553 results on '"Yogo, A."'
Search Results
2. Financial Economics of Insurance
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KOIJEN, RALPH S. J., YOGO, MOTOHIRO, KOIJEN, RALPH S. J., and YOGO, MOTOHIRO
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- 2023
3. Safety, immunogenicity, and efficacy of a COVID-19 vaccine (NVX-CoV2373) co-administered with seasonal influenza vaccines: an exploratory substudy of a randomised, observer-blinded, placebo-controlled, phase 3 trial
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Seth Toback, Eva Galiza, Catherine Cosgrove, James Galloway, Anna L Goodman, Pauline A Swift, Sankarasubramanian Rajaram, Alison Graves-Jones, Jonathan Edelman, Fiona Burns, Angela M Minassian, Iksung Cho, Lakshmi Kumar, Joyce S Plested, E Joy Rivers, Andreana Robertson, Filip Dubovsky, Greg Glenn, Paul T Heath, Roy L. Soiza, Robin Brittain-Long, Chiara Scicluna, Carole Edwards, Lynn Mackay, Mariella D'Allesandro, Amy Nicol, Karen Norris, Sandra Mann, Heather Lawrence, Ruth Valentine, Marianne Elizabeth Viljoen, Carol H. Pretswell, Helen Nicholls, Imrozia Munsoor, Agnieszka Meyrick, Christina Kyriakidou, Shalini Iyengar, Arham Jamal, Nick Richards, Helen Price, Bridie Rowbotham, Danielle Bird, Karen Smith, Olga Littler, Kirsty Fielding, Anna Townsend-Rose, Karen Miller, Jessica Davis, Alison Elliot-Garwood, Lauren Trottier, Paul Edwards, Margaret McFarland, Orod Osanlou, Laura Longshaw, Jane Stockport, Lynne Grundy, Katharine Lucy Broad, Karen Regan, Kim Storton, Declan Ryan-Wakeling, Brad Wilson, Malathy Munisamy, John Wright, Anil Shenoy, Beverley English, Lucy Brear, Paola Cicconi, Marta Boffito, Ana Milinkovic, Ruth Byrne, Roya Movahedi, Rosalie Housman, Naveed Kara, Ellen Brown, Andrea Cipriani, Mary-Jane Attenburrow, Katharine A. Smith, Jonathan Packham, Geoff Sparrow, Richard Smith, Josephine M. Rosier, Khalid Saja, Nyasha Nago, Brian Camilleri, Anita Immanuel, Mike Hamblin, Rawlings Osagie, Mahalakshmi Mohan, Hilary Floyd, Suzanne Goddard, Sanjay Mutgi, John Evans, Sean McKeon, Neringa Vilimiene, Rosavic Chicano, Rachel Hayre, Alice Pandaan, Catherine Henshall, Sonia Serrano, Andrea Mazzella, Thurkka Rajeswaran, Moncy Mathew, Karen Bisnauthsing, Laura Bremner, Henry Fok, Franca Morselli, Paola Cinardo, Blair Merrick, Lucy Sowole, Samantha Broadhead, Natalie Palmer, Jessica Cordle, Jaimie Wilson Goldsmith, Enya Cooney, Beth Jackson, Thilina Jayatilleke, Zelda Cheng, Toby Helliwell, Adrian Chudyk, Rafaela Giemza, John Lord Villajin, Noah Yogo, Esther Makanju, Pearl Dulawan, Deepak Nagra, April Buazon, Alice Russell, Georgie Bird, Amardeep Heer, Rex Sarmiento, Balraj Sanghera, Melanie Mullin, Adam Champion, Aisling Bevan, Kinzah Iqbal, Alshia Johnson, Rebecca Clark, Sarah Shaw, Steven Shaw, Amanda Chalk, Martin Lovatt, Caroline Lillicrap, Angela Parker, Jan Hansel, Zhi Wong, Galvin Gan, Eyad Tuma, Jane Minton, Jennifer Murira, Razan Saman, Alistair Hall, Kyra Holliday, Zara Khan, James Calderwood, George Twigg, Helena Baker, Julie Corrigan, Katy Houseman, Subhra Raguvanshi, Dominic Heining, Jake Weddell, Liz Glaves, Kim Thompson, Francis Davies, Ruth Lambley Burke, Emma C. Thomson, Dinesh Saralaya, Lisa Berry, Nancy Hopewell, Leigh Gerdes, Mihaela Pacurar, Saul N. Faust, Jeremy Turner, Christopher Jeanes, Adele Cooper, Jocelyn Keshet-Price, Lou Coke, Melissa Cambell-Kelly, Ketan Dhatariya, Claire Williams, Georgina Marks, James Sudbury, Lisa Rodolico, Judy Bradley, Sharon Carr, Roisin Martin, Angelina Madden, Paul Biagioni, Sonia McKenna, Alison Clinton, Maurice O'Kane, Justin Carter, Matthew Dewhurst, Bill Wetherill, Thandiwe Hoggarth, Katrina Lennon Collins, Marie Chowdhury, Adil Nathoo, Anna Heinen, Orla MacDonald, Claudia Hurducas, Liliana Cifuentes, Harjeevan Gill, Andy Gibson, Raha West, Jane Ewing, Rachel Blacow, John Haughney, Jonathan MacDonald, John Paul Seenan, Stewart Webb, Colin O'Leary, Scott Muir, Beth White, Neil Ritchie, Daniel F. McAuley, Jonathan Stewart, Mariella D'Alessandro, Nicki Lakeman, Laura Purandare, Duncan Browne, David Tucker, Peter Luck, Angharad Everden, Lisa Trembath, Michael Visick, Nick Morley, Laura Reid, Helen Chenoweth, Kirsty Maclean, Ray P. Sheridan, Tom Burden, Craig Francis Lunt, Shirley Todd, Stephanie Estcourt, Jasmine Marie Pearce, Suzanne Wilkins, Cathryn Love-Rouse, Eva Torok-Pollok, Mike Youle, Sara Madge, Danielle Solomon, Aarti Nandani, Janet M. North, Nargis Hemat, Rachel Newport, Philip A. Kalra, Chukwuma Chukwu, Olivia Wickens, Vikki O'Loughlin, Hema Mistry, Louise Harrison, Robert Oliver, Anne-Marie Peers, Jess Zadik, Katie Doyle, David R. Chadwick, Kerry Colling, Caroline Wroe, Marie Branch, Alison Chilvers, Sarah Essex, Mark Stone, Alberto San Francisco Ramos, Emily Beales, Olivia Bird, Zsofia Danos, Hazel Fofie, Cecilia Hultin, Sabina Ikram, Fran Mabesa, Aoife Mescall, Josyanne Pereira, Jennifer Pearce, Natalina Sutton, Emma Snashall, David Neil Baxter, Sara Bennett, Debbie Suggitt, Kerry Hughes, Wiesia Woodyatt, Lynsey Beacon, Alissa Kent, Chris Cooper, Milan Rudic, Simon Tunstall, Matthew Jackson, Claire Hombersley, Patrick Moore, Rebecca Cutts, Andrew Higham, Marwan Bukhari, Mohamed Elnaggar, Michelle Glover, Fiona Richardson, Alexandra Dent, Shahzeb Mirza, Rajiv Ark, Jennie Han, Suzy V. Hope, Philip J. Mitchelmore, Rostam Osanlou, Andrew Freedman, Alison Cooper, Katherine Burton, Kashyap Katechia, Michael Barrett, Jo Salkeld, Natalie Hill, Nathaniel Lee, Jon Perkins, and Polly Fox
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Adult ,Pulmonary and Respiratory Medicine ,Trivalent influenza vaccine ,medicine.medical_specialty ,COVID-19 Vaccines ,Adolescent ,Influenza vaccine ,Population ,Placebo ,Young Adult ,Immunogenicity, Vaccine ,Double-Blind Method ,Internal medicine ,Humans ,Medicine ,education ,Adverse effect ,Aged ,education.field_of_study ,Reactogenicity ,SARS-CoV-2 ,business.industry ,COVID-19 ,Articles ,Middle Aged ,Vaccine efficacy ,Vaccination ,Influenza Vaccines ,Seasons ,business - Abstract
Background The safety and immunogenicity profile of COVID-19 vaccines when administered concomitantly with seasonal influenza vaccines have not yet been reported. We therefore aimed to report the results of a substudy within a phase 3 UK trial, by evaluating the safety, immunogenicity, and efficacy of NVX-CoV2373 when co-administered with licensed seasonal influenza vaccines. Methods We did a planned exploratory substudy as part of the randomised, observer-blinded, placebo-controlled, phase 3 trial of the safety and efficacy of the COVID-19 vaccine (NVX-CoV2373) by co-administrating the influenza vaccine at four study hospitals in the UK. Approximately, the first 400 participants meeting the main study entry criteria—with no contraindications to influenza vaccination—were invited to join the substudy. Participants of the main study were randomly assigned (1:1) to receive two intramuscular injections of either NVX-CoV2373 (5 μg) or placebo (normal saline) 21 days apart; participants enrolled into the substudy were co-vaccinated with a single (0·5 mL) intramuscular, age-appropriate (quadrivalent influenza cell-based vaccine [Flucelvax Quadrivalent; Seqirus UK, Maidenhead] for those aged 18–64 years and adjuvanted trivalent influenza vaccine [Fluad; Seqirus UK, Maidenhead] for those ≥65 years), licensed, influenza vaccine on the opposite deltoid to that of the first study vaccine dose or placebo. The influenza vaccine was administered in an open-label manner and at the same time as the first study injection. Reactogenicity was evaluated via an electronic diary for 7 days after vaccination in addition to monitoring for unsolicited adverse events, medically attended adverse events, and serious adverse events. Immunogenicity was assessed with influenza haemagglutination inhibition and SARS-CoV-2 anti-spike protein IgG assays. Vaccine efficacy against PCR-confirmed, symptomatic COVID-19 was assessed in participants who were seronegative at baseline, received both doses of study vaccine or placebo, had no major protocol deviations affecting the primary endpoint, and had no confirmed cases of symptomatic COVID-19 from the first dose until 6 days after the second dose (per-protocol efficacy population). Immunogenicity was assessed in participants who received scheduled two doses of study vaccine, had a baseline sample and at least one post-vaccination sample, and had no major protocol violations before unmasking (per-protocol immunogenicity population). Reactogenicity was analysed in all participants who received at least one dose of NVX-CoV2373 or placebo and had data collected for reactogenicity events. Safety was analysed in all participants who received at least one dose of NVX-CoV2373 or placebo. Comparisons were made between participants of the substudy and the main study (who were not co-vaccinated for influenza). This study is registered with ClinicalTrials.gov, number NCT04583995. Findings Between Sept 28, 2020, and Nov 28, 2020, a total of 15 187 participants were randomised into the main phase 3 trial, of whom 15 139 received treatment (7569 received dose one of NVX-CoV2373 and 7570 received dose one of placebo). 431 participants were co-vaccinated with a seasonal influenza vaccine in the substudy (217 received NVX-CoV2373 plus the influenza vaccine and 214 received placebo plus the influenza vaccine). In general, the substudy participants were younger, more racially diverse, and had fewer comorbid conditions than those in the main study. Reactogenicity events were more common in the co-administration group than in the NVX-CoV2373 alone group: tenderness (113 [64·9%] of 174 vs 592 [53·3%] of 1111) or pain (69 [39·7%] vs 325 [29·3%]) at injection site, fatigue (48 [27·7%] vs 215 [19·4%]), and muscle pain (49 [28·3%] vs 237 [21·4%]). Incidences of unsolicited adverse events, treatment-related medically attended adverse events, and serious adverse events were low and balanced between the co-administration group and the NVX-CoV2373 alone group. No episodes of anaphylaxis or deaths were reported within the substudy. Co-administration resulted in no change to influenza vaccine immune response although a reduction in antibody responses to the NVX-CoV2373 vaccine was noted. NVX-CoV2373 vaccine efficacy in the substudy (ie, participants aged 18 to
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- 2022
4. Interleukin-6: evolving role in the management of neuropathic pain in neuroimmunological disorders
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Kenji Yogo, Kenichi Serizawa, Shota Miyake, Yoshihiro Matsumoto, and Haruna Tomizawa-Shinohara
