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The article presents a clinical case of papulopustular rosacea from our own practice. First of all, the patient's anamnesis is extremely interesting: family history (his brother has episodes of reddening of the face), the onset of rosacea against the background of a stressful situation, the presence of gastric diseases, the connection with nutritional factors. One of the first mentions of rosacea belongs to Avicenna, who in his writings described the clinical picture of rhinophyma ("badschenan", later renamed "abedsamen"). The pineal nose, dotted with "serpentine" vessels, has traditionally been associated with excessive drinking. Currently, the role of alcohol as an etiological factor is not paramount, but its aggravating effect has been proven. Despite the typical picture of rosacea, our patient has been receiving therapy for seborrheic dermatitis and other diseases several times over the course of several years. Probably, the specialists had doubts about the possible diagnosis of rosacea in a male patient under the age of 30.

In the present article, relevant data on the characteristics of the course of infections transmitted through sexual contact (hereinafter STIs) are considered at the present stage. Particular attention is paid to mixed infections, in particular the combination of syphilis and HIV. Since the presence of both infections in a patient simultaneously significantly complicates the clinical picture, and also contributes to their spread in the population, which is an acute social problem. The article presents modern data on the epidemiology, level and dynamics of the incidence of syphilis and HIV infection in the Russian Federation, including among high-risk groups. Research data on the incidence of STIs (urogenital infections caused by Mycoplasma genitalium, Ureaplasma spp., Mycoplasma hominis, Chlamydia trachomatis, syphilis) and viral hepatitis B and C in 60 HIV-positive prisoners in the Kirov region are presented. The features of the development and course of syphilitic infection, the difficulties of diagnosis and therapy that occur with HIV are described. A case of own clinical observation of the malignant course of syphilis associated with HIV infection is presented. Both infections have been identified in the hospital where the patient is admitted with a diagnosis of spreading pyoderma, exhibited on the basis of complaints and clinical picture (ektimatoznye rash).

Two clinical cases of a complicated course of the primary period of syphilis are present. Attention deserves the severity of the clinical picture of a solid chancre, which could cause certain diagnostic difficulties.

The article provides a current overview of the correlation between a rare dermatosis — subcorneal pustulosis (Sneddon — Wilkinson disease) — and various diseases of internal organs; features of immunological changes; the role of desmocollin 1, chemoatractants, interleukin-1β, interleukin-6, interleukin-8, interleukin-10, leukotriene B4, tumour necrosis factor-alpha and K5a complement fraction in the pathogenesis of the disease. In this work, the authors describe the features of the clinical picture of the disease, as well as diagnostic criteria, including the use of serum protein electrophoresis. Histological features of the disease are discussed in detail. In addition, modern methods for treating this disease, including the use of dapsone, acitretin, infliximab, PUVA therapy are presented.

The reason for writing this article was the difficulty in the differential diagnosis of skin lesions in a patient of 40 years, with a preliminary diagnosis of T-cell lymphoma. During the examination, including histological, immunomorphological, immunohistochemical methods, markers of various cell lines (T, B, myeloid) were detected. This feature is characteristic of lymphomas from plasmacytoid dendritic cells (MAC), a new nosological unit. In the WHO classification (2001), tumors with a similar phenotype were included in the lymphoma section of natural killer cells (NK-blast lymphomas). The clinical case described by us illustrates the need for an integrated approach in the diagnosis of lymphomas, which makes it possible to promptly assign adequate therapy.

Renewable energy use is spreading worldwide presenting the future of the power engineering - its renewable resources and low ecological impact characterize one of the best technologies to support permanently growing energy consumption and contribute to sustainable development. But its development is sometimes hampered by lack of suitable technologies and strong positions of the competing conventional energy production. Moreover, critics emphasize such problems of renewable energy use as unstable energy production, complicated connection to power lines, some ecological problems. To prove its efficiency renewable energy development needs support by relevant resource and ecological assessments. This paper presents our research concerning wind farm location issue regarding both production efficiency and minimal ecological impact. Our field research in Crimea was directed at on-site assessment of wind farm location efficiency as well as studies of public opinion concerning local wind farms and wind energy use in general. It was found out that Crimean wind farms have controversial location efficiency related to its power production. But their ecological impact was minimal proved by both on-site measurements and sociological survey results. It was also found that wind turbine noise impact had a very complicated character, but had no significant ecological impact.

Two clinical cases of extragenital localization of primary syphiloma are presented in this article. In both cases, the connivance of patients towards their own health deserves attention. Infection with syphilis occurred as a result of contact with obviously ill people, and self-medication aggravated the clinical picture of the disease.

