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1. Treatment of gastric fundal varices by balloon-occluded retrograde transvenous obliteration

Author

Toshikazu Uchida, Hiroshi Kanagawa, Kunio Okuda, Satoaki Mima, Harukazu Kouyama, and Kenichiroh Gotoh

Subjects
Adult, Male, medicine.medical_specialty, Time Factors, medicine.medical_treatment, Oleic Acids, Esophageal and Gastric Varices, Balloon, Catheterization, Sclerotherapy, medicine, Humans, Internal jugular vein, Aged, Hepatology, business.industry, Hemostasis, Endoscopic, Gastroenterology, Balloon catheter, Middle Aged, Gastric varices, medicine.disease, Sclerosing Solutions, Surgery, Radiography, Portal hypertension, Female, Radiology, Liver function, Gastrointestinal Hemorrhage, Varices, business, Follow-Up Studies
Abstract

Although less common than oesophageal varices in portal hypertension, gastric fundal varices carry a higher mortality rate when they rupture. They are less amenable to sclerotherapy. We have developed a minimally invasive balloon-occluded retrograde transverse obliteration (B-RTO) procedure to treat gastric fundal varices. B-RTO involves inserting a balloon catheter into an outflow shunt (gastric-renal or gastric-vena caval inferior) via the femoral or internal jugular vein. Blood flow is then blocked by inflating the balloon, and 5% ethanolamine oleate iopamidol is injected in a retrograde manner. The embolized gastric varix subsequently disappears. B-RTO was performed in 32 patients with gastric varices. Follow-up endoscopies were performed at intervals of 2-4 months for an average observation period of 14 months. Eradication of the varices has been confirmed in 31 of 32 patients. No recurrence occurred in any patients in the follow-up period. There were no significant changes in liver function after the procedure. We conclude that B-RTO is a safe and effective procedure for the treatment of gastric fundal varices.

Published
1996
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2. Ursodeoxycholic acid (UDCA) therapy for autoimmune hepatitis

Author

Chihiro Sekiya, Hiroshi Kanagawa, Toshikazu Uchida, and Satoaki Mima

Subjects
Every other day, medicine.medical_specialty, Hepatology, business.industry, Low dose, Autoimmune hepatitis, medicine.disease, Gastroenterology, Ursodeoxycholic acid, Endocrinology, Refractory, Internal medicine, Prednisolone, Medicine, In patient, Alanine aminotransferase, business, medicine.drug
Abstract

To assess the efficacy of ursodeoxycholic acid (UDCA) in autoimmune hepatitis we administered UDCA (600 mg/day, orally) to four patients who had autoimmune hepatitis refractory to treatment with prednisolone alone (20 mg every other day). During the treatment, serum levels of alanine aminotransferase (ALT) normalized and we were able to taper the dose of prednisolone to 5 mg every other day. The results indicate that UDCA administered concomitantly with very low doses of prednisolone may prove effective in patients who have autoimmune hepatitis.

Published
1994
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3. Abstracts of selected papers presented at the 34th annual meeting of the Japanese Society of Gastroenterology October 12–14, 1992, Utsunomiya, Japan

