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Lin Wang,1,* Jun Xiao,2,* Min-Zhe Li,3 Wen-Hao Teng,2 Jing Jia,1 Lu Lin,1 Sheng Liu,2 Xing-ming Ye,1 Wei-Dong Zang,2 Ying Chen1 1Central Laboratory, Fujian Cancer Hospital & Fujian Medical University Cancer Hospital, Fuzhou 350000, People’s Republic of China; 2Department of Gastrointestinal Surgery, Fujian Cancer Hospital & Fujian Medical University Cancer Hospital, Fuzhou 350000, People’s Republic of China; 3General Surgery Department, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wei-Dong ZangDepartment of Gastrointestinal Surgery, Fujian Cancer Hospital & Fujian Medical University Cancer Hospital, Fuzhou 350000, People’s Republic of ChinaEmail zwddoctor@126.comYing ChenCentral Laboratory, Fujian Cancer Hospital & Fujian Medical University Cancer Hospital, Fuzhou 350000, People’s Republic of ChinaEmail fjbccy@fjmu.edu.cnIntroduction: The aim of the present study was to evaluate a nomogram model for predicting the 5-year overall survival (OS) in lymph node-metastatic colorectal cancer (CRC) patients by combining inflammation markers with some traditional prognostic factors.Methods: A total of 399 patients with stage III (pTXN1-3M0) CRC operated from January 2007 to December 2012 were enrolled in this retrospective study. All patients underwent D2 lymphadenectomy in the hospital. A prognostic nomogram based on the integration of traditional prognostic factors and NLR (neutrophil-to-lymphocyte ratio) and PLR (platelet-to-lymphocyte ratio) was established and compared with the nomogram based on the traditional prognostic factors alone. ROC curves were further applied to verify the predictive accuracy of the established model.Results: Both NLR (P=0.00) and PLR (P=0.01) predicted the 5-year OS. In multivariate analysis, age, T3 category, T4 category, N2 category, N3 category, Pgp (P-glycoprotein), NLR and PLR are proven to be independent (all P≤ 0.05). The established nomogram showed better predictive power than that of traditional profile (c-index: 0.66 versus 0.63) in both training and validation cohorts. External assessment by ROC curve analysis demonstrated that the established model had a good prediction accuracy of 5-year OS in stage III CRC patients, with area under curve values of 0.657 and 0.629 in training and validating sets, respectively.Conclusion: A nomogram based on the integration of traditional prognostic factors and inflammatory markers (NLR and PLR) could provide more precise long-term prognosis information for lymph node-metastatic CRC patients than the model based on traditional profile alone. This model might be useful for clinical application in personalized evaluation.Keywords: nomogram, TNM staging system, lymph node metastasis, colorectal cancer, prognosis

Introduction: Body weight perception (BWP) directly determines weight management behaviors. Although child neglect is a well-established risk factor for managing body weight, little is known about its association with the accuracy of BWP. This study aimed to assess the cross-sectional and longitudinal associations between child neglect and BWP accuracy in primary schoolchildren, and explore how these differ based on the sex of the child.Methods: The sample included 1,063 primary schoolchildren (557 boys and 506 girls, aged 8–10 years) from a two-wave observational study between 2018 and 2019 in Wuhan, China. Child neglect and BWP were investigated using self-administered questionnaires. The accuracy of BWP was defined by comparing the BWP and actual body weight, and it was categorized into three groups—consistent, underestimated, and overestimated. Multinomial logistic regression analysis was conducted with fitting child neglect as the independent variable and the accuracy of BWP as the dependent variable.Results: The prevalence of weight misperception was ~44% at baseline (underestimation 40%; overestimation 4%) in Chinese primary schoolchildren. In the cross-sectional analysis, children with a higher level of neglect were more likely to misperceive their body weight. Moreover, there was an apparent sex-related difference that boys who experienced a higher level of neglect significantly reported more underestimation, while girls reported more overestimation. There was no significant longitudinal association between child neglect and the change in BWP accuracy.Conclusions: This study revealed that a higher level of neglect was significantly associated with underestimated BWP in boys and overestimated BWP in girls. The mechanisms of sex-related difference and whether child neglect is involved in the change in BWP, merit further investigations.

