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Purpose To evaluate whether the bony impingement lesion in elbow osteoarthritis can be removed accurately, as planned during arthroscopy, by using the computer-aided navigation system and performing mock surgery using 3-dimensional (3D)-printed bone models for clinical applications. Methods We performed mock surgery using 3D-printed plaster bone models of the humerus of 15 actual patients with elbow osteoarthritis. Two types of experiments were conducted to evaluate the surgical accuracy. Three surgeons performed the mock surgery, each with 15 bone models (total, 45 trials). Surgical accuracy was based on the mean of 45 trials. The differences in surgical accuracy among the 3 surgeons were also evaluated (mean 15 trials). The same surgeon performed 30 trials, and the difference in surgical accuracy between the first and the second halves was also evaluated (mean 15 trials). Results The spatial error in the entire elbow joint was 1.13 mm. In terms of resection volume, a mean of 8% more volume was resected than was planned, and 85% of the planned area was resected. In our experiments, the surgical accuracy was significantly lower in the anterior than in the posterior joint. Intrarater reliability was intraclass correlation (ICC)2,1 0.81 and inter-rater reliability was ICC1,1 0.87. Conclusions Surgery using computer-aided navigation systems for arthroscopic debridement of the elbow provided accuracy comparable to that in other joints. Arthroscopic debridement of elbow osteoarthritis requires advanced surgical skills because accurate identification of the bony impingement legion is difficult during surgery. Surgery using computer-aided navigation systems for arthroscopic debridement of the elbow will provide real-time tracking of both the surgical instruments and bony impingement lesions as well as solve the technical difficulties of arthroscopic surgery of the elbow joint. Clinical Relevance Level Basic Science Study; Computer Modeling.

Background Proximal horizontal tears of the triangular fibrocartilage complex (TFCC) represent the tears at the proximal surface of the articular disk with a normal appearance of the distal surface. Preoperative diagnosis of TFCC flap tears is challenging. Objectives This report aims to present a diagnostic method using computed tomography (CT) arthrography for the proximal horizontal flap tears of the TFCC and to report our clinical outcomes. Patients and Methods Six patients were included who were preoperatively suspected to have proximal horizontal flap tears of the TFCC via CT arthrography. Arthrography was conducted by injecting dye into the distal radioulnar joint (DRUJ), and CT images were obtained immediately following arthrography. We performed arthroscopic or direct flap debridement with concomitant surgeries: ulnar shortening with positive ulnar variance and corrective osteotomy with the malunion following distal radius fracture. Results Preoperative CT arthrography clearly revealed the flaps to be flipped over toward the radiopalmar side of the DRUJ in four cases and a teardrop-shaped dye defect in two. We were able to identify the dislocated flap by arthroscopy avulsed from the proximal aspect of the articular disk within the DRUJ in all six cases. The mean pain level decreased from 10 preoperatively to 0.3 postoperatively on the visual analog scale. The mean patient-rated wrist evaluation score decreased from 43.5 preoperatively to 11.2 postoperatively. Conclusions Our study shows that CT arthrography can be a promising method for diagnosing proximal horizontal flap tears of the TFCC. Debridement of the flaps and concomitant surgeries showed satisfactory clinical results. Level of Evidence This is a Level 4, diagnostic study.

Background In missed Monteggia fracture (MMF) cases, ulnar angulation and lengthening by osteotomy are required to reduce the dislocated radial head. This study aimed to clarify the abnormal discrepancy in length between the radius and ulna in MMF. We tested the hypothesis that the increase in the abnormal discrepancy in length between the radius and ulna relates with the duration of radial head dislocation. Methods In total, 24 patients with MMF were studied and classified into 2 groups, according to the duration of radial head dislocation, including the early group (n=9, within 3 y) and the long-standing group (n=15, older than 3 y). The lengths of the radius (Lr) and ulna (Lu) were measured. The difference in length between the ulna and radius (DL=Lu-Lr) was calculated on both the affected (DLaff) and normal (DLnor) sides. DLnor-DLaff, which represented an abnormal discrepancy in both bones, was analyzed for correlation with the duration of radial head dislocation and the age at initial injury. Results The affected and normal sides had no differences in the Lr of both the groups and in the Lu of the early group. However, in the long-standing group, Lu was significantly smaller in the affected side than in the normal side (P=0.001). In the long-standing group, DLaff was significantly smaller, owing to decreased length of the ulna, than DLnor (P=0.003). The DLnor-DLaff was positively correlated with the duration of radial head dislocation and was negatively correlated with the age at injury. Conclusions In chronic MMF cases, the length of the ulna was shorter in the affected side than in the normal side. Therefore, ulnar lengthening is necessary to resolve this abnormal discrepancy and reduce the radial head. Because excessive ulnar lengthening has risks of postoperative complications, one of the surgical options is gradual ulnar lengthening or shortening osteotomy of the radius. Level of evidence Level III-Prognosis study.

