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Here, we review the effects of non-invasive brain stimulation (NIBS) such as transcranial magnetic stimulation (TMS) or transcranial direct current stimulation (tDCS) in the rehabilitation of neglect. We found 12 studies including 172 patients (10 TMS studies and 2 tDCS studies) fulfilling our search criteria. Activity of daily living (ADL) measures such as the Barthel Index or more specifically for neglect, the Catherine Bergego Scale were the outcome measure in 3 studies. Five studies were randomized controlled trials with a follow-up time after intervention of up to 6 weeks. One TMS study fulfilled criteria for Class I and one for Class III evidence.The studies are heterogeneous concerning their methodology, outcome measures, and stimulation parameters making firm comparisons and conclusions difficult. Overall, there are however promising results for theta burst stimulation, suggesting that TMS is a powerful add-on therapy in the rehabilitation of neglect patients. © 2013 Müri, Cazzoli, Nef, Mosimann, Hopfner and Nyffeler.

The optimal treatment of calcaneal fractures remains controversial [2–4, 6–11, 14, 18, 19, 23, 24]. During the last few years an increasing number of surgeons have reported encouraging results of internal fixation for displaced intra-articular fractures of the calcaneus [2, 6, 12, 15, 17, 20, 22, 26–28]. The prerequisites for open reduction and internal fixation are: good general condition, good soft tissues, an interval of less than 3 weeks after injury, no arterial occlusive disease, and a reliable patient. In contrast functional treatment is indicated for patients in bad general condition, for unreliable patients, those with severe arterial occlusive disease or with severe soft tissue problems, when there has been an interval of more than 3 weeks since the injury, and in cases of undisplaced or completely “smashed” fractures.

Das Problem der uramischen Perikarditis wurde anhand von 296 Krankengeschichten und 136 Sektionsprotokollen von Patienten mit einem Rest-N uber 120 mg-% studiert. Die Perikarditis war bei chronischer Niereninsuffizienz haufiger als akuter, und bei Glomerulonephritis haufiger als bei Pyelonephritis. Sie trat vorwiegend dann auf, wenn uramische Stoffwechsellage allgemein verschlechterte, eine eindeutige Korrelation zum Wert des Rest-N, des Kaliums, der Alkalireserve, des Hamoglobins oder zum Hydratationszustand bestand jedoch nicht. Die Moglichkeit einer Autoimmunopathogenese der uramischen Perikarditis wird wegen der auffallenden Haufigkeit bei Glomerulonephritis diskutiert. Klinisch waren der meist schmerzfreie Verlauf und die geringen hamodynamischen Auswirkungen der Perikarditis bemerkenswert. Die ST-Hebung im EKG erwies sich als recht inkonstantes Symptom, die Voltage war fur die Ergusdiagnose unbrauchbar. Bei den Sektionen wurden relativ oft grose Ergusmengen gefunden. In einzelnen Fallen ist die Pericarditis uraemica auch bei chronischer Uramie nicht unbedingt ein signum mali ominis. Eine Herztamponade mus deshalb in jedem Fall lege artis behandelt werden.

Background and purpose: In acute ischaemic stroke (AIS) of the anterior circulation (AC) treated with mechanical thrombectomy (MT), data point to a decline of treatment effect with increasing time from symptom onset to treatment. However, the magnitude of the decline will depend on the clinical setting and imaging selection used. The aims of this study were (1) to evaluate the clinical effect of time to reperfusion (TTR); and (2) to assess the safety and technical efficacy of MT according to strata of TTR. Methods: Using the retrospective multicentre BEYOND-SWIFT registry data (ClinicalTrials.gov identifier: NCT03496064), we compared safety and efficacy of MT in 1461 patients between TTR strata of 0–180 min ( n = 192), 180–360 min ( n = 876) and >360 min ( n = 393). Clinical effect of TTR was evaluated using multivariable logistic regression analyses adjusting for pre-specified confounders [adjusted odds ratios (aOR) and 95% confidence intervals (95% CI)]. Primary outcome was good functional outcome (modified Rankin Scale: mRS 0–2) at day 90. Results: Every hour delay in TTR was a significant factor related to mRS 0–2 (aOR 0.933, 95% CI 0.887–0.981) with an estimated 1.5% decreased probability of good functional outcome per hour delay of reperfusion, and mRS 0–1 (aOR 0.929, 95% CI 0.877–0.985). Patients with late TTR had lower rates of successful and excellent reperfusion, higher complication rates and number of passes. Conclusions: TTR is an independent factor related to long-term functional outcome. With increasing TTR, interventional procedures become technically less effective. Efforts should be made to shorten TTR through optimized prehospital and in-hospital pathways.