Due to the fact that the higher density of mobile devices is expected, the fifth generation (5G) mobile networks introduce small cell networks (SCNs) to prevent exhausting radio resources. SCNs improve radio spectrum utilization by deploying more base stations (BSs) in the networks. Even though authenticated key exchange (AKE) is still essential to ensure entity authentication and confidentiality in mobile communications. Besides, user anonymity is required to guarantee the footprints of mobile communications being concealed. However, AKE with user anonymity may increase the latency of communications dramatically in total due to several times more frequency in SCNs. The increase of latency will be more serious when an AKE protocol supports user anonymity, where traceability and revocability to users are necessary. Thus, this paper presents a secure region-based handover scheme (ReHand) with user anonymity and fast revocation for SCNs. ReHand greatly reduces the communication latency when user equipments (UEs) roam between small cells within the region of a macro BS, i.e., eNB, and the computation costs due to the employment of symmetry-based cryptographic operations. Compared to the three related prior arts, ReHand dramatically reduces the latency from 82.92% to 99.99% by region-based secure handover. Nevertheless, this paper demonstrates the security of ReHand by theoretically formal proofs.

Background Suicide has become a severe public health issue worldwide. Body weight has been put forward as a potentially modifiable element for suicide thought and behavior. However, there are discrepancies across previous studies. Furthermore, the relationships of body weight with suicidal ideation and suicide attempt among low- and middle-income countries (LMICs) remain unclear. Therefore, we addressed this issue among 104,907 adolescents of 12–15 years old in 45 LMICs. Methods The present study used data from the Global School-based Student Health Survey (GSHS). Suicidal ideation and suicide attempt during the last year were self-reported. Participants were classified intro underweight, normal weight, overweight and obesity according to their body mass index classification. Multivariable logistic regression and meta-analyses based on country-wise estimates were conducted. Results The prevalence of suicidal ideation and suicide attempt were 11.8% and 13.0%, respectively. Countrywide meta-analysis demonstrated that overweight and obesity were significantly associated with increased risks of suicidal ideation (For overweight: OR = 1.10; 95% CI = 1.01–1.20; for obesity: OR=1.17; 95%CI: 1.01–1.35) and suicide attempt (For overweight: OR = 1.12; 95% CI = 1.02–1.23; for obesity: OR=1.12; 95%CI: 1.00–1.25). Subgroup analyses showed that the associations between overweight/obesity and suicide attempt were significant for girls but not for boys. Limitations The cross-sectional design cannot explore causality; mental health factors were not assessed; suicidal behaviors were self-reported; significant heterogeneity across countries; only students attending school were included. Conclusions Overweight/obesity was significantly associated with the risk of suicidal ideation and suicide attempt among adolescents in LMICs.

Child neglect (CN) has been associated with eating disorders, but little is known about its prospective association with the eating habits (EHs) of children. This study aimed to assess the cross-sectional and prospective associations of baseline CN with six common EHs in Chinese primary schoolchildren. We analyzed two-wave data of 1102 children (aged 9.1 ± 0.5 years) in Wuhan, China. Baseline CN was investigated by the Child Neglect Scale. Baseline and follow-up EHs, including fruit, vegetables, milk, sugar-sweetened beverages, and high-calorie snack and breakfast consumption frequency, were assessed by the Food Frequency Questionnaires. The association of baseline CN with baseline/follow-up EHs was analyzed by the generalized linear model (GLM). The association of baseline CN with the change of EHs from baseline to follow-up was examined by the Generalized estimating equation (GEE) model. After adjusting for demographic characteristics, pubertal stage, and body mass index, GLM indicated that higher baseline CN was associated with lower frequency of consuming fruit/vegetables/milk/breakfast and higher frequency of consuming sugar-sweetened beverages and high-calorie snacks at baseline, while it was only associated with lower frequency of vegetables/breakfast consumption and higher frequency of sugar-sweetened beverages consumption at follow-up. GEE results indicated that children with higher CN had a more rapid increase for the frequency of fruit/milk/breakfast consumption and a steeper decrease for the frequency of sugar-sweetened beverages consumption. In conclusion, higher CN was associated with unhealthy EHs. Yet simultaneously, children with higher CN have more scope to promote the health of their EHs. Targeting and reducing CN may be a promising approach for future interventions to improve subsequent EHs.

