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2. Overhydration Negatively Affects Quality of Life in Peritoneal Dialysis Patients: Evidence from a Prospective Observational Study

Author

Byoung Geun Han, Hye Eun Yoon, Tae Won Lee, Yong-Soo Kim, Ki Ryang Na, Jong Tae Cho, Hyung Wook Kim, Jin Kuk Kim, Jong Hoon Chung, Kitae Bang, Young Rim Song, Seong Suk Kim, Yang Wook Kim, Young Joo Kwon, Ho Cheol Song, Jong Hyeok Jeong, Kyoung Hyoub Moon, Byung Soo Kim, Kwang Young Lee, Young Ok Kim, Sung Ro Yun, Yoon Kyung Chang, Chang Hwa Lee, Seok Joon Shin, and Eun Ah Hwang

Subjects
Adult, Male, medicine.medical_specialty, Pediatrics, medicine.medical_treatment, 030232 urology & nephrology, 030204 cardiovascular system & hematology, Gastroenterology, Peritoneal dialysis, 03 medical and health sciences, 0302 clinical medicine, Vascular Stiffness, Quality of life, Bioimpedance spectroscopy, Internal medicine, bioimpedance, Medicine, Humans, quality of life, fluid overload, Hydration status, Aged, Heart Failure, Dehydration, business.industry, overhydration, General Medicine, Middle Aged, medicine.disease, humanities, Quartile, peritoneal dialysis, Heart failure, Dielectric Spectroscopy, Quality of Life, Observational study, Female, Kidney Diseases, business, Kidney disease, Research Paper
Abstract

Backgound: This study evaluated whether the hydration status affected health-related quality of life (HRQOL) during 12 months in peritoneal dialysis (PD) patients. Methods: The hydration status and the HRQOL were examined at baseline and after 12 months using a bioimpedance spectroscopy and Kidney Disease Quality of Life-Short Form, respectively in PD patients. Four hundred eighty-one patients were included and divided according to the baseline overhydration (OH) value; normohydration group (NH group, -2L≤ OH ≤+2L, n=266) and overhydration group (OH group, OH >+2L, n=215). Baseline HRQOL scores were compared between the two groups. The subjects were re-stratified into quartiles according to the OH difference (OH value at baseline - OH value at 12 months

Published
2016

3. The Physiological Responses of Material-improved Working Clothes for Construction Site Worker

Author

Seong-Suk Kim and Hee-Eun Kim

Subjects
Engineering, Temperature sensation, business.industry, Applied psychology, Skin temperature, Rectal temperature, Operations management, business, Clothing, Oxygen uptake, Physiological responses
Abstract

In this paper, experiments to develop working clothes and evaluated, including the current and material-improved working clothes in relation to physiological functionality measurement. Experiments were conducted on sub-jects after wearing working clothes in an climate chamber, and the thermo-physiological response, such as human bodytemperature, micro-climate within the clothes, blood pressure, heart rate were measured. In this manner, the phys-iological functionality of improved working clothes was compared with that of current working clothes and evaluated. Thesummary of obtained results is as follows: For physiological functionality evaluation through material-improved workingclothes, P working clothes showed significantly lower rectal temperature than C working clothes. For mean skin tem-perature, P's skin temperature was significantly higher than C's in the second half of the experiment. P working clothes'stemperature around the thighs in Micro climate was significantly lower than that of the C working clothes. Also, humiditywithin the clothes showed similar trends. During the exercise period, C working clothes showed higher blood pressurethan P, but P showed higher heart rates than C. Also, the oxygen uptake amount was higher in C than P during the exer-cise period, it explains that the energy consumption amount of P working clothes was smaller than that of C workingclothes. Of the subjective evaluation, for temperature sensation, workers wearing P working clothes felt cooler. Forhumidity, C working clothes showed more humidity. For comfort, P working clothes were better, and for sense of fatigue,workers felt less tired wearing P working clothes. From results above, we can see that physiological functionality improvedin the material-improved working clothes in the working clothes for construction site workers. The improvement of workingclothes through functionality improvements not only will provide personal pleasantness to constriction site workers, but willalso generate efficiency and productivity improvements at construction sites. All in all, the continuous study of functionalityimprovements in working clothes taking into consideration the human body's physiological responses is required.Key words:construction field, material-improved working clothes, physiological responses

