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The purpose of this study was to evaluate the association of hyperuricemia and metabolic syndrome (MS) in Thai postmenopausal women.A total of 740 consecutive Thai postmenopausal women were reviewed who were not receiving uric acid or lipid-lowering agents at the Menopause Clinic, Faculty of Medicine Siriraj Hospital, Bangkok, from January 2004 to January 2016. Hyperuricemia was defined as serum uric acid level5.7 mg/dl. The revised National Cholesterol Education Program (rNCEP) 2004 criteria were used for diagnosis of MS. The association of hyperuricemia and MS was evaluated.Among 740 women, 162 patients (21.9%) were hyperuricemic. The prevalence of MS was 43.8% and 21.8% for hyperuricemic and normo-uricemic women, respectively. Hyperuricemia was significantly associated with increased risk of MS (odds ratio 2.79, 95% confidence interval 1.93-4.0; p 0.001).There was a significant association of hyperuricemia and MS in Thai postmenopausal women. These two co-morbidities were common after menopause. When hyperuricemia is diagnosed, MS should be screened, prevented or treated to decrease cardiovascular disease in the future.