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1. Comparison of effectiveness and safety of imipenem/clavulanate- versus meropenem/clavulanate-containing regimens in the treatment of MDR- and XDR-TB

Author

Fabrizio Palmieri, Aurora Jazmín Roby Arias, Alena Skrahina, Gina Gualano, Giovanni Sotgiu, Dante Vargas Vasquez, Eduardo Henrique Bonini, Marina Tadolini, Gerard de Vries, Saverio De Lorenzo, Jose A. Caminero, Pietro Viggiani, Marcos Abdo Arbex, Valentina Alarcon Guizado, Apostolos Papavasileiou, Lorena Collahuazo López, Simon Tiberi, Simone Dore, Andrea Piana, Anna Scardigli, Vera Auchynka, Marie-Christine Payen, Antonio Spanevello, Felix Antonio Chong Marin, Alena Aleksa, Edith Alarcon Arrascue, Janina Artsukevich, Heinke Kunst, Alberto Matteelli, Onno W. Akkerman, Giorgia Sulis, Alimuddin Zumla, Giovanni Battista Migliori, Lia D'Ambrosio, Ivan Solovic, Jan-Willem C. Alffenaar, Mina Gaga, Charalampos Moschos, Veronica White, Rosella Centis, Tiberi, Simon, Sotgiu, Giovanni, D'Ambrosio, Lia, Centis, Rosella, Arbex, Marcos Abdo, Arrascue, Edith Alarcon, Alffenaar, Jan Willem, Caminero, Jose A., Gaga, Mina, Gualano, Gina, Skrahina, Alena, Solovic, Ivan, Sulis, Giorgia, Tadolini, Marina, Guizado, Valentina Alarcon, De Lorenzo, Saverio, Arias, Aurora Jazmín Roby, Scardigli, Anna, Akkerman, Onno W., Aleksa, Alena, Artsukevich, Janina, Auchynka, Vera, Bonini, Eduardo Henrique, Marín, Félix Antonio Chong, López, Lorena Collahuazo, De Vries, Gerard, Dore, Simone, Kunst, Heinke, Matteelli, Alberto, Moschos, Charalampo, Palmieri, Fabrizio, Papavasileiou, Apostolo, Payen, Marie-Christine, Piana, Andrea, Spanevello, Antonio, Vasquez, Dante Varga, Viggiani, Pietro, White, Veronica, Zumla, Alimuddin, Migliori, Giovanni Battista, and Microbes in Health and Disease (MHD)

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, Imipenem, medicine.drug_class, DELAMANID, Antibiotics, Drug resistance, MULTIDRUG-RESISTANT, Meropenem, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, COMPASSIONATE USE, polycyclic compounds, Culture conversion, MEROPENEM-CLAVULANATE, Medicine, 030212 general & internal medicine, business.industry, Medicine (all), DRUG-RESISTANT TUBERCULOSIS, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, EFFICACY, BEDAQUILINE, Multiple drug resistance, 030228 respiratory system, Tolerability, TOLERABILITY, MYCOBACTERIUM-TUBERCULOSIS, Delamanid, business, LINEZOLID SAFETY, medicine.drug
Abstract

No large study to date has ever evaluated the effectiveness, safety and tolerability of imipenem/clavulanateversusmeropenem/clavulanate to treat multidrug- and extensively drug-resistant tuberculosis (MDR- and XDR-TB). The aim of this observational study was to compare the therapeutic contribution of imipenem/clavulanateversusmeropenem/clavulanate added to background regimens to treat MDR- and XDR-TB cases.84 patients treated with imipenem/clavulanate-containing regimens showed a similar median number of antibiotic resistances (8versus8) but more fluoroquinolone resistance (79.0%versus48.9%, pversus49.0%, p=0.01) in comparison with 96 patients exposed to meropenem/clavulanate-containing regimens. Patients were treated with imipenem/clavulanate- and meropenem/clavulanate-containing regimens for a median (interquartile range) of 187 (60–428)versus85 (49–156) days, respectively.Statistically significant differences were observed on sputum smear and culture conversion rates (79.7%versus94.8%, p=0.02 and 71.9%versus94.8%, pversus77.5%, p=0.03). Adverse events to imipenem/clavulanate and meropenem/clavulanate were reported in 5.4% and 6.5% of cases only.Our study suggests that meropenem/clavulanate is more effective than imipenem/clavulanate in treating MDR/XDR-TB patients.