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medicine.medical_specialty ,Immunology ,Review ,Disease ,Neuropathic pain ,Placebo ,law.invention ,Multiple sclerosis ,Randomized controlled trial ,law ,Internal medicine ,medicine ,Pathology ,Immunology and Allergy ,RB1-214 ,MR16-1 ,IL-6 ,Neuromyelitis optica ,Experimental autoimmune encephalomyelitis ,business.industry ,Satralizumab ,medicine.disease ,Anti–IL-6 receptor antibody ,Review article ,Neuromyelitis optica spectrum disorder ,business - Abstract
Background Neuropathic pain in neuroimmunological disorders refers to pain caused by a lesion or disease of the somatosensory system such as multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). MS and NMOSD are autoimmune disorders of the central nervous system, and ≥ 50% of patients with these disorders experience chronic neuropathic pain. The currently available medications for the management of neuropathic pain have limited effectiveness in patients with MS and NMOSD, and there is an unmet medical need to identify novel therapies for the management of chronic neuropathic pain in these patients. In this review article, we summarize the role of interleukin-6 (IL-6) in the pathogenesis of MS and NMOSD and the ameliorative effects of anti–IL-6 therapies in mouse models of experimental autoimmune encephalomyelitis (EAE). Main body Intraperitoneal injection of MR16-1, an anti–IL-6 receptor (IL-6R) antibody, reduced mechanical allodynia and spontaneous pain in EAE mice, which was attributed to a reduction in microglial activation and inhibition of the descending pain inhibitory system. The effect of anti–IL-6 therapies in ameliorating neuropathic pain in the clinical setting is controversial; a reduction in pain intensity has been reported with an anti–IL-6 antibody in four studies, namely a case report, a pilot study, a retrospective observational study, and a case series. Pain intensity was evaluated using a numerical rating scale (NRS), with a lower score indicating lesser pain. A reduction in the NRS score was reported in all four studies. However, in two randomized controlled trials of another anti–IL-6R antibody, the change in the visual analog scale pain score was not statistically significantly different when compared with placebo. This was attributed to the low mean pain score at baseline in both the trials and the concomitant use of medications for pain in one of the trials, which may have masked the effects of the anti–IL-6R antibody on neuropathic pain. Conclusion Thus, anti–IL-6 therapies might have a potential to reduce neuropathic pain, but further investigations are warranted to clarify the effect of inhibition of IL-6 signaling on neuropathic pain associated with MS and NMOSD.
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- 2021
5. A Case of Anaphylactic Shock due to Hydrocortisone Sodium Succinate Suspected to Be Associated with Aspirin Asthma
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Sakurako Imamura, Shoko Yogo, Kayo Harada, and Kazunori Urabe
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business.industry ,Hydrocortisone sodium succinate ,Anaphylactic shock ,Medicine ,Dermatology ,Pharmacology ,business ,Aspirin asthma - Published
- 2021
6. SNAIL2 contributes to tumorigenicity and chemotherapy resistance in pancreatic cancer by regulating IGFBP2
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Toshihiko Masui, Shigeo Takaishi, Kenji Masuo, Ru Chen, Aiko Sugiyama, Akihisa Fukuda, Hiroshi Seno, Akitada Yogo, and Shinji Uemoto
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cancer stem cells ,Cancer Research ,Epithelial-Mesenchymal Transition ,Carcinogenesis ,pancreatic cancer ,Antineoplastic Agents ,Mice, SCID ,Cell Line ,SNAIL2 ,Cell, Molecular, and Stem Cell Biology ,Cancer stem cell ,RNA interference ,Mice, Inbred NOD ,Pancreatic cancer ,Cell Line, Tumor ,medicine ,Animals ,Humans ,Epithelial–mesenchymal transition ,Transcription factor ,epithelial‐mesenchymal transition ,biology ,Microarray analysis techniques ,business.industry ,Gene Expression Profiling ,CD44 ,General Medicine ,Original Articles ,medicine.disease ,tumor spheroid ,Xenograft Model Antitumor Assays ,Gemcitabine ,Gene Expression Regulation, Neoplastic ,Pancreatic Neoplasms ,Insulin-Like Growth Factor Binding Protein 2 ,HEK293 Cells ,Oncology ,Drug Resistance, Neoplasm ,biology.protein ,Cancer research ,Neoplastic Stem Cells ,Original Article ,RNA Interference ,Snail Family Transcription Factors ,business ,medicine.drug - Abstract
Pancreatic cancer has an extremely poor prognosis because of its resistance to conventional therapies. Cancer stem cell (CSC)‐targeted therapy is considered a promising approach for this disease. Epithelial‐mesenchymal transition‐inducing transcription factors (EMT‐TFs) contribute to CSC properties in some solid tumors; however, this mechanism has not been fully elucidated in pancreatic cancer. Zinc finger protein, SNAIL2 (also known as SLUG), is a member of the SNAIL superfamily of EMT‐TFs and is commonly overexpressed in pancreatic cancer. Patients exhibiting high SNAIL2 expression have a poor prognosis. In this study, we showed that the suppression of SNAIL2 expression using RNA interference decreased tumorigenicity in vitro (sphere formation assay) and in vivo (xenograft assay) in 2 pancreatic cancer cell lines, KLM1 and KMP5. In addition, SNAIL2 suppression resulted in increased sensitivity to gemcitabine and reduced the expression of CD44, a pancreatic CSC marker. Moreover, experiments on tumor spheroids established from surgically resected pancreatic cancer tissues yielded similar results. A microarray analysis revealed that the mechanism was mediated by insulin‐like growth factor (IGF) binding protein 2. These results indicate that IGFBP2 regulated by SNAIL2 may represent an effective therapeutic target for pancreatic cancer., SNAIL2 knockdown reduces tumorigenicity and resistance to gemcitabine in tumor spheroid established from resected tissue of human pancreatic cancer as well as human pancreatic cancer cell lines.
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- 2021
7. The evolution from life insurance to financial engineering
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Ralph S. J. Koijen and Motohiro Yogo
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Economics and Econometrics ,Equity risk ,Actuarial science ,Life insurance industry ,business.industry ,COVID-19 crisis ,Net worth ,Minimum return guarantee ,EGRIE Keynote Address ,Financial engineering ,Global financial crisis ,Variable annuity ,Accounting ,Life insurance ,Tax advantage ,Longevity insurance ,Economics ,Business, Management and Accounting (miscellaneous) ,G32 ,G22 ,business ,Finance ,Risk management ,Financial services - Abstract
Since the mid-1980s, the share of household net worth intermediated by US financial institutions has shifted from defined benefit plans to life insurers and defined contribution plans. Life insurers have primarily grown through variable annuities, which are mutual funds with longevity insurance, a potential tax advantage, and minimum return guarantees. The minimum return guarantees change the primary function of life insurers from traditional insurance to financial engineering. Variable annuity insurers are exposed to interest and equity risk mismatch and their stock returns were especially low during the COVID-19 crisis. We consider regulatory changes, such as more detailed financial disclosure and standardized stress tests, to monitor potential risk mismatch and to ensure stability of the insurance sector.
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- 2021
8. Simulation-Based Optimization of Fixed-Bed Continuous CO2 Capture Process with an Amine-Impregnated Solid Sorbent
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Katsunori Yogo and Tomohiro Kinoshita
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Sorbent ,Materials science ,Simulation-based optimization ,business.industry ,Fixed bed ,General Chemical Engineering ,Scientific method ,Amine gas treating ,General Chemistry ,Process engineering ,business ,Industrial and Manufacturing Engineering - Published
- 2021
9. Three-dimensional dose-distribution measurement of therapeutic carbon-ion beams using a ZnS scintillator sheet
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Ryo Horita, Katsunori Yogo, Hiromichi Ishiyama, Hikaru Souda, Seiichi Yamamoto, Masato Tsuneda, Tatsuaki Kanai, Kazushige Hayakawa, and Akihiko Matsumura
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Materials science ,Physics::Instrumentation and Detectors ,Health, Toxicology and Mutagenesis ,Sobp ,Linear energy transfer ,Heavy Ion Radiotherapy ,Bragg peak ,Sulfides ,Scintillator ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Imaging, Three-Dimensional ,0302 clinical medicine ,Optics ,Ionization ,Linear Energy Transfer ,Radiology, Nuclear Medicine and imaging ,Fundamental Radiation Science ,Radiometry ,linear energy transfer (LET) ,Scintillation ,Radiation ,business.industry ,Water ,Dose-Response Relationship, Radiation ,Equipment Design ,silver-activated zinc sulfide (ZnS) ,3D dose distribution ,Zinc Compounds ,030220 oncology & carcinogenesis ,Ionization chamber ,AcademicSubjects/SCI00960 ,AcademicSubjects/MED00870 ,carbon-ion beam ,business ,Beam (structure) - Abstract
The accurate measurement of the 3D dose distribution of carbon-ion beams is essential for safe carbon-ion therapy. Although ionization chambers scanned in a water tank or air are conventionally used for this purpose, these measurement methods are time-consuming. We thus developed a rapid 3D dose-measurement tool that employs a silver-activated zinc sulfide (ZnS) scintillator with lower linear energy transfer (LET) dependence than gadolinium-based (Gd) scintillators; this tool enables the measurement of carbon-ion beams with small corrections. A ZnS scintillator sheet was placed vertical to the beam axis and installed in a shaded box. Scintillation images produced by incident carbon-ions were reflected with a mirror and captured with a charge-coupled device (CCD) camera. A 290 MeV/nucleon mono-energetic beam and spread-out Bragg peak (SOBP) carbon-ion passive beams were delivered at the Gunma University Heavy Ion Medical Center. A water tank was installed above the scintillator with the water level remotely adjusted to the measurement depth. Images were recorded at various water depths and stacked in the depth direction to create 3D scintillation images. Depth and lateral profiles were analyzed from the images. The ZnS-scintillator-measured depth profile agreed with the depth dose measured using an ionization chamber, outperforming the conventional Gd-based scintillator. Measurements were realized with smaller corrections for a carbon-ion beam with a higher LET than a proton. Lateral profiles at the entrance and the Bragg peak depths could be measured with this tool. The proposed method would make it possible to rapidly perform 3D dose-distribution measurements of carbon-ion beams with smaller quenching corrections.