Background The identification and precise removal of bony impingement lesions during arthroscopic debridement arthroplasty for elbow osteoarthritis is technically difficult. Surgical navigation systems, combined with preoperative 3-dimensional (3D) assessment of bony impingements, can provide real-time tracking of the surgical instruments and impingement lesions. This study aims to determine the registration accuracy of the navigation system for the humerus and ulna during elbow arthroscopy. Methods We tested the registration procedure using resin bone models of 3 actual patients with elbow osteoarthritis. We digitized bone surface points using navigation pointers under arthroscopy. We initially performed paired-point registration, digitizing 6 preset anatomical landmarks, and then refined the initial alignment with surface matching registration, digitizing 30 points. The registration accuracy for each trial was evaluated as the mean target registration error in each reference marker. Three observers repeated the registration procedure 5 times each with the 3 specimens (total, 45 trials). The median of the registration accuracy was evaluated in total (45 trials) as the accuracy of the registration procedure. The differences in the registration accuracy among the 3 observers (median of 15 trials) were also examined. Results The total registration accuracies were 0.96 mm for the humerus and 0.85 mm for the ulna. No significant differences were found in the registration accuracy for the humerus and ulna among the 3 observers. Conclusions This arthroscopic-assisted registration procedure is sufficiently feasible and accurate for application of the navigation system to arthroscopic debridement arthroplasty in clinical settings.

Understanding the complex fragmentation of intra-articular distal radial fractures contributes to achieving anatomical reduction during surgery. This study aimed to clarify three-dimensional displacement patterns of intra-articular fragmentation in dorsally angulated, intra-articular distal radial fractures. We identified five characteristic intra-articular fragments: a key fragment, dorsal ulnar corner, dorsal wall, radial column and anterior radial column. The key fragment was displaced with radial deviation, pronation and extension and with dorsal, proximal and radial translations. The dorsal ulnar corner displacement resulted in a gap, a step-off and a deepened concavity for the lunate facet and sigmoid notch. The dorsal wall displacement resulted in a deepened concavity, a gap and a step-off of the dorsal scaphoid facet. The displacements of the radial column and anterior radial column caused a step-off between the scaphoid and lunate facets. The five characteristic intra-articular fragments each created a characteristic gap and step-off in the articular surface. Level of evidence: IV

Malunited distal radius fractures (DRFs) occasionally restrict forearm rotation, but the underlying pathology remains unclear. We aimed to elucidate the mechanism of rotational restriction by retrospective analysis of 23 patients with unilateral malunited DRFs who presented restricted forearm rotation. We conducted computed tomography during forearm rotation on both sides. Three-dimensional (3D) bone surface models of the forearm were created, and 3D deformity of the distal radius, translation of the distal radius relative to the ulna, distal radioulnar joint (DRUJ) contact area, and estimated path length (EPL) of distal radioulnar ligaments (DRUL) during forearm rotation were evaluated. In total, 18 patients had dorsal angular deformities (DA group) and five had volar angular deformities (VA group). In the DA group, the closest point between the distal radius and ulna on DRUJ was displaced to the volar side during supination and pronation (p < 0.001); DRUJ contact area was not significantly different between the DA and normal groups. In bone-ligament model simulation, the EPL of dorsal DRUL was longer in the DA group than in the normal group (p < 0.001); opposite phenomena were observed in the VA group. In the DA group, translation of the distal radius in a volar direction relative to the ulna during pronation was impaired presumably due to dorsal DRUL tightness. Anatomical normal reduction of the distal radius by corrective osteotomy may improve forearm rotation by improving triangular fibrocartilage complex tightness and normalizing translation of the distal radius relative to the ulna. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:1881-1891, 2019.

Measuring three-dimensional (3D) forearm rotational motion is difficult. We aimed to develop and validate a new method for analyzing 3D forearm rotational motion. We proposed biplane fluoroscopic intensity-based 2D–3D matching, which employs automatic registration processing using the evolutionary optimization strategy. Biplane fluoroscopy was conducted for forearm rotation at 12.5 frames per second along with computed tomography (CT) at one static position. An arm phantom was embedded with eight stainless steel spheres (diameter, 1.5 mm), and forearm rotational motion measurements using the proposed method were compared with those using radiostereometric analysis, which is considered the ground truth. As for the time resolution analysis, we measured radiohumeral joint motion in a patient with posterolateral rotatory instability and compared the 2D–3D matching method with the simulated multiple CT method, which uses CTs at multiple positions and interpolates between the positions. Rotation errors of the radius and ulna between these two methods were 0.31 ± 0.35° and 0.32 ± 0.33°, respectively, translation errors were 0.43 ± 0.35 mm and 0.29 ± 0.25 mm, respectively. Although the 2D–3D method could detect joint dislocation, the multiple CT method could not detect quick motion during joint dislocation. The proposed method enabled high temporal- and spatial-resolution motion analyses with low radiation exposure. Moreover, it enabled the detection of a sudden motion, such as joint dislocation, and may contribute to 3D motion analysis, including joint dislocation, which currently cannot be analyzed using conventional methods.

