Search

Directed self-assembly of vertically aligned block copolymer (BCP) thin films has been extensively explored as one of the possible bottom-up routes for sub-10 nm patterning technology. To achieve a vertical orientation, it has been imperative to incorporate neutralization layers to balance the interfacial energy difference, which inevitably accompanies processing complexity. Here, a gradient random-copolymer block copolymer system, poly[(styrene-gradient-pentafluorostyrene)-b-methyl methacrylate] [P(S-g-PFS)-b-PMMA] BCP, which realizes universal vertical alignment of sub-10 nm block copolymer lamellae without any top-coat and neutral brush layers, is demonstrated. The surface energy difference between the block junction region and the tail of the gradient random-copolymer block provides a strong energetic preference for vertical lamellae on almost any type of surface, which is well supported by a thermodynamic model. Furthermore, we show that the gradient BCPs can be assembled on EUV lithography patterns to enhance their aspect ratios. This strategy of encoding surface energy balance could be potentially extended to a variety of other self-assembling systems, realizing universal orientation-controllability of nanoscale objects.

Despite the fact that research into most high-performance thermoelectric (TE) materials is focused on tellurides, compelling demand has arisen to replace tellurium (Te) with selenium (Se) due to the scarcity of Te. Silver bismuth diselenide (AgBiSe2, ABS) has been widely studied in relation to thermoelectric applications due to its intrinsically low thermal conductivity. However, its low power factor (PF) has been considered as an underlying issue preventing improvements of the TE properties of ABS. Here, it is demonstrated that a high PF can be achieved by incorporating Cu into the ABS system via the nestification of conduction bands when a disordering between Ag and Bi occurs. Degenerate electronic bands simultaneously increase the density-of-states effective mass and carrier concentration while not reducing the carrier mobility significantly. Therefore, improved TE performance with a maximum PF of 8.2 μW cm−1 K−2 and a peak zT value of 1.14 was achieved at 773 K, opening a new horizon for the development of environmentally benign TE materials with high performance capabilities.

We revisit the concept of the cloud vertical structure (CVS) classes we have previously employed to classify the planet's cloudiness (Oreopoulos et al., 2017). The CVS classification reflects simple combinations of simultaneous cloud occurrence in the three standard layers traditionally used to separate low, middle, and high clouds and was applied to a dataset derived from active lidar and cloud radar observations. This classification is now introduced in an atmospheric global climate model, specifically a version of NASA's GEOS-5, in order to evaluate the realism of its cloudiness and of the radiative effects associated with the various CVS classes. Such classes can be defined in GEOS-5 thanks to a subcolumn cloud generator paired with the model's radiative transfer algorithm, and their associated radiative effects can be evaluated against observations. We find that the model produces 50 % more clear skies than observations in relative terms and produces isolated high clouds that are slightly less frequent than in observations, but optically thicker, yielding excessive planetary and surface cooling. Low clouds are also brighter than in observations, but underestimates of the frequency of occurrence (by ∼20 % in relative terms) help restore radiative agreement with observations. Overall the model better reproduces the longwave radiative effects of the various CVS classes because cloud vertical location is substantially constrained in the CVS framework.

Rapid, accurate, and intuitive detection of unknown liquids is greatly important for various fields such as food and drink safety, management of chemical hazards, manufacturing process monitoring, and so on. Here, we demonstrate a highly responsive and selective transparency-switching medium for on-site, visual identification of various liquids. The light scattering–based sensing medium, which is designed to be composed of polymeric interphase voids and hollow nanoparticles, provides an extremely large transmittance window (95%) with outstanding selectivity and versatility. This sensing medium features ternary transparency states (transparent, semitransparent, and opaque) when immersed in liquids depending on liquid-polymer interactions and diffusion kinetics. Several different types of these transparency-changing media can be configured into an arrayed platform to discriminate a wide variety of liquids and also quantify their mixing ratios. The outstanding versatility and user friendliness of the sensing platform allow the development of a practical tool for discrimination of diverse organic liquids.

