1. Percutaneous microwave ablation versus robot-assisted hepatectomy for early hepatocellular carcinoma: A real-world single-center study
- Author
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Xiaoling Yu, Zhiyu Han, Ping Liang, Wenzhen Ding, Zhigang Cheng, Fangyi Liu, and Jie Yu
- Subjects
Male ,medicine.medical_specialty ,Carcinoma, Hepatocellular ,Percutaneous ,medicine.medical_treatment ,Urology ,Single Center ,Robotic Surgical Procedures ,medicine ,Hepatectomy ,Humans ,Early Hepatocellular Carcinoma ,Microwaves ,Propensity Score ,Aged ,Retrospective Studies ,Radiofrequency Ablation ,Hepatology ,business.industry ,Liver Neoplasms ,Microwave ablation ,Therapeutic effect ,Gastroenterology ,Middle Aged ,Survival Rate ,Treatment Outcome ,Propensity score matching ,Female ,Liver function ,business ,Follow-Up Studies - Abstract
Background Both microwave ablation and robot-assisted hepatectomy are representative minimally invasive treatments for early hepatocellular carcinoma. Our study compares the practicability and medium-term therapeutic efficacy between them. Methods Patients with early HCC treated by MWA or RH from 2013 to 2019 were included. Propensity score matching (PSM) and inverse probability of treatment weight (IPTW) were used to minimize baseline imbalance. Operation trauma, postoperative recovery, complications, cost and oncological efficacy were compared. Results 401 patients with a median follow-up of 28 months were included (MWA n = 240; RH n = 161). After PSM, 3-year recurrence-free survival (RFS), overall survival (OS) and cancer-specific survival (CSS) of MWA group and RH group were 52.2% vs 65.8%, 91.5% vs 91.3% and 91.5% vs 91.3%, respectively. OS and CSS were comparable (p = 0.44 and 0.96), while RFS of MWA was slightly lower but not significant (p = 0.097). The above results after IPTW followed the same trend. After PSM, MWA showed advantages in operation time and blood loss, while RH performed better in postoperative liver function. There was no significant difference in incidence of severe complications between two groups. Conclusions For early HCC parents, both treatments can achieve good, safe and comparable medium-term therapeutic effects. MWA is more minimally invasive, while RH has better accuracy and causes less damage to liver parenchyma.
- Published
- 2022