Published
2011
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4. Peritoneal dialysis - 3

Author

J. Rottembourg, Ea Wha Kang, Yilmaz Selcuk, Yong-Lim Kim, Declan de Freitas, Friedrich Prischl, Yoshiko Fujita, Javier Villacorta, Yiu Wing Ho, Ingrid Hofinger, Anna Casula, Yu Ting Tan, Jose C. Divino Filho, Watske Smit, Mustafa Comert, Miguel Perez Fontan, Juan Pérez-Martínez, Serhan Tuglular, Kyung-Woo Yoon, Ana Rodriguez-Carmona, Yoko Tanihata, Yasemin Soyoral, Vera M.S. Belangero, Alena Parikova, Kay B. Tan, Hye-Myung Ryu, José Luis Górriz Teruel, Annemarie Liegeois, Peter Rutherford, Annemieke M. Coester, Carmen A. Vlahu, Paul Taylor, Byung-Hee Lee, Adriana Loza, Yoko Nishijima, Yu Jin Jung, Terrance Wu, Hirofumi Hitomi, Keitaro Yokoyama, Murvet Yilmaz, Kyung Jin Lee, Selahattin Bicak, Hans Vink, Huseyin Toz, Sik Lee, Giovanni Cancarini, Woon Or Lam, Duk Hee Kang, Kumiko Kaifu, Carmen Gómez, Maurice Wan, Young-Hee Kim, Eyup Kulah, Luigi Manili, Hideki Nishimura, Lynne Curtis, Simon J. Davies, Hiroshi Hayakawa, Ayse Arar, Yoshitaka Maeda, W. Pronai, Elbis Ahbap, Giuseppe Mazzola, Ravi Pararajasingham, Ira Davis, Ya-fei Yang, Eveline Lee, Hyuk-Joon Choi, Roberto Pecoits-Filho, Raymond T. Krediet, Ho Yung Lee, Jose A. Meneses, Dae Suk Han, Lawrence P. McMahon, Ozge Timur, Yan Li, Natalia Fernandes, Joaquín Ortuño, Jun-Young Do, Stanley Fan, Tsutomu Sanaka, Maria C. Villegas, Sennur Kose Budak, Julia Klein, Bregtje A. Lemkes, Hugo Breien, Young Sook Lee, Haridian Sosa, Martin Zeier, Vedat Schwenger, Akihiko Matsuda, Friedo W. Dekker, Baris Doner, Jung Eun Lee, Yalcin Solak, Mourad Farouk, Antonio Alberto Lopes, Abdulkadir Unsal, Mina Yu, Kleyton A. Bastos, Lutfullah Altintepe, Jesus Montenegro, Andres Lopez Muñiz, Betul Erismis, Murat Can, Devrim Bozkurt, Takenori Funaki, Lars P. Kihm, Wieneke Michels, Renato T. Goncalves, Louese Dunn, Seung Hyun Lee, Marina Avramovic, Francesca Valerio, Kyu-Bok Choi, Chieko Higuchi, Tatsuo Hosoya, Paul Brenchley, Reinhard Kramar, Jong Won Park, Hideyasu Kiyomoto, Els Boeschoten, Jeung Eun Lee, Afshin Tavakoli, Cetin Ozener, Yoshindo Kawaguchi, Tadashi Sofue, Chan-Duck Kim, J. De Meester, Minoru Kubota, Sandra van Dijk, Gregory Ehrlich, Sandhya Seneviratne, Seung Hyeok Han, Burak Sayin, Juan Pérez, Anurag Singh, Kyung Pyo Kang, Ibrahim Guney, Kyu Hun Choi, Gulsah Sasak, Arafat Mirza, Arzu Kahveci, Yener Koc, Kyu-Hyang Cho, Dick G. Struijk, Siren Sezer, Zeynep Biyik, Hasan Kayabasi, Huang-Joe Wang, Huseyin Atalay, Jung-Ju Seo, Hidetomo Nakamoto, Angela Summers, Kumiko Moriwaki, Archna Sinha, Jin-Jhung Yeh, Tsun Gun Ng, Ahmet Dursun, Sang Choel Lee, Dong Ryeol Ryu, Elif Ari, Ken Izumori, Marija Andjelkovic, Anita Saxena, Marie-Luise Gross, Mehdi Yeksan, Pinar Cetin, Hiromichi Suzuki, Murat Biyik, Massimo Sandrini, David Ansell, Hee-Jeong Choi, Masaaki Tokuda, Zeki Tonbul, Sung Kwang Park, Bratislav Apostolovic, Satoshi Nishioka, Soo Young Yoon, Osamu Ikehara, Masakazu Kohno, Ae Sin Lee, In-Kyong Hur, Audrey M. Hutchcraft, Taiga Hara, John E. Sanderson, Nurhan Ozdemir, Amit Gupta, Ju-Min Yook, Kyun-Il Yoon, Zhangsuo Liu, Sang Yong Lee, Sung Kyew Kang, Yuk Yee Cheng, Seng Hoe Tan, Teresa Garcia Falcon, Huseyin Begenik, Biju John, Raziye Yazici, Dick Struijk, Soner Duman, Ian Bridges, Shin Wook Kang, Sun-Hee Park, Ji-Hyung Cho, Sara Jiménez, Valerio Vizzardi, Hakki Arikan, Guldeniz Karadeniz, Suleyman Turk, Jose Ramon Rodriguez-Palomares, Ana Marta Gomes, Tetsuya Mitarai, Jakob Arhem, Mehmet Naci Aldemir, A. Oguz Akgun, Manfred Wallner, Won Kim, Mari Ishida, Tae Hwan Lee, Sait Şen, Paul J. Thornalley, Mehmet Emin Kucukoglu, Rosalind Williams, F. Wenzelburger, Carmen Gómez-Roldán, M. Feriani, Eva Seiringer, Yudo Tanno, Bruno Remacle, Yoshihiro Obara, Marion Verduijn, Titus Augustine, Maite Rivera, Bo Ekelund, Erol Aktunç, Victor Burguera, Akira Nishiyama, Kitae Bang, Duk Hoon Kim, Synke van der Heyden, Sung-Bok Jung, Hiroyasu Yamamoto, Seung-Jung Kim, Erkan Oztekin, Ana Guitian, Helen Hurst, Raj Kumar Sharma, Ji-Young Choi, Kia Chong Chua, Seong Suk Kim, Narayan Prasad, Meng Eng Tay, Reha Erkoc, Sonja Zehetmayer, Sandra Mueller-Krebs, and Catherine De Vos

