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7 Pág. Departamento de Tecnología de Alimentos​​, In recent years, concerns about fish welfare have increased in aquaculture, most pointedly regarding the slaughter process. Immersion in ice water (live chilling) is still commonly used as a stunning method in salmonids, but can have negative effects on the stress response and flesh quality. A valid alternative is electronarcosis, but the specific details of the intensity and frequency of the current applied depend on the species and size, and little is known about how that may affect fish welfare or product quality. In this study, adult rainbow trout (294 ± 8.44 g average weight) were subjected to three different stunning methods before slaughter: immersion in ice water and electronarcosis at two different current intensities (200 or 400 mA). Electronarcosis caused fish to lose consciousness faster than those live chilled. Plasma concentration of cortisol was lower in fish stunned with 400 mA (400 mA: 5.2 ± 0.67 vs. Ice: 9.1 ± 0.90; 200 mA: 9.3 ± 1.20 ng/ml). Creatine-phosphokinase enzyme levels were higher in ice stunned fish compared to electronarcosis (Ice: 168 ± 2.32 vs. 200 mA: 114 ± 0.89; 400 mA: 104 ± 0.62 U/l). Regarding flesh quality, initial muscle pH was lower in fish stunned by ice immersion than by electronarcosis (Ice: 6.49 ± 0.034 vs. 200 mA: 6.76 ± 0.050; 400 mA: 6.61 ± 0.04), presenting also an earlier onset of rigor mortis. Fish stunned with 400 mA electronarcosis also presented higher levels of muscle glycogen than those stunned with ice water (0.181 ± 0.029 vs. 0.101 ± 0.013 mg/g). In conclusion, electronarcosis is a stunning method that can produce an immediate loss of consciousness in rainbow trout, reducing stress response before slaughter and improving flesh quality (with higher benefits using a current intensity of 400 mA), in contrast to immersion in ice water., This project was financed by the Spanish Ministry of Economy and Competitiveness (MINECO), project AGL2013-45557-P.

12 Pág. Departamento de Tecnología de Alimentos​​, Obesity is considered a risk factor for the development of colorectal cancer. In rodents, high-fat (HF) diets are able to increase the formation of azoxymethane (AOM)-induced polyps. Polyphenol-rich apple extracts have antioxidant and anti-inflammatory activities and may induce an amelioration of the manifestations of colorectal cancer. Twenty-seven male Crl:CD-1 mice received AOM during four weeks and were subsequently divided into three groups fed a HF diet (n = 9 each group): a non-supplemented group, a second group supplemented with apple extract at 1%, and a third group supplemented with the same apple extract at 1.5%. Energy metabolism and the respiratory quotient were not affected by the supplementation with the apple extract. Although body weight was not affected by the treatment, the mice supplemented with the apple extract showed less signs of cachexia than the non-treated mice. In the intestine, the mice supplemented with the apple extract showed lower sucrase, dipeptidyl-peptidase IV, and aminopeptidase N activities, and less intestinal lesions (aberrant crypt foci and polyps). Administration of a polyphenol-rich apple extract reduces the number of neoplastic lesions in mice with AOM-induced colorectal cancer and contributes to preserve adipose tissue mass., This research was funded by the Government of Spain grant number (AGL 2006-1029-C02-01/ALI), CIBER (grant number: CB12/03/30002), and the Department of Innovation, Business and Employment of the Government of Navarra.

Meat consumption has been related to a higher risk of heart disease due to its saturated fat content. As a consequence, there has been a growth in research on how to increase unsaturated fat content in meat. However, a high content of unsaturated fat favours the development of oxidative processes. The aim of the study was to evaluate the effectiveness of a red wine extract (RWE) rich in polyphenols (50, 100, and 200 mg gallic acid equivalents/kg meat) as a natural antioxidant in lamb meat patties enriched with omega-3 polyunsaturated fatty acids (n-3 PUFA) (100 mg n-3 PUFA/100 g meat), compared to using -tocopherol (TOC) (100 mg/kg meat). Adding RWE delayed metmyoglobin formation, lipid oxidation and loss of n-3 PUFA relative to controls, while TOC had no effect on preventing meat oxidation. Lamb odour was lower (p &lt, 0.01) and odd odour higher (p &lt, 0.001) in patties at the highest dose of RWE, compared to controls, but the overall liking score was not affected. The results suggest that RWE could be used as a natural antioxidant in the meat industry, even when n-3 PUFA content is high.