Background : Glass-ionomer cements (GICs) are biomaterial compounds of basic glasses and an acid polymer with a setting reaction of acid-base type. They are booming these decades due to the improvement in their properties and the development of minima dentistry. Aim: The present study aims at assessing the awareness, aptitudes and practices of dental surgeons in Abidjan with regard to the use of glass ionomer cements. Methods and Materials : A cross-sectional study was carried out using a self-administered questionnaire to 102 dental surgeons in Abidjan (Cote d’Ivoire). Results: This study has shown that 100% of the surveyed practitioners were trained to use the glass ionomer cements restorations at the university, but 19.61% did not realize it. For 22.55%, GIC restorations concern only primary teeth while 55.88% concluded that they concern both primary and permanent teeth. Finally, for 1,96%, GIC concern solely permanent teeth. In their daily practice, 14.71% of practitioners had made GCI their preferred material in restorative therapeutics. Conclusions: A better indication accuracy of those materials and practitioners’ motivation is needed with the view of increasing their use. Keywords: Abidjan, Glassionomer cements, Restorative dentistry.

The posterior suprascapular nerve block has been proposed as an analgesic alternative for shoulder surgery based on the publication of several comparisons with interscalene block that failed to detect differences in analgesic outcomes. However, quantification of the absolute treatment effect of suprascapular nerve block on its own, in comparison with no block (control), to corroborate the aforementioned conclusions has been lacking. This study examines the absolute analgesic efficacy of suprascapular nerve block compared with control for shoulder surgery. We systematically sought electronic databases for studies comparing suprascapular nerve block with control. The primary outcomes included postoperative 24-h cumulative oral morphine consumption and the difference in area under the curve for 24-h pooled pain scores. Secondary outcomes included the incidence of opioid-related side-effects (postoperative nausea and vomiting) and patient satisfaction. Data were pooled using random-effects modelling. Ten studies (700 patients) were analysed; all studies examined landmark-guided posterior suprascapular nerve block performed in the suprascapular fossa. Suprascapular nerve block was statistically but not clinically superior to control for postoperative 24-h cumulative oral morphine consumption, with a weighted mean difference (99%CI) of 11.41 mg (-21.28 to -1.54; p = 0.003). Suprascapular nerve block was also statistically but not clinically superior to control for area under the curve of pain scores, with a mean difference of 1.01 cm.h. Nonetheless, suprascapular nerve block reduced the odds of postoperative nausea and vomiting and improved patient satisfaction. This review suggests that the landmark-guided posterior suprascapular nerve block does not provide clinically important analgesic benefits for shoulder surgery. Investigation of other interscalene block alternatives is warranted.

Patient: Male, 56 Final Diagnosis: Exfoliative dermatitis Symptoms: Edema • erythema • pruritus • rash • sepsis • shivers Medication: Vancomycin Clinical Procedure: Skin biopsy Specialty: General and Internal Medicine Objective: Unusual clinical course Background: Erythroderma is an exfoliative dermatitis that manifests as generalized erythema and scaling that involves 90% of the body surface. If untreated, erythroderma can be fatal because of its metabolic burden and risk of secondary infections. Case Report: The patient was a 56-year-old male with prior rash attributed to group A Streptococcal cellulitis and discharged on Augmentin, Clindamycin with hydrocortisone cream, and Bactrim, but he had been noncompliant. He was admitted again for rash involving the face, torso, and extremities characterized by diffuse, desquamative, dry scales in morbilliform pattern. The patient was septic with Staphylococcus aureus bacteremia and compromised skin barrier. He was started on vancomycin and switched to Cefazolin IV due to concern for drug reaction. Autoimmune workup included antibodies for anti-Jo-1, anti-dsDNA, anti-centromere, and ANCA. However, only antinuclear antibody and scleroderma antibody were positive. Given the unclear workup results and lack of response to antibiotics, the patient was started on prednisone 60 mg PO and topical Triamcinolone 0.1% cream. A skin biopsy revealed psoriasiform hyperplasia with atypical T cell infiltrate and eosinophils, but negative for T cell gene rearrangement. The rash resolved after day 12 of application of topical Triamcinolone. Conclusions: This case is unique in terms of the rarity of erythroderma and the diagnostic challenge given confounding factors such as noncompliance and drug reaction. Serious causes, such as SLE and cutaneous T cell lymphoma, were ruled out. Fortunately, the rash responded well to steroids; however, given the adverse effects of long-term use of topical steroids, the patient will need follow up with Dermatology.

