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Objective: To evaluate the mean values of Genial angle measured by Lateral cephalogram and Orthopantomogram. Study Design: comparative cross sectional study. Place and Duration of Study: Armed Forces Institute of Dentistry, Rawalpindi, from Aug 2018 to Feb 2019. Methodology: Patients irrespective of gender between the ages of 13-20 who reported for the treatment of class I malocclusion with complete anterior dentition were included. Orthopantomogram and lateral cephalogram were drawn by the same person. Gonial angle on orthopantomogram was measured by drawing tangents on posterior border of ramus and lower border of mandible on both halves of orthopantomogram. On lateral cephalogram the angle was measured between ramus and mandible. Gonial angle measured from lateral cephalogram and orthopantomogram were compared. T-test was applied. Results: Mean age of the individuals was 18.33 ± 3.97 years. The mean gonial angle measured on lateral cephalogram was 122.66 ± 1.64 degrees while the mean gonial angle measured on right and left side of orthopantomogram was 122.41 ± 1.56 degrees and 122.33 ± 1.55 degrees respectively. Conclusion: Orthopantomogram can also be used to measure gonial angle as accurately as a lateral cephalogram with the advantage that there are no superimpositions and both the gonial angles can be measured simultaneously on orthopantomogram.

Objective: To compare the rate of accelerated tooth movement in canine retraction with micro-osteoperforation on one side and control on the other. Study Design: Quasi experimental study. Place and Duration of Study: Orthodontics department, Armed Forces Institute of Dentistry, Rawalpindi Pakistan, from Jul 2018 to Jan 2019. Methodology: A total of 30 patients were inducted. After alignment and extraction of maxillary first premolars, canine retraction was started with closed NiTi coil spring on both sides of the maxillary arch. Micro-osteoperforation was done on the right side and other side was a control side. The distance between the lateral incisor and the canine was measured on both sides before micro-osteoperforation. The same measurements were recorded after three weeks of retraction. The difference between pre and post retraction measurements was recorded. The difference in the rate of canine retraction between both modalities was compared using independent sample t-test. Results: The study included 17 males (56%) and 13 females (43%). The mean rate of tooth movement at experimental side of maxilla was 1.6 ± 0.52 mm and on control side was 0.66 ± 0.31 mm (p

Objective: To compare the frequency of clinical failure of lingual retainers bonded with primerless flowable adhesives and conventional bonding adhesives. Study Design: Quasi experimental study. Place and Duration of Study: Department of Orthodontics, Armed Forces Institute of Dentistry Rawalpindi, from Jul 2017 to Jun 2018. Methodology: As per selection criteria, 76 patients were selected by non-probability consecutive sampling technique. Patients were divided into two groups: the conventional bonding adhesive and the primerless flowable adhesive group with 38 patients in each group. Retainers were bonded using standardized procedure with conventional bonding adhesive in one group and primerless flowable adhesive for bonding in the other group. After bonding of retainers, patients were recalled after 3 months and any bonding failures were recorded. Results: Failure rate with conventional bonding adhesive was 10.5% while on the other hand, failure with primerless flowable adhesive was 31.6% with a p-value of 0.047 which showed a statistically significant difference. Conclusion: There was a statistically significant difference of clinical failure rate of lingual retainers bonded with conventional bonding adhesive versus primerless flowable adhesive with greater failure rate of the primerless flowable adhesive.

Introduction We evaluated the knowledge of non-steroidal antiinflammatorydrugs (NSAIDs) including their dosage, side effects,contraindications, and drug interactions among the patients in anoutpatient rheumatology clinic. Methods Patients in a rheumatology clinic completed a short surveyassessing their knowledge of over-the-counter NSAIDs. Results The survey was provided to 400 participants and 275(68.5%) were using over-the-counter (OTC) NSAIDs. The majorityof the participants identified their commonly used NSAID. Almost athird were unaware of the contraindication of NSAIDs such as pepticulcer disease, chronic kidney disease, and hypertension. Nearly 53.9%participants denied having any discussion of OTC medications withtheir providers. Two-thirds of the respondents reported seeing onlythe medication packaging for the dose determination (67.8%). Conclusions The gap in patient knowledge of the potential sideeffects and the lack of discussion of OTC medications by the providersmay be predisposing the patients to preventable side effects fromNSAIDs.