Subjects
Transplantation, medicine.medical_specialty, Nephrology, business.industry, medicine.medical_treatment, Urology, medicine, business, Peritoneal dialysis
Published
2009
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5. Cardiovascular complications - 3

Author

Carolyn van Eps, Simon J. Davies, Ercan Ok, Gillian McNaught, Mireille Griuncelli, Brian Haluska, Sima Abedi Azar, M.G. Signorini, Mehmet Ozkahya, Ioan Mihai Patiu, Abbes Benmaadi, Paul E. Barre, Christelle Loridon, agri Agirgün, Sendogan Aker, Kultigin Turkmen, Jose M. Valdivielso, Numan Gorgulu, Bhupinder Virk, Erik Serné, Zhaohui Ni, Muhammad Shahed Ahmed, Demetra Bacharaki, Helen Jefferies, Siu-Fai Lui, Christopher W. McIntyre, Qin Wang, Crina Rusu, Devrim Bozkurt, Xuemei Li, Brigitte Schiller, Mehmet Haberal, Hong Xu, Eric Illouz, Robert J. Unwin, Grigore Dogaru, Christos Bantis, Kitae Bang, Silvio Henrique Barberato, Eva Castañer, Meral Kayıkçıoğlu, Yasemin Erten, Angela Yee-Moon Wang, Kateri Champagne, Zac Varghese, Maani Hakimi, M.-Pau Valenzuela, Tiziano Lusenti, Iris H.S. Chan, Emily P. McQuarrie, Cian Chan, Serkan Saygi, Hamad Dheir, Xiong Ruan, Yvo Smulders, Muriel P.C. Grooteman, Peter Kotanko, Christina Lam, Sara Panizo, Katrin Ivens, Bogdan Ghigolea, M Espinoza, Abdul Rashid Qureshi, Grant Heatlie, David C. Wheeler, Marta Palomo, Musa Bali, Qiangwen Pan, Mei Wang, Lucia del Vecchio, Monica Zanella, Hari Nair, Aleix Cases, Leanne Jeffries, Huseyin Toz, Biju John, Pinar Ozen, Philip Harvey, Thomas Marwick, Diana Moldovan, Sonia Cillero, Simona Stancu, Menso J. Nubé, Heike Ziebart, Xiaohong Fan, Peter Stenvinkel, Flavio Basso, Jonas Axelsson, Lorelei Betancourt, Ezio degli Esposti, Jianling Tao, Ana Dambiski, A. Salim, Abdullah Ozkok, Janine Jeffries, Carmel M. Hawley, Attilio Losito, Peter Heering, Navdeep Tangri, Mümtaz Yilmaz, lver Derici, Stephan Thijssen, David W. Johnson, Liou Cao, Aluisio Barbosa Carvalho, Johann Nicholas, Petya Valcheva, Maria Aparecida da Glória, Abdulkadir Unsal, Tsu-Wang Shen, Andréa E.M. Stinghen, R. John Kimoff, James O. Burton, Juan F. Navarro, Henry J. Dargie, Tracey Steedman, Sofia Kalogeropoulou, Francisco Valdes, Yan Zhang, Kadriye Altiok Reis, Ülkem Yakupoglu, Helio V. Cassi, Gines Escolar, Dittmar Böckler, Ashley Holt, Luciana Piekala, Fernando González, Ebru Sevinc, Sunna Snaedal, Massimo de Cal, Spiros