Achieving high emission efficiency in solid-state quantum dots (QDs) is an essential requirement for high-performance QD optoelectronics. However, most QD films suffer from insufficient excitation and light extraction efficiencies, along with nonradiative energy transfer between closely adjacent QDs. Herein, we suggest a highly effective strategy to enhance the photoluminescence (PL) of QD composite films through an assembly of QDs and poly(styrene

Background A cardiac myxoma in a young person may pose a diagnostic challenge as symptoms may be variable and the differential diagnosis is wide. The differential diagnosis can include rheumatic mitral valve disease, pulmonary hypertension, endocarditis, myocarditis and vasculitis. Case presentation This case report involves a 49 years old female with a 2.8 cm × 3.4 cm myxoma in the left atrium causing mitral valve obstruction. She presented with fatigue, fever of unknown origin, transient ischemic attack and shortness of breath. Prompt surgery is often recommended due to the risk of embolic complications or complete obstruction. Due to her symptoms, patient underwent successful cardiothoracic surgery to excise the myxoma within 2 weeks of confirmation by cardiac echocardiography. Conclusion This case also emphasizes the diagnostic challenge as symptoms may be variable, ranging from fatigue, fever and shortness of breath to transient ischemic attack and at worst, sudden cardiac death. In conclusion, if a cardiac mass is suspected, echocardiography should be performed early. Surgical resection is curative and recurrence rate is very rare in sporadic isolated myxomas, however, recurrence can be higher in genetic diseases associated with increased frequency of myxomas such as Carney complex. This subpopulation of patients may present further research opportunity to learn more about the perioperative management of patients with myxomas such as determining the optimal time to surgical intervention and decision to anticoagulate.

The co-variability of cloud and precipitation in the extended tropics (35° N–35° S) is investigated using contemporaneous datasets for a 13-year period. The goal is to quantify the relationship between cloud types and precipitation events of particular strength. Particular attention is paid to whether the relationship exhibits different characteristics over tropical land and ocean. A major analysis metric is correlation coefficients between fractions of individual cloud types and frequencies within precipitation histogram bins that have been matched in time and space. The cloud type fractions are derived from Moderate Resolution Imaging Spectroradiometer (MODIS) joint histograms of cloud top pressure and cloud optical thickness in one-degree grid cells, and the precipitation frequencies come from the Tropical Rainfall Measuring Mission (TRMM) Multi-satellite Precipitation Analysis (TMPA) dataset aggregated to the same grid. It is found that the strongest coupling (positive correlation) between clouds and precipitation occurs for cumulonimbus clouds and heaviest rainfall over ocean. While the same cloud type and rainfall bin are also best correlated over land compared to other combinations, the correlation magnitude over land is weaker than over ocean. The difference is attributed to the greater size of convective systems over ocean. It is also found both over ocean and land that the anti-correlation of strong precipitation with weak (i.e., thin and/or low) cloud types is of greater absolute strength than positive correlations between weak cloud types and weak precipitation. Cloud type co-occurrence relationships explain some of the cloud-precipitation anti-correlations. Couplings between weaker rainfall and clouds are also distinct in ocean vs. land, with precipitation predictability when cloud type is known being quite poor in general, particularly over land.