Background Three-dimensional preoperative planning was applied for the osteosynthesis of distal radius fractures. The objective of this study was to evaluate the reproducibility of three-dimensional preoperative planning for the osteosynthesis of distal radius fractures with three-dimensional reference points. Methods Sixty-three wrists of 63 distal radius fracture patients who underwent osteosynthesis with three-dimensional preoperative planning were evaluated. After taking preoperative CT scans of the injured wrists, 3D images of the distal radius were created. Fracture reduction, implants choices, and placements simulation were performed based on the 3D images. One month after the surgery, postoperative CT images were taken. The reproducibility was evaluated with preoperative plan and postoperative 3D images. The images were compared with the three-dimensional coordinates of radial styloid process, volar and dorsal edges of sigmoid notch, and the barycentric coordinates of the three reference points. The reproducibility of the preoperative plan was evaluated by the distance of the coordinates between the plan and postoperative images for the reference points. The reproducibility of radial inclination and volar tilt on three-dimensional images were evaluated by intra-class correlation coefficient (ICC). Results The distances between the preoperative plan and the postoperative reduction for each reference point were (1) 2.1±1.3 mm, (2) 1.9±1.2 mm, and (3) 1.9±1.2 mm, respectively. The distance between the preoperative plan and postoperative reduction for the barycentric coordinate was 1.3±0.8 mm. ICCs were 0.54 and 0.54 for the volar tilt and radial inclination, respectively (P Conclusions Three-dimensional preoperative planning for the osteosynthesis of distal radius fracture was reproducible with an error of about 2 mm for each reference point and the correlations of reduction shapes were moderate. The analysis method and reference points may be helpful to understand the accuracy of reductions for the three-dimensional preoperative planning in the osteosynthesis of distal radius fractures. Trial registration Registered as NCT02909647 at ClinicalTrials.gov

Background Osteoporotic fragility fractures frequently occur at the distal part of the radius. This suggests that initial osteoporosis evaluation at this site may inform screening and treatment to prevent additional fractures. The purpose of this study was to investigate the utility of distal forearm dual x-ray absorptiometry (DXA) as a screening tool to assess the risk of fragility fractures at the distal part of the radius. Methods This retrospective, case-control study included postmenopausal women who had sustained a distal radial fracture (fracture group, n = 110) and postmenopausal women with no history of fracture (control group, n = 95). DXA measurements at the spine, hip, and distal part of the forearm (ultra-distal, mid-distal, and one-third distal sections) were compared between the groups on the basis of bone mineral density (BMD), T-score, and the proportion of patients with a T-score of ≤-2.5 standard deviations (SD). We also investigated the regional differences on the basis of T-score among the skeletal sites. Furthermore, the reliability of distal forearm DXA measurements was validated by assessing the statistical correlation (r) with volumetric BMD by computed tomography (CT). Results Compared with the control group, the fracture group showed significantly lower BMD and T-scores and higher proportions of patients with a T-score of ≤-2.5 SD at the ultra-distal, mid-distal, and one-third distal forearm; however, the spine and hip measurements did not differ significantly between the 2 groups. With respect to regional differences, in the fracture group, T-scores were significantly lower and the proportions of patients with a T-score of ≤-2.5 SD were significantly higher for the 3 distal forearm sites compared with the spine and hip. DXA measurements at all 3 of the distal forearm regions exhibited high correlation with volumetric BMD by CT (r = 0.83 to 0.92). Conclusions Some postmenopausal women were found to exhibit bone loss preferentially at the distal part of the radius, which may render them vulnerable to fragility fractures. Forearm DXA for the assessment of local bone loss may demonstrate benefit in screening for those at risk for distal radial fractures and facilitate the early identification of patients who require intervention for osteoporosis. Level of evidence Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.

Background The identification and precise removal of bony impingement lesions during arthroscopic debridement arthroplasty for elbow osteoarthritis require a high level of experience and surgical skill. We have developed a new technique to identify impinging osteophytes on a computer display by simulating elbow motion using the multiple positions of 3-dimensional (3D) elbow models created from computed tomography data. Moreover, an actual color-coded 3D model indicating the impinging osteophytes was created with a 3D printer and was used as an intraoperative reference tool. This study aimed to verify the efficacy of these new technologies in arthroscopic debridement for elbow osteoarthritis. Methods We retrospectively studied 16 patients treated with arthroscopic debridement for elbow osteoarthritis after a preoperative computer simulation. Patients who underwent surgery with only the preoperative simulation were assigned to group 1 (n = 8), whereas those on whom we operated using a color-coded 3D bone model created from the preoperative simulation were assigned to group 2 (n = 8). Elbow extension and flexion range of motion (ROM), the Mayo Elbow Performance Score (MEPS), and the severity of osteoarthritis were compared between the groups. Results Although preoperative elbow flexion and MEPS values were not significantly different between the groups, preoperative extension was significantly more restricted in group 2 than in group 1 (P = .0131). Group 2 tended to include more severe cases according to the Hastings-Rettig classification (P = .0693). ROM and MEPS values were improved in all cases. No significant differences in postoperative ROM or MEPS values were observed between the groups. There were no significant differences in the improvement in ROM or MEPS values between the 2 groups. Conclusions The use of preoperative simulation and a color-coded bone model could help to achieve as good postoperative ROM and MEPS values for advanced elbow osteoarthritis as those for early and intermediate stages.