Published
2016

2. Effectiveness and safety of meropenem/ clavulanate-containing regimens in the treatment of MDR- and XDR-TB

Author

Fabrizio Palmieri, Jose A. Caminero, Marcos Abdo Arbex, Onno W. Akkerman, Pietro Viggiani, Eduardo Henrique Bonini, Giorgia Sulis, Gina Gualano, Charalampos Moschos, Veronica White, Simone Dore, Alimuddin Zumla, Heinke Kunst, Aurora Jazmín Roby Arias, Alena Skrahina, Giovanni Battista Migliori, Lorena Collahuazo López, Lia D'Ambrosio, Gerard de Vries, Alberto Matteelli, Rosella Centis, Valentina Alarcon Guizado, Anna Scardigli, Jan-Willem C. Alffenaar, Mina Gaga, Felix Antonio Chong Marin, Antonio Spanevello, Ivan Solovic, Marina Tadolini, Marie-Christine Payen, Edith Alarcon Arrascue, Saverio De Lorenzo, Apostolos Papavasileiou, Vera Avchinko, Giovanni Sotgiu, Simon Tiberi, Dante Vargas Vasquez, Alena Aleska, Tiberi, Simon, Payen, Marie Christine, Sotgiu, Giovanni, D'Ambrosio, Lia, Guizado, Valentina Alarcon, Alffenaar, Jan Willem, Arbex, Marcos Abdo, Caminero, Jose A., Centis, Rosella, De Lorenzo, Saverio, Gaga, Mina, Gualano, Gina, Arias, Aurora Jazmín Roby, Scardigli, Anna, Skrahina, Alena, Solovic, Ivan, Sulis, Giorgia, Tadolini, Marina, Akkerman, Onno W., Arrascue, Edith Alarcon, Aleska, Alena, Avchinko, Vera, Bonini, Eduardo Henrique, Marín, Félix Antonio Chong, López, Lorena Collahuazo, De Vries, Gerard, Dore, Simone, Kunst, Heinke, Matteelli, Alberto, Moschos, Charalampo, Palmieri, Fabrizio, Papavasileiou, Apostolo, Spanevello, Antonio, Vasquez, Dante Varga, Viggiani, Pietro, White, Veronica, Zumla, Alimuddin, Migliori, Giovanni Battista, and Microbes in Health and Disease (MHD)

Subjects
Adult, Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, DELAMANID, Drug resistance, MULTIDRUG-RESISTANT, Meropenem, 03 medical and health sciences, Antitubercular Agent, 0302 clinical medicine, Interquartile range, Retrospective Studie, Internal medicine, COMPASSIONATE USE, Tuberculosis, Multidrug-Resistant, medicine, Culture conversion, MEROPENEM-CLAVULANATE, 030212 general & internal medicine, Thienamycin, Adverse effect, METAANALYSIS, Clavulanic Acid, business.industry, Medicine (all), DRUG-RESISTANT TUBERCULOSIS, EFFICACY, BEDAQUILINE, Surgery, Multiple drug resistance, Regimen, Treatment Outcome, 030228 respiratory system, Tolerability, Extensively Drug-Resistant Tuberculosi, TOLERABILITY, Female, business, LINEZOLID SAFETY, medicine.drug, Human
Abstract

No large study has ever evaluated the efficacy, safety and tolerability of meropenem/clavulanate to treat multidrug- and extensively drug-resistant tuberculosis (MDR- and XDR-TB). The aim of this observational study was to evaluate the therapeutic contribution, effectiveness, safety and tolerability profile of meropenem/clavulanate added to a background regimen when treating MDR- and XDR-TB cases.Patients treated with a meropenem/clavulanate-containing regimen (n=96) showed a greater drug resistance profile than those exposed to a meropenem/clavulanate-sparing regimen (n=168): in the former group XDR-TB was more frequent (49% versus 6.0%, pversus 5 (4–6)). Patients were treated with a meropenem/clavulanate-containing regimen for a median (IQR) of 85 (49–156) days.No statistically significant differences were observed in the overall MDR-TB cohort and in the subgroups with and without the XDR-TB patients; in particular, sputum smear and culture conversion rates were similar in XDR-TB patients exposed to meropenem/clavulanate-containing regimens (88.0% versus 100.0%, p=1.00 and 88.0% versus 100.0%, p=1.00, respectively). Only six cases reported adverse events attributable to meropenem/clavulanate (four of them then restarting treatment).The nondifferent outcomes and bacteriological conversion rate observed in cases who were more severe than controls might imply that meropenem/clavulanate could be active in treating MDR- and XDR-TB cases.