Ulcerative colitis (UC) is a chronic inflammatory disease of intestinal tract, and Periplaneta americana has been found to be effective in the treatment for UC. The purpose of the study was to investigate the therapeutic effect of Periplaneta americana extract Ento-A on UC in rats induced by 2,4,6-trinitrobenzene sulfonic acid (TNBS) and to explore its mechanism. The Sprague-Dawley (SD) rats were randomly divided into normal control group; TNBS-treated group; sulfasalazine (SASP) treated group; Ento-A low- (50 mg/kg), medium- (100 mg/kg), and high-dose (200 mg/kg) groups, respectively. The UC model of rats was induced via TNBS. Disease activity index (DAI) was used to evaluate the severity of UC in rats. The macroscopic and microscopic damages of colon were accessed by colon mucosa damage index (CMDI) and histopathological score (HS), respectively. The levels of interleukin-4 (IL-4), interleukin-17 (IL-17), tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ) in serum and the contents of myeloperoxidase (MPO), transforming growth factor-β1 (TGF-β1), and epidermal growth factor (EGF) in colonic mucosa were measured by enzyme-linked immunosorbent assay (ELISA). Compared with the normal control group, the TNBS-treated group showed increase in DAI, CMDI, HS, IL-17, TNF-α, IFN-γ as well as MPO and decrease in the levels of IL-4, EGF, and TGF-β1. However, Ento-A-administrated groups reversed the changes in the DAI, CMDI, HS, and the cytokines caused by TNBS. The study indicates that Periplaneta americana extract Ento-A can effectively alleviate the inflammation in TNBS-induced UC of rats, and the mechanism of that may be related to restoring the balance of T helper 1 (Th1)/Th2/Th17/T regulatory (Treg) cytokines.

Coupled vibration of water and stop log gate in the layered water intake structure will occur under the condition of the sudden load changes. A fluid-structure interaction (FSI) finite element model of the layered water intake structure of a hydropower station was established by using the finite element software ADINA to simulate the process of power on and off and the FSI phenomena of stop log gate during each process, and also verify the security of the scheme. The results show that fluid-structure interaction has a significant impact on the running of the layered water intake.

In this paper, a 3-D finite element model was established for stop log gates. It is used for researching its force situation in process of power on and power off. The vertical pressure distribution around stop log gates shows that with water depth increasing, the difference of downstream pressure and upstream pressure of gates become more obvious. Between power on and power off processes, the stop log gates’ pressure differences and horizontal displacements are opposite.

This paper gives a solution of prepayment and software design in the intelligent electric meter. Firstly introduces the development and the future trend of the meter, the overall design scheme is given, a software platform built. Then the design of the CPU IC card circuit, IC card processing program, and the main program, real-time power program and electricity consumption measurement program are also designed. System uses LPC2290 as the main control chip, using ADI company ADE7755 electric energy metering chip, the software uses the modular design, not only can realize the measurement of electric energy, but also can accomplish the communication with the host computer, easy to build energy platform for energy management and control etc.

Combined with a multi-level intake structure, using the standard two-equation turbulence model to carry on the three-dimensional numerical simulation for the hydraulic characteristics of this intake .The flow velocity, fluid flow distribution and head loss were analyzed and summarized. The vertical velocity distribution near the intake has been significantly changed after placed stop log gate, the flow velocity of the reservoir surface water near the intake increases significantly, more surface water enter the power plant unit, and the head loss increases greatly.

