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Invasive meningococcal disease has high morbidity and mortality, with infants and young children among those at greatest risk. This phase III, open-label, randomised study in toddlers aged 12–23 months evaluated the immunogenicity and safety of meningococcal tetanus toxoid-conjugate vaccine (MenACYW-TT), a tetanus toxoid conjugated vaccine against meningococcal serogroups A, C, W and Y, when coadministered with paediatric vaccines (measles, mumps and rubella [MMR]; varicella [V]; 6-in-1 combination vaccine against diphtheria, tetanus, pertussis, polio, hepatitis B and Haemophilus influenzae type b [DTaP-IPV-HepB-Hib] and pneumococcal conjugate vaccine [PCV13])(NCT03205371). Immunogenicity to each meningococcal serogroup was assessed by serum bactericidal antibody assay using human complement (hSBA). Vaccine safety profiles were described up to 30 days post-vaccination. A total of 1183 participants were enrolled. The proportion with seroprotection (hSBA ≥1:8) to each meningococcal serogroup at Day 30 was comparable between the MenACYW-TT and MenACYW-TT + MMR + V groups (≥92 and ≥96%, respectively), between the MenACYW-TT and MenACYW-TT + DTaP-IPV-HepB-Hib groups (≥90% for both) and between the MenACYW-TT and MenACYW-TT + PCV13 groups (≥91 and ≥84%, respectively). The safety profiles of MenACYW-TT, and MMR + V, DTaP-IPV-HepB-Hib, and PCV13, with or without MenACYW-TT, were generally comparable. Coadministration of MenACYW-TT with paediatric vaccines in toddlers had no clinically relevant effect on the immunogenicity and safety of any of the vaccines.

Innovative development of important mechanical engineering industries necessitates very high demands on graduates of engineering universities who plan to devote their professional activity to gears, specifically: their qualification by the time of graduation, their knowledge, abilities and skills in regard to innovation, and their communication abilities. The present paper analyzes the recent trends and fundamental aspects of higher education in Russia with regard to the successful training of gear experts at a technical university within the Bachelor program. Issues related to the teaching of various courses involving gears within the curricula of mechanical engineers and obtainment of a BS are also considered in the paper. Attention is paid to foreign language (English) competences for future gear experts. Agreement on the valid syllabi for mechanical engineers and requirements specified for graduates by the present manufacturing industry is studied through the example of one of the most sought-after majors in the field of mechanical engineering.