Background Extension deformity of the distal humerus after a malunited supracondylar fracture can restrict elbow flexion. Here we report a computer-assisted operative procedure and review the results of clinical cases in which corrective surgery was performed. Methods The medical records of the patients who underwent corrective osteotomy for hyperextended elbow malunion of the distal humerus with limited elbow flexion (flexion angle ≤100°) were reviewed retrospectively. Osteotomy was performed using patient-specific instruments designed based on preoperative 3-dimensional computer simulation. Results Three patients, a 55-year-old woman and two 12-year-old boys, met the inclusion criteria. The angles of hyperextension of the affected distal humerus were 29°, 29°, and 25°, respectively. The range of flexion/extension of the elbow motion in the first patient improved from 95°/25° preoperatively to 140°/−10° postoperatively, in the second patient from 100°/20° to 145°/5°, and in the third patient from 80°/25° to 140°/10°. Bone union was achieved in all patients. There were no major complications. The corrective operations not only improved elbow flexion but also increased the total range of motion in the elbow by rebuilding the anterior curve of the distal humerus. Conclusions Correction of the extension deformity of the distal humerus after a malunited supracondylar fracture is a reasonable option for patients older than 10 years with restricted elbow flexion. Preoperative computer simulation and the use of patient-specific instruments can be a useful alternative that enables accurate deformity correction and improves the total range of motion.

The partial physeal arrest of the distal radius could result in progressive deformities and functional problems of the wrist. Despite being the most preferred surgical intervention, physeal bar resection (Langenskiöld procedure) is technically demanding. This manuscript aims to illustrate the technical tricks and present an illustrative case of premature physeal arrest of the distal radius managed with a novel method for the Langenskiöld procedure, involving complete removal of the bar using a patient-specific guide in combination with an intramedullary endoscopy technique that facilitated direct observation.

To quantify the bone density and stress distribution patterns in long-standing cubitus varus and clarify the effects of the deformity on bone density.We created three-dimensional computed tomography (CT) elbow models from 21 patients with long-standing cubitus varus deformities without advanced osteoarthritis (OA) and assessed the deformity by superimposing the affected humerus onto a mirror-image of the contralateral normal. Elbows were divided into 13 regions before measuring the bone density of each region and comparing the percentage of high-density volume (%HDV) between affected and normal sides. We constructed finite element models and quantitatively analyzed stress distribution.Average degrees of deformities were 20.1° of varus, 6.4° of extension, and 12.7° of internal rotation. The medial side of the affected humerus and ulna, Anteromedial trochlea (P 0.001), Medial coronoid (P = 0.004), and Medial olecranon (P = 0.049) had significantly higher %HDVs than their normal counterparts. Conversely, %HDVs on the affected lateral side, Capitellum (P 0.001), Anterolateral trochlea (P = 0.010), Posterolateral trochlea (P 0.001), Lateral coronoid (P = 0.007), and Lateral olecranon (P 0.001) were significantly lower than the normal side. The affected radial head %HDVs at Anterolateral and Posteromedial quadrants were high (P = 0.007) and low (P = 0.007), respectively. The bone density distribution coincided with stress distribution patterns revealed by finite element analysis (FEA), except in the lateral region influenced by forearm rotation.Repetitive stress on the medial elbow may alter bone density distribution patterns, probably presenting from early stage of OA.

This paper shows vibration characteristics of a sliding bearings. Especially, we study self-excited vibration (Oil whirl) of the sliding bearings. We tried three analysis methods, which are trajectory of shaft vibration and tracking analysis, and particle number of wear debris in lubricant generated by direct contact between a shaft and outer race of the sliding bearing. In a sliding bearing, an oil whirl, which is a characteristic self-oscillation, occurs at a rotation speed less than twice the critical speed of the experiment system. In addition, since the vibration of the foundation affects the vibration of the slide bearing when installed on a base with low rigidity, it is necessary to install it on the one with high rigidity. It seems that the bearing inner ring and the outer ring did not contact in the runout due to the natural frequency of the experiment system. The oil whirl contacted and the increase of wear debris in lubricant generated by the direct contact was confirmed.