Objective To determine the frequency of coincidence of facial and dental midlines in a sample of Pakistani subjects. Study design Cross-sectional study. Place and duration of study Department of Prosthodontics, Fatima Jinnah Dental College and Hospital, Karachi, from October to December 2017. Methodology Subjects of either gender (n=117) were selected from pool of otherwise healthy dental students. Facial portrait photographs using a DSLR camera were obtained while keeping the teeth in maximum inter-cuspation position. Auto-CAD software was used to analyse the coincidence of facial, maxillary and mandibular midlines. SPSS Version 23.0 was used for data analysis. The coincidence of the midlines were determined using Pearson correlation test. Level of significance was set at 0.05. Results The coincidence of maxilla-mandible midlines was 64.1% (75/117); whereas, coincidence of facial midline with maxillary and mandibular midlines were 47.9% (56/117) and 46.1% (54/117), respectively. Left sided deviations of dental midlines were more frequent than the right side. Conclusion The coincidence of inter-maxillary midlines was seen in two-thirds of the participants only. The dental midlines were coincident with the facial midline in less than half of the sample.

Objective To evaluate the parallelism of natural maxillary occlusal plane with inter-pupillary line and ala-tragus line, and to evaluate the anatomic relationship of natural mandibular occlusal plane with retromolar pad among dentate subjects. Methods The cross-sectional study was conducted from September 2017 to February 2018 at Fatima Jinnah Dental College, Karachi, and comprised front and profile photographs of subjects aged 20-28 years while holding the camper's plane against the maxillary occlusal plane. The photographs were imported in a software and an interpupillary line was drawn and the angle with Camper's plane was measured. On both profile pictures, lines were drawn from base of the ala to the superior, middle and inferior points on the tragus. The angle between ala-tragus line and Camper's plane were measured. Intra-orally, height of the mandibular occlusal plane in relation to the retromolar pad was evaluated using a stainless steel scale. Data was analysed using SPSS 23. Results Of the 109 subjects with a mean age of 23.03±1.36 years, 76(69.72%) were females. Horizontal parallelism of occlusal plane with inter-pupillary line was observed with a mean angle of 1.17±1.27 degrees. The angle between the occlusal plane and the inferior ala-tragus line was 4.25 degrees on the right side, and 4.50 degrees on the left. Intraorally, mandibular occlusal plane coincided with the inferior 48(44%) and the middle third 48(44%) of the retromolar pad. Conclusions Inter-pupillary line and retromolar pad area should be used as a guide in the determination of plane of occlusion. The ala-tragus line was not found to be a reliable guide.

A series of twelve Acceptor-π-Donor-π-Acceptor (A-π-D-π-A) topology-based donor molecules, where diketopyrrolopyrrole (DPP) as donor core unit is connected through furan which acts as conjugated π-bridge (CB) to aromatic derivatives (Ar) as acceptor units, have been investigated by making substitutions in acceptor units by using density functional theory(DFT) and time-dependent density functional theory (TD-DFT) for organic solar cell applications. The comparative study of optoelectronic properties indicates that thiadiazole with pyridine units containing molecules (M6b) exhibit lower energy of highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) energy levels than those of oxadiazole and pyridine containing units (M6b). Among our investigated donors, the smallest Eg of 1.60 eV was observed for both M6a and M6b with distinctive broad absorption at 843 and 857 nm, respectively. Overall, smaller electron transfer (λe) values in contrast to hole transfer (λh) demonstrate that these donor compounds would be best for λe. The calculated open circuit voltage (Voc) is 2.45 and 2.17 eV, regarding bisPCBM and PC60BM (phenyl-C61-butyric acid methyl ester) acceptors. Thus, these theoretical calculations not only endorse the deep consideration between the chemical structures and optoelectronic characteristics of the donor-acceptor systems but also suggest appropriate materials for high-performance Organic Photovoltaics (OPV).

Objectives The purpose of this study was to determine whether spironolactone use is associated with fractures in men with congestive heart failure (CHF). Background In rats with aldosteronism, spironolactone preserves skeletal strength. However, in humans, the relationship of spironolactone to fractures is not known. Methods The medical records of all male patients with CHF from 1999 to 2005 treated at the Veterans Affairs Medical Center, Memphis, Tennessee, were reviewed (n = 4,735). Odds ratios with 95% confidence intervals of having a fracture associated with spironolactone use were estimated using conditional logistic regression. Results We identified 167 cases with a single-incident fracture and matched these by age and race to 668 control subjects without fractures. After adjustment for covariates, spironolactone use was inversely associated with total fracture (odds ratio: 0.575; 95% confidence interval: 0.346 to 0.955, p = 0.0324). Conclusions The use of spironolactone is inversely associated with fractures in men with CHF.