The educational experience that we present here seeks to encourage change in the university training of future teachers, promoting interdisciplinarity and cooperative work based on the premise that project based teaching, as opposed to direct teaching, now represents the best didactic guarantee for an effective contribution to the development of basic competences and the learning of the curricular contents as it is a student-centred learning process which deals with learners’ needs and encourages learners to become more involved in the learning process of which they are the protagonists. Thus, we sought to study whether or not the balance between planning, flexibility and adaptation to the new situations that are made possible by project based teaching justifies its adoption as the didactic strategy to be implemented in the new syllabus plan for the Nursery School Education Degree. The aim of this teaching initiative has been to promote the following improvements in the learning process of future Nursery School teachers: - Increasing student performance by also acquiring cross-curricular skills that include reflection, synthesis, expression, communication, group work, public speaking, etc. - Developing student involvement in course work and boosting active learning. - Improving communication between students and lecturers in tutorials and making these tutorials more relevant for students. - Enhancing the quality of the teaching materials produced by students through the use of new technology.

Objective:Prevention of catheter-related bloodstream infection is a basic objective to optimize patient safety in the ICU. Building on the early success of a patient safety unit-based comprehensive intervention (the Keystone ICU project in Michigan), the Bacteremia Zero project aimed to assess its e

In this paper, we aim to provide information on music courses which are currently being taught in higher education music conservatoires in Spain in order to reflect upon the features of such schools and the music model which is being produced, teacher-training and the relation between the teaching processes and what students are actually learning. All of which will lead to facilitating informed decision making to improve theses courses of study in the contest of the European Higher Education Area.

Although inflammation in disc hernia (DH) has been recognized and it is a well-known process mediated by loss of the cellular redox balance, only a few studies about the impact of chronic oxidative stress on this neurological disorder have been made. Ozone therapy has been widely used with clinical efficacy in DH. This work aimed at characterizing the systemic redox status of patients with low back pain and neck pain as well as studying if ozone oxidative post-conditioning modified the pathological oxidative stress and protected against oxidative protein damage and if there is any relationship between oxidative changes and pain in both DH.Redox status of 33 patients with diagnosis of DH by computerized axial tomography, nuclear magnetic resonance, and clinical evaluations was studied. Ozone was administered by paravertebral way. After ozone treatment, plasmatic levels of antioxidant/pro-oxidant markers, pain, and life quality disability parameters were evaluated.One hundred percent of patients showed a severe oxidative stress. Major changes in superoxide dismutase activity, total hydroperoxides, advanced oxidation protein products, fructolysine content, and malondialdehyde were observed. After ozone oxidative post-conditioning, there was a re-establishment of patients' cellular redox balance as well as a decrease in pain in both DH. A relationship between indicators of oxidative protein damage and pain was demonstrated.Ozone therapy protected against oxidation of proteins and reduced the pain. Relationship between markers of oxidative protein damage, disability parameters, and pain suggests the role of oxidative stress in the pathological processes involved in DH.

Although the appeal of rural houses for tourists lies mainly in the natural surroundings and their intrinsic rural characteristics, there are other factors which are also important such as their size, type of building, quality of equipment, services and activities offered. To evaluate the tourists' preferences for these potential or effective attributes, a stated preference experiment was conducted in the Northwest area of the Region of Murcia and the data are analysed using discrete choice modelling methodology. Consistent specifications for multinomial logit and mixed logit models that consider variations in tastes within tourists' preferences are found. The results could be of use to promoters and owners of rural houses when planning marketing and promotional campaigns or when taking effective investment decisions.

SummaryDespite current guidelines, venous thromboembolism (VTE) prophylaxis is underused. Computerized programs to encourage physicians to apply thromboprophylaxis have been shown to be effective in selected populations. Our aim was to analyze the impact of the implementation of a computer- alert system for VTE risk in all hospitalized patients of a teaching hospital. A computer program linked to the clinical record database was developed to assess all hospitalized patients’VTE risk daily. The physician responsible for patients at high risk was alerted, but remained free to order or withhold prophylaxis. Over 19,000 hospitalized, medical and surgical, adult patients between January to June 2005 (pre-intervention phase), January to June 2006 and January to June 2007 (postintervention phase), were included. During the first semesters of 2006 and 2007, an electronic alert was sent to 32.8% and 32.2% of all hospitalized patients, respectively. Appropriate prophylaxis among alerted patients was ordered in 89.7% (2006) and 88.5% (2007) of surgical patients, and in 49.2% (2006) and 64.4% (2007) of medical patients. A sustained reduction of VTE during hospitalization was achieved, Odds ratio (OR): 0.53, 95% confidence interval (CI) (0.25–1.10) and OR: 0.51, 95%CI (0.24–1.05) during the first semesters of 2006 and 2007 respectively, the impact being significant (p

Dyslexia is a controversial issue today. There are many different approaches to study this learning disability (medical, educational, psychological and social). The media have tried to show some points of view about dyslexia’s aetiology, diagnosis and intervention models. In this paper we will try to describe quotidian situations related to this learning difficulty through the film “Taare Zameen Par”. RESUMEN La dislexia es un tema controvertido de actualidad cuyo estudio se aborda desde distintas opticas (medica, educa-tiva, psicologica y social). Los medios audiovisuales han intentado mostrar al publico algunas posturas sobre su etiologia, diagnostico y modelos de intervencion. En este trabajo pretendemos acercar al lector a situaciones cotidianas relacionadas con esta dificultad de aprendizaje a traves de una muestra cinematografica:“Taare Zameen Par”.