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- 2021
10. Inspecting the mechanism of quantitative easing in the euro area
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Francois Koulischer, Motohiro Yogo, Ralph S. J. Koijen, and Benoît Nguyen
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040101 forestry ,Economics and Econometrics ,Government ,050208 finance ,Strategy and Management ,Bond ,Yield (finance) ,05 social sciences ,04 agricultural and veterinary sciences ,Monetary economics ,Basis point ,Accounting ,Quantitative easing ,0502 economics and business ,Government bond ,0401 agriculture, forestry, and fisheries ,Portfolio ,Business ,Finance ,Credit risk - Abstract
Using security-level holdings for all euro-area investors, we study portfolio rebalancing during the quantitative easing program from March 2015 to December 2017. Foreign investors outside the euro area accommodated most of the Eurosystem’s purchases. Duration, government credit, and corporate credit risk did not get concentrated in particular regions or investor sectors. We estimate a demand system for government bonds by instrumental variables to relate portfolio rebalancing to yield changes. Government bond yields decreased by 65 basis points on average, and this estimate varies from 38 to 83 basis points across countries.
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- 2021
11. COMPANY PERFORMANCE IMPROVEMENT STRATEGY AT PT ANGKASA PURA 1 BRANCH OF GENERAL AHMAD YANI AIRPORT, SEMARANG.
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Ardhianza, Dzaky Yogo and Raharjo, Susilo Toto
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ORGANIZATIONAL performance , *STRATEGIC planning , *COVID-19 pandemic , *COST leadership - Abstract
Business is a daily activity that produces goods or services, has the aim of creating jobs, meeting daily needs with goods and services, and improving the economy of society. Business people must implement strategic steps due to increasingly fierce business competition and the emergence of the Covid-19 pandemic resulting in paralysis of the world economy (Agung, et. all 2022). analyze whether the cost leadership strategy can improve revenue performance at PT Angkasa Pura 1 Semarang. The research used is a type of qualitative research that involves the use and collection of various materials derived from potential data collection activities, namely by interviews, observations, and collecting data as necessary from documents. Techniques used in data collection by conducting in-depth interviews with respondents. Competitive strategy and business strategy, which includes industrial organization, resource-based viewpoints, dynamic capabilities, and theory. The overall cost leadership strategy is implemented to gain competitive advantage by reducing operating costs below operating costs incurred, cost suppression will have an impact on low product selling prices, so as to attract consumers while still generating profits. This research is qualitative research by conducting in-depth interviews with resource persons both from internal and external companies, where there is limited time to meet with resource persons because the interview process is carried out during working operational hours and the many activities of resource persons. [ABSTRACT FROM AUTHOR]
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- 2023
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12. Usefulness of adhesive strapping for umbilical hernias of infants
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Takahiko Oohira, Yogo Haraguchi, Yoshiko Suginohara, Eiichi Suefuji, Yuichi Miura, Kimiyasu Egami, Toshihiro Moroi, Akito Kitano, and Toshiko Kuwahara
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medicine.medical_specialty ,030204 cardiovascular system & hematology ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Pediatric Surgery ,Randomized controlled trial ,Japan ,Healing rate ,law ,030225 pediatrics ,Adhesives ,medicine ,Humans ,Observation group ,Hernia ,Prospective Studies ,Strapping ,Proportional Hazards Models ,umbilical hernia ,business.industry ,Infant ,adhesive strapping ,medicine.disease ,Umbilical hernia ,Surgery ,Log-rank test ,Pediatrics, Perinatology and Child Health ,Original Article ,Adhesive ,ORIGINAL ARTICLES ,business ,Hernia, Umbilical - Abstract
Background Using a controlled trial, this study aimed to evaluate the effectiveness of adhesive strapping to improve the natural healing rate of umbilical hernia. Methods This prospective, observational study included 128 patients from Kumamoto, Japan (97 in the adhesive strapping group, and 31 in observation group), from 2012–2015. The duration from first hospital visit to the hernia orifice closure was compared between the two groups. Result Kaplan‐Meier curves showed that the probability of umbilical hernia in the adhesive strapping group was lower until approximately 200 days, but it was not statistically significant in the log rank test. According to multivariate Cox proportional hazard models, the hazard risk of umbilical hernia in the adhesive strapping group was significantly higher within 0–60 days after adjusting for confounding factors such as hernial cavity and hernia orifice area (P < 0.0001). Conclusion Adhesive strapping of umbilical hernia was significantly associated with earlier closure of the hernia orifice from baseline until at least 60 days.
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- 2021
13. Localization method using planar LiDAR for mobile robots to support bridge inspection
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Yogo Takada, Hyunwoo Song, and Jun Nakahama
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Planar ,Lidar ,Computer science ,business.industry ,Mobile robot ,Computer vision ,Artificial intelligence ,business ,Bridge inspection - Published
- 2021
14. Establishment of a method for correcting the image coordinates of a target captured by a robotic fish with rolling motion
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Yogo Takada, Takuya Aritani, and Naoki Kawasaki
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Computer science ,business.industry ,%22">Fish ,Computer vision ,Artificial intelligence ,business ,Motion (physics) ,Image (mathematics) - Published
- 2021
15. Impact of vascular abnormality on contrast-enhanced CT and high C-reactive protein levels on postoperative pancreatic hemorrhage after pancreaticoduodenectomy: A multi-institutional, retrospective analysis of 590 consecutive cases
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Kenzo Nakano, Toshihiko Masui, Asahi Sato, Yuichiro Uchida, Shinji Uemoto, Kyoichi Takaori, Kazuyuki Nagai, Takayuki Anazawa, Takafumi Machimoto, Kazuki Hashida, and Akitada Yogo
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Adult ,Male ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Postoperative Hemorrhage ,Gastroenterology ,Pancreaticoduodenectomy ,Pancreatic Fistula ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,Risk Factors ,Internal medicine ,Ascites ,medicine ,Humans ,Aged ,Retrospective Studies ,Aged, 80 and over ,Hepatology ,biology ,business.industry ,C-reactive protein ,Perioperative ,Odds ratio ,Middle Aged ,medicine.disease ,C-Reactive Protein ,Pancreatic fistula ,030220 oncology & carcinogenesis ,biology.protein ,Blood Vessels ,Female ,030211 gastroenterology & hepatology ,Abnormality ,medicine.symptom ,Tomography, X-Ray Computed ,business ,Complication ,Aneurysm, False - Abstract
Background /Objectives: This study aimed to elucidate the efficacy of CT findings and perioperative characteristics to predict post-pancreatectomy hemorrhage (PPH): a critical complication after pancreaticoduodenectomy. Methods The records of 590 consecutive patients who underwent pancreaticoduodenectomy at three institutes between 2012 and 2018 were included. The presence of a vascular wall abnormality or ascites with high density (vascular abnormality) on postoperative day (POD) 5–10 contrast-enhanced CT (early CT), perioperative characteristics, and any PPH or pseudoaneurysm formation (PPH events) were analyzed through a multivariate analysis. Results PPH events occurred in 48 out of 590 patients (8%). The vascular abnormality on early CT and the C-reactive protein (CRP) value on POD 3 were independent risk factors for PPH events after POD5 (vascular abnormality: odds ratio 6.42, p = 0.001; CRP on POD 3: odds ratio 1.17, p = 0.016). The sensitivity of vascular abnormality for PPH events was 24% (7/29), and the positive predictive value was 30% (7/23). The combination of vascular abnormality and a high CRP value (≥15.5 mg/dL) on postoperative day 3 had a higher positive predictive value of 64% (7/11) than the vascular abnormality alone. None of the seven PPH events that occurred more than one month after surgery were foreseen via early CT. Conclusion The combination of vascular abnormality and high CRP value was associated with increasing risk of PPH events after pancreaticoduodenectomy, but the low sensitivity of early CT must be noted as an important shortcoming. The normal findings on early CT could not eliminate the risk of late PPH.