This paper firstly introduces the development of the electric energy meter and the future trend, the overall design scheme of intelligent electric meter is given, a software development platform built. Then the design of voltage and current detection circuit, TCP/IP communication circuit, network interface driver and embedded WEB page. System uses LPC2290 as the main control chip, using the United States ADI company's ADE7755 chip energy metering, can not only realize the measurement of electric energy, but also can accomplish the communication with the host computer, easy to build energy management platform for energy management and control etc..

This paper analyzes the concrete mixing station control system problems, puts forward the total design scheme, and designs the hardware and software of programmable logic controller. In the software project, focusing on the automatic run program, aggregate discharge procedures, two feeding procedures, alarm procedures. The design also uses intermediate temporary storage technology, pressurized water discharge technology. The experiments prove that the system is reliable, simple operation, convenient maintenance, good effect.

This paper analyzes the concrete mixing station control system problems, put forwards the total design scheme, communication and database configuration, designs the PC management software. Monitoring, introduces user management, basic setting, process parameters, production process monitoring, alarm system, the running task information, material weight measurement; management, focuses on the proportioning management, task management, report management and invoice etc. From the debugging situation, reliable operation, simple operation, convenient maintenance, good results.

Documents are closely related to our daily life, from morning papers to various corporate reports, and even to site maps issued by tourist attractions. Before the advent of the Internet in the 1970s, documents were certain physical objects on which significant text and graphic symbols were drawn, written, printed or shown in a way to be visible. With the emergence of the Internet, the presentation of documents has become diversified. Traditional physical documents are gradually replaced by digital documents and those changes have altered how we communicate to each other. Although documents are so important, many documents attract less attention from users due to the lackluster content and to many perplexing problems in information structure, graphic symbols, layout. Document design has accumulated considerable practical experience and design methods nowadays. The design category has also been widening. Digitization can bring freer presentation and wider communication to documents; paper documents also have advantages in reading habits, execution efficiency and convenience. No matter how the information is presented, being easy to understand, being easy to use and creating a pleasant reading atmosphere are still the common goals of all the document designs. On this basis, it is essential to pay great attention on the various of document for different requirement.

While the tunnel crossing the ancient Great Wall, we must take effective measures to control ground deformation, prevent ground deformation is too large, destroying the heritage. In order to study the effects of tunnel excavation types on strata deformation, a three-dimensional computational model is built to simulate surface settlement and horizontal displacement by three different excavation types which are both-side heading method, CRD method, and hole pile method. Following comparative analysis, in line with the realistic program is recommended. The results show that both-side heading method can better control the surface deformation, and has a high efficiency of construction, which was selected as the construction scheme of tunnel crossing the ancient great wall. The results of this study are expected to provide construction experience to the works of a similar background.

Scutellarein, the main metabolite of scutellarin in vivo, has relatively better solubility, bioavailability and bio-activity than scutellarin. However, compared with scutellarin, it is very difficult to obtain scutellarein from Nature. Therefore, the present study focused on establishing an efficient route for the synthesis of scutellarein by hydrolyzing scutellarin. Neurological deficit score and cerebral infarction volume with the administration of scutellarein were then used to compare its neuroprotective effects on focal cerebral ischemia/reperfusion in rats induced by middle cerebral artery occlusion (MCAO) with those of scutellarin. The results showed that scutellarein had better protective effect on focal cerebral ischemia/reperfusion than scutellarin, which laid the foundation for further research and development of scutellarein as a promising candidate for ischemic cerebro-vascular disease.

Steel reinforced concrete (SRC) structure is a kind of building structure with excellent mechanical performance, but the theory of crack width is not very clear. In recent years, the fracture energy is more and more applied to research concrete materials, which has opened up a new field for concrete materials modeling. In this paper, crack width model for SRC structure based on fracture energy concept is put forward. A uniaxial tension model is employed in the analysis for simplification. On the ground of the stress equilibrium as well as the relation among relative slip, steel strain and concrete strain, the basic equations are derived. By introducing the interfacial nonlinear bond stress versus slip constitutive relation between embedded steel and concrete, the analytical solution for distribution of slip along the interface is obtained. And based on this result, the influence of the interfacial bond-slip on tension stiffening of the steel is considered. The displacements of steel and concrete at the crack face under different load levels are computed and analyzed respectively. Finally according to the principle of work and power as well as the fracture energy concept of plain concrete, expression for fracture energy of SRC structures is obtained, and the relation of crack width and concrete fracture energy is established. The comparison shows that the fracture energy based on the model agrees with the test results well.

