1. An Optical Fiber Immunosensor With a Low Detection Limit Based on Plasmon Coupling Enhancement
- Author
-
Ming Ding, Yanxiong Niu, Zheng Shaowei, Wang Botao, and Yiheng Yin
- Subjects
Detection limit ,Optical fiber ,Materials science ,business.industry ,Graphene ,02 engineering and technology ,Atomic and Molecular Physics, and Optics ,law.invention ,020210 optoelectronics & photonics ,law ,0202 electrical engineering, electronic engineering, information engineering ,Optoelectronics ,Nanorod ,business ,Biosensor ,Refractive index ,Plasmon ,Photonic-crystal fiber - Abstract
An optical fiber immunosensor with a low detection limit based on plasmon coupling enhancement is proposed for detecting human immunoglobulin G (IgG). Graphene oxide (GO)-gold nanorod composites are synthesized and modified onto a photonic crystal fiber (PCF) surface coated with a Au film. GO, as a biosensitive layer, is used to decorate the gold nanorods and concentrate target molecules. The experimental result indicates that the refractive index sensitivity is drastically enhanced to 22248 nm/RIU because of plasmon coupling. Correspondingly, the human IgG detection limit decreases to 6 ng/mL. Moreover, the PCF is insensitive to temperature fluctuation, which can further reduce the measurement error.
- Published
- 2020