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Identificar as ações realizadas pela equipe de SCIH e Gestão da Qualidade para alcançar a meta redução do risco de infecções relacionadas à assistência à saúde. Pesquisa qualitativa, exploratória e descritiva, realizada em duas instituições hospitalares. Houve triangulação de dados com entrevistas, observação e análise documental. Para a análise dos dados utilizou-se a análise de conteúdo. As ações mais realizadas foram educação permanente, identificação e correções de problemas em procedimentos, busca ativa, vigilância e higienização das mãos. Foi possível identificar a ocorrência de eventos adversos. A comunicação e os problemas estruturais aparecem como dificultadores no alcance da meta. As ações identificadas foram práticas tradicionais e muitas vezes ineficientes. A prevenção e o controle de infecções ainda são desafios para as instituições de saúde. Há necessidade de adoção de estratégias inovadoras para alcançar a meta de redução do risco de infecção relacionada à assistência à saúde.

The use of phytotherapy expands the possibility of therapeutic resources for the population, often offering reduced costs when compared to the pharmaceutical industry. In this perspective, the JACBIO® dermocosmetic ointment revealed, in non-clinical trials, its antibacterial and healing potential, with a great stimulating effect in increasing the production of images. This work aimed to carry out the clinical phase study on dermal toxicity, in serious humans, by applying JACBIO®, based on extracts from the leaves of Piptadenia gonoacantha (Pau Jacaré). The phase I randomized clinical trial was carried out with 28 clinically healthy patients at a public university in Minas Gerais, with no period from August to December 2018. The toxicological trial was developed with the intervention group that received a JACBIO® dermatological ointment and the Placebo group. From the experimental protocol, participants were followed for four weeks. An analysis between the ointment and placebo groups, without reference to anticholinergic and cardiovascular events, showed no statistically significant difference. Likewise, there was no difference in laboratory results performed before and after treatment, both for the placebo group and for the intervention group. A low toxicity of the product indicates that this adjustment is safe and serves as a basis for phase II clinical trials in patients with lesions.

Introduction: ketamine is a dissociative anesthetic and, recently, its antidepressant properties has been described. Besides, its safety has been proven in the treatment of Stimulant Use Disorders. Objective: to evaluate the use of ketamine in the treatment of Stimulant Use Disorders (specially cocaine and its byproducts). Methods: patient's motivation for change was measured by URICA scale and psychiatric symptoms by EAS-40 score, both before and after the intervention. Results: it was verified, after the comparison between the Readiness Score means, an increase in the motivation for change after ketamine’s single administration, when compared to the moments before and after the intervention. Analyzing the Global Severity Index before and after ketamine administration, by EAS-40 score, we noticed a slight reduction of the psychiatric symptoms before and after the intervention. Conclusion: it was proven that ketamine's single administration led to a quick and lasting improvement on the user's motivation without worsening the mental health status.

Objective: to understand the professional practice challenges in reaching the goals and objectives of the National Patient Safety Program (Programa Nacional de Segurança do Paciente). Method: qualitative case study, based on the Comprehensive Sociology, carried out with 31 professionals from the Patient Safety Center (Núcleo de Segurança do Paciente) and the nursing team, working in a teaching hospital. Data collection took place between May and December 2015 through interviews, observation and documentary analysis. The analysis proceeded according to the prerogatives of the Content Analysis. Results: three categories emerged: the prescribed reality; material resources and their impact on care; and human resources related to the reality. Final considerations: challenges to safe professional practice are caused by inadequate physical structure, insufficient physical and human resources, but mainly invade the transition from the prescriptive reality scope. RESUMEN Objetivo: comprender los desafíos de la práctica profesional para el logro de las metas y objetivos del Programa Nacional de Seguridad del Paciente. Método: estudio de caso cualitativo, fundamentado en la Sociología Comprensiva, realizado con 31 profesionales del Núcleo de Seguridad del Paciente y del equipo de enfermería, que trabajaban en un hospital de enseñanza. La recolección de datos ocurrió entre mayo y diciembre 2015 a través de entrevistas, observación y análisis documental. El análisis procedió conforme a las prerrogativas del Análisis de Contenido. Resultados: surgieron tres categorías, siendo ellas la realidad prescrita; los recursos materiales y sus impactos en el cuidado; y la realidad relacionada con los recursos humanos. Consideraciones finales: los desafíos para la práctica profesional segura atraviesan la estructura física inadecuada y la insuficiencia de recursos materiales y humanos, pero principalmente invaden la transición de los cambios en el ámbito prescriptivo para el real. RESUMO Objetivo: compreender os desafios da prática profissional para o alcance das metas e objetivos do Programa Nacional de Segurança do Paciente. Método: estudo de caso qualitativo, fundamentado na Sociologia Compreensiva, realizado com 31 profissionais do Núcleo de Segurança do Paciente e da equipe de enfermagem, que trabalhavam em um hospital de ensino. A coleta de dados ocorreu entre maio e dezembro de 2015 por meio de entrevistas, observação e análise documental. A análise procedeu conforme as prerrogativas da Análise de Conteúdo. Resultados: emergiram três categorias, sendo elas: A realidade prescrita; Os recursos materiais e seus impactos no cuidado; e A realidade relacionada aos recursos humanos. Considerações finais: os desafios para a prática profissional segura perpassam pela estrutura física inadequada, insuficiência de recursos materiais e humanos, mas, principalmente, invadem a transição das mudanças no âmbito prescritivo para o real.

This study aimed to evaluate the anti-inflammatory and antinociceptive effects of hydroalcoholic extract of P.gonoacantha leaves (EPG). The toxic effect of the EPG was tested against A.salina in order to determine a secure dose for subsequent assays. The antinociception was evaluated using the acetic acid-induced writhing and hot plate tests in Wistar rats. The anti-inflammatory effect of EPG was evaluated by carrageenan-induced paw edema tests in rats. The bioassay with A.salina showed low toxicity of EPG (LC50=1,508mg/L). Oral administration of EPG (50, 100 and 150mg/kg) significantly decreased the number of acetic acid-induced writhes, around 61.3%, 71.8% and 64.9% respectively. However, EPG failed to prolong the latency time in the hot plate test, suggesting that EPG predominantly inhibits peripheral pain mechanisms. The oral administration of EPG at doses of 50 and 100mg/kg significantly inhibited paw edema at 3rd h after the injection of the phlogistic agent by 34.5% and 37.5%, respectively. These data suggest that EPG has both antinociceptive and anti-inflammatory activities, and these effects may be attributed to inhibition of COX-2 and prostaglandin release.