1. Clinical features and outcome of Streptococcus agalactiae bone and joint infections over a 6-year period in a French university hospital
- Author
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Paul Loubet, Sophie Schuldiner, Jean-Philippe Lavigne, Nicolas Cellier, Catherine Lechiche, Yatrika Koumar, Albert Sotto, Pascal Kouyoumdjian, Virulence bactérienne et maladies infectieuses (VBMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Centre d'Investigation Clinique [Bron] (CIC1407), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Groupement Hospitalier Est [Bron], Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), and Salvy-Córdoba, Nathalie
- Subjects
Male ,medicine.medical_treatment ,Antibiotics ,medicine.disease_cause ,Hospitals, University ,Medical Conditions ,Endocrinology ,MESH: Streptococcal Infections ,Skeletal Joints ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Medicine and Health Sciences ,Streptococcus Agalactiae ,Oral Administration ,Musculoskeletal System ,Pathology and laboratory medicine ,Routes of Administration ,MESH: Treatment Outcome ,MESH: Aged ,Polymicrobial Infections ,[SDV.MHEP.RSOA] Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system ,Prosthetics ,MESH: Middle Aged ,Multidisciplinary ,Feet ,MESH: Bone and Bones ,Middle Aged ,Medical microbiology ,Anti-Bacterial Agents ,Treatment Outcome ,Infectious Diseases ,[SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system ,Staphylococcus aureus ,Group B streptococci ,[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Engineering and Technology ,Legs ,Medicine ,Vancomycin ,Female ,France ,Pathogens ,Anatomy ,Research Article ,Biotechnology ,medicine.drug ,medicine.medical_specialty ,Endocrine Disorders ,medicine.drug_class ,Science ,Prosthetic Device Infections ,Bioengineering ,Microbiology ,Bone and Bones ,MESH: Anti-Bacterial Agents ,Streptococcal Infections ,Internal medicine ,Diabetes Mellitus ,medicine ,Humans ,Internal fixation ,Skeleton ,Aged ,Retrospective Studies ,MESH: Hospitals, University ,Pharmacology ,MESH: Humans ,Biology and life sciences ,Bacteria ,business.industry ,Osteomyelitis ,Organisms ,Streptococcus ,MESH: Retrospective Studies ,medicine.disease ,MESH: Streptococcus agalactiae ,Comorbidity ,MESH: Male ,Microbial pathogens ,MESH: France ,Assistive Technologies ,Streptococcus agalactiae ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,Metabolic Disorders ,Body Limbs ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Bacterial pathogens ,Medical Devices and Equipment ,Septic arthritis ,business ,MESH: Female - Abstract
Background Bone and joint infections (BJIs) due to Streptococcus agalactiae are rare but has been described to increase in the past few years. The objective of this study was to describe clinical features and outcomes of cases of S. BJIs. Methods We conducted a retrospective analysis of adult cases of S. agalactiae BJIs that occurred between January 2009 and June 2015 in a French university hospital. The treatment success was assessed until 24 months after the end of antibiotic treatment. Results Among the 26 patients included, 20 (77%) were male, mean age was 62 years ± 13 and mean Charlson comorbidity index score was 4.9 ± 3.2. Diabetes mellitus was the most common comorbidity (n = 14, 54%). Six had PJI (Prosthetic Joint Infections), five osteosynthesis-associated infections, 11 osteomyelitis and four native septic arthritis. Eleven patients had a delayed or late infection: six with a prosthetic joint infection and five with an internal fixation device infection. Sixteen patients (62%) had a polymicrobial BJI, most commonly with Gram-positive cocci (75%) notably Staphylococcus aureus (44%). Polymicrobial infections were more frequently found in foot infections (90% vs 44%, p = 0.0184). During the two-year follow-up, three patients died (3/25, 12%) and seven (7/25, 28%) had treatment failure. Conclusion Diabetes mellitus was the most common comorbidity. We observed an heterogenous management and a high rate of relapse.
- Published
- 2021
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