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Stroke causes systemic immunosuppression. T lymphocytes are involved in infarct size in the early stages of stroke. However, the phenotypes of T lymphocytes and their functions in peripheral immune organs and the brain have not been well analyzed in the acute and chronic phases of stroke. Here, we investigated pathological phenotypic alterations in the systemic immune response, especially changes in T lymphocytes, from one day to six months after ischemic stroke in mice. Impairment in thymocyte numbers, development, proliferation, and apoptosis were observed for up to two weeks. The number of mature T cells in the spleen and blood decreased and showed reduced interferon-γ production. Increased numbers of CD4-CD8-CD3+ double-negative T cells were observed in the mouse brain during the early stages of stroke, whereas interleukin (IL)-10+Foxp3+ regulatory T lymphocytes increased from two weeks during the chronic phase. These phenotypes correlated with body weight and neurological severity scores. The recovery of T lymphocyte numbers and increases in IL-10+Foxp3+ regulatory T lymphocytes may be important for long-term neurological outcomes. Dynamic changes in T lymphocytes between the acute and chronic phases may play different roles in pathogenesis and recovery. This study provides fundamental information regarding the T lymphocyte alterations from the brain to the peripheral immune organs following stroke.

Purpose: This study was conducted to describe the knowledge and attitudes of nursing and non-nursing college students toward HIV/AIDS and Hepatitis B. Methods: A descriptive design was used for this study. The subjects were 123 nursing college students and 128 non-nursing college students. Self-administered questionnaires were used for data collection. Descriptive statistics, -test, t-test, ANOVA, and Pearson correlation coefficient were used for data analysis. Results: Nursing students showed a greater understanding and more favorable attitudes towards HIV/AIDS and hepatitis B than non-nursing college students. Most non-nursing college students learned about HIV/AIDS and hepatitis B from Mass Media. In contrast, many nursing college students learned about HIV/AIDS and hepatitis B from technical books and lecture. Students who learned from technical books and lecture showed a higher score for knowledge and more favorable attitudes regarding HIV/AIDS and hepatitis B. Conclusion: The findings of this study demonstrated that educational opportunities in school are crucial to enhancing knowledge and attitudes toward HIV/AIDS and Hepatitis B. A structured education program using strategies to improve attitudes is necessary for college students.