La implantación del título de Grado en Relaciones Laborales y Recursos Humanos en la Universidad de Murcia se hizo en el curso académico 2009-10. En ese mismo año ofertamos un curso de adaptación al Grado a los diplomados que titularon con el plan de estudios anterior. Esta decisión supuso que tuviésemos que organizar, planificar y gestionar la asignatura de Trabajo Fin de Grado (TFG) al tiempo que implantábamos los nuevos estudios. Así, en los últimos cinco cursos académicos, hemos acumulado una valiosa experiencia sobre la materia referida.El TFG es una asignatura más del plan de estudios, pero con características especiales, tales como que no tiene docencia, está tutorizada por un docente a lo largo de un número determinado de sesiones, se defiende una vez cursadas y superadas todas las asignaturas que conforman el plan de estudios, etc. Nuestra comunicación presenta, para su discusión, la experiencia llevada a cabo en la Facultad de Ciencias del Trabajo de la Universidad de Murcia sobre el TFG, desde el punto de vista de la organización, gestión y evaluación de la asignatura y los resultados académicos obtenidos por los alumnos.; The implementation of the Degree in Labor Relations and Human Resources at the University of Murcia was in the academic year 2009-10. In the same year we offer an adaptation to the degree to graduates who titled the previous curriculum. This decision meant that we had to organize, plan and manage the subject of Final Project (TFG) while we set up new studies. Thus, in the last five academic years, we have accumulated valuable experience on the said matter. The TFG is a subject of the curriculum, but with special features, such as having no teaching, it is supervised by a teacher over a number of sessions and defends once taken and passed all the subjects included in the curriculum, etc. Our communication presents for discussion, the experiment carried out at the Faculty of Labour Sciences at the University of Murcia on the TFG, from the point of view of organization, management and evaluation of the course and the academic results obtained by students.

This paper develops a methodology which will enable the determination of the tourist profile which corresponds to the different types of existing accommodations in a certain destination of rural tourism. This is accomplished through the use of a two-stage method (a correspondence analysis followed by a cluster analysis) to classify the accommodations in a reduced number of groups, so that each group constitutes a type. The estimation of a Multinomial Logit model determines the characteristics of tourist who is most likely to opt for each type of accommodation. Results from a study in Murcia indicate that the wide variety of accommodations with respect to size and type is a suitable form of attracting individuals of different profiles.

This study involved 53 Talaverana-breed lambs fattened until reaching a slaughter weight of 28 kg. After weaning at 45 days of age, the lambs were divided into four study groups. The lambs of two of the groups were fattened at pasture, while those of the other two groups were kept on a drylot. One group at pasture and another on the drylot received a commercial fattening concentrate. The other two groups received whole barley with a protein supplement. Drylot lambs displayed better carcass dressing, greater carcass fatness, higher carcass conformation values and a superior refriger- ated carcass weight than lambs fattened at pasture. Lambs fattened with concentrate displayed better carcass dressing, higher carcass compactness and less digestive tract development (due to a lower proportion of stomach and digestive content) than those fed barley. The fat colour of lambs fattened at pasture was lighter (greater L*) than that of the drylot lambs, and the lambs fed concentrate exhibited a higher redness index (a*) than those fed barley. The longissimus dorsi (LD) muscle was used to evaluate meat quality. The lambs fattened at pasture displayed a lower lightness value, lower cooking losses and greater pleasantness scores in the sensorial analysis than drylot lambs. The lambs fattened at pasture presented lower values of fatty acids with an odd number of carbon atoms and monounsaturated fatty acids and higher linolenic acid (C18:3) levels than drylot lambs in both the in- tramuscular fat of the LD muscle and in subcutaneous fat. The lambs fed barley exhibited a higher proportion of fatty acids with an odd number of carbon atoms and lower C18:3 values than the lambs given the concentrate.