The article describes modern views on predisposing factors, histological and genetic changes, the role of ATP2C1 encoding a mutant gene, localized on chromosome 3 in the pathogenesis of Hailey — Hailey disease. Diagnostic criteria, differential diagnostics with other diseases and methods of modern treatment of this disease are presented.

A clinical case of secondary fresh syphilis in a pregnant woman at 36 weeks is presented. A ttention deserves infection of a woman in the second half of pregnancy, which was resolved by the birth of a healthy child.

A case of Norwegian scabies is described in a patient of 19 years with a lesion of the scalp, face, trunk, upper and lower extremities that occurred against the background of acute lymphoblastic leukemia. A good effect was obtained from conducting etiotropic, pathogenetic and symptomatic therapy in combination with specific treatment of the underlying disease.

This article presents information about the distribution of antigens of the second class in patients with papulo-pustular and nodulous forms of acne. Class II antigens distribution was estimated as the total Group and groups of patients allocated depending on the severity of the clinical picture. Association revealed the presence of severe acne with antigens of histocompatibility of HLA-complex that confirms the importance of immunogenetic factors in the pathogenesis of this condition.

The article describes modern views on the predisposing factors, features, immunological changes and link with the histocompatibility antigens HLA, the role of circulating autoantibodies, cytokines, chemokines, matrix metalloproteinases and BP180 (BPAg2) и BP230 (BPAg1), those role in the pathogenesis of the bullous pemphigoid and their correlation with the activity of pathological process in patients with bullous pemphigoid. Described experimental model of the disease in animals, modern medications and methods of treatment of this disease.

Sixty patients with different clinical symptoms of secondary syphilis (ulcer chancres, pustular syphilis, hypertrophic papules, widespread leukoderma and alopecia) were examined in order to study the distribution pattern of histocompatibility antigens of the first class in patients with secondary syphilis of the skin and mucous membranes. As a result of the study, the presence of an associative relationship between the distribution pattern of histocompatibility antigens of the first class and various clinical manifestations in patients with secondary syphilis was established.

The paper describes 2 cases of congenital lamellar ichthyosis debuting state «collodion baby». Presented features of clinical manifestations: in newborn all skin is covered with a thin dry yellowish-brown film, resembling collodion, also ectropion and eklabium are frequently marked. After some time cracks appear, the film turns into large squamas, which exfoliate completely in 1.5 months, and so the clinical picture of congenital ichthyosis is formed. Timely initiated therapy, including external moisturizers and lipid-replenishing funds, contributed to the rapid relief of clinical symptoms and infectious-inflammatory process.

The principal cause of death in cancer involves tumor progression and metastasis. Since only a small proportion of the primary tumor cells, cancer stem cells (CSCs), which are the most aggressive, have the capacity to metastasize and display properties of stem cells, it is imperative to characterize the gene expression of diagnostic markers and to evaluate the drug sensitivity in the CSCs themselves. Here, we have examined the key genes that are involved in the progression of colorectal cancer and are expressed in cancer stem cells. Primary cultures of colorectal cancer cells from a patient's tumors were studied using the flow cytometry and cytological methods. We have evaluated the clinical and stem cell marker expression in these cells, their resistance to 5-fluorouracil and irinotecan, and the ability of cells to form tumors in mice. The data shows the role of stem cell marker Oct4 in the resistance of primary colorectal cancer tumor cells to 5-fluorouracil.

Clinical and experimental data suggest that carcinoembryonic antigen (CEA, CD66e, CEACAM-5) plays a key role in the formation of hepatic metastasis from colorectal and other types of epithelial cancers. The molecular events involved in CEA-induced metastasis have yet to be defined. Our group first cloned the gene (CEAR) for CEA-binding protein from the surface of fixed liver macrophages, (Kupffer cells). In this study to further elucidate the role of CEAR in colorectal cancer progression, its expression in colorectal cancer cells was suppressed by short hairpin RNAs (shRNAs) in CEA-overexpressing and CEA - negative MIP-101 colorectal cancer cell lines. The data show that targeted suppression of endogenous CEAR in tumor cells resulted in changes in cell invasiveness. RT-PCR data indicated reduced levels of E-cadherin, Snail, MMP-2, and Oct-4 in the clones with suppressed CEAR suggesting a role in the epithelial mesenchymal transition. The comparative analysis of tumorigenic activity to the liver of the cell lines with suppressed CEAR has also been conducted using an intrasplenic injection model in immuno-deficient mice. This data shows a decrease in tumor progression associated with CEAR suppression. In summary the results of this study revealed a novel role for CEAR gene in the regulation of colorectal cancer cell invasiveness and progression.