Esayas Tadesse Gebremariam,1 Diriba Alemayehu Gadisa2 1Unit of Pharmaceutics and Social Pharmacy, Department of Pharmacy, Ambo University, Ambo, Ethiopia; 2Unit of Pharmacology, Department of Pharmacy, Ambo University, Ambo, EthiopiaCorrespondence: Esayas Tadesse GebremariamUnit of Pharmaceutics and Social Pharmacy, Department of Pharmacy, Ambo University, PO Box 19, Ambo, EthiopiaTel +251911925214Email esayastadesse23@yahoo.comDiriba Alemayehu GadisaUnit of Pharmacology, Department of Pharmacy, Ambo University, PO Box 19, Ambo, EthiopiaTel +251915958190Email direalexphar@ymail.comBackground: One of the problems facing higher education institutions in developing countries such as Ethiopia is the poor quality of undergraduate studentsâ academic work. However, there is a scarcity of empirical data on the specific causes of the poor quality of undergraduate study. Therefore, the aim of this research is to explore factors that influence the quality of undergraduate pharmacy studentsâ research projects at Ambo University in Ethiopia, from the perspective of research advisors.Methods: A qualitative study was held in Ambo University, Department of Pharmacy from March 2 to March 27, 2020. A total number of 15 research advisors were the participants of the study. A semi-structured interview questionaire was prepared to explore participantsâ ideas about the current situation of research quality, underlying causes and perception towards outcomes of poor quality of undergraduate pharmacy studentsâ research projects. The necessary data were collected through in-depth interview and qualitative content analysis was employed to analyze the data.Results: The majority of the key informants thought that the quality of undergraduate pharmacy students research projects is decreasing from time to time in their university due to studentsâ research knowledge gap, poor commitment, and motivation, lack of communication between students and advisors, plagiarism, financial problems, shortage of experienced research advisors, advisors less motivation and dedication, insufficient research facilities, lack of research fund, poor management support, and limitation of the undergraduate curriculum. They also revealed weak studentsâ research capacity, absence of knowledge transfer through research publication and presentation, and inadequate baseline evidence for the policymakers are the potential outcomes of poor quality undergraduate pharmacy studentsâ research projects.Conclusion: Undergraduate research quality is a persistent problem in the department of pharmacy of Ambo University. The problem is exacerbated due to multiple factors. As a result, the university should establish a framework for collaboration among students, advisors, and university research leaders; it should also boost studentsâ research capacity by hiring qualified researchers, equipping the research facility with appropriate technology, and instituting a system for monitoring and evaluating research project results.Keywords: research, undergraduate, contributing factors, quality of research, Ethiopia