Background Corrective osteotomy of malunited intra-articular distal radius fracture is challenging. In this study, we investigated the results in patients with malunited intra-articular distal radius fracture who underwent intra-articular corrective osteotomy through an extra-articular approach using three-dimensional (3-D) computer simulation and a patient-matched instrument (PMI). Methods We retrospectively studied five consecutive patients with symptomatic malunited intra-articular distal radius fracture who underwent corrective osteotomy using a PMI. The maximal step-off on computed tomography and the deformity angle on plain radiographs were evaluated. The clinical examination parameters included range of motion (ROM), grip strength, pain according to visual analog scale (VAS), and Patient-Rated Wrist Evaluation (PRWE) score. Results The maximal step-off was significantly reduced from 4.9 ± 1.8 to 1.0 ± 0.2 mm (p = 0.008). The absolute differences between the affected side and the normal contralateral side in radial inclination were significantly reduced from 5.4° ± 3.4°–1.2° ± 1.1° (p = 0.043). These differences were not significantly reduced postoperatively in the volar tilt and ulnar variance. VAS was significantly reduced from 4.1 ± 1.6 to 0.9 ± 0.7 cm (p = 0.006). The PRWE score significantly improved from 41.6 ± 22.0 to 15.7 ± 19.5 (p = 0.043). Grip strength was significantly increased from 54.0% ± 14.8%–85.8% ± 18.8% (p = 0.003). The preoperative and postoperative total arc of the wrist and forearm ROM were not significantly different. Conclusions Intra-articular corrective osteotomy using PMI could be one of the reliable treatment options for intra-articular malunion. PMI has exceptionally high precision performance, and it is also anticipated to yield superior surgical results.

Introduction: Osteoid osteoma (OO) is a benign but painful tumour that arises from osteoblasts. Spinal lesions account for 20% of OOs. Surgical excision of spinal OO has been the standard treatment when conservative therapy is not effective. However, excisional surgery can lead to spinal instability and sometimes necessitates stabilization with spinal instrumentation. Radiofrequency ablation (RFA) is an attractive option for treating spinal OO, but thermal damage to neural tissues limits its application when the OO is located adjacent to neural tissues. Case presentation: We report novel 2 cases using navigation-guided RFA for OO in the lumbar spine with a continuous cooling system for preventing neural damage. During the 5 min ablation at 90 °C, the temperature at the nerve roots adjacent to the OO was maintained at

Renocolic fistula is rare. Renal cyst infection is a serious complication in patients with autosomal dominant polycystic kidney disease (ADPKD). We present a case of refractory renal cyst infection due to renocolic fistula in a patient with ADPKD. A 65-year-old man with ADPKD on hemodialysis visited our hospital with complaints of fever and left abdominal pain. We diagnosed renal cyst infection with abdominal computed tomography scans. After hospitalization, gas shadow was observed in the left renal cyst. Percutaneous puncture of the cyst was performed. Because contrast medium into the left renal cyst through nephrostomy was flowing into the descending colon, renocolic fistula was diagnosed. The patient underwent nephrectomy combined with partial descending colonic resection and splenectomy, but he died. Renocolic fistula is probably hidden in some refractory renal cyst infection cases. This case report aims to create awareness of renocolic fistula, so that early diagnosis and intervention can salvage such patients.

Nearly 60% tomato seedlings are grafted in Japan. However, almost all of them are being done manually, which is labor-intensive, tedious and expensive. In order to develop a fully-automatic grafting robot for tomato seedlings, the machine vision system for sorting grafting seedling and inspecting grafted seedlings was studied. In this paper, the images acquired with selected devices and different lighting (Front lighting, Backlight, and Front lighting & Backlight) were processed based on the theory of machine vision. The experimental result shows that a blue backlight without a filter device is the best to inspect the seedlings. The images of inspecting seedlings were captured using the selected machine vision system. The algorithm developed using the machine vision system was found functional in inspecting the grafted seedlings; it can even detect a very small gap (≤0.2 mm) between the scion and rootstock after they have been grafted.

Background Computer-assisted corrective osteotomy using a mirror image of the normal contralateral shape as reference is increasingly used. Instead, we propose to use the shape predicted by statistical learning to deal with cases demonstrating bilateral abnormality, such as bilateral trauma, congenital disease, and metabolic disease. Methods Computed tomography (CT) scans of 100 normal forearms were used in this study. The whole bone shape was predicted from its partial shape based on statistical learning of the other 99 bones. Accuracy was evaluated by average symmetric surface distance (ASD), and translational and rotational errors. Results ASDs for predicted shapes were 0.71–1.03 mm. Mean absolute translational and rotational errors were 0.48–1.76 mm and 0.99–6.08°, respectively. Conclusion Normal bone shape was predicted with an acceptable accuracy from its partial shape using statistical learning. Predicted shape can be an alternative to a mirror image, which may enable reduced radiation exposure and examination costs.

