Masters athletes (MAs) have been referred to as models of successful ageing . Shephard and colleagues were one of the first to investigate MAs’ health, with the premise being that regular physical activity/exercise conferred substantial health benefits on middle- to older-aged adults. Regarding cardiorespiratory fitness, it is well documented that a higher aerobic fitness is related to better longevity, reduced cardiovascular disease morbidity, and all-cause mortality in men and women.. The prevailing view is that MAs who are “fitter” are less prone to develop well-established cardiometabolic risk factors (i.e., non-optimal lipids, hypertension, blood glucose, C-reactive protein) than their sedentary counterparts. Yet, it has been proposed that MAs are not immune to developing risk factors, which may subsequently develop into chronic diseases. Thus, this chapter outlines whether there is a risk associated with exercise in MAs, and what the health benefits of being an MA are.