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Based on Solidworks software, the three-dimensional model of two wheels scooter is set up. The finite element model of two wheels scooter is generated. Modal analysis of driving system and telescopic mechanism of bar on two wheels scooter is investigated. The first five orders natural frequency and major modes of driving system and telescopic mechanism of bar are clarified. The method and the result can be used as a reference of dynamic design and lay foundation for calculation and analysis of dynamic response for the two wheels scooter.

Through the research on the change of system input and output energy in time-varying speed cutting, the influence of variable-speed waveforms on vibration suppression effect in time-varying speed cutting is quantitatively analyzed in this paper. A conclusion can be drawn that sine wave speed variation is better than triangle wave speed variation in vibration suppression.

In this study, we investigated the effects of astragaloside IV (As-IV) on pulmonary fibrosis and its mechanisms of action. Sprague-Dawley rats were used in a model of pulmonary fibrosis induced by an intratracheal instillation of bleomycin (BLM). Rats were intraperitoneally injected with As-IV (10, 20, 50 mg/kg) daily for 28 days, while the rats in control and BLM groups were injected with a saline solution. The effects of As-IV treatment on pulmonary injury were evaluated with the lung wet/dry weight ratios, cell counts, and histopathologic. Oxidative stress was evaluated by detecting the levels of malondialdehyde (MDA), superoxide dismutase (SOD), total antioxidant capacity (T-AOC), and reactive oxygen species (ROS) in lung tissue. Inflammation was assessed by measuring the levels of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 in bronchoalveolar lavage fluid (BALF). The results indicated that As-IV treatment remarkably ameliorated BLM-induced pulmonary fibrosis and attenuated BLM-induced oxidative stress and inflammation. Our findings indicate that As-IV-mediated suppression of fibroproliferation may contribute to the anti-fibrotic effect against BLM-induced pulmonary fibrosis. Its mechanisms of action are associated with inhibiting oxidative stress and inflammatory response. In summary, our study suggests a therapeutic potential of As-IV in the treatment of pulmonary fibrosis.

Kinematic characteristics of Hoeken mechanism is analyzed. Variable ratio transmission characteristics of oval gear is obtained. Oval geared Hoeken mechanism is presented. Kinematic characteristics of oval geared Hoeken mechanism is clarified. Eccentricity is optimized. The oval geared Hoeken mechanism with approximate uniform rectilinear motion is designed. The methods in this paper facilitate the innovation design of the mechanism with approximate uniform rectilinear motion.

Study of recombinant human interleukin-12 for treatment of complications after radiotherapy for tumor patients