This case involves a 62-year-old male with a prior history of epidural abscess and L1-L2 osteodiscitis who was admitted because of low back pain. The patient was previously treated for methicillin-susceptible Staphylococcus aureus (MSSA) discitis in the L1/L2 vertebral region with intravenous (IV) nafcillin through a peripherally inserted central catheter (PICC). However, he returned after four months with recurrent low back pain along with chills and fever. He was admitted for severe sepsis related to the L1-L2 region osteomyelitis and discitis. The Infectious Disease department initially started the patient on IV vancomycin and cefepime; however, routine labs on the second day of IV antibiotics showed concern for pancytopenia with white blood cell count (WBC) decreased to 2.5 thou/mm3, Hgb to 6.2 g/dL, Hct to 20.8%, and platelets to 82 thou/mm3 from baseline values of WBC 3.9 thou/mm3, Hgb 8.3 g/dL, Hct 28%, and platelets 126 thou/mm3. Due to concern for pancytopenia in the setting of severe sepsis, extensive hematologic workup was pursued to evaluate for disseminated intravascular coagulation (DIC) and bone marrow suppression. The patient also had a positive fecal occult blood test, so the Gastroenterology department was consulted for esophagogastroduodenoscopy (EGD) and colonoscopy. Furthermore, despite appropriate outpatient treatment for MSSA osteodiscitis, the patient was bacteremic with Staphylococcus aureus. Hence, the Cardiology department was consulted to rule out cardiac valvular vegetation. This case presents a unique case of pancytopenia involving elements of drug-induced aplastic anemia as well as DIC-related sepsis. The agranulocytosis may have been a consequence of drug reaction to IV vancomycin. The anemia and thrombocytopenia may have been caused by DIC. Repeat computed tomography (CT) guided spinal aspiration confirmed pan-sensitive Staphylococcus aureus infection of the L1/L2 vertebral region. Treatment was reverted to nafcillin monotherapy and fortunately his hematologic function normalized, avoiding the need for advanced treatments such as intravenous immunoglobulin infusion therapy (IVIG) or high dose steroids.

Controversy exists whether the ECG pattern of ST elevation (STE) in lead aVR with diffuse ST depression is associated with left main coronary artery occlusion versus insufficiency. This may also be seen with left anterior descending artery (LAD) occlusion, severe triple vessel disease or

Wireless technology, such as local area telecommunication networks and surveillance cameras, causes severe interference for weather radars because they use the same operational radio frequencies. One or two disturbances can be removed from the radar image, but the number and power of the interfering wireless devices are growing all over the world, threatening that one day the radars could become useless for weather observations. Some agencies have already changed or are considering changing frequency bands, but now even other bands are under threat. Use of equipment at radio frequencies is regulated by laws and international agreements. Technologies have been developed for peaceful coexistence. If wireless devices use these technologies to protect weather radars, their data transmission capabilities become limited, so it is tempting to violate the regulations. Hence, it is an important task for the worldwide weather community to involve themselves in the radio frequency management process and work in close contact with their national radio authorities to ensure that meteorological interests be duly taken into account in any decision-making process toward the future usage of wireless devices.

Laboratory testing of rectangular beams using a synthetic rock was used to investigate the onset of dilation and spalling. The beams are axially compressed and subjected to 4-point bending to provide non-uniform compressive stresses. The maximum tangential stress occurs at the top of the beam and rapidly decreases with distance from the top of the beam. This stress distribution was used to simulate the maximum tangential stress distribution found around circular excavations. The results showed using this beam test configuration that the onset of dilation based on beam displacement and visually observed spalling began at approximately the same stress level. Discrete element numerical analyses (particle flow code) were used to evaluate the stress path at various locations in the beams. The analyses revealed that spalling and dilation in the beams occurred well below the peak strength failure envelope determined from conventional laboratory tests. The findings suggest that the onset of dilation in laboratory tests appears to be a good indicator for assessing the stress magnitudes required to initiate spalling.

The Large Size Telescope (LST) of the Cherenkov Telescope Array (CTA) is designed to achieve a threshold energy of 20 GeV. The LST optics is composed of one parabolic primary mirror 23 m in diameter and 28 m focal length. The reflector dish is segmented in 198 hexagonal, 1.51 m flat to flat mirrors. The total effective reflective area, taking into account the shadow of the mechanical structure, is about 368 m$^2$. The mirrors have a sandwich structure consisting of a glass sheet of 2.7 mm thickness, aluminum honeycomb of 60 mm thickness, and another glass sheet on the rear, and have a total weight about 47 kg. The mirror surface is produced using a sputtering deposition technique to apply a 5-layer coating, and the mirrors reach a reflectivity of $\sim$94% at peak. The mirror facets are actively aligned during operations by an active mirror control system, using actuators, CMOS cameras and a reference laser. Each mirror facet carries a CMOS camera, which measures the position of the light spot of the optical axis reference laser on the target of the telescope camera. The two actuators and the universal joint of each mirror facet are respectively fixed to three neighboring joints of the dish space frame, via specially designed interface plate., In Proceedings of the 34th International Cosmic Ray Conference (ICRC2015), The Hague, The Netherlands. All CTA contributions at arXiv:1508.05894