Published
2016

3. Effectiveness and Safety of Imipenem-Clavulanate Added to an Optimized Background Regimen (OBR) Versus OBR Control Regimens in the Treatment of Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis

Author

Valentina Alarcon Guizado, Giovanni Sotgiu, Alberto Matteelli, Veronica White, Eduardo Henrique Bonini, Marina Tadolini, Mina Gaga, Saverio De Lorenzo, Fabrizio Palmieri, Lorena Collahuazo López, Aurora Jazmín Roby Arias, Rosella Centis, Ivan Solovic, Anna Scardigli, Edith Alarcon Arrascue, Alena Skrahina, Antonio Spanevello, Marie-Christine Payen, Heinke Kunst, Janina Artsukevich, Vera Avchinko, Apostolos Papavasileiou, Giorgia Sulis, Gerard de Vries, Pietro Viggiani, Charalampos Moschos, Lia D'Ambrosio, Onno W. Akkerman, Jan-Willem C. Alffenaar, Simone Dore, Dante Vargas Vasquez, Simon Tiberi, Alimuddin Zumla, Giovanni Battista Migliori, Andrea Piana, Alena Aleksa, Felix Antonio Chong Marin, Jose A. Caminero, Marcos Abdo Arbex, Gina Gualano, Microbes in Health and Disease (MHD), Tiberi, Simon, Sotgiu, Giovanni, D'Ambrosio, Lia, Centis, Rosella, Arbex, Marcos Abdo, Alarcon Arrascue, Edith, Alffenaar, Jan Willem, Caminero, Jose A., Gaga, Mina, Gualano, Gina, Skrahina, Alena, Solovic, Ivan, Sulis, Giorgia, Tadolini, Marina, Alarcon Guizado, Valentina, De Lorenzo, Saverio, Roby Arias, Aurora Jazmín, Scardigli, Anna, Akkerman, Onno W., Aleksa, Alena, Artsukevich, Janina, Avchinko, Vera, Bonini, Eduardo Henrique, Chong Marín, Felix Antonio, Collahuazo López, Lorena, De Vries, Gerard, Dore, Simone, Kunst, Heinke, Matteelli, Alberto, Moschos, Charalampo, Palmieri, Fabrizio, Papavasileiou, Apostolo, Payen, Marie Christine, Piana, Andrea, Spanevello, Antonio, Vargas Vasquez, Dante, Viggiani, Pietro, White, Veronica, Zumla, Alimuddin, and Migliori, Giovanni Battista

Subjects
Infectious Diseases, Microbiology (medical), Medicine (all), Extensively Drug-Resistant Tuberculosis, Treatment outcome, Antitubercular Agents, Microbiology, Antitubercular Agent, 03 medical and health sciences, 0302 clinical medicine, Humans, Medicine, 030212 general & internal medicine, Clavulanic Acid, METAANALYSIS, OUTCOMES, business.industry, Imipenem, Treatment Outcome, TB, 030228 respiratory system, Extensively Drug-Resistant Tuberculosi, Drug Therapy, Combination, business, Humanities, Human
Abstract

Simon Tiberi, Giovanni Sotgiu, Lia D’Ambrosio, Rosella Centis, Marcos Abdo Arbex, Edith Alarcon Arrascue, Jan Willem Alffenaar, Jose A. Caminero, Mina Gaga, Gina Gualano, Alena Skrahina, Ivan Solovic, Giorgia Sulis, Marina Tadolini, Valentina Alarcon Guizado, Saverio De Lorenzo, Aurora Jazmin Roby Arias, Anna Scardigli, Onno W. Akkerman, Alena Aleksa, Janina Artsukevich, Vera Avchinko, Eduardo Henrique Bonini, Felix Antonio Chong Marin, Lorena Collahuazo Lopez, Gerard de Vries, Simone Dore, Heinke Kunst, Alberto Matteelli, Charalampos Moschos, Fabrizio Palmieri, Apostolos Papavasileiou, Marie-Christine Payen, Andrea Piana, Antonio Spanevello, Dante Vargas Vasquez, Pietro Viggiani, Veronica White, Alimuddin Zumla and Giovanni Battista Migliori