Katsoudas, Yu-Hsien Lai, Gulay Asci, Yu Ting Tan, Anette Melk, Xavier Gallardo, Isabel Rodriguez, Nicole M. Isbel, Rüya Mutluay, Milica Bozic, Maribel Diaz-Ricart, Demetrios Vlahakos, Luminita Voroneanu, Nadezda Koleganova, Marie Luise Gross, Sergio G. Bucharles, Elvira Fernandez, Fotis Panou, Ozlem Cigerli, Nicholas M. Selby, Alessandra Brendolan, Dimitrios Kremastinos, Jochen G. Raimann, Jill T. Norman, Adrian Covic, Sonja Steppan, John F. Moorhead, Christina Schwandt, F. Wenzelburger, Philip Reis, Te-Chao Fang, K. Vithlani, Maria C. Cardoso, Hue Danh Thang, Fabio Branco, Eduardo Lorca, Federico Nalesso, Manel Vera, Gabriel Mircescu, Dinna N. Cruz, Mohammad Kazem Tarzamni, Mustafa Cirit, Juan Jesus Carrero, M. Ferrario, Betina Gruber, Blai Coll, Sahng Lee, Mukremin Uysal, Alan Jardine, Mohammadreza J. Nakhjavani, Kyung Jin Lee, Patrick B. Mark, Indranil Dasgupta, John E. Sanderson, Huseyin Oflaz, Nurhan Ozdemir, Jesus Calviño, Patricia Molina, Guy Rostoker, Carlos Zavala, L. C. Rump, Peter Bárány, Sukru Sindel, Jutta Passlick-Deetjen, Mario Timio, Eveline Lee, Yang Sun, Joanna R. Powell, Sameena Iqbal, C.F. Wong, Seong Suk Kim, Fatma Ayerden Ebinç, Bang-Gee Hsu, José Rocha Faria-Neto, Elise Tanigushi, Jiaqi Qian, Sevim Gönen, Panagyota Flevari, Anja Kruse, Stephen G. John, Xuewang Li, Yong Zeng, Christopher W.K. Lam, Remus Orasan, Turgay Arinsoy, Sumi Sun, Eva Parisi, Pedro Villaverde, Alan G. Jardine, Tamer Sakaci, Carmen Caldararu, Ilie Barb, Olof Heimbürger, Alaattin Yildiz, P. Pai, Geert Jan Tangelder, S. Cerutti, Mirela Liana Gliga, K. Rafalia, Rajan K. Patel, Thais Lopez, Karl Thomaseth, Joan-Carles Martinez, Guangli Ge, Soner Duman, Manuel Garcia, Martin Zeier, Claudio Ronco, Shan Mou, Piet M. ter Wee, Kay B. Tan, Yasar Caliskan, John Moran, Roberto Pecoits-Filho, Chih-Hsien Wang, Mustafa Demirturk, Alexandre Varela, Nicola Kuhr, Kim M. Kloske, Paolo Lentini, Zhenni Guo, Jaume Almirall, Rafel Valls, C. McCoy, Mhairi K. Sigrist, Fulgencio Navalon, Ceyla Konca, Luis E. Becker, Nadia Martin, Goffredo del Rosso, Steven C. Campbell, Elisa Mieko Suemitsu Higa, Young Sook Lee, Nathan W. Levin, Fatih Kircelli, Alessandra Sturani, Stefanie M. Bode-Boeger, Francesco Garzotto, Dionyssios Leftheriotis, David W. Mudge, Kenneth B. Christopher, Jan T. Kielstein, Violeta Roman, Mirela Gherman, Limeng Chen, Bengt Lindholm, and Sheila Doss