The differentiation of left ventricular pseudoaneurysm from true aneurysm is sometimes difficult. Given the propensity for pseudoaneurysms to rupture leading to cardiac tamponade, shock, and death, compared with a more benign natural history for true aneurysms, accurate diagnosis of these conditions is clinically important. Clinical symptoms, physical examination findings, electrocardiograms, and routine x-rays are not sensitive or specific for diagnosing left ventricular aneurysms nor for distinguishing true from pseudoaneurysm once detected. Our aim is to present a case report demonstrating these difficulties and to review the use of various cardiac imaging modalities in differentiating between these 2 entities.

We measured and analyzed the subthreshold degradation of the gate-all-around (GAA) silicon nanowire field-effect transistors with the length of 300/500 nm and the radius of 5 nm. An analytical model incorporating the effect of interface traps quantitatively explained the measured subthreshold swing (SS) degradation. A simple electrostatic argument showed that the GAA device had smaller degradation of SS values than planar devices for the same interface trap densities.

Leakage current characteristics have been investigated for nitride-based InGaN light-emitting diodes (LEDs) with different levels of Si-doping conditions applied to the n-type InGaN/GaN layer. The tested LED samples had an emission wavelength of 445 nm. Based on the analysis of temperature-dependent characteristics measurements, the reverse leakage current, IR, was predominantly influenced by the lowering of Poole-Frenkel (PF) barrier for low electric field ( ;8 × 107 V/cm), phonon-assisted tunneling (PAT) dominates the IR mechanism. The IR is influenced by the Si-doping density of InGaN/GaN layer that may be present near the end of depletion regions of tested samples.

Repeated stress and chronically elevated glucocorticoids cause exaggerated cardiovascular responses to novel stress, elevations in baseline blood pressure, and increased risk for cardiovascular disease. We hypothesized that elevated corticosterone (Cort) within the dorsal hindbrain (DHB) would: 1) enhance arterial pressure and neuroendocrine responses to novel and repeated restraint stress, 2) increase c-Fos expression in regions of the brain involved in sympathetic stimulation during stress, and 3) recruit a vasopressin-mediated blood pressure response to acute stress. Small pellets made of 10% Cort were implanted on the surface of the DHB in male Sprague-Dawley rats. Blood pressure was measured by radiotelemetry. Cort concentration was increased in the DHB in Cort-treated compared with Sham-treated rats (60 ± 15 vs. 14 ± 2 ng Cort/g of tissue, P < 0.05). DHB Cort significantly increased the integrated arterial pressure response to 60 min of restraint stress on days 6, 13, and 14 following pellet implantation (e.g., 731 ± 170 vs. 1,204 ± 68 mmHg/60 min in Sham- vs. Cort-treated rats, day 6, P < 0.05). Cort also increased baseline blood pressure by day 15 (99 ± 2 vs. 108 ± 3 mmHg for Sham- vs. Cort-treated rats, P < 0.05) and elevated baseline plasma norepinephrine and neuropeptide Y concentrations. Cort significantly enhanced stress-induced c-Fos expression in vasopressin-expressing neurons in the paraventricular nucleus of the hypothalamus, and blockade of peripheral vasopressin V1 receptors attenuated the effect of DHB Cort to enhance the blood pressure response to restraint. These data indicate that glucocorticoids act within the DHB to produce some of the adverse cardiovascular consequences of chronic stress, in part, by a peripheral vasopressin-dependent mechanism.

The Large Size Telescopes, LSTs, located at the center of the Cherenkov Telescope Array, CTA, will be sensitive for low energy gamma-rays. The camera on the LST focal plane is optimized to detect low energy events based on a high photon detection efficiency and high speed electronics. Also the trigger system is designed to detect low energy showers as much as possible. In addition, the camera is required to work stably without maintenance in a few tens of years. In this contribution we present the design of the camera for the first LST and the status of its development and production.