Purpose Certain distal ulna fractures may contribute to distal radioulnar joint (DRUJ) instability. We hypothesized that residual distal ulna translation could affect DRUJ stability by slackening the distal interosseous membrane (DIOM). We aimed to test this hypothesis in a cadaver model. Methods We created an ulnar translated distal ulna fracture model in 6 cadavers. Dorsal and palmar displacements of the ulna relative to the radius were measured and DRUJ instability was staged under the following conditions: (1) 0-, 2-, and 4-mm ulnar translation of the distal ulna with an intact triangular fibrocartilage complex (TFCC) and DIOM; (2) 0-, 2-, and 4-mm translations with TFCC divided and an intact DIOM; and (3) a 0-mm translation with TFCC and DIOM divided. Results With an intact TFCC, dorsal and palmar displacements were not increased with any amount of distal ulna translation. After TFCC division with 0-mm translation, dorsal displacement increased significantly with DRUJ dislocation, whereas palmar displacement increased to a lesser extent with DRUJ subluxation. Palmar displacement gradually increased as the translation increased, and with 4-mm translation the ulnar head displaced to a perched position off the sigmoid notch. With TFCC and DIOM division, displacements increased markedly with DRUJ dislocation both dorsally and palmarly. Conclusions Dorsal dislocation occurred when the TFCC was divided regardless of the amount of distal ulna translation. Palmar subluxation occurred when the TFCC alone was divided. Palmar displacement to a perched position occurred because of slackening of the DIOM as a result of translation of the distal ulna. Bidirectional DRUJ instability with dorsal dislocation and palmar displacement to a perched position occurred when the TFCC was divided and the distal ulna was ulnarly translated. Clinical relevance Bidirectional DRUJ instability might occur when distal ulna translation deformity is associated with TFCC injury because the DIOM loses its function as a secondary stabilizer.

Summary:. Cutaneous myxoma is a rare neoplasm typically occurring as an asymptomatic nodule on the head, neck, and chest regions of adults. However, multiple cutaneous myxoma of the subungual space is even rarer. Here, we report a case of multiple cutaneous myxoma of the subungual space in which the tumor was removed by creating a mid-radial incision while preserving the nail matrix. The excisional biopsy samples were dispatched for histopathological examination and confirmed to be cutaneous myxoma. To the best of our knowledge, this is the first report on multiple cutaneous myxoma of the subungual space.

During elbow procedures, reconstruction of the joint (including the articular cartilage) is important in order to restore elbow function; however, the regional distribution of elbow cartilage is not completely understood. The purpose of the present study was to investigate the 3-dimensional (3-D) distribution patterns of cartilage thickness of elbow bones (including the distal part of the humerus, proximal part of the ulna, and radial head) in order to elucidate the morphological relationship among them. Methods Two 3-D surface models were created with use of a laser scanner: (1) a cartilage-bone model based on 20 elderly cadaveric elbows exhibiting normal cartilaginous conditions and (2) a bone model that was created after dissolving the cartilage. The 2 models were superimposed, and cartilage thickness was measured as the interval distance on the articular surface. Measurements were made at categorized anatomical points of the individual bones, and 3-D distributions on the entire articular surface were analyzed. The spatial relationship among individual bones was also assessed. Results In the distal part of the humerus, the cartilage was thickest in the intermediate region between the capitellum and the trochlea (mean [and standard deviation], 1.27 ± 0.17 mm); in the proximal part of the ulna, it was thickest at the anterolateral edge of the coronoid (2.20 ± 0.39 mm) and the anteroproximal edge of the proximal sigmoid notch (2.49 ± 0.55 mm); and in the radial head, it was thickest at the articular zone on the rim circumference within the dish (1.10 ± 0.17 mm) and on the proximal circumference around the side (1.02 ± 0.17 mm) (p < 0.001 for all). These thicker cartilage regions gathered on the joint center, facing each other. Conclusions The present study demonstrated regional variations in elbow cartilage thickness. The combined findings in individual bones showed "cartilage gathering" at the center of the elbow joint, which we believe to be a novel anatomical finding. Clinical Relevance An enhanced understanding of elbow cartilage geometry will provide additional insights into elbow procedures in elderly individuals, such as hemiarthroplasties, in which anatomical contours could help to restore normal joint function and improve postoperative outcomes.

The aim of this study was to clarify the mechanisms of rotational restriction in malunited forearm diaphyseal fractures.We retrospectively analyzed the cases of 18 patients with malunited forearm diaphyseal fractures and rotational restriction. All patients underwent bilateral computed tomography (CT) of the forearm in maximum supination, pronation, and neutral positions. From these images, we created 3-dimensional (3-D) bone surface models. We quantified the 3-D deformities, identified instances of osseous impingement between the radius and the ulna during forearm rotation, calculated the path length of the central band (CB) of the interosseous membrane, and measured forearm range of motion.Sixteen patients had extension deformity of the radius (the RE group) and 2 had flexion deformity (the RF group). In the RE group, extension deformity of the radius and valgus deformity of the ulna had significant negative correlation with pronation range of motion (R = -0.50, p = 0.046) and supination range of motion (R = -0.63, p = 0.027), respectively. Osseous impingement was mainly observed during pronation (15 of 16 patients). The CB path with the largest changes in length originated from the distal CB attachment area of the radius and ran toward the proximal area of the ulna (the transverse CB). The transverse CB significantly increased in length in supination compared with that in pronation (p0.001). Therefore, tightness of the transverse CB appeared to cause supination restriction in the RE group. In the RF group, osseous impingement caused supination restriction. The greatest increases in the transverse CB length were observed in pronation in the RF group, which appeared to cause pronation restriction.In the RE group, pronation restriction was associated with osseous impingement that was due to extension deformity of the radius, and supination restriction was associated with CB tightness that was due to valgus deformity of the ulna. In the RF group, our results suggested that pronation restriction was caused by CB tightness and that supination restriction was caused by osseous impingement.Three-dimensional corrective osteotomy for extension deformity of the radius in malunited forearm diaphyseal fractures would improve rotational restriction by relieving osseous impingement during pronation and CB tightness during supination.