Published
2016

4. Faster for less: The new 'shorter' regimen for multidrug-resistant tuberculosis

Author

Mina Gaga, Rosella Centis, Lia D'Ambrosio, Jan-Willem C. Alffenaar, Giovanni Sotgiu, Aurora Jazmín Roby Arias, Jose A. Caminero, Marcos Abdo Arbex, Alena Skrahina, Valentina Alarcon Guizado, Simon Tiberi, Simone Dore, Alena Aleksa, Marie-Christine Payen, Ivan Solovic, Heinke Kunst, Alimuddin Zumla, Giovanni Battista Migliori, Marina Tadolini, Gina Gualano, Giorgia Sulis, Sotgiu, Giovanni, Tiberi, Simon, D'Ambrosio, Lia, Centis, Rosella, Alffenaar, Jan Willem, Caminero, Jose A., Arbex, Marcos Abdo, Guizado, Valentina Alarcon, Aleksa, Alena, Dore, Simone, Gaga, Mina, Gualano, Gina, Kunst, Heinke, Payen, Marie Christine, Arias, Aurora Jazmín Roby, Skrahina, Alena, Solovic, Ivan, Sulis, Giorgia, Tadolini, Marina, Zumla, Alimuddin, Migliori, Giovanni Battista, and Microbes in Health and Disease (MHD)

Subjects
Drug, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Tuberculosis, media_common.quotation_subject, Antitubercular Agents, Pharmacology, Mycobacterium tuberculosis, 03 medical and health sciences, 0302 clinical medicine, MEROPENEM/CLAVULANATE-CONTAINING REGIMENS, WORLD, Internal medicine, Tuberculosis, Multidrug-Resistant, medicine, Humans, DRUGS, 030212 general & internal medicine, XDR-TB, media_common, biology, business.industry, medicine.disease, biology.organism_classification, Multiple drug resistance, Regimen, 030228 respiratory system, SAFETY, business
Abstract

Evaluation of drug resistances is needed to identify candidates for the shorter regimen in MDR-TB hot spots http://ow.ly/wZV33022VXt

Published
2016

5. Tuberculosis elimination: theory and practice in Europe

Author

D'Ambrosio, L., Dara, M., Tadolini, M., Centis, R., Sotgiu, G., Van Der Werf, M. J., Gaga, M., Cirillo, D., Spanevello, Antonio, Raviglione, M., Blasi, F., Migliori, G. B., Hafizi, H., Wanlin, M., Oñate, W. A., Groenen, G., Janković, V. K., Šimunović, A., Wallenfels, J., Voniatis, C., Andersen, P. H., Viiklepp, P., Danilovits, M., Kummik, T., Ruutu, P., Comolet, T. M., Haas, W., Korr, G., Rüsch Gerdes, S., Bauer, T., Hauer, B., Brodhun, B., Papavenstsis, K., Papadima, S., Pusztai, Z., O'Donnell, J., Chemtob, D., Girardi, E., Mehmeti, R., Riekstina, V., Asciak, A. P., Arnesen, T. M., Augustynowicz Kopeć, E., Korzeniewska Kosela, M., Miskiewicz, P. M., Miecznikowska, D., Duarte, R., Correia, A. M., Diniz, A. M. S. C., Talevski, S., Zakoska, M., Popescu, G., Chiotan, D., Asic, . R. J., Solovic, I., Ivanuša, M., Košnik, M., Valín, E. R., Anchuela, O. T., Jonsson, J., Helbling, P., Zellweger, J. P., De Vries, G., Erkens, C., Anderson, L., Laurenson, I., European National Programme Representatives, D'Ambrosio, Lia, Dara, Masoud, Tadolini, Marina, Centis, Rosella, Sotgiu, Giovanni, Van Der Werf, Marieke J., Gaga, Mina, Cirillo, Daniela, Spanevello, Antonio, Raviglione, Mario, Blasi, Francesco, Migliori, Giovanni Battista, Hafizi, Hasan, Wanlin, Maryse, Oñate, Wouter Arrazolade, Groenen, Guido, Janković, Vera Katalinić, Šimunović, Aleksandar, Wallenfels, Jiri, Voniatis, Constantia, Andersen, Peter Henrik, Viiklepp, Piret, Danilovits, Manfred, Kummik, Tiina, Ruutu, Petri, Comolet, Thierry M., Haas, Walter, Korr, Gerit, Rüsch-Gerdes, Sabine, Bauer, Torsten, Hauer, Barbara, Brodhun, Bonita, Papavenstsis, Konstantinou, Papadima, Spala, Pusztai, Zsofia, O'Donnell, Joan, Chemtob, Daniel, Girardi, Enrico, Mehmeti, Rukije, Riekstina, Vija, Asciak, Analita Pace, Arnesen, Trude M., Augustynowicz-Kopeć, Ewa, Korzeniewska-Kosela, Maria, Miskiewicz, Paulina Marianna, Miecznikowska, Dominika, Duarte, Raquel, Correia, Ana Maria, Diniz, Antonio Manuel S.C., Talevski, Stefan, Zakoska, Maja, Popescu, Gilda, Chiotan, Domnica, Asic, Gordana Radosavl Jevic, Solovic, Ivan, Ivanuša, Marijan, Košnik, Mitja, Valín, Elena Rodríguez, Anchuela, Odorina Tello, Jonsson, Jerker, Helbling, Peter, Zellweger, Jean Pierre, De Vries, Gerard, Erkens, Connie, Anderson, Laura, and Laurenson, Ian