Subjects
Transplantation, medicine.medical_specialty, Nephrology, business.industry, Medicine, business, Intensive care medicine
Published
2009
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6. Epidemiology and CKD - 2

Author

Mayuri Jain, José Luis Górriz, Margarita Gjata, Nobuo Yoshiike, Christopher J. Deighan, Graham Lipkin, Jamie P. Traynor, Tatemitsu Rai, C. O. Alebiosu, Xiaobei Dong, Weidong Zhou, Roberto Pecoits, Ichiei Narita, Wonho Hahn, Hyung Jik Kim, W. Sui, Giuseppe Garigali, Dwomoa Adu, G. Zou, Alberto Martínez Castelao, Karina Kocharyan, Lieselot De Vos, Terumasa Hayashi, Mai Wakabayashi, Young Rim Song, Nan Chen, Eli Iola Andrade, Wei Fong Siew, Hiromi Rakugi, Patrick B. Mark, Helen Benghiat, F. Catalano, F. Marino, Pragnya Singh, Michel Jadoul, Shouichi Fujimoto, Ulia Tishova, Monica Beaulieu, A. Pisano, Jay Nath, Emma Vaux, Mobin Mohteshamzadeh, Flaviana de Jesus Moreira, Tom Rafferty, Alessandra Almeida, Pornpen Sangthawan, Yoshitsugu Obi, Piergiorgio Messa, Yoshitaka Isaka, Daoyuan Sun, Norberto Perico, Marina Vysheslavtseva, Joseph Gligorov, Dirk Verbeelen, Jean-Philippe Spano, FS Wokoma, Krish Ramanthan, Gilbert Deray, Matthew J. Bottomley, Yoshihiro Takeda, Kazuyuki Shimada, Claudio Cricelli, Chatchai Kreepala, Maria Novikova, Noriaki Iino, Giuseppe Remuzzi, Jean-François Morere, Chanya Kerdchantuk, B. Spoto, Aline Hausen, Suthee Rattanamongkolgul, P C Emem-Chioma, Toshihiko Yamaka, Ursula Weiss, Jean Krzesinski, Giovanni B. Fogazzi, Gordon Prescott, P. Pizzini, N. Perico, Seong Suk Kim, Ayodele Arije, Mihal Tase, Mariangela Chercheglia, Evgeniy Shilov, Shinichi Uchida, X. Sun, Hania Al-Shahrouri, Dere Akobo, Marc Maillard, Obinna Onodugo, Sadayoshi Ito, Sasivimol Rattanasiri, Oluwatoyin Amira, Lin Tze Seet, Weiming Wang, H. Chao, Richard Ishmael Oko-Jaja, Isabelle Ray-Coquard, Sungsin Park, P. Finocchiaro, Wajeh Y. Qunibi, Toshio Ogihara, Tomonori Kimura, Francisco de Assis Acurcio, José Portolés, Juan F. Navarro, Olugbenga Awobusuyi, Claude Renaud, Sanyasi Rao Gedela, Tomokazu Okado, Keith Simpson, R. Tripepi, Akaraphan Suravilas, Peter Nightingale, Philippe Beuzeboc, L. Peng, S. Cutrupi, Paul Harden, Hao Shi, Xavier Pourrat, Ramesh Naik, Adeera Levin, G. Remuzzi, Alessandro Filippi, G. Caridi, Sabrina Gill, Amalraj Raja, Lorena Zardo, Galina