Author

Koichiro Tamura, Akira Terano, Tsutomu Katsuyama, Hitoshi Ohkubo, Akiyoshi Saga, Takashi Harada, Ken Haruma, Tetsunori Hasebe, Takeshi Okanoue, Catherine H. Wu, Takeshi Itoh, M. Tanaka, Hiromitsu Saisho, Hiroshi Takagi, Reiji Kasukawa, Hajime Takikawa, Yujiro Takao, Suguru Yonezawa, Satoaki Mima, Masaru Harada, Miyoko Hirose, Yoshito Itoh, Masao Ohsuki, Shunichi Okushiba, Yuichi Sugiyama, Koji Ishii, Masaru Baba, Akihiko Nishioka, Yukari Murazumi, Yasuyuki Arakawa, Akio Harada, Masatake Seki, Keiichi Mitsuyama, Michio Imawari, Tatsuya Sekiyama, Yasuo Suda, Kazuhito Rokutan, Jinkan Sai, C. Balabaud, K. K. Han, Hitoshi Ikeda, Katsuhiko Kamei, Kazuo Tarao, Yasuo Naitoh, Hideo Kobayashi, Tomoe Beppu, Hironobu Kohda, Yoshifumi Takeyama, Hiroyuki Maguchi, Chihiro Sekiya, Allan W. Wolkoff, Iwao Kurose, Susumu Shiomi, Hidetoshi Kajita, Yasushi Shiratori, Tomokazu Matsuura, Keishi Kimura, K. Tanikawa, Kayoko Hayashi, Osamu Nakano, Masanori Sugiyama, Takahiko Funabiki, Nobuhiro Sato, Sumio Watanabe, Makoto Naito, Mikio Zeniya, Atsushi Watari, Hideo Nagai, Yasunari Tsuchihashi, Ikuro Kimura, Hiroshi Suzuki, Takeshi Obara, Yuji Horiguchi, Chikao Shimamoto, Akira Aoike, Michiro Otaka, Choitsu Sakamoto, Shuhei Hige, Akio Shimizu, Toshiki Ehata, Tsuneo Fukushima, Shuichi Kaneko, Masaya Shimodaira, Akira Uehara, Izumi Kumon, Akio Inui, Shuichi Miyakawa, Toshio Sawada, Yutaka Atomi, Tsuneo Kitamura, Hiroyoshi Mieno, Hiroshi Ashida, Saburo Onishi, Shigeru Harasawa, Hideyuki Hiraishi, Masahiko Osak, Yuji Naito, Gotaro Toda, Toshikazu Yoshikawa, Amane Hideshima, Shingo Moriishi, Yoshiki Hirooka, Morikazu Onji, Takashi Shimoyama, Akira Kamei, Hiroshi Miyakawa, Hiromi Ishibashi, Hiroshi Kanagawa, Keizo Sugimachi, Kaoru Ohashi, Fukuji Mochizuki, Tomoe Katsumata, Akimichi Chonan, Masayo Yamazaki, Tsuneya Nakamura, Yoshikazu Kinoshita, Kazuhiro Katayama, Masaru Ohshita, Hiroshi Tatsuta, Katsutoshi Obara, Masato Kasuga, Yasumasa Baba, Naoaki Hashimoto, Shoichi Matsutani, Kazuhiko Tokita, Masao Omata, Norishige Takemoto, Munenori Azuma, Kazuhiko Ohashi, Makoto Hoshino, Yoshihisa Tsukamoto, Tetsuo Kuroki, Soichiro Maekawa, Hiroshi Adachi, Yoichi Saitoh, Takaaki Mizushima, Takashi Moriyama, Yutaka Komatsu, Tetsuo Nakamura, Shigemitu Shida, Kogoro Kasahara, Toshiji Saibara, Shinichiro Obata, Hiroshi Hasegawa, Taketo Yamaguchi, Hiroyuki Katoh, Hiroshi Ota, Jo Ariyama, Bert Geerts, Hirokazu Nagawa, Makoto Kako, Tohru Narita, Minoru Tanaka, Hisato Nakajima, Kyuichi Tanikawa, Hideyuki Fusamoto, Toshiaki Watanabe, Nobuyuki Sumida, Tsuneo Matsuike, Itaru Hasegawa, Yasumoto Suzuki, Atsushi Toyonaga, Yoshiro Kubota, Shigeru Kitamori, Hidenori Kanazawa, Osamu Masamune, Yukihiko Adachi, Katsumi Yamauchi, Hirofumi Harada, Hideaki Mizumoto, Eddie Wisse, Yasuji Arase, Tadashi Iwao, Dai Fukumura, Yoshida H, S Hasumura, Hiroko Tsutsui, Tsutomu Chiba, Takumi Aramaki, Seigo Kitano, Yoshio Aizawa, Seishi Nagamori, Hiroaki Kobayashi, Tomihiro Hayakawa, Shin’ichi Takahashi, Kazuhiko Inoue, Hiromitsu Kumada, and Kenji Maeda

Subjects
medicine.medical_specialty, Surgical oncology, business.industry, Internal medicine, General surgery, Gastroenterology, medicine, Library science, Hepatology, business, Colorectal surgery, Abdominal surgery
Published
1993
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4. Detection of precore/core-mutant hepatitis B virus genome in patients with acute or fulminant hepatitis without serological markers for recent HBV infection

Author

Satoaki Mima, Thein Thein Aye, Fumihiko Komine, Toshio Shikata, Sven O. Becker, Toshikazu Uchida, Shyujirou Takase, Masanori Hirashima, Mitsuhiko Moriyama, and Yasuyuki Arakawa

Subjects
Adult, Hepatitis B virus, HBsAg, Hepatitis B virus DNA polymerase, Fulminant, Molecular Sequence Data, Radioimmunoassay, Genome, Viral, medicine.disease_cause, Polymerase Chain Reaction, medicine, Humans, Amino Acid Sequence, Hepatitis Antibodies, Fulminant hepatitis, Hepatitis, Hepatitis B Surface Antigens, Base Sequence, Hepatology, biology, business.industry, Viral Core Proteins, virus diseases, Middle Aged, Hepatitis B, medicine.disease, Hepatitis B Core Antigens, Virology, digestive system diseases, Immunoglobulin M, Acute Disease, DNA, Viral, Mutation, Immunology, biology.protein, Female, business
Abstract

To confirm the possibility that some hepatitis B virus (HBV) variants do not induce HB s antigen (HBsAg), anti-HB core antibody (anti-HBc) and anti-HBc IgM in a transient infection, polymerase chain reaction (PCR) was performed in 20 patients with acute hepatitis and 7 patients with fulminant hepatitis. Patients were diagnosed with non-A, non-B hepatitis by serological markers at admission. PCR successfully amplified the precore/core gene in 5 (25%) of the patients with acute hepatitis and 2 (29%) of the patients with fulminant hepatitis. Subsequent sequencing revealed frequent mutations including precore-defects in the precore/core gene.

