1. New-Onset Cancer in the HF Population: Epidemiology, Pathophysiology, and Clinical Management
- Author
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Giovanni D'Angelo, Giovanni Perrotta, Flora Pirozzi, Martina Iengo, Francesca Paudice, Alessandra Cuomo, Francesco Fiore, Antonio Carannante, Valentina Mercurio, Carlo G. Tocchetti, Umberto Attanasio, Cuomo, A., Paudice, F., D'Angelo, G., Perrotta, G., Carannante, A., Attanasio, U., Iengo, M., Fiore, F., Tocchetti, C. G., Mercurio, V., and Pirozzi, F.
- Subjects
medicine.medical_specialty ,Epidemiology ,Physiopathology ,Population ,Cancer and heart failure risk factor ,030204 cardiovascular system & hematology ,Bioinformatics ,medicine.disease_cause ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Neoplasms ,Physiology (medical) ,Humans ,Medicine ,Neoplastic transformation ,education ,Cancer ,Heart Failure ,education.field_of_study ,business.industry ,Translational Research in Heart Failure (E. Bertero, Section Editor) ,Vascular surgery ,Prognosis ,medicine.disease ,Cardiotoxicity ,Pathophysiology ,Cardio-oncology ,030220 oncology & carcinogenesis ,Heart failure ,Emergency Medicine ,Cardiology and Cardiovascular Medicine ,business ,Carcinogenesis ,Cancer and heart failure risk factors - Abstract
Purpose of ReviewOncological treatments are known to induce cardiac toxicity, but the impact of new-onset cancer in patients with pre-existing HF remains unknown. This review focuses on the epidemiology, pathophysiological mechanisms, and clinical implications of HF patients who develop malignancies.Recent FindingsNovel findings suggest that HF and cancer, beside common risk factors, are deeply linked by shared pathophysiological mechanisms. In particular, HF itself may enhance carcinogenesis by producing pro-inflammatory cytokines, and it has been suggested that neurohormonal activation, commonly associated with the failing heart, might play a pivotal role in promoting neoplastic transformation.SummaryThe risk of malignancies seems to be higher in HF patients compared to the general population, probably due to shared risk factors and common pathophysiological pathways. Additionally, management of these patients represents a challenge for clinicians, considering that the co-existence of these diseases significantly worsens patients’ prognosis and negatively affects therapeutic options for both diseases.
- Published
- 2021