The maintenance of model predictive control (MPC) systems is one of the major problems identified by industrial process control engineers. Since performance deterioration is usually caused by changes in process characteristics, effective re-modeling is the key to success. Obviously, not all sub-models have to be reconstructed; thus, it is crucial to identify sub-models that have significant model-plant mismatch. In the present work, a novel method is proposed for significant model-plant mismatch detection from routine closed-loop operation data on the basis of the statistical test concept. The effectiveness of the proposed method is demonstrated through case studies. The results clearly show not only that the proposed method can detect sub-models that have significant mismatch but it is superior to the other methods based on multivariate analysis.

Highlights • Oxidative stress in the arthritis joint is involved in generating mediators for inflammation. • Oxidative stress-induced expression of Cox-2 was mediated by MAPKs and NF-κB. • ROS-induced MAPKs and NF-κB were attenuated by inhibition of MAPKKK TAK1. • Inhibition of TAK1 activity resulted in reduced expression of Cox-2 and PGE2. • ROS-induced TAK1 activation and Cox-2 expression was inhibited by antioxidants N-acetyl cysteamine and hyaluronic acid., Oxidative stress within the arthritis joint has been indicated to be involved in generating mediators for tissue degeneration and inflammation. COX-2 is a mediator in inflammatory action, pain and some catabolic reactions in inflamed tissues. Here, we demonstrated a direct relationship between oxidative stress and Cox-2 expression in the bovine synovial fibroblasts. Furthermore, we elucidated a novel mechanism, in which oxidative stress induced phosphorylation of MAPKs and NF-κB through TAK1 activation and resulted in increased Cox-2 and prostaglandin E2 expression. Finally, we demonstrated that ROS-induced Cox-2 expression was inhibited by supplementation of an antioxidant such as N-acetyl cysteamine and hyaluronic acid in vitro and in vivo. From these results, we conclude that oxidative stress is an important factor for generation of Cox-2 in synovial fibroblasts and thus its neutralization may be an effective strategy in palliative therapy for chronic joint diseases.

We examined 718 epistaxis cases who visited or were hospitalized in the Tokyo Women's Medical University Daini Hospital.1) Many of the epistaxis cases were men, and a relation to arteriosclerosis was strongly suggested.2) A relation to changes in the diastolic pressure was strongly suggested by the number of epistaxis patients with hypertension.3) The bleeding area, excluding the Kiesselbach area, increased with aging.

Data were collected and analyzed from 348 patients who presented with untreated nasal allergies at the Tokyo Women's Medical College Daini Hospital and the following results were obtaind:1) The most common symptom was nasal obstruction in patients having perennial nasal allergies, and nasal discharge in patients with seasonal allergies.2) Testing for HD mites showed a higher positivity rate in patients with perennial allergies or allergies in the autumn and winter.3) Testing for Japanese cedar pollen showed a higher positivity rate in patients showing allergic symptoms in the spring, spring and summer, or spring and autumn.4) The BAST scores correctly determined whether allergy was seasonal or non-seasonal in 77.1 of patients.5) However, RAST scores could not distinguish winter allergies from any other types of seasonal allergies.6) Despite this, RAST scores determined the type of seasonal allergy correctly in 56.7% of patients after excluding those with winter allergies.7) HD mite, Japanese cedar, and hogweed antigens are useful for determining the type of seasonal allergy.8) Testing with allergens characteristic of summer and winter, but not spring and autumn is indispensable for determining the type of seasonal allergy.

Research was conducted to acquire knowledge of the ultraviolet and visible spectrums from 300 -800 nm of some common varieties of Japanese citrus, to investigate the best wave-lengths for fluorescence excitation and the resulting fluorescence wave-lengths and to provide a scientific background for the best quality fluorescent imaging technique for detecting surface defects of citrus. A Hitachi U-4000 PC-based microprocessor controlled spectrophotometer was used to measure the absorption spectrum and a Hitachi F-4500 spectrophotometer was used for the fluorescence and excitation spectrums. We analyzed the spectrums and the selected varieties of citrus were categorized into four groups of known fluorescence level, namely strong, medium, weak and no fluorescence.The level of fluorescence of each variety was also examined by using machine vision system. We found that around 340-380 nm LEDs or UV lamps are appropriate as lighting devices for acquiring the best quality fluorescent image of the citrus varieties to examine their fluorescence intensity. Therefore an image acquisition device was constructed with three different lighting panels with UV LED at peak 365 nm, Blacklight blue lamps (BLB) peak at 350 nm and UV-B lamps at peak 306 nm. The results from fluorescent images also revealed that the findings of the measured spectrums worked properly and can be used for practical applications such as for detecting rotten, injured or damaged parts of a wide variety of citrus.