Published
1993
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5. Mass survey of hepatocellular carcinoma by ultrasound

Author

Kenichiro Hirata, Morimichi Fukuda, and Satoaki Mima

Subjects
Oncology, Western hemisphere, medicine.medical_specialty, business.industry, Ultrasound, Focal nodular hyperplasia, medicine.disease, digestive system diseases, Causes of cancer, Hepatocellular carcinoma, Internal medicine, medicine, Radiology, business, Mass survey
Abstract

Hepatocellular carcinoma (HCC) is rather rare in the Western Hemisphere and in Europe, however, it is far more prevalent in the Orient and Africa and is indeed one of the most common causes of cancer death in these areas [1–3].

Published
1992
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6. Studies on early detection of hepatocellular carcinoma - Mass survey by real-time ultrasound and serum battery tests

Author

Yutaka Suzuki, Shoki Terada, Toshio Tanabe, Harutaka Itaya, Shigeyuki Ikeda, Wataru Hirata, Kiyoshi Kanagawa, Morimichi Fukuda, Kenichiro Hirata, Satoaki Mima, Hitoshi Mizuo, Kainosuke Saito, Kazumasa Watanabe, Hiroo Ogura, and Kiyoshi Uchiyama

Subjects
Battery (electricity), medicine.medical_specialty, Hepatology, business.industry, Hepatocellular carcinoma, medicine, Early detection, Real time ultrasound, Radiology, medicine.disease, business, Surgery, Mass survey
Abstract

肝癌のhigh risk groupを対象に昭和56年11月から超音波を主体とした肝癌の集団検診を実施した.対象者はHBVキャリアおよび肝疾患歴のあるものを主体とし,GOT, GPT, LDH, ALP, Ch-E, r-GTP, TTT, ZTTなどの肝機能検査,HBs抗原抗体系,AFPその他の腫瘍マーカーの検索と超音波検診を併用した.昭和59年4月までの2年6ヵ月間に,札幌,函館,帯広,旭川の道内主要都市を中心に計9回の検診を行い,受診者は延べ2,028名を数えた.受診者は30～60代を主体とし,男女比は1:0.49であり,なんらかの肝機能検査異常を呈したものは60.9%に上り,HBs抗原の陽性率は23.2%を示した.肝癌は21名,1.04%に発見されたが,19名は超音波検査のみによりスクリーニングされ,他はAFP高値例の追跡により診断しえた.その他,肝血管腫22名,1.1%,肝嚢胞52名,2.6%,胆石症91名,4.5%, FNH 1名も発見された.

Published
1985
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7. Studies on hepatic bile duct epithellal antigens in bile

Author

Masaju Sano, Kenichi Ito, Takao Takeuchi, Masahike Adachi, and Satoaki Mima

Subjects
Pathology, medicine.medical_specialty, medicine.anatomical_structure, Hepatology, Antigen, business.industry, medicine, business, Hepatic bile, Duct (anatomy)
Abstract

原発性胆汁性肝硬変症は自己免疫症と考えられるが,臓器特異抗原を含有すると推定される肝内胆管上皮の単離が困難なため,本症成立に関する免疫学的検討を著しく困難にしている.今回家兎-抗人胆汁蛋白血清を用い,蛍光抗体間接法によって人胆汁中には,胆管上皮由来の蛋白が存在することを明らかにした.又二元免疫拡散法により,人胆汁中には胆管上皮由来抗原を含めて,少くとも3種類の抗原蛋白が存在することを明らかにした.これら抗原蛋白は何れもSephadex G-200によるゲル濾過で第1峰に溶出される高分子群に含有されると推定された.又これらの抗原蛋白は臓器特異性の高いものであることを明らかにし得た.原発性胆汁性肝硬変症患者は人胆汁蛋白のSephadex G-200第1峰を添加抗原としたLMTで陽性反応を示し,この抗原に対する細胞性免疫の成立が本症発現に重要な役割を演じていることが示唆された.

Published
1978
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8. A case of lupoid hepatitis observed from acute hepatitis to hepatocellular carcinoma for 7 years

Author

Morimichi Fukuda, Teruki Hanew, Hitoshi Mizuo, Hiroshi Kanagawa, Satoaki Mima, Toshio Tanabe, Toshiji Siino, Wataru Hirata, and Hiroto Samejima

Subjects
Hepatitis, medicine.medical_specialty, Thesaurus (information retrieval), Hepatology, business.industry, Hepatocellular carcinoma, Internal medicine, Medicine, business, medicine.disease, Gastroenterology, Acute hepatitis
Published
1985
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