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Objective According to prevalence studies, at least 5–6 % of women in Europe experience rape in their lives. The initial treatment after a sexual assault can influence the individual healing process positively. In Germany, there are hardly any studies that investigate larger collection of cases of sexual assault treated in hospitals. However, knowledge about characteristics of cases of sexual assault is a prerequisite for the optimal processing of primary care. Study design For this study, the retrospective collection of data on cases of suspected sexual assault of patients presented for treatment at the Charite was carried out. Standardized findings sheets as part of a rape kit used in all cases were evaluated. Overall, 850 cases from the period between 01.01.2011 and 30.06.2016 were analyzed. The statistical evaluation was descriptive. Results The median age of patient was 26 years (range 16–92). Penetration (vaginal/anal/oral) occurred in 75 % of cases. The suspect was unknown to 48,4 % of those affected, 26 % came from a circle of friends or acquaintances. 15,5 % were partners or expartners. 2/3 of the sexual assaults took place in private rooms, especially in the apartments of the victims. More than 2/3 of the women had drunk alcohol in temporal proximity to the crime. Extragenital injuries were present in 61,4 % of those affected and anogenital injuries in 25,4 %. Extragenital injuries were predominantly classified as mild (92,9 % in general physical examination and 62,4 % in eyes-nose-throat-examination). 42,1 % of the assaults took place on the weekend. 74,8 % of the patients presented themselves within 24 h of the suspected offence. Conclusion To our knowledge, this is the largest analysis of cases of sexually assaulted women treated at a hospital in Germany. The results point to important components of primary care, e.g. standardized injury recording and alcohol measurement, as these can serve as evidence in subsequent court proceedings. The structures of the first care of victims after sexual assault should consider that the majority of those affected present themselves at the weekend.

Objective: Trefoil factor family peptide 3 (TFF3) has been shown to support catabolic functions in cases of osteoarthritis (OA). As in joint physiology and diseases such as OA, the synovial membrane (SM) of the joint capsule also plays a central role. We analyze the ability of SM to produce TFF compare healthy SM and its secretion product synovial fluid (SF) with SM and SF from patients suffering from OA or rheumatoid arthritis (RA). Methods: Real-time PCR and ELISA were used to measure the expression of TFFs in healthy SM and SM from patients suffering from OA or RA. For tissue localization, we investigated TFF1-3 in differently aged human SM of healthy donors by means of immunohistochemistry, real-time PCR and Western blot. Results: Only TFF3 but not TFF1 and -2 was expressed in SM from healthy donors as well as cases of OA or RA on protein and mRNA level. In contrast, all three TFFs were detected in all samples of SF on the protein level. No significant changes were observed for TFF1 at all. TFF2 was significantly upregulated in RA samples in comparison to OA samples. TFF3 protein was significantly downregulated in OA samples in comparison to healthy samples and cases of RA significantly upregulated compared to OA. In contrast, in SM TFF3 protein was not significantly regulated. Conclusion: The data demonstrate the production of TFF3 in SM. Unexpectedly, SF contains all three known TFF peptides. As neither articular cartilage nor SM produce TFF1 and TFF2, we speculate that these originate with high probability from blood serum.

Immer wieder leiden Kinder an Verletzungen, die einen Verdacht aufwerfen: Dies war vermutlich kein Sturz auf dem Spielplatz, sondern eine mutwillige Misshandlung. Das richtige Einordnen solcher Verletzungen und das weitere Vorgehen bestimmen oftmals das weitere Schicksal des Kindes.

Physicians frequently represent the first contact person for victims of intimate partner violence (IPV) within the health care system, yet adequate training to comply with these expectations is frequently not incorporated into graduate and post-graduate medical curricula. We developed the first mandatory university-wide training in Germany for the management of IPV victims focusing on communication and legally admissible documentation. Concurrently, we acquired information about previous experiences, attitudes, and barriers for active inquiry about IPV among medical staff. Ninety one percent of the 825 participants completed pre- and post- training surveys and a subgroup participated in a 6–18 month follow-up. Experience, training, and subjective comfort in asking were the most significant predictors of active inquiry in multivariable analyses. Structural limitations, such as time constraints, language barriers, and lack of safe locations represented the primary barriers for active inquiry.