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- 2021
16. Source position measurement by Cherenkov emission imaging from applicators for high‐dose‐rate brachytherapy
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Hiroyuki Okamoto, Kuniyasu Okudaira, Yumiko Noguchi, Hiroshi Oguchi, Hiroshi Yasuda, Hiromichi Ishiyama, Marika Nozawa, Katsunori Yogo, and Seiichi Yamamoto
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Diagnostic Imaging ,Materials science ,medicine.medical_treatment ,Brachytherapy ,Uterine Cervical Neoplasms ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Optics ,Position (vector) ,medicine ,Humans ,Single image ,Cherenkov radiation ,Phantoms, Imaging ,business.industry ,Radiotherapy Planning, Computer-Assisted ,Device Camera ,Radiotherapy Dosage ,General Medicine ,High-Dose Rate Brachytherapy ,030220 oncology & carcinogenesis ,Female ,Light emission ,business - Abstract
Purpose We developed a novel and simple method to measure the source positions in applicators directly for high-dose-rate (HDR) brachytherapy based on Cherenkov emission imaging, and evaluated the performance. Methods The light emission from plastic applicators used in cervical cancer treatments, irradiated by an 192 Ir γ-ray source, was captured using a charge-coupled device camera. Moreover, we attached plastics of different shapes, including tapes, tubes, and plates to a metal applicator, to use as screens for the Cherenkov imaging. We determined the source positions and dwell intervals from the light profiles along with the applicator and compared these with preset values and dummy marker measurements. Results The source positions and dwell intervals measured from the light images were comparable to the dummy marker measurements and preset values. The distance from the applicator tip to the first source positions agreed with the dummy marker measurements within 0.2 mm for the plastic tandem. The dwell intervals measured using the Cherenkov method agreed with the preset values within 0.6 mm. The distances measured with three plastic types on the metal applicator also agreed with the dummy marker measurements within 0.2 mm. The dwell intervals measured using the plastic tape agreed with the preset values within 0.7 mm. Conclusions The proposed method should be suitable for rapid and easy quality assurance (QA) investigations in HDR brachytherapy, as it enables source position using a single image. The method allows for real-time, filmless measurements of the source positions to be obtained and is useful for rapid feedback in QA procedures.
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- 2020
17. Left-posterior approach for artery-first en bloc resection in laparoscopic distal pancreatectomy for left-sided pancreatic cancer
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Akitada Yogo, Kazuyuki Nagai, Kyoichi Takaori, Gozo Kiguchi, Shintaro Yagi, Kojiro Taura, Takayuki Anazawa, and Toshihiko Masui
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Male ,medicine.medical_specialty ,medicine.medical_treatment ,Pancreatic Intraepithelial Neoplasia ,030230 surgery ,Splenic artery ,03 medical and health sciences ,Pancreatectomy ,0302 clinical medicine ,Mesenteric Artery, Superior ,medicine.artery ,Pancreatic cancer ,medicine ,Humans ,Superior mesenteric artery ,Pancreas ,Gastric emptying ,business.industry ,medicine.disease ,Surgery ,Pancreatic Neoplasms ,medicine.anatomical_structure ,Pancreatic fistula ,030220 oncology & carcinogenesis ,Female ,Laparoscopy ,Lymphadenectomy ,business - Abstract
We describe a “left-posterior approach” in which the important steps in laparoscopic distal pancreatectomy (LDP) for left-sided pancreatic cancer are accomplished in the direction caudal and dorsal to the pancreas. The patients who underwent LDP with a left-posterior approach at our hospital from January 2016 to April 2020 were reviewed to evaluate the short-term postoperative outcomes. In LDP, we first dissected retroperitoneal tissues above the left renal vein and superior mesenteric artery, yielding the mobilization of the pancreatic body widely. Then, the splenic artery was divided behind the ventrally lifted pancreas as an artery-first approach. The regional lymphadenectomy was performed in an en bloc manner consecutively in the same operative field. The neck of the pancreas was transected with a linear stapler after mobilization of the spleen. In nine patients (five men and four women) aged 76 years (range: 64–82 years), the operative time was 398 min (276–482 min) with the estimated blood loss of 40 ml (0–80 ml). No patients developed grade B/C pancreatic fistula or delayed gastric emptying. Postoperative complications classified as grade III in the Clavien–Dindo classification occurred in one patient (abdominal abscess). The pathology confirmed R0 resection in all patients who had pancreatic cancer (n = 5), IPMNs (n = 3), and high-grade pancreatic intraepithelial neoplasia (PanIN) (n = 1). The number of retrieved lymph nodes was 35 (11–49). The procedure with a left-posterior approach is a rational surgical technique in LDP for left-sided pancreatic cancer.
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- 2020
18. Laparoscopic surgery for sigmoid colon cancer with complicated communication between the superior and inferior mesenteric arteries
- Author
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Satoru Kawai, Atsushi Ogura, Satoaki Kamiya, Kiyotaka Kawai, Ryutaro Kobayashi, Masanori Sando, Kenji Takagi, Takashi Maeda, Natsuki Nagano, and Konosuke Yogo
- Subjects
Left colic artery ,medicine.medical_specialty ,business.industry ,General Medicine ,medicine.disease ,Inferior mesenteric artery ,Surgery ,Vascular anomaly ,03 medical and health sciences ,Stenosis ,Middle colic artery ,0302 clinical medicine ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,medicine.artery ,medicine ,030211 gastroenterology & hepatology ,Superior mesenteric artery ,business ,Median arcuate ligament syndrome ,Mesenteric arteries - Abstract
To perform complete mesocolic excision with central vessel ligation, it is important to recognize the vessel anomaly and the location of the tumor. For left-sided colon cancer, the variations in the course of the left colic artery and accessary middle colic artery must be recognized preoperatively. Here, we describe our experience with a 57-year-old man who was diagnosed with sigmoid colon cancer with complicated inter-mesenteric connections between the inferior mesenteric artery (IMA) and superior mesenteric artery (SMA), possibly due to median arcuate ligament syndrome. We performed laparoscopic sigmoidectomy with low ligation of the IMA to preserve the extremely enlarged left colic artery. The total operative time was 155 minutes, and the estimated total blood loss was 10 mL. The patient was discharged on postoperative day 9 without any postoperative complications. For patients with vascular anomalies in the left-sided mesocolon, preoperatively ruling out SMA stenosis by using angiography and 3-D CT might be important.
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- 2020
19. Short hydration with 20 mEq of magnesium supplementation for lung cancer patients receiving cisplatin-based chemotherapy: a prospective study
- Author
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Takahiro Hatta, Kiyofumi Yamada, Masashi Kondo, Kazuya Ichikawa, Yoshinori Hasegawa, Naoyuki Yogo, Naoya Ozawa, Mitsuo Sato, Masayuki Miyazaki, Tetsunari Hase, and Masahiko Ando
- Subjects
Adult ,Male ,0301 basic medicine ,medicine.medical_specialty ,Lung Neoplasms ,medicine.medical_treatment ,Renal function ,Antineoplastic Agents ,Kidney Function Tests ,Protective Agents ,Gastroenterology ,Nephrotoxicity ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Internal medicine ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Humans ,Magnesium ,Prospective Studies ,Renal Insufficiency ,Lung cancer ,Aged ,Cisplatin ,Chemotherapy ,Creatinine ,business.industry ,Hematology ,General Medicine ,Middle Aged ,medicine.disease ,Palonosetron ,Regimen ,030104 developmental biology ,Oncology ,chemistry ,030220 oncology & carcinogenesis ,Dietary Supplements ,Antiemetics ,Female ,Kidney Diseases ,Surgery ,business ,Chemoradiotherapy ,medicine.drug - Abstract
Intravenous administration of magnesium with a short hydration regimen is recommended for patients receiving high-dose cisplatin to protect against cisplatin-induced nephrotoxicity. However, the optimal dose of magnesium supplementation has not been clarified. The aim of this trial was to investigate the safety and efficacy of a short hydration regimen with 20 mEq of magnesium supplementation for lung cancer patients receiving cisplatin-based chemotherapy. The key eligibility criteria included cytologically or histologically diagnosed lung cancer, candidacy for cisplatin-based (≥ 60 mg/m2) chemotherapy or chemoradiotherapy, no prior chemotherapy, aged 20–75 years, and adequate renal function. Cisplatin was administered with pre-hydration with 20 mEq of magnesium sulfate. Mannitol was administered just before cisplatin infusion to enforce diuresis. The primary endpoint was the proportion of patients who underwent cisplatin-based chemotherapy with a short hydration regimen with 20 mEq of magnesium supplementation without a grade 2 or higher elevation in creatinine. Forty patients with a median age of 66 years (range 35–74) were prospectively enrolled. Median baseline creatinine was 0.71 mg/dL. Median dose of cisplatin in the first cycle was 80 mg/m2. In the first cycle, no patients developed grade 2 creatinine toxicity. During the treatment period, one patient developed grade 2 creatinine elevation; thus, the proportion of patients without a grade 2 or higher elevation in creatinine was 97.5% (95% confidence interval 86.8–99.9). A short hydration regimen with 20 mEq of magnesium supplementation is safe and feasible for patients with lung cancer receiving cisplatin-based chemotherapy.
- Published
- 2020
20. Usefulness of 18 F‐FDG‐PET/CT in the diagnosis and prediction of recurrence of pancreatic neuroendocrine neoplasms
- Author
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Yuji Nakamoto, Asahi Sato, Takayuki Anazawa, Yuichiro Uchida, Akitada Yogo, Kazuyuki Nagai, Kyoichi Takaori, Shinji Uemoto, Kenzo Nakano, and Toshihiko Masui
- Subjects
Oncology ,medicine.medical_specialty ,Univariate analysis ,Multivariate analysis ,Hepatology ,business.industry ,Disease ,Neuroendocrine tumors ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Internal medicine ,medicine ,030211 gastroenterology & hepatology ,Surgery ,Avidity ,Fdg pet ct ,Pancreas ,business ,Pathological - Abstract
Background Although 18 F-FDG-PET/CT is a widely used diagnostic tool for several malignancies, its efficacy in diagnosing pancreatic neuroendocrine tumors is reported to be controversial because of the short-term follow-up. Methods We retrospectively compared demographics and pathological features between 18 F-FDG-positive and -negative diseases. Additionally, we evaluated whether the avidity of 18 F-FDG-PET/CT affected earlier recurrence after curative treatment of non-functioning tumors. The median duration of observation was 65.6 months. Results Seventy-two patients were enrolled. 18 F-FDG-positive diseases were pathologically advanced and significantly associated with metastatic behavior. In a multivariate analysis, metastatic behavior and WHO tumor grade was independently associated with 18 F-FDG accumulation. Only 25% of functional tumors (4/16) and 8% of insulinomas (1/12) were 18 F-FDG-positive. In a Kaplan-Meier analysis in patients with non-functioning tumors (n = 56), 18 F-FDG-positivity was significantly correlated with poorer recurrence-free survival (RFS) but had no correlation with overall survival. In univariate analysis of factors associated with shorter RFS, male gender, prevalence of nodal metastasis, WHO tumor grade ≥G2, or 18 F-FDG-positive disease were significantly higher in patients with shorter RFS, whereas only 18 F-FDG-positivity was associated with shorter RFS in multivariate analyses. Conclusions The avidity of 18 F-FDG-PET/CT was associated with metastatic behavior of pancreatic neuroendocrine tumors and recurrence after treatment of non-functioning tumors.