Volgina, Alagoma Iyagba, Chetan Mevada, Ognjenka Djurdjev, Raymond Vanholder, Michela Re, Daniel P.K. Ng, Mario Plebani, Madina Gadzhikulieva, Laura Sciacovelli, Bin Zhu, Ammarin Thakkinstian, Tetsuro Takeda, Takesih Tokura, Anderson Goncalves, Wim Van Biesen, Norberto Cabral, Suteetat Sukumalchantra, Heizo Tanaka, Nusaraporn Kessomboon, Alan G. Jardine, Hiroaki Naritomi, Dhavee Sirivongs, Emily P. McQuarrie, Giuseppe Noberasco, Elaine Tan, Catherine Stirling, Giacomo Deferrari, Prapaipim Thirakhupt, Liyan Ni, Adunola Oyegbata, Yuji Sato, Mari Iwamoto, Rie Okutsu, Keiko Yasuda, Shelley Burnett, Fatiu A Arogundade, Luiz Flavio Giordano, EB Arodiwe, Yoshiyuki Nagai, Enyu Imai, Njideka U Okubadejo, Michel Burnier, Sandra Secchiero, Johanna Urena, Sungdo Kim, Shigeto Kobayashi, Ifeoma Ulasi, Akihiko Saito, Shigehiro Uezono, Kazuo Kitamura, Atiporn Ingsathit, Xunmiao Zhang, Chinwuba K. Ijoma, F. Mallamaci, Angel L.M. de Francisco, Rossella Cannavò, Rommel Bataclan, D. Leonardis, Fumitake Gejyo, Aleh Kalachik, H. Zou, Michael Reschen, Aleix Cases, José Luño, Y. Zhang, Grégoire Wuerzner, Agustina Anabaya, Y. Xiang, Hans Warrinnier, Leena Ongaiyooth, Haijin Yu, Christian Tielemans, Peter C. Thomson, Fumie Sato, G. Hu, Deep K. Raman, Stéphane Oudard, Byoungsoo Cho, Jinsun Suh, Takashi Shigematsu, G. Tripepi, Datonye Dennis Alasia, Sergio Carminati, Aporanee Chaiyakam, Andrea Panozo Rivero, Y. Chen, Bogdan Ene-Yordache, G. Parlongo, A. Otero, Kazuo Suzuki, Eisei Sohara, Dumnern Srinualta, Helbert do Nascimento Lima, Shuichi Hisanaga, Maura Ravera, L. Chen, Carmine Zoccali, T.S. Ramakrishnan, Ergita Nelaj, Menno Pruijm, Dom Pensiero, Tim James, Alexander Howie, H. Leong, Thananda Trakarnvanich, Prem P. Varma, Soo Jin Kim, V. Panuccio, Anthony A. Fryer, Pascal Bovet, Jung Woo Noh, J. Xiao, Amnart Chaiprasert, Anna Maria Gallina, F. Garcia, Akihito Ohta, Antonietta Dial, Jean-Baptiste Rey, Jonathan G. Fox, Rodolfo X. Flores Bravo, Kraiwiporn Kiattisunthorn, Lindsey Barker, Wataru Akita, Isabel Cristina Gomes, Nicolas Janus, Phisitt Wchakama, David W. Johnson, Kazuaki Shimamoto, Catherine Weber, Fernando de Alvaro, Seong Gyun Kim, Siribha Changsirikulchai, Sei Sasaki, Murielle Bochud, Tosifumi Sakaguchi, Hope Ilanye Bell-Gam, Svetlana Kalinchenko, and Vincent Launay-Vacher