In order to attenuate low frequency vibration induced by metro train and reduce the influence on inhabitants and sensitive equipment nearby the traffic line, it becomes more important to improve the dynamic characteristics and vibration isolation performance of floating slab track system under the low frequency excitation. A detailed derivation of vibration differential equations is given to analyze the vibration responses by monitoring the modal parameters and dynamics characteristics of floating slab track system. Based on the theoretical analysis, a 3D finite element model is employed to assess mode interactions and vibration isolation ranges of floating slab system with various parameters. Two kinds of key parameters were evaluated, which include structural parameters (such as length and thickness of slab, etc.) and dynamic parameters (such as railpad stiffness and bearing stiffness, etc.). The result demonstrates that adjusting special parameters can conspicuously improve the vibration isolation performance of floating slab track under low frequency excitation. For vertical vibration and bending vibration, both the dynamic parameters and structural parameters can effect conspicuously. The length should be in the range of 20~50 m for a desirable vibration isolation range and reasonable cost, while the thickness should be selected more than 0.4 m.

A double-beam model on rigid foundation subject to a harmonic moving load is employed in this paper to assess vibration isolation performance of floating slab system with various parameters. The track is assumed to act as infinitely long double Euler-Bernoulli beam on elastic foundation. By means of moving coordinate and Fourier transformation method, the differential equations of floating slab track system are established and solved in the wavenumber-frequency domain. The contour integration method is used to convert the responses of the track system from wavenumber-frequency domain into space-time domain. The results of transmitted force are obtained by MATLAB software to assess vibration isolation effectiveness of the track with various parameters. The result demonstrates that track system will tend to instability when the load velocity reaches to critical load velocity, endangering the metro traffic operation and discomforting passengers. Decreasing stiffness and increasing damping factor can conspicuously reduce the force transmission to improve the vibration isolation effectiveness, while the increasing mass has no obvious effect for low frequency excitation. Increasing slab mass and decreasing bearing stiffness can reduce the resonance frequency of floating slab track to expand the vibration isolation range.

A new design of an integrated two-stage class-F power amplifier (PA) for wireless application operating in the 1.65 GHz frequency range is described. The circuit utilizes a simple method to drive the output stage with a half sinusoidal waveform that is optimal for class-F operation. The circuit was fabricated in a Silterra's standard 0.18 mum RF CMOS technology. Measurement result shows a maximum power-added efficiency (PAE) of 42% and a maximum gain of 19.7 dB. When operating from a 3 V voltage supply, the PA delivers an output power of 18.9 dBm. This work demonstrates the feasibility of using class-F PAs for short-range and low-power applications.

This work will explore the integration of a class-F power amplifier using CMOS technology. At 2.4 GHz, the fully integrated on-chip CMOS power amplifier can deliver 21.8 dBm output power with 43.95% efficiency. The design makes use of the C18 RF models provided by Silterra and design of spiral inductor using commercial synthesis software.

An input driver circuit for driving a cascode stage Class F RF Power Amplifier in deep submicron CMOS technology is proposed. The input driver circuit will deliver an improvement to the RF Power Amplifier's efficiency by reducing drain current distortion and provide better breakdown voltage protection for the transistor. The proposed input driver and Class F Power Amplifier are designed using Silterra RF CMOS 0.18?m technology and simulated using Hspice.

A design approach for differential CMOS active inductor with a self-resonant frequency around 1.58GHz-3.98GHz is presented. The architecture is based on a differential gyrator-C topology to transform intrinsic capacitance of a MOSFET to the emulated inductance. Due to high power consumption of active inductor, only a current source is used. This design has the capability to tune the inductor and Q-factor values from 10nH-60nH and 20-60 respectively. Furthermore, a technique is proposed to ensure smaller inductance value can be achieved with smaller power consumption and die area.