- Published
- 2020
21. The path to shared prosperity: Leveraging financial services outreach to create decent jobs in developing countries
- Author
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Aïssata Coulibaly, Urbain Thierry Yogo, Centre d'Études et de Recherches sur le Développement International (CERDI), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), CEREG - University of Yaounde 2, ANR-10-LABX-0014,IDGM+,Designing new international development policies from research outcomes. An enhanced(2010), and ANR-10-LABX-0014,IDGM+,Designing new international development policies from research outcomes. An enhanced 'Initiative for Development and Global Governance'(2010)
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Economics and Econometrics ,Private credit ,media_common.quotation_subject ,JEL: J - Labor and Demographic Economics/J.J8 - Labor Standards: National and International/J.J8.J80 - General ,Developing country ,Developing countries ,JEL: G - Financial Economics/G.G2 - Financial Institutions and Services/G.G2.G21 - Banks • Depository Institutions • Micro Finance Institutions • Mortgages ,0502 economics and business ,Development economics ,JEL: I - Health, Education, and Welfare/I.I3 - Welfare, Well-Being, and Poverty/I.I3.I30 - General ,Economics ,Bank penetration ,Trickle-down hypothesis ,Asset (economics) ,050207 economics ,10. No inequality ,Financial services ,media_common ,Decent job ,Financial outreach ,Financial inclusion ,[SHS.STAT]Humanities and Social Sciences/Methods and statistics ,050208 finance ,Poverty ,business.industry ,05 social sciences ,1. No poverty ,JEL: O - Economic Development, Innovation, Technological Change, and Growth/O.O1 - Economic Development/O.O1.O16 - Financial Markets • Saving and Capital Investment • Corporate Finance and Governance ,JEL: O - Economic Development, Innovation, Technological Change, and Growth/O.O1 - Economic Development/O.O1.O15 - Human Resources • Human Development • Income Distribution • Migration ,[SHS.ECO]Humanities and Social Sciences/Economics and Finance ,Investment (macroeconomics) ,JEL: D - Microeconomics/D.D3 - Distribution/D.D3.D31 - Personal Income, Wealth, and Their Distributions ,Working poverty ,Outreach ,Remittances ,[SHS.ENVIR]Humanities and Social Sciences/Environmental studies ,8. Economic growth ,Prosperity ,business - Abstract
International audience; Understanding the channels through which financial inclusion affects poverty reduction remains a key policy issue in development debates. Considering that labour is the main asset of the poor, this paper investigates the effect of financial outreach on the number of workers living below the poverty line. It also analyses whether this effect may occur through increasing investment, remittances, private credit and the number of rich workers who can provide employment opportunities to the poorest. The study finds that improving financial outreach through additional bank branches reduces the number of poor workers, especially in developing countries hit by macro economic instability. In addition, this effect occurs mainly through credit expansion, while other channels substitute financial outreach in countries with a low level of financial development.
- Published
- 2020
22. The Effect of Activity Ratio on Profitability in Automotive Companies and Components Registered on the IDX
- Author
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Yogo Heru Prayitno and Djoko Roespinoedji
- Subjects
Psychiatry and Mental health ,Clinical Psychology ,business.industry ,Automotive industry ,Profitability index ,Pshychiatric Mental Health ,business ,Industrial organization - Published
- 2020
23. Effect of Profitability on Stock Returns of Companies in the Food and Beverage Sector in Indonesia
- Author
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Syakieb Arsalan, Acep Edison, Yogo Heru Prayitno, Tria Apriliana, and Suryana
- Subjects
Psychiatry and Mental health ,Clinical Psychology ,Return on equity ,Profitability index ,Business ,Monetary economics ,Pshychiatric Mental Health ,Stock return ,Stock (geology) - Published
- 2020
24. The Effect of Der on Stock Return in Manufacturing Companies of Consumption Industrial Goods Sector
- Author
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Mohd Haizam Mohd Saudi, Obsatar Sinaga, and Yogo Heru Prayitno
- Subjects
Consumption (economics) ,Psychiatry and Mental health ,Clinical Psychology ,Debt-to-equity ratio ,Business ,Monetary economics ,Pshychiatric Mental Health ,Stock return - Published
- 2020
25. A Case of Indeterminate Cell Histiocytosis
- Author
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Taketoshi Ide, Masutaka Furue, Maiko Yoshida, Noriko Kitagawa, Takeshi Nakahara, Shoko Yogo, Maiko Wada-Ohno, Makiko Kido-Nakahara, Gaku Tsuji, and Seisho Sato
- Subjects
Pathology ,medicine.medical_specialty ,P16 ink4a ,business.industry ,medicine ,Dermatology ,Indeterminate Cell Histiocytosis ,medicine.disease ,business - Published
- 2020
26. A case of chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) without relapse after early steroid treatment
- Author
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Shinji Miyagawa, Yuki Asahara, Makiko Yogo, and Masahiko Suzuki
- Subjects
Adult ,Inflammation ,Male ,Pathology ,medicine.medical_specialty ,Chronic lymphocytic inflammation ,business.industry ,Methylprednisolone ,Diffusion Magnetic Resonance Imaging ,Treatment Outcome ,Steroid therapy ,Pulse Therapy, Drug ,Chronic Disease ,Encephalitis ,Humans ,Medicine ,Neurology (clinical) ,Infusions, Intravenous ,business ,Lymphatic Diseases ,Brain Stem ,Follow-Up Studies - Abstract
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a brainstem predominant lymphocytic inflammatory disease, which often relapses without oral immunosuppressants. This report describes a 37-year-old male case of CLIPPERS without relapse for 1 year after early steroid treatment. He was admitted to our hospital because of sensory disturbance in the left side of his body and ataxic gait. Gadolinium-enhanced T
- Published
- 2020
27. Long-term outcome and progression of osteoarthritis in uncomplicated cases of cranial cruciate ligament rupture treated by tibial plateau leveling osteotomy in dogs
- Author
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Nichika Mizokami, Yasushi Hara, Shuji Suzuki, Masakazu Shimada, Takuya Yogo, Yasuji Harada, Tom Ichinohe, and Nobuo Kanno
- Subjects
medicine.medical_specialty ,orthopedic surgery ,040301 veterinary sciences ,Stifle joint ,Osteoarthritis ,0403 veterinary science ,Cruciate ligament ,03 medical and health sciences ,Dogs ,Animals ,Medicine ,Dog Diseases ,Anterior Cruciate Ligament ,030304 developmental biology ,0303 health sciences ,Full Paper ,Tibia ,General Veterinary ,business.industry ,Anterior Cruciate Ligament Injuries ,tibial plateau leveling osteotomy ,04 agricultural and veterinary sciences ,medicine.disease ,Stifle ,Osteotomy ,Surgery ,Treatment Outcome ,medicine.anatomical_structure ,cranial cruciate ligament rupture ,Tibial-plateau-leveling osteotomy ,dog ,Orthopedic surgery ,stifle joint ,Disease Progression ,Ligament ,Tears ,business ,Medial meniscus - Abstract
The object of this study is to evaluate the long-term outcome of hind limb weight-bearing function and progression of stifle osteoarthritis (OA) after tibial plateau leveling osteotomy (TPLO). Groups were classified by the degree of cranial cruciate ligament (CrCL) damage and presence or absence of medial meniscus damage as macroscopically evaluated during surgery. Weight-bearing function was assessed via the peak vertical force (PVF), and OA progression was assessed via the radiographic OA score (OAS) preoperatively and 1, 3, 6, 12, 18, 24, and 36 months postoperatively. In all stifles, PVF was significantly higher within 6 months postoperatively than preoperatively, and this high ratio was maintained for 36 months. The OAS was significantly higher 24 months postoperatively than preoperatively in stifles with a partial CrCL tear, and significantly increased at each timepoint after 3 months postoperatively in stifles with complete CrCL rupture. The OAS remained consistently lower in stifles with a partial CrCL tear and no treatment of the medial meniscus than in stifles with complete rupture. Thus, after TPLO, the weight-bearing function improved in the early postoperative period and was maintained for as long as 36 months. Although OA progressed over time after TPLO, the progression was more gradual in stifles with partial tears than in those with complete rupture. Canine patients would benefit from earlier surgical intervention through development of technology that enables early detection of ligament degeneration.
- Published
- 2020
28. Evaluation of Hot Forging Lubricants for Steel by Ring Compression Test with Rotating Die
- Author
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Michiaki Kamiyama, Noritoshi Iwata, Sawamura Masatoshi, and Yasuhiro Yogo
- Subjects
business.product_category ,Materials science ,Mechanics of Materials ,Mechanical Engineering ,Die (manufacturing) ,Compression test ,General Materials Science ,Composite material ,Ring (chemistry) ,business ,Forging - Published
- 2020
29. Successful Management of Airway and Esophageal Foreign Body Obstruction in a Child
- Author
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Chiaki Toida, Naoki Yogo, Masayasu Gakumazawa, Takashi Muguruma, Mafumi Shinohara, and Ichiro Takeuchi
- Subjects
Asphyxia ,medicine.medical_specialty ,business.industry ,Mortality rate ,lcsh:Medical emergencies. Critical care. Intensive care. First aid ,Esophageal foreign body ,Case Report ,lcsh:RC86-88.9 ,General Medicine ,030204 cardiovascular system & hematology ,medicine.disease ,03 medical and health sciences ,High morbidity ,0302 clinical medicine ,medicine.anatomical_structure ,Swallowing ,030225 pediatrics ,medicine ,Esophagus ,Foreign body ,medicine.symptom ,Intensive care medicine ,business ,Airway - Abstract
Foreign body asphyxia is a serious clinical problem with high morbidity and mortality rates. It is relatively common among children, especially those younger than 3 years, because they have a high risk of aspirating foreign bodies owing to their tendency to place objects in their mouth and lack of a well-developed swallowing reflex. Moreover, the neurologic outcome after out-of-hospital cardiac arrests (OHCA) in pediatric patients remains generally poor. Here, we report an unusual pediatric case of asphyxial OHCA caused by foreign bodies obstructing the airway, complicating esophageal foreign body, with a neurologically favorable outcome. This case highlights the importance of adequate treatment for pediatric patients with OHCA, as well as the prompt and efficient management for pediatric patients with foreign bodies obstructing the airway and esophagus.