Subjects
Transplantation, medicine.medical_specialty, Nephrology, business.industry, Epidemiology, Medicine, business, Intensive care medicine
Published
2009
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7. Detection of Axillary Lymph Node Micrometastases in Breast Cancer Using RT-PCR Comparison the Results of MUC1, Cytokeratin 19

Author

Seung Keun Oh, Ryung-Ah Lee, Seong Suk Kim, Kuk Jin Choe, Yeo Kyu Yun, Dong Young Noh, Sung-Won Kim, Hee Joon Kang, and Han Sung Kang

Subjects
Oncology, medicine.medical_specialty, Cytokeratin, medicine.anatomical_structure, Real-time polymerase chain reaction, Breast cancer, business.industry, Internal medicine, Medicine, business, medicine.disease, Lymph node, MUC1
Published
2002
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9. Usefulness of 99mTx Methoxyisobutylisonitrile Lung SPECT in Benign andMalignant Lesion of the Lungs

Author

Jin Hong Chung, In Ho Cho, Mi Jin Kim, Kyung Hee Lee, Hyun Woo Lee, Kwan Ho Lee, Seong Suk Kim, Young Bok Cho, Ki-Beom Kim, and Hyoung Woo Lee

Subjects
Pulmonary and Respiratory Medicine, Pathology, medicine.medical_specialty, Lung, medicine.diagnostic_test, business.industry, respiratory system, medicine.disease, Small-cell carcinoma, respiratory tract diseases, Metastasis, Lesion, Myocardial perfusion imaging, Infectious Diseases, medicine.anatomical_structure, medicine, Carcinoma, Neoplasm, medicine.symptom, business, Lung cancer, Nuclear medicine
Abstract

Background: MIBI(Methoxyisobutylisonitrile complex), a member of the isonitrile class of coordination compounds, is a lipophilic cation presently under investigation for clinical use as myocardial perfusion imaging agent and is widely used to detect myocardial infarction. Preliminary reports indicate that -201 accumulate in human neoplasm and several authors reported MIBI may also localized in primary malignant tumor and metastatic deposits from lung cancer. We evaluated the uptake of MIBI in lung cancer and localization of mediastinal and other site metastasis, and compared the benign lesion of the lung. Method: Thirty four patients of lung cancer and ten patients of benign lung lesion were studied with chest CT and MIBI Lung SPECT. MIBI uptake ratio was assessed by TR/NL(Lung lesion/ Normal area), HT/NL (Heart/Normal area) and HT/TR(Heart/Lung lesion). Results: 1) All lung cancer patients showed increased uptakes of MIBI in malignant lung lesion and Tc-99m MIBI uptake was also increased in mediastinal and lymph node metastasis except two cases. 2) There was significant different ratio of TR/NL between malignant and benign lesion, and on planar images, respectively(p MIBI uptake ratio between squamous cell carcinoma, small cell carcinoma and adeno carcinoma(, , respectively). Conclusion: MIBI lung SPECT was useful in the localization of tumor and mediastinal or other site metastatic lesion in lung cancer and also in the differential diagnosis between benign and malignant lesion.

Published
1996
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