Torrejon, JM Torre, DF Tramacere, A Troi, A Turriziani, S Uter, P Uttley, P Vacchi, A Varniere, P Vaughan, S Vercellone, S Vrba, V Walton, D Watanabe, S Wawrzaszek, R Webb, N Weinberg, N Wende, H Wheatley, P Wijer, R Wijnand, R Wille, M Wilson-Hodge, CA Winter, B Wood, K Zampa, G Zampa, N Zampieri, L Zdziarski, A Zhang, Pohl, Martin, Cadoux, Franck, and Favre, Yannick

Subjects
[PHYS.ASTR.IM]Physics [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], Vision, X-ray timing, Astronomy, SPIE Proceedings, Observatories, X-ray timing, X-ray spectroscopy, X-ray imaging, compact objects, Silicon Drift Chambers, FOS: Physical sciences, ddc:500.2, X-ray missions, Space (mathematics), Astrophysics, 01 natural sciences, 7. Clean energy, Settore FIS/05 - Astronomia E Astrofisica, X-rays, 0103 physical sciences, Electronic, Optical and Magnetic Materials, Instrumentation (computer programming), Electrical and Electronic Engineering, Aerospace engineering, Diagnostics, Compact objects, 010303 astronomy & astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), Physics, Spatial resolution, sezele, Sensors, 010308 nuclear & particles physics, business.industry, Applied Mathematics, X-ray imaging, Silicon Drift Chamber, Computer Science Applications1707 Computer Vision and Pattern Recognition, Condensed Matter Physics, X-ray spectroscopy, Electronic, Optical and Magnetic Materials, [SDU.ASTR.IM]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], Instrumentation and Methods for Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, business
Abstract

The LOFT mission concept is one of four candidates selected by ESA for the M3 launch opportunity as Medium Size missions of the Cosmic Vision programme. The launch window is currently planned for between 2022 and 2024. LOFT is designed to exploit the diagnostics of rapid X-ray flux and spectral variability that directly probe the motion of matter down to distances very close to black holes and neutron stars, as well as the physical state of ultra-dense matter. These primary science goals will be addressed by a payload composed of a Large Area Detector (LAD) and a Wide Field Monitor (WFM). The LAD is a collimated (, Proceedings of SPIE, Vol. 8443, Paper No. 8443-85, 2012

Published
2012
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5. HIV-1 Incidence among Opiate Users in Northern Thailand

Author

Chris Beyrer, David D. Celentano, Kenrad E. Nelson, Jaroon Jittiwutikarn, Surinda Kawichai, M J Hodge, Myat Htoo Razak, and J P Cegielski

Subjects
Adult, Male, Rural Population, medicine.medical_specialty, Epidemiology, HIV Infections, Cohort Studies, Acquired immunodeficiency syndrome (AIDS), Risk Factors, Humans, Medicine, Seroconversion, Substance Abuse, Intravenous, Retrospective Studies, business.industry, Incidence (epidemiology), Retrospective cohort study, Opioid-Related Disorders, Thailand, medicine.disease, Substance abuse, Socioeconomic Factors, Relative risk, Immunology, HIV-1, Female, business, Demography, Cohort study
Abstract

The incidence of human immunodeficiency virus type 1 (HIV-1) infection among opiate users was determined in a retrospective cohort of 436 patients with multiple admissions to the only inpatient drug treatment program in northern Thailand between October 1993 and September 1995. During 323.4 person-years of follow-up, 60 patients presenting for detoxification acquired HIV-1 infection, for a crude incidence rate of 18.6 per 100 person-years (95% confidence interval 14.4-23.9). All seroconverters were male. HIV-1 incidence varied by the current route of drug administration: 31.3 per 100 person-years for injectors and 2.8 per 100 person-years for noninjectors (smoking and ingestion). Significant differences were found by ethnicity: HIV-1 incidence was 29.3 per 100 person-years for Thai lowlanders and 8.5 per 100 person-years for hill tribes. Multivariate relative risk estimates showed that injecting opiates (vs. use by other routes), being unmarried, being under age 40 years, being a Thai lowlander, having a primary and secondary education, and being employed in the business sector were each independently associated with human immunodeficiency virus seroconversion. This HIV-1 incidence rate is double that reported for Bangkok and suggests that prevention and control programs for drug users need to be expanded throughout Thailand. Improved availability of more-effective treatment regimens and increased access to sterile injection equipment are needed to confront the HIV-1 epidemic among opiate users in northern Thailand.The incidence of HIV-1 infection among opiate users was assessed in a retrospective cohort of 436 patients with multiple admissions to the only inpatient drug treatment program in northern Thailand between October 1993 and September 1995. During 323.4 person-years of follow-up, 60 patients presenting for detoxification acquired HIV-1 infection, for a crude incidence rate of 18.6/100 person-years. All seroconverters were male. HIV-1 incidence varied by the current route of drug administration: 31.3/100 person-years for injectors and 2.8/100 person-years among those who smoked or ingested the drug. HIV-1 incidence was 29.3/100 person-years for Thai lowlanders and 8.5/100 person-years for hill tribes. Multivariate analysis found that injecting opiates, being unmarried, being under age 40 years, being a Thai lowlander, having a primary and secondary education, and being employed in the business sector were each independently associated with HIV seroconversion. The HIV-1 incidence rate in this population is double that reported for Bangkok. As such, HIV prevention and control programs for drug users need to be expanded throughout Thailand. Moreover, improved availability of more effective treatment regimens and increased access to sterile injection equipment are needed to confront the HIV-1 epidemic among opiate users in northern Thailand.