We analyze boundary layer velocity and temperature measurements acquired by aircraft at 22 Hz. The calculated longitudinal velocity third-order structure function yields approximate agreement with Kolmogorov's four-fifths law for the scale range ∼10–100 m with a downscale energy flux of ∼4×10−5 m2 s−3. For scales greater than ∼10 km the sign is reversed, implying an inverse energy cascade with an estimated flux of ∼10−5 m−2 s−3 associated with two-dimensional stratified turbulence. The mixed structure function of longitudinal velocity and squared temperature increment follows Yaglom's four-thirds law in the same scale range, yielding an estimated downscale temperature variance flux of ∼5×10−7 K2 s−1. Analysis of higher-order structure functions yields anomalous scaling for both velocity and temperature. The scaling also reveals second-order multifractal phase transitions for both velocity and temperature data. Above the transition moments, asymptotes varying with the number of realizations argue against the log-Poisson model. The log-Levy model is better able to explain the observed characteristics.

We report simultaneous meteor echo observations using the Arecibo 430-MHz and 46.8-MHz radars. Using identical data-taking and meteor selection criteria, 1868 and 367 meteors were found in the 430-MHz and 46.8-MHz beams, respectively, while 145 were found in both beams during the 7 hours of observation. Of the 367 VHF echoes, there were only 10 trail echoes, while the rest were head echoes, which was quite contrary to expectation. The smaller number of meteors detected by the VHF system and its wider beam width show that UHF meteors are far smaller than the VHF meteors. We estimate that VHF head echoes have a typical effective scattering cross section of the order of 10−3 m2, while the accompanying UHF echoes have an effective scattering cross section of the order of 10−6 m2. The paucity of VHF trail echoes observed leads us to suggest that the ratio of head echo power to the trail echo power increases with decreasing meteor size. When a meteor is too small, a radar can observe the head echo but not the trail echo. Of the 145 meteors observed by both radars, the powers received by the two systems were not correlated. Although antenna beam pattern contributes to the lack of correlation, it is also possible that UHF and VHF echoes may be enhanced by different scattering mechanisms.

We extend the incoherent backscatter radar equation for the weakly ionized, collision-dominated case to include polydisperse charged dust, using the fluid-equation approach. Calculations with this equation show that the main effect of charged dust on the radar Doppler spectrum is to narrow it, except in the case of very small, negatively charged dust, which widens the spectrum. The results are encouraging for the use of incoherent scatter radar as an instrument for meteoric dust measurement. We also note that if the effects of meteoric dust are not taken into account, one may get a systematic bias in the D-region parameters deduced from the radar spectra. This may account for the discrepancy between observed and calculated spectra reported in earlier papers, c 1998 Elsevier Science Ltd. All rights reserved

This note describes the new spatial interferometry (SI) capability of the 430-MHz radar system of the Arecibo Observatory (AO). Three limitations exist when the 430-MHz radar is used for observations in the tropospheric and stratospheric regions. First, the AO radar currently has a lower height limitation of approximately 6 km because of the existing transmit/receive switch. Second, fading ground clutter limits the useful data which can be obtained and complicates the analysis. Third, the large mass of the feed system, which slows down beam steering, reduces the temporal resolution of any measurements requiring multiple beam positions. For these reasons, an SI system has been developed which will be shown to reduce these limitations. A brief description of the hardware is provided, and preliminary data are presented.

The Ni-dot/Ag/Pt layer, where Ni-dot layer is formed of nanometer sized Ni dots, has been used to improve the reflectivity from the surface of p-type GaN in a light emitting diode (LED). Comparing with Ni/Ag/Pt layer, where Ni layer is a thin film, the Ni-dot/Ag/Pt structure shows significantly improved reflectivity with stable contact resistivity. The optical output power and external quantum efficiency of InGaN LEDs with Ni-dot/Ag/Pt structure for p-metal have improved by 28% and 29%, respectively, over the results of Ni/Ag/Pt structure.