- Published
- 2019
30. Impulse Generation and Stabilization Performance of a Doughnut–Spherical Laser Launch System
- Author
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Akifumi Yogo, Ducthuan Tran, H. Nishimura, Chongfa Xie, and Koichi Mori
- Subjects
Orbital speed ,Physics::Optics ,Aerospace Engineering ,02 engineering and technology ,Impulse (physics) ,01 natural sciences ,010305 fluids & plasmas ,law.invention ,Computer Science::Robotics ,Optics ,0203 mechanical engineering ,law ,0103 physical sciences ,Physics::Atomic Physics ,Laser beams ,Blast wave ,Propellant ,Physics ,020301 aerospace & aeronautics ,business.industry ,Mechanical Engineering ,Laser ,Aerodynamic force ,Fuel Technology ,Space and Planetary Science ,Physics::Accelerator Physics ,Charge-coupled device ,business - Abstract
A conceptual laser launch system of a spherical vehicle propelled by a doughnut-shaped laser beam is expected to accelerate the spherical vehicle continuously to the orbit velocity along a laser be...
- Published
- 2019
31. Immune-related Liver Injury is a Poor Prognostic Factor in Patients with Nonsmall Cell Lung Cancer Treated with Immune Checkpoint Inhibitors
- Author
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Takafumi Yamamoto, Tetsunari Hase, Hiroki Kawashima, Masatoshi Ishigami, Takanori Ito, Naoyuki Yogo, Naozumi Hashimoto, Takashi Abe, Kenta Yamamoto, Takashi Honda, Takahiro Hatta, Norihiro Imai, Satoshi Yasuda, Hidenori Toyoda, Hirofumi Shibata, Mitsuhiro Fujishiro, Kazuyuki Mizuno, and Yoji Ishizu
- Subjects
Oncology ,Male ,Cancer Research ,medicine.medical_specialty ,Lung Neoplasms ,Immune checkpoint inhibitors ,Cell ,Drug Administration Schedule ,Immune system ,Internal medicine ,Carcinoma, Non-Small-Cell Lung ,medicine ,Carcinoma ,Humans ,Adverse effect ,Lung cancer ,Immune Checkpoint Inhibitors ,Aged ,Retrospective Studies ,Liver injury ,Lung ,business.industry ,General Medicine ,Middle Aged ,medicine.disease ,Prognosis ,Survival Analysis ,medicine.anatomical_structure ,Treatment Outcome ,Female ,Chemical and Drug Induced Liver Injury ,business - Abstract
It remains unclear whether severe liver immune-related adverse events (liver-irAEs) can affect the prognosis in non-small cell lung carcinoma (NSCLC) patients. Of the 365 NSCLC patients treated with immune checkpoint inhibitors (ICIs), 19 suffered from severe liver-irAEs (grade ≥3). The median time-to-onset of liver-irAEs was 53 days post-injection of the first ICI. The progression-free survival and overall survival of the liver-irAEs group (median 69 and 262 days, respectively) were significantly worse than the non-liver-irAEs group (128 and 722 days; P = 0.010 and P = 0.007; respectively). In conclusion, liver-irAEs were associated with poor prognosis in NSCLC patients.
- Published
- 2021
32. Author Correction: Proof-of-principle experiment for laser-driven cold neutron source
- Author
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D. Golovin, M. Nagata, Takuya Ishimoto, T. Mori, Akifumi Iwamoto, Yasuhiro Abe, Yuki Honoki, Akifumi Yogo, R. Kodama, S. R. Mirfayzi, Zechen Lan, D. Neely, Shinsuke Fujioka, S. Shokita, Hiroaki Nishimura, Kiyoko Okamoto, K. Mima, Satyabrata Kar, Yasunobu Arikawa, and M. Nakai
- Subjects
Physics ,Multidisciplinary ,business.industry ,Science ,Published Erratum ,Laser ,law.invention ,Optics ,law ,Proof of concept ,Medicine ,Neutron source ,business ,Author Correction ,General - Abstract
The scientific and technical advances continue to support novel discoveries by allowing scientists to acquire new insights into the structure and properties of matter using new tools and sources. Notably, neutrons are among the most valuable sources in providing such a capability. At the Institute of Laser Engineering, Osaka, the first steps are taken towards the development of a table-top laser-driven neutron source, capable of producing a wide range of energies with high brightness and temporal resolution. By employing a pure hydrogen moderator, maintained at cryogenic temperature, a cold neutron ([Formula: see text]) flux of [Formula: see text]/pulse was measured at the proximity of the moderator exit surface. The beam duration of hundreds of ns to tens of [Formula: see text] is evaluated for neutron energies ranging from 100s keV down to meV via Monte-Carlo techniques. Presently, with the upcoming J-EPoCH high repetition rate laser at Osaka University, a cold neutron flux in orders of [Formula: see text] is expected to be delivered at the moderator in a compact beamline.
- Published
- 2021
33. Expert System of Land Suitability for Fruit Cultivation Using Case-Based Reasoning Method
- Author
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Yogo Dwi Prasetyo, Condro Kartiko, and Bayu Anggoro Krisnamurti
- Subjects
business.industry ,Computer science ,Economic sector ,Cyclomatic complexity ,Agricultural engineering ,computer.software_genre ,Plot (graphics) ,Expert system ,Test case ,Agriculture ,Case-based reasoning ,business ,Productivity ,computer - Abstract
Agriculture is one of the economic sectors in Indonesia that has the potential to be developed to support the achievement of the nation's food independence. Horticultural farming has great opportunities to be developed. However, there are problems in the productivity and management of existing gardens. An example is the empty plot of land because often the planted plants can not survive, especially when the dry season arrives. Lack of information about land suitability and the limited ability of garden extension about the condition of land characteristics is the cause of the problem that occurs. This research aims to design and implement an expert system of land suitability selection for fruit crops. The method used for problem-solving using case-based reasoning is to compare new cases with old cases and calculate case similarity values. The result of this study is an expert system of determining the suitability of land for the cultivation of fruit crops that can provide recommendations on what plants are suitable for the land analyzed. The proposed case-based reasoning method can analyze the condition of the land by taking into account the conditions with their respective weights. Accuracy testing using the cyclomatic complexity method obtained expert system accuracy obtained results of 80% of 30 test cases.
- Published
- 2021
34. A Case of Folliculosebaceous Cystic Hamartoma Adjacent to a Trichilemmal Cyst
- Author
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Takeshi Nakahara, Shoko Yogo, Keiko Sakamoto, Hiromaro Kiryu, Masutaka Furue, and Makiko Kido-Nakahara
- Subjects
Pathology ,medicine.medical_specialty ,Trichilemmal cyst ,business.industry ,Medicine ,Folliculosebaceous cystic hamartoma ,Dermatology ,business ,medicine.disease - Published
- 2020
35. Laparoscopic sacrocolpopexy in a patient with vault prolapse of the sigmoid stump after vaginoplasty in Mayer-Rokitansky-Küster-Hauser syndrome: A case report
- Author
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Yogo Sawada, Tokumasa Hayashi, Auran Rosanne Cortes, Manisha Yadav, Ratih Krisna, Masayoshi Nomura, Pattiya Nutthachote, and Shino Tokiwa
- Subjects
medicine.medical_specialty ,MRKH Syndrome ,RD1-811 ,Sigmoid stump prolapse ,MRKH syndrome, Mayer-Rokitansky-Küster-Hauser syndrome ,digestive system ,Article ,03 medical and health sciences ,0302 clinical medicine ,Mayer-Rokitansky-Küster-Hauser syndrome ,Neovagina ,medicine ,Mayer-Rokitansky-Kuster-Hauser Syndrome ,Laparoscopic sacrocolpopexy ,030212 general & internal medicine ,030219 obstetrics & reproductive medicine ,business.industry ,Obstetrics and Gynecology ,Sigmoid function ,Gynecology and obstetrics ,medicine.disease ,digestive system diseases ,Surgery ,Müllerian agenesis ,LSC, laparoscopic sacrocolpopexy ,NTR, native tissue repair ,medicine.anatomical_structure ,Vagina ,RG1-991 ,Vaginoplasty ,Complication ,business - Abstract
Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a rare congenital anomaly that results in Müllerian agenesis that affects the uterus and upper two-thirds of the vagina. Sigmoid vaginoplasty is a surgical treatment option; however, vaginal prolapse may result as a complication of the sigmoid neovagina. There are no standards for treatment due to the rarity of this condition. We present the case of a 59-year-old woman with a history of sigmoid vaginoplasty who underwent laparoscopic sacrocolpopexy (LSC) for grade IV sigmoid stump prolapse. The patient had a successful outcome and no evidence of recurrent prolapse. This clinical case reveals the feasibility of LSC as a surgical treatment for sigmoid stump prolapses in patients with MRKH syndrome., Highlights • There is no gold standard treatment for neovaginal prolapse, due to its rarity. • Laparoscopic sacrocolpopexy (LSC) can be considered as an optimal treatment of choice for neovaginal prolapse. • LSC for sigmoid stump prolapse in a patient with MRKH syndrome results to a good functional and anatomical outcome at 3-year follow up.