Subjects
Pulmonary and Respiratory Medicine, tuberculosis eradication, Tuberculosis, Tuberculosi, International Cooperation, Population, HIV Infections, World Health Organization, World health, Health services, Environmental health, Surveys and Questionnaires, medicine, Surveys and Questionnaire, Humans, HIV Infection, Disease Eradication, education, tuberculosis control, education.field_of_study, Infectious Disease Medicine, Group screening, business.industry, Incidence (epidemiology), Incidence, Monitoring and evaluation, medicine.disease, Drug Resistance, Multiple, Europe, Treatment Outcome, Preparedness, Communicable Disease Control, Practice Guidelines as Topic, Health Services Research, business, Human
Abstract

Although Europe identified the pathway to tuberculosis (TB) elimination in 1990, no information on programmes for country preparedness is available. A questionnaire investigating TB elimination activities was submitted to 38 national TB programme representatives of low TB incidence (

Published
2014

6. Pregnancy in patients with tuberculosis: a TBNET cross-sectional survey

Author

Lorenzo Guglielmetti, Ivan Solovic, Irina Salonka, Angels Orcau, Claudia M. Denkinger, Maurizio Ferrarese, Cordula Ehlers, Luis Anibarro, Andrii Dudnyk, Dragica Pesut, Marco Confalonieri, Graham H. Bothamley, Inge Muylle, Luigi Codecasa, Alena Skrahina, Bothamley, Graham H., Ehlers, Cordula, Salonka, Irina, Skrahina, Alena, Orcau, Angel, Codecasa, Luigi R., Ferrarese, Maurizio, Pesut, Dragica, Solovic, Ivan, Dudnyk, Andrii, Anibarro, Lui, Denkinger, Claudia, Guglielmetti, Lorenzo, Muylle, Inge, and Confalonieri, Marco

Subjects
0301 basic medicine, Delayed Diagnosis, Cross-sectional study, Prevalence, TBNET, 0302 clinical medicine, Pregnancy, Obstetrics and Gynaecology, Diagnosis, Pregnancy Complications, Infectious, Birth Rate, education.field_of_study, 030219 obstetrics & reproductive medicine, Obstetrics, Incidence (epidemiology), Incidence, Delayed Diagnosi, Infectious, Obstetrics and Gynecology, Pulmonary, Postpartum, Tuberculosis, Adult, Cross-Sectional Studies, Europe, Female, Humans, Tuberculosis, Pulmonary, United States, Diagnosi, Human, Research Article, United State, medicine.medical_specialty, Tuberculosi, Population, Reproductive medicine, 03 medical and health sciences, medicine, education, Cross-Sectional Studie, business.industry, medicine.disease, Pregnancy Complications, 030104 developmental biology, Pregnancy Complications, Infectiou, business, Postpartum period
Abstract

Background: Objectives: To determine whether the incidence of tuberculosis with pregnancy is more common than would be expected from the crude birth rate; to see whether there is significant delay in the diagnosis of tuberculosis during pregnancy. Method: Design: A cross-sectional survey. Setting: 13 tuberculosis clinics within different European countries and the USA. Population/sample: All patients with tuberculosis seen at these clinics for a period > 1 year. Instrument: Questionnaire survey based on continuous data collection. Main outcome measures: number and proportion of women with tuberculosis who were pregnant; timing of diagnosis in relation to pregnancy, including those who were pregnant or delivered in the 3 months prior to the diagnosis of TB and those who developed TB within 3 months after delivery. Results: Pregnancy occurred in 224 (1.5 %) of 15,217 TB patients and followed the expected rate predicted from the crude birth rate for the clinic populations. TB was diagnosed more commonly in the 3 months after delivery (n = 103) than during pregnancy (n = 68; chi(2) = 25.1, P < 0.001). Conclusions: TB is diagnosed more frequently after delivery, despite variations in local TB incidence and healthcare systems.

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