Applications of insulated metal substrates (IMS) for high-density and high-power mounting are rapidly extending with the miniaturization of electronic devices. The recent progress in insulation reliability and thermal conductivity of IMS has been making applications as substitutes for alumina DBC substrates possible. However, customers and/or potential customers are not satisfied with performance of conventional IMS for high-powered applications and an improved IMS equipping higher thermal conductive insulating layers is desired to widen the applications for high-powered devices. The influence of materials of which the IMS consists, i.e. base metals, insulating layers and copper conductors, were analyzed theoretically using FEM, and experimental data measured with a temperature distribution measuring instrument "Thermoviewer" were compared with the analytical data. The influence of the materials have been clarified through the analysis. In addition, an alumina DBC substrate and "GPS", which is a special IMS developed newly for large-current and high-powered devices, were also investigated comparatively by simulation and experiments.

Bare chips are used in multichip modules for high packaging density and high processing speed devices. Obtaining known good dies (KGD) is a significant problem in achieving high MCM yields. Therefore, a probing technique for bare chips with high reliability is a matter of importance. In order to achieve good contact properties at a low probing pressure, a new membrane probe with pyramidal tips is developed for bare chip testing. By using anisotropic etching of silicon, quadrangular pyramidal pits are formed as the cast of probe tips. By nickel plating these pits, nickel pyramidal tips with copper wiring are formed on the polyimide film. The silicon wafer cast is then dissolved completely by etching. This membrane probe is then attached to a socket. This pyramidal probe is vertically inserted into an aluminum pad. Contact resistance remained stable at 0.1-0.2 /spl Omega/.

A fabrication process for Cu-polyimide thin film multilayer circuit has been developed for advanced multichip module. The multilayer circuit realizes a high wiring density circuit by applying Cu studs which are deposited by electroplating using the guide patterns made of thick positive photoresist, photosensitive polyimide for insulating layers which has low reactivity against Cu, and a polishing process for planarizing dielectric layers. This paper reports on the structure of the circuit and on the thin film process technology.

A 15-year-old boy presented with a cervical ventral epithelial cyst manifesting as intractable cervical pain. Neurological examination revealed weakness of his left grasp and increased deep tendon reflexes. The anterior approach was selected because the lesion was located directly ventral to the spinal cord. He underwent C4-5 anterior corpectomy and subtotal resection of the cyst wall. He made a good recovery without additional deficits. Most previously reported cases have been treated using the posterior approach despite the ventral location of the lesion. The anterior approach offers a safer and more effective means of treating such lesions because it allows direct access to the lesion without manipulation of the spinal cord.

It has long been known that the incidence and course of otitis media are influenced by the const- itution of the patient. In order to contribute to further clarification of the above situation in terms of the antigen antibody factor, 22 infants with otitis media purulenta chronica were examined for allergy, and the following knowledge has ther- eby been obtained. 1) Otitis media purulenta chronica of infancy may be divided into the suppurative type (simple type) and allergic type; and the latter may be subdivided into the bacterial allergic type, food allergic type, and allergic type due to an unident- ified antigen. 2) In infancy, the food allergy type is of higher incidence than the bacterial allergy type, The incidence of a mixture of these types is very low. 3) Many of the drum membranes have large perforation in the allergic type and small perfora- tion in the suppurative type. 4) The otorrhea in the allergic type is mostly mucopurulent ; in the suppurative type, mostly purulent. Bacteriologically, the otorrhea in the allergic type is mostly of mixed infection; in the suppurative type, mostly of simple infection. 5) Many of the allergic cases have allergic diseases in their past history and/or family histo- ry. Their otitis media often takes long to heal, and the disease is often recurrent.

The polarized reflectivity spectra are measured on the oriented films of (SN) x by the synchrotron radiation. From the Kramers-Kronig analysis of the spectra, we demonstrate quasi-one-dimensional behaviours of electronic states around the Fermi level. Observed spectrum for E // b is in a good agreement with the theoretical curve calculated by Grant et al. on the OPW band structures, but there is a considerable discrepancy between the experimental and theoretical curves for E ⊥ b .

In this paper are described improvements of the level indicator fixed in a cryostat by using combination of Ta short coils and a Ta long solenoid wound together with insulated heater wire. The short coil indicates accurately whether liquid surface is above or below it even when liquid He is being transferred. Its response time is a few tenths of a second. The long solenoid indicates liquid level continuously and with much less response time, but its indication is always about 5 mm more than actual depth in static condition and 10∼20 mm more during liquid transfer. Total power consumption in the probe is less than 20 milliwatts.

Periosteal chondromas are rare benign cartilaginous tumors that arise adjacent to the cortex beneath the periosteum. These lesions are usually slow-growing and rarely exceed 3 cm in the greatest dimension. Here, we describe a 17-year-old boy who had a giant periosteal chondroma of the right distal femur, which was treated with intralesional resection and intensive curettage. In addition, we report a novel application of a bioresorbable plate in the management of the large bone defect after resection of a benign bone tumor.