At radar frequencies in the range 50 MHz to 250 MHz, at times even to over 1 GHz, strong enhancements of scattering cross section occur between approximately equal to 80 km and approximately 95 km altitude in summer at high latitudes. These echoes, termed 'Polar Mesosphere Summer Echoes' (PMSE) have attracted considerable experimental effort. Observations of this phenomenon are reviewed in the context of atmospheric dynamics and of scattering processes. Recent rocket and radar measurements indicate that a partial reflection from a multitude of ion layers and constructive interference causes at least some of the PMSE. It is discussed which further observations are necessary and some possible practical consequences of PMSE are pointed out.

On the night of August 9-10, 1991, two rocket payloads were launched into simultaneously occurring noctilucent clouds (NLC) and polar mesospheric summer echoes (PMSE) above Esrange, a third rocket payload was launched into a NLC where a PMSE was detected 5 minutes later above Esrange, in Sweden as part of the NLC-91 campaign. An aim of this experiment was to compare the vertical structures and locations of the NLC and PMSE events. To this end, in-situ optical photometers and particle impact sensors were used to measure the altitude and vertical structure of the NLC layer, while the Cornell University portable radar interferometer (CUPRI) was used to probe the PMSE. Although this comparison is complicated by the horizontal separations between the in-situ measurements and the radar volume, and low electron densities which reduced the overall radar reflectivity, we conclude that the PMSE layer in the CUPRI radar volume remained above the NLC layer detected by the in-situ instruments by 300 to 2000 m throughout the experiment. We interpret this result as supporting the view that PMSE are more likely to result from the presence of aerosols smaller than the ones optically detectable as NLCs.

Though the demand on the LCCE for civil infrastructures is rapidly growing with the broad range of application areas including highway and railroad bridges, highway construction and pavement, dams, and water resource structures, harbor structures, underground structures, geotechnical structures, and sanitary structures, etc., yet the understanding of LCC and the application of LCCA software system by practitioners are not in mature state in civil engineering practice. Mainly because theoretically the LCCE problems, as stated above, become extremely complex simply because time-variant degrading resistance and stochastic nature of extreme load effects incur various damages/failures related with strength serviceability, durability, deterioration throughout the life span of a structure, which in turn, bring forth highly complicated cost and uncertainty assessment that often involves the lack of cost data associated with various direct and indirect losses, and the absence of uncertainty data available for the assessment.

We report about a quantitative comparison of rocket observations of electron density fluctuations and simultaneous 53.5 MHz radar measurements that were obtained during the MAC/SINE campaign in northern Norway in summer 1987. Out of three rockets launched during the Tur-bulence/Gravity Wave salvo on 14 July 1987, two were flown during conditions that allowed a detailed investigation. For a large part of the data from these rocket flights it is found that the radar reflectivity is about 10 dB, enhanced over what would be expected from the rocket observations in the case of isotropic electron density fluctuations. The observations can be reconciled under the assumption of an anisotropic turbulence. Assuming a simple model spectrum for the electron density fluctuations, we derive a relation between the rocket and radar observations that covers the whole range from isotropic turbulent scatter to Fresnel scatter at horizontal density stratifications. For the observed dataset, an anisotropy which typically corresponds to a ratio of the horizontal to the vertical coherence length of about 10 is consistent with the comparison of rocket and radar observations. A similar anisotropy is found also from the observed aspect sensitivity of the radar echoes. The variation of the anisotropy with height and time shows an anticorrelation with the turbulence level of the mesosphere as deduced from the spectral width of the radar echoes. The anisotropy is found to maximize in heights where the electron density displays deep ‘bite-outs’. These depletions in the electron density were independently observed by a Langmuir and an admittance probe on board two of the rockets.