- Published
- 2021
36. Hepatocellular carcinoma with duodenal invasion resected subsequent to multimodal therapies: A case report
- Author
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Tetsuro Hirose, Tomoko Okuno, Ryuichiro Doi, Takashi Ito, Atsushi Matsumoto, and Akitada Yogo
- Subjects
Sorafenib ,medicine.medical_specialty ,Hepatocellular carcinoma ,medicine.medical_treatment ,Duodenal invasion ,TACE, transarterial chemoembolization ,Pancreas-preserving partial duodenectomy ,Gastroenterology ,Article ,Disease course ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Case report ,medicine ,Hepatectomy ,Embolization ,Collateral vessels ,neoplasms ,DEB-TACE, drug-eluting beads-transarterial chemoembolization ,AFP, α-fetoprotein ,business.industry ,BCLC, Barcelona Clinic Liver Cancer ,medicine.disease ,GI, gastrointestinal ,digestive system diseases ,PIVKA-2, protein induced by vitamin K absence or antagonist -Ⅱ ,Major duodenal papilla ,medicine.anatomical_structure ,JSH, the Japan Society of Hepatology ,HPPD, hepatectomy with pancreas-preserving partial duodenectomy ,030220 oncology & carcinogenesis ,Duodenum ,030211 gastroenterology & hepatology ,Surgery ,HPD, hepatectomy with pancreaticoduodenectomy ,business ,HCC, hepatocellular carcinoma ,medicine.drug - Abstract
Highlights • Hepatocellular carcinoma (HCC) with duodenal invasion is a very rare occurrence. • Aggravated disease condition of HCC with duodenal invasion usually makes surgical treatment not advisable. • We present the first case of HCC with duodenal invasion resected following a multimodal therapy that included sorafenib. • Partial hepatectomy in conjunction with partial duodenectomy was selected to lessen surgical stress. • Surgical resection should be taken into consideration as a therapeutic choice even in progressive HCC disease condition., Introduction Gastrointestinal (GI) involvement in hepatocellular carcinoma (HCC) is uncommon. In particular, HCC with duodenal invasion is known to be a rare condition. In such cases, surgical indication has been generally negative except in few reported cases. To our knowledge, this report describes the first case of HCC with duodenal invasion, resected by hepatectomy accompanied by pancreas-preserving partial duodenectomy (HPPD) following multimodal therapies including systemic sorafenib administration. Case presentation A 65-year-old man had been repeatedly treated for multiple HCCs by transarterial chemoembolization (TACE) and sorafenib. However, the main tumor formerly ruptured began to involve his duodenum, causing GI bleeding. The collateral vessels from the pancreatic and omental branches entered the tumor and nullified the transarterial hemostatic embolization. Hence, HPPD was performed to preserve the major Vater papilla. Histopathological examination revealed poorly-to -moderately differentiated HCC cells invading the duodenum. Discussion and conclusion HPPD treatment successfully removed HCC with duodenal invasion achieving viable tumor clearance status (R0). We underline the importance of achieving viable tumor clearance status at any time during the treatment course of patients with advanced HCC as this approach may be the only approach to enable HCC patients with duodenal invasion to resume a healthy life.
- Published
- 2019
37. Estimation of the three-dimensional (3D) dose distribution of electron beams from medical linear accelerator (LINAC) using plastic scintillator plate
- Author
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Katsunori Yogo, Seiichi Yamamoto, Ryo Horita, Hiroshi Oguchi, Masataka Komori, Fumitaka Kawabata, Takayoshi Nakaya, Yoshiyuki Hirano, and Kuniyasu Okudaira
- Subjects
010302 applied physics ,Scintillation ,Radiation ,Materials science ,Physics::Instrumentation and Detectors ,business.industry ,Electron ,Scintillator ,01 natural sciences ,Linear particle accelerator ,Imaging phantom ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Optics ,Ionization ,0103 physical sciences ,Cathode ray ,Charge-coupled device ,business ,Instrumentation - Abstract
Measurements of three-dimensional (3D) dose distribution of electron-beams in water are important for high-energy electron beams from medical linear accelerators (LINAC). Although ionization chambers are commonly used for this purpose, measurements take a long time for precise 3D dose distribution. To solve the problem, we tried the measurements of the 3D dose distributions using a scintillator plate combined with a mirror. After we placed a 1 mm thick plastic scintillator plate at the upper inside of a black box, a water phantom was set above the plastic scintillator plate outside the black box, and electron beam was irradiated to the water phantom from the upper side. The attenuated electron-beam by the water in the phantom was detected by the plastic scintillator plate and the scintillation image was formed in the plate. The image was reflected by a surface mirror set below the plastic scintillator plate and detected by a cooled charge coupled device (CCD) camera from the side. We changed the depths of the water in the phantom, obtained the scintillation images, and calculated a 3D scintillation image using the measured images. Measurements were made for 9 MeV and 12 MeV electron-beams using the imaging system. From the images, we could successfully form 3D scintillation images. The depth profiles measured from the 3D images showed almost identical distribution with those calculated by the planning system within the difference of 5%. The lateral profiles also showed almost identical within the difference of the widths less than 2.5 mm. We conclude that the proposed method is promising for 3D dose distribution measurements of electron-beams.
- Published
- 2019
38. Successful Conservative Treatment of Traumatic Intraperitoneal Bladder Rupture in a Child: A Case Report
- Author
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Naoki Yogo, Makoto Kato, Ichiro Takeuchi, Mafumi Shinohara, Chiaki Toida, Ko Takahashi, Takashi Muguruma, and Masayasu Gakumazawa
- Subjects
Conservative treatment ,medicine.medical_specialty ,Bladder rupture ,business.industry ,Medicine ,General Medicine ,urologic and male genital diseases ,business ,Surgery - Abstract
The urinary bladder is protected by the pelvic bones and hence is a site less susceptible to external force injury than other organs. As children’s bones are not fully developed, the risk of bladder injury by external force is greater in children than adults. Pelvic fractures often cause the bladder to rupture, as do strong external forces when the bladder is filled. Bladder rupture is categorized as extraperitoneal or intraperitoneal, and treatments differ between the two. Extraperitoneal injury usually heals after drainage alone, whereas intraperitoneal injury usually requires surgical intervention such as a combination of surgical repairs and drainage. Herein, we report a pediatric case of intraperitoneal bladder rupture successfully treated without surgical repair (i.e., with drainage via an intraperitoneal tube and a urethral catheter only). Our report suggests that nonoperative treatment is an option for pediatric patients with intraperitoneal bladder rupture if certain conditions are met.
- Published
- 2019
39. Pancreatic acinar cell carcinoma diagnosed by BCL10 staining: A case report
- Author
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Kyouichi Takaori, Kei Yamane, Seiichiro Tada, Yuichiro Uchida, Kenta Inoguchi, Shinji Uemoto, Toshihiko Masui, Kenzo Nakano, Akitada Yogo, Takayuki Anazawa, and Kazuyuki Nagai
- Subjects
Pathology ,medicine.medical_specialty ,business.industry ,medicine ,business ,BCL10 ,Pancreatic Acinar Cell Carcinoma ,Staining - Published
- 2019
40. Clinical and experimental studies of intraperitoneal lipolysis and the development of clinically relevant pancreatic fistula after pancreatic surgery
- Author
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Asahi Sato, Kyoichi Takaori, Yasuhiko Tabata, Toshihiko Masui, Yuichiro Uchida, Kazuyuki Nagai, Takayuki Anazawa, Shinji Uemoto, Kenzo Nakano, and Akitada Yogo
- Subjects
Male ,medicine.medical_specialty ,Lipolysis ,Fistula ,Fatty Acids, Nonesterified ,Intra-Abdominal Fat ,Gastroenterology ,Pancreaticoduodenectomy ,Rats, Sprague-Dawley ,Pancreatic Fistula ,03 medical and health sciences ,chemistry.chemical_compound ,Pancreatectomy ,Postoperative Complications ,0302 clinical medicine ,Pancreatic Juice ,Risk Factors ,Internal medicine ,medicine ,Animals ,Humans ,Aged ,Triglyceride ,business.industry ,Lipase ,Middle Aged ,medicine.disease ,Disease Models, Animal ,Orlistat ,medicine.anatomical_structure ,chemistry ,Pancreatic fistula ,Obesity, Abdominal ,030220 oncology & carcinogenesis ,Lipase inhibitors ,Pancreatic juice ,Female ,030211 gastroenterology & hepatology ,Surgery ,Pancreas ,business ,medicine.drug - Abstract
Background Visceral obesity is one of the risk factors for clinically relevant pancreatic fistula after pancreatic resection. The objective of this study was to evaluate the impact of intraperitoneal lipolysis on postoperative pancreatic fistula. Methods The degree of intraperitoneal lipolysis was investigated by measuring the free fatty acid concentration in drain discharge in patients after pancreatic resection. An experimental pancreatic fistula model was prepared by pancreatic transection, and the impact of intraperitoneal lipolysis was evaluated by intraperitoneal administration of triolein (triglyceride) with, or without orlistat (lipase inhibitor). Results Thirty-three patients were included in the analysis. The free fatty acid concentration in drain discharge on postoperative day 1 was significantly associated with the development of a clinically relevant pancreatic fistula (P = 0·004). A higher free fatty acid concentration in drain discharge was associated with more visceral adipose tissue (P = 0·009). In the experimental model that included 98 rats, intraperitoneal lipolysis caused an increased amount of pancreatic juice leakage and multiple organ dysfunction. Intraperitoneal administration of a lipase inhibitor reduced lipolysis and prevented deterioration of the fistula. Conclusion Intraperitoneal lipolysis significantly exacerbates pancreatic fistula after pancreatic resection. Inhibition of lipolysis by intraperitoneal administration of a lipase inhibitor could be a promising therapy to reduce clinically relevant postoperative pancreatic fistula. Surgical relevance Clinically, there are two types of pancreatic fistula after pancreatic resections: harmless biochemical leak and harmful clinically relevant pancreatic fistula. Visceral obesity is one of the known risk factors for clinically relevant pancreatic fistula; however, the underlying mechanisms remained to be elucidated. Patients with clinically relevant pancreatic fistula had a higher free fatty acid concentration in the drain discharge, suggesting a relationship between intraperitoneal lipolysis and pancreatic fistula. The experimental model of pancreatic fistula demonstrated that intraperitoneal lipolysis caused deterioration in pancreatic fistula, suggesting that intraperitoneal lipolysis is one of the mechanisms that drives biochemical leakage to clinically relevant pancreatic fistula. Intraperitoneal administration of a lipase inhibitor prevented lipolysis as well as pancreatic fistula deterioration in the experimental model, suggesting a future clinical application for lipase inhibitors in prevention of clinically relevant pancreatic fistula.