Published
1999
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6. Splenic cysts in the pediatric population: a report of 21 cases with review of the literature

Author

Nancy Elawabdeh, M G Hodge, Bahig M. Shehata, Richard R. Ricketts, S F Simoneaux, and Carlos R. Abramowsky

Subjects
Male, Pediatrics, medicine.medical_specialty, Splenic cyst, Adolescent, business.industry, Cysts, medicine.medical_treatment, Splenectomy, Treatment method, General Medicine, medicine.disease, Pathology and Forensic Medicine, Child, Preschool, parasitic diseases, Pediatrics, Perinatology and Child Health, medicine, Humans, Cyst, Female, business, Child, Pediatric population, Splenic Diseases
Abstract

Splenic cysts are rare lesions that can occur in parasitic and non-parasitic forms. Because they are uncommon, the classification, pathogenesis, and management techniques are still debated. The continual review of splenic cyst cases in the pediatric population is essential for establishing a clear diagnosis and course of treatment. This report presents 21 cases of pediatric splenic cysts observed at Children's Healthcare of Atlanta over an 18 year period (1993-2011). The cases include both parasitic and and nonparasitic cysts. The current splenic cyst classification and treatment methods are analyzed through a review of the current theories and based on our experiences.

Published
2012

7. Passivated Optical Fibers For Harsh Environments

Author

M. H. Hodge, B. J. Skutnik, and J. P. Clarkin

Subjects
Aqueous solution, Materials science, Optical fiber, business.industry, Environmental exposure, engineering.material, Cladding (fiber optics), law.invention, Optical coating, Semiconductor, Coating, law, Boiling, engineering, Composite material, business
Abstract

Glass optical fibers have high strengths but under tensile stress and in the presence of aqueous media their strength diminishes through fatigue. Analogous to the semiconductor field, where the electronic properties of chips are protected by passivating coatings, optical fiber strength can be protected by passivating the glass surface. Optical fibers have been developed with such a primary coating/cladding, namely HCSR fibers. These fibers not only have high initial strength but also have excellent fatigue resistance. Their stability to environmental exposure is demonstrated by comparing static fatigue results for exposure to hot water, to boiling water, to steam and to acid/base solutions ranging from 10 M acid to 10 M base to results obtained in ambient water. HCS fibers maintain high static fatigue parameters at elevated temperatures and exposure to these temperatures under low stress does not change their fatigue behavior. Except at the extremes in pH, the static fatigue behavior is unchanged across the acid/base spectrum. This insensitivity to environmental changes and the good fit of the data to the power law model permits the prediction of lifetimes for long term exposure to aqueous environments.© (1987) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.

Published
1987
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8. Performance Of A Low Loss Tunable Coupling Ratio Multiple Tap Network

Author

M. H. Hodge and J. A. Moras

Subjects
Engineering, business.industry, Electrical engineering, Electronic engineering, Insertion loss, Systems design, business, Coupling ratio
Abstract

The introduction of linear networks with greater than 20 nodes has been inhibited by the loss associated with conventional discrete couplers. Typical excess and insertion loss are 0.5 dB and 1.0 dB respectively. This paper describes the development of a low loss, tunable coupling ratio tap which enables the expansion of linear networks to a hundred nodes or more. It analyzes the characteristics of the coupler and shows the impact on system design and performance.

Published
1988
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10. Hazards For Fiber Optics In The Medical Application Environment

Author

B. J. Skutnik, W. B. Beck, and M. H. Hodge

Subjects
Materials science, Optical fiber, business.industry, Single fiber, law.invention, Optics, Optical sensing, law, Fiber laser, Computer data storage, Electronic engineering, sense organs, business, Sensing system
Abstract

Fiber optic devices such as endoscopes have been in general use in the medical field for some time. More recently many doctors and instrument companies have begun developing fiber optic sensing systems and fiber optic laser power delivery systems to accomplish less traumatic surgery or localized irradiation treatment. These new systems are primarily single fibers rather than the coherent fiber bundles used in endoscopes, and thus the effects of the environments the fiber will encounter during fabrication/preparation, and during storage and use, must be considered more thoroughly. The changes arising from sterilization procedures and power delivery, specifically those associated with the fiber's strength and some of the effects related to optical degradation, will be discussed. Often the fiber must meet unique strength, fatigue and optical criteria to provide satisfactory performance in the particular medical application.

Published
1987
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11. Finite Element Education Survey

Author

W. M. Mair, M. H. Hodge, and A. Creechan

Subjects
Engineering, Computational Theory and Mathematics, Operations research, business.industry, Agency (sociology), General Engineering, business, Software, Construction engineering, Finite element method, Computer Science Applications
Abstract

In view of the importance of finite element (FE) techniques in the design, analysis and validation of many engineering products, the National Agency for Finite Element Methods and Standards (NAFEMS) was established in 1983 to take an overview of the FE scene in the United Kingdom. NAFEMS is currently funded by the Department of Trade and Industry, but it is expected that it will eventually be self‐funding. Its headquarters is located at the National Engineering Laboratory, East Kilbride, Glasgow.

Published
1985
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