To determine if health literacy is associated with patient understanding of prenatal screening tests for fetal aneuploidy and neural tube defects.We performed a prospective observational study on a cohort of English-speaking patients receiving prenatal care in two resident-staffed ambulatory clinics. Health literacy was measured using the Rapid Estimate of Adult Literacy in Medicine-7. Understanding of the prenatal screening tests was assessed using a modified Maternal Serum Screening Knowledge Questionnaire.Over an 8-month period, 125 patients were approached, and 101 (81%) consented to the study. Thirty-eight (38%) women demonstrated low health literacy. Patients with low health literacy were more likely to demonstrate inadequate understanding when compared to those with adequate health literacy (97% versus 11%, respectively; P0.01). Similarly, patients with12th grade education were more likely to have inadequate understanding when compared to patients with12th grade education (53% versus 30%, respectively; P = 0.02). Health literacy is a more sensitive and specific predictor of inadequate understanding than education (sensitivity 84% versus 70%, respectively, P0.05; specificity 98% versus 47%, respectively, P0.05).Patients with low health literacy are more likely to demonstrate inadequate understanding of these prenatal screening tests than women with adequate health literacy.

To examine the effects of caregiver's burden, depression, and support on post-stroke depression (PSD), cross-sectional data were obtained from an epidemiologic survey of 225 stroke survivors and their caregivers living in Seoul, Korea. Multivariate analyses showed that, taking the clinical status of patients into account, caregiver's burden, depression and support were related to higher PSD. Perceived burden exerts adverse effects on PSD through its influence on the depression in caregivers. Hence, the care of stroke survivors that incorporates the care of caregivers is likely to reduce the risk of post-stroke depression in patients.

A compartmental model was used to study a number of empirical observations on myocardial thallium-201 kinetics in ischemic disease. Measurements of plasma Tl-201 and myocardial kinetics in 30 subjects and simulation studies showed that low plasma Tl-201 levels caused increased and accelerated redistribution in viable myocardium, contrary to wide-spread notions. Reinjection at rest causes a worsening of Tl-201 defects in regions with critically stenosed arteries. Reinjection produces an improvement in relative uptake in regions with impaired myocardial retention and none or mild stenoses. This benefit was more notable when plasma Tl-201 level was low. This benefit was transient and disappeared when steady state conditions were reached. This work helps in the understanding of the use of a valuable clinical tool. >

It is proposed that using management support systems (MSS) will improve knowledge by providing managers with more information and analytic tools that they can use to learn more about the nature of their environment, the effectiveness of various strategies, and the relationship between actions and outcomes. Techniques ranging from qualitative analysis to multivariate statistical techniques are proposed as methods for measuring knowledge. Previous research is also reviewed on both the importance of knowledge to managers and the impact of MSS on knowledge. >

Local synthesis of immunoglobulin G (IgG) in the central nervous system was investigated in 10 patients with tuberculous meningitis (TBM), 15 patients with aseptic meningitis (AM), and 15 patients with pulmonary tuberculosis only (PTBO). The IgG synthesis rate for patients with TBM was 56.4 +/- 18.9 mg/day (mean +/- standard deviation), which was significantly higher than that for patients with AM (8.0 +/- 6.7 mg/day, P < 0.001) and that for patients with PTBO (7.5 +/- 4.4 mg/day, P < 0.001). Therefore, the increased IgG synthesis rate in the central nervous system provided supporting evidence for differentiating the diagnosis of TBM from that of AM (sensitivity, 100%; specificity, 83.3%). Simultaneous measurement by enzyme-linked immunosorbent assay of IgG seroreactivity to lipoarabinomannan and purified protein derivative antigens in cerebrospinal fluid (CSF) demonstrated seropositivity in all 6 patients with TBM, 4 of 15 patients with AM, and 4 of 10 patients with PBTO. All patients showing false-positive reactivity in CSF demonstrated seropositivity in sera and normal ranges for IgG synthesis rates in CSF. Also, the semiquantitive measurement of IgG antibody (Ab) titers in these patients demonstrated higher IgG Ab titers in serum than in CSF except for one patient with a highly elevated albumin quotient, suggesting a leaky blood-brain barrier. The results strongly suggested that the Mycobacterium tuberculosis-specific IgG Abs were diffusible through the blood-brain barrier, which addresses the pitfall of serological tests for the early diagnosis of TBM. The serological detection of IgG Abs to lipoarabinomannan and purified protein derivative antigens in CSF could be misleading in the presence of simultaneously elevated of IgG Abs in serum.

e14653 Background: Biliary tract carcinoma (BTC) is rare in the West, but not uncommon in Asia and is highly fatal malignancy. While gemcitabine-based regimen is considered as reasonable option for...