Use of peripherally inserted central catheters (PICCs) has markedly increased during the last decade. However, there are few studies on use of PICCs in patients with haematological malignancies (HM) receiving intensive chemotherapy. Preliminary data suggest a higher rate of PICC-related complications in these high-risk patients. This prospective observational single-centre study aimed to investigate PICC-related complications after implementation of a multidisciplinary approach to PICC care and compared it with previous literature. A total of 44 PICCs were inserted in 36 patients (27.3 %, thrombocytopenia

In many studies in which the relationship between blood pressure and blood lead level has been examined, investigators have found significant--but small--associations. There was only one previous report of a significant association of blood lead with blood pressure in pregnant women. We measured blood lead level and sitting blood pressure of 1,627 women in their third trimester of pregnancy. We eliminated subjects with known causes of hypertension. Most women (98.4%) were normotensive. We controlled for body mass index, age, and stress--among other factors--and constructed multiple-regression models of lead association with diastolic and systolic blood pressures. Immigrants (73% of total) had significantly higher blood lead levels and different blood pressures than nonimmigrants, suggesting that analysis be stratified by "immigrant, nonimmigrant" status. Positive relationships between blood lead level and blood pressure were found only for immigrants (por = .001). From the 5th to 95th blood-lead percentiles (0.9-6.2 microg/dl) in immigrants, systolic blood pressure increased 2.8 mm Hg, and diastolic blood pressure increased 2.4 mm Hg. Higher prior lead exposure of immigrants (97.7% from Latin countries) than nonimmigrants might explain the differential effect of these low levels of blood lead on blood pressure in nonimmigrants. Perhaps some immigrants are at higher risk than nonimmigrants for lead-associated elevated blood pressure during pregnancy, despite blood lead levels within the currently considered acceptable range.

The complexity of contemporary clinical practice demands that increasingly skilled high quality health and social care is provided to individuals. However, the failure of health and social care professionals to work collaboratively has been widely reported in the international literature. Hence, interprofessional education has been suggested as a means of improving both interprofessional understanding and respect across a diverse range of practice disciplines. In this way, functional barriers can be challenged or broken down; teamwork enhanced and healthcare outcomes improved. Lack of conclusive evidence to substantiate the above healthcare benefits has been attributed to weak methodological approaches when evaluating such educational initiatives. In Spain barriers to implementing interprofessional education are potentially less challenging. Recent legislative demands following the Bologna Agreement on European Higher Education is compelling Spanish higher education institutes to engage in radical educational reforms. Consequently, this paper examines some of the advantages and disadvantages of introducing interprofessional education into health and social care curricula in Spain to see when and how interprofessional initiatives might be assimilated into the health care curricula. In this way lessons learned from a thorough review of the relevant literature might help to inform such educational reforms across mainland Europe and beyond.

Twenty-five years of public health efforts produced a striking reduction in lead exposure; the blood lead average in the United States has decreased to less than 20% of levels measured in the 1970s. However, poor minority groups that live in large urban centers are still at high risk for elevated lead levels. In this study, our data showed that pregnant immigrants (n = 1,428) who live in South Central Los Angeles--one of the most economically depressed regions of California--have significantly higher (p.0001) blood lead levels (geometric mean = 2.3 microg/dl [0.11 micromol/l]) than 504 pregnant nonimmigrants (geometric mean = 1.9 microg/dl [0.09 micromol/l]). The most important factors associated with lower blood lead levels in both groups were younger age; more-recent date of blood sampling (i.e., decreasing secular trend); and blood sampling in mid-autumn, instead of mid-spring (i.e., seasonal trend). Blood lead levels of immigrants were strongly dependent on time elapsed since immigration to the United States; each natural log increase in years of residence was associated with an approximately 19% decrease in blood lead levels. Although blood lead means for both groups were almost the same as the estimated national average, 25 of the 30 cases of elevated blood lead (i.e.,or = 10 microg/dl [0.48 micromol/l) occurred in the immigrant group. The odds ratio (95% confidence intervals within parentheses) for having elevated blood lead levels (a) was 9.3 (1.9, 45.8) if the immigrant engaged in pica; (b) was 3.8 (1.4, 10.5) if the immigrant had low dietary calcium intake during pregnancy; and (c) was .65 (.43, .98) for every natural log unit increase of years of residence in the United States. The control of pica and dietary calcium intake may offer a means of reducing lead exposure in immigrants.

This study investigated the antitumoral activity in colorectal cancer and toxicity of a 5-day continuous infusion of a new cytostatic agent, Mitonafide, that had previously shown to be neurotoxic when administered as a short daily x 5 days infusion.Seventeen chemotherapy-naive patients with advanced or relapsed colorectal cancer and measurable disease entered the study. All but one received a 120-hour (5-day) continuous infusion of Mitonafide at a starting dose of 200 mg/m2/day every 3 weeks. Toxicity evaluation was performed after each course and response assessment every 2 courses using the standard World Health Organization (WHO) criteria completed by the "Mini-mental state" test for cognitive status examination.Sixteen patients received a total of 41 courses of Mitonafide which resulted to be severely myelotoxic. In total, 13/16 patients had WHO grade 3-4 neutropenia, 7 of them with infection, and the treatment had to be stopped in 3 patients after only 1 course due to excessive toxicity. No central nervous system toxicity was observed. No objective responses were evidenced.At the dose and schedule of administration used, Mitonafide is not active in colorectal cancer and induces severe myelotoxicity thus not deserving further studies in this indication.