- Published
- 2019
41. Investigation of Rotors Imitating Bird Wings to Reduce Electricity Consumption of HORNET
- Author
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Yogo Takada, Takahiro Tanaka, Tatsuki Kanada, and Yodai Matsumura
- Subjects
Consumption (economics) ,Thesaurus (information retrieval) ,Engineering ,Database ,business.industry ,Bird flight ,Robot ,Electricity ,computer.software_genre ,business ,computer - Published
- 2019
42. Development of a Compact Wall-Climbing Robot Capable of Transitioning among Floor, Vertical Wall and Ceiling
- Author
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Yogo Takada, Yodai Matsumura, and Koyo Kawamoto
- Subjects
business.industry ,Wall climbing ,Computer science ,Robot ,Structural engineering ,Ceiling (cloud) ,business ,Bridge inspection - Published
- 2019
43. Gallbladder Metastases of Invasive Ductal Carcinoma of the Breast Resected 9 Years after Initial Mastectomy
- Author
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Takashi Ito, Hideaki Oe, Ryuichiro Doi, Tetsuro Hirose, Jun Matsubayashi, Tomoko Okuno, Akitada Yogo, Naoto Nakamura, and Yusuke Abe
- Subjects
medicine.medical_specialty ,medicine.anatomical_structure ,business.industry ,Gallbladder ,medicine.medical_treatment ,Gastroenterology ,medicine ,Surgery ,Radiology ,Invasive ductal carcinoma ,business ,Mastectomy - Published
- 2018
44. Relative risks of Internet-related addictions and mood disturbances among college students: a 7-country/region comparison
- Author
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Anise M. S. Wu, J.H. Kwon, J.H.C. Ko, Elsie Yan, Catherine So-kum Tang, Yiqun Gan, Masao Yogo, and Yee Woen Koh
- Subjects
Adult ,Cross-Cultural Comparison ,Male ,Risk ,Asia ,Adolescent ,Universities ,media_common.quotation_subject ,education ,Anxiety ,Social Networking ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Surveys and Questionnaires ,Intervention (counseling) ,mental disorders ,medicine ,Humans ,Students ,China ,Depression (differential diagnoses) ,media_common ,Internet ,Depression ,business.industry ,Addiction ,Public Health, Environmental and Occupational Health ,General Medicine ,United States ,030227 psychiatry ,Behavior, Addictive ,Cross-Sectional Studies ,Video Games ,Relative risk ,Female ,The Internet ,Health education ,medicine.symptom ,business ,Psychology ,030217 neurology & neurosurgery ,Clinical psychology - Abstract
Objectives This study aimed to determine the relative risks of addiction to the Internet, online gaming and online social networking of college students in six Asian countries/regions (Singapore, Hong Kong [HK]/Macau, China, South Korea, Taiwan and Japan) compared with students in the United States (US). It also explored the relative risks of depression and anxiety symptoms among students with Internet-related addictions from these countries/regions. Study design This is a cross-sectional survey. Methods A convenience sample of 8067 college students aged between 18 and 30 years was recruited from seven countries/regions. Students completed a survey about their use of the Internet, online gaming and online social networking as well as the presence of depression and anxiety symptoms. Results For all students, the overall prevalence rates were 8.9% for Internet use addiction, 19.0% for online gaming addiction and 33.1% for online social networking addiction. Compared with the US students, Asian students showed higher risks of online social networking addiction but displayed lower risks of online gaming addiction (with the exception of students from HK/Macau). Chinese and Japanese students also showed higher risks of Internet addiction compared with the US students. In general, addicted Asian students were at higher risks of depression than the addicted US students, especially among Asian students who were addicted to online gaming. Addicted Asian students were at lower risks of anxiety than the addicted US students, especially among Asian students who were addicted to online social networking, and addicted students from HK/Macau and Japan were more likely to have higher relative risks of depression. Conclusions There are country/regional differences in the risks of Internet-related addictions and psychiatric symptoms. It is suggested that country/region-specific health education programmes regarding Internet-related addictions are warranted to maximise the efficiency of prevention and intervention. These programmes should attempt to tackle not only problematic Internet-related behaviours but also mood disturbances among college students.
- Published
- 2018
45. Preoperative risk stratification of lymph node metastasis for non-functional pancreatic neuroendocrine neoplasm: An international dual-institutional study
- Author
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Etsuro Hatano, Emily K. Bergsland, Grace E. Kim, Bryan K. Le, Eric K. Nakakura, Asahi Sato, Thomas A. Hope, Kazuyuki Nagai, Toshihiko Masui, Kyoichi Takaori, Yosuke Kasai, Takayuki Anazawa, Yuichiro Uchida, Kenzo Nakano, Akitada Yogo, Shinji Uemoto, and Julia Whitman
- Subjects
Male ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Lymph node metastasis ,Logistic regression ,Gastroenterology ,Risk Assessment ,California ,Japan ,Predictive Value of Tests ,Risk Factors ,Internal medicine ,medicine ,Humans ,Neoplasm Invasiveness ,Aged ,Neoplasm Staging ,Retrospective Studies ,Pancreatic duct ,Hepatology ,business.industry ,Odds ratio ,Middle Aged ,Confidence interval ,Pancreatic Neuroendocrine Neoplasm ,Pancreatic Neoplasms ,medicine.anatomical_structure ,Lymphatic Metastasis ,Lymph Node Excision ,Lymphadenectomy ,Female ,Lymph ,Lymph Nodes ,business - Abstract
BACKGROUND /Objectives: Although the presence of lymph node metastasis (LNM) defines malignant potential, preoperative prediction of LNM has not been established for non-functional pancreatic neuroendocrine neoplasm (NF-PNEN). We sought to develop a prediction system using only preoperatively available factors that would stratify the risk of LNM for NF-PNEN. METHODS We retrospectively reviewed patients who underwent R0/1 resection of NF-PNEN at Kyoto University (2007-2019) and the University of California, San Francisco (2010-2019). Risk stratification of LNM was developed using preoperative factors by the logistic regression analysis. Long-term outcomes were compared across the risk groups. RESULTS A total of 131 patients were included in this study. Lymph nodes were pathologically examined in 116 patients, 23 (20%) of whom had LNM. Radiological tumor size [1.5-3.5 cm (odds ratio: 13.5, 95% confidence interval: 1.77-398) and >3.5 cm (72.4, 9.06-2257) against ≤1.5 cm]
- Published
- 2021
46. Methaemoglobinaemia due to food protein-induced enterocolitis syndrome
- Author
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Naoki Yogo and Shota Fujito
- Subjects
medicine.medical_specialty ,Sodium bicarbonate ,business.industry ,Bicarbonate ,medicine.disease ,Food protein-induced enterocolitis syndrome ,chemistry.chemical_compound ,Endocrinology ,Blood pressure ,chemistry ,Term Infant ,Shock (circulatory) ,Internal medicine ,Pediatrics, Perinatology and Child Health ,Heart rate ,medicine ,medicine.symptom ,business ,Oxygen saturation (medicine) - Abstract
A 25-day-old term infant presented with fever, diarrhoea and 10% wt loss since birth (figure 1A) and 80% oxygen saturation in ambient air. His heart rate was 178 beats/min and blood pressure was 64/45 mmHg. Blood tests revealed a pH of 7.0, and bicarbonate, lactate and methaemoglobin levels of 6.2 mmol/L, 5.2 mmol/L, and 21%, respectively. After rehydration with fluid for shock, administration of sodium bicarbonate and stopping formula milk, …
- Published
- 2021
47. The role of bacterial symbionts in the biodegradation of chlorpyrifos in the digestive tract of Plutella xylostella larvae
- Author
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Hagus Tarno, Abdul Latief Abadi, Yogo Setiawan, Masruri Masruri, Mochammad Syamsul Hadi, Luqman Qurata Aini, Safira Rizka Lestari, Toto Himawan, and Bambang Tri Rahardjo
- Subjects
QH301-705.5 ,Plant Science ,Serratia ,Toxicology ,03 medical and health sciences ,chemistry.chemical_compound ,Biology (General) ,Molecular Biology ,030304 developmental biology ,biodegradation, chlorpyrifos, digestive insect, plutella xylostella, symbiont bacteria ,0303 health sciences ,biology ,030306 microbiology ,business.industry ,fungi ,Pseudomonas ,Pest control ,food and beverages ,Plutella ,Pesticide ,biology.organism_classification ,chemistry ,Chlorpyrifos ,Animal Science and Zoology ,PEST analysis ,business ,Bacteria - Abstract
Hadi MS, Abadi AL, Himawan T, MAsruri, Lestari SR, Rahardjo BT, Aini LQ, Setiawan Y, Tarno H. 2021. The role of bacterial symbionts in the biodegradation of chlorpyrifos in the digestive tract of Plutella xylostella larvae. Biodiversitas 22: 702-712. Several species in the order Lepidoptera act as plant pests, one of which is Plutella xylostella. Plutella xylostella is one of the most destructive pests of cabbage and other horticultural crops. The use of chemical insecticides as pest control for P. xylostella causes many problems, such as the increased pest resistance to pesticides. The objectives of this study are: (i) to obtain and characterize symbiont bacteria in the digestive tract of P. xylostella collected from organic and conventional agriculture soils; (ii) to evaluate the potential of bacterial symbionts in the digestive tract of P. xylostella from organic and conventional soils in degrading the active ingredient of chlorpyrifos insecticide; (iii) To determine the biodegradation process of chlorpyrifos insecticide by symbiont bacteria in the digestive tract of P. xylostella; and (iv) to identify the derivative compounds from the biodegradation of chlorpyrifos insecticide. The results showed 30 symbiont bacteria isolated from the digestive tract of P. xylostella collected from organic soil and 36 symbiont bacteria isolated from the digestive tract of P. xylostella from conventional farming soil. There are 15 species of symbiont bacteria in 5 genera from the digestive tract of P. xylostella from organic and conventional farming capable of degrading the chlorpyrifos insecticide. They are identified as Providencia sp., Pseudomonas sp., Serratia sp., Proteus sp., and Aeromonas sp. Chlorpyrifos-derived compounds from the biodegradation of symbiont bacteria are less toxic than chlorpyrifos compounds.
- Published
- 2021
48. Potentials of gas emission reduction (GHG) by the glass sheet industry through energy conservation
- Author
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Hery Susanto, Danny Faturahman, Yahya Jani, Satriyo Krido Wahono, Kiman Siregar, Yogo Adhi Nugroho, Kamaruddin Abdullah, Abubakar Yaro, Washington Purba, Roy Hendroko Setyobudi, and Erkata Yandri
- Subjects
emission factor ,lcsh:GE1-350 ,Flue gas ,business.industry ,020209 energy ,Electric potential energy ,Environmental engineering ,flue gas ,02 engineering and technology ,global ,Combustion ,Energy conservation ,020401 chemical engineering ,greenhouse gas ,Natural gas ,Greenhouse gas ,0202 electrical engineering, electronic engineering, information engineering ,Environmental science ,TA170 ,Electricity ,0204 chemical engineering ,business ,energy efficiency ,lcsh:Environmental sciences ,Efficient energy use - Abstract
Sheet Glass Industry is one industry that uses 75 % natural gas energy and 25 % electricity. Using the Intergovernmental Panel on Climate Change, IPCC-2006 emission calculation method, the average greenhouses gas (GHG) emissions obtained from the calcination process obtained 112 211 t CO2 yr–1 per plant and an average emission factor (EFkl) of 0.18 CO2 t–1 yr–1 of pull. With the technology of converting heat into electrical energy, residual combustion as flue gases has the potential to be used to produce electrical energy. Referring to the analysis and calculation; one of factories has potential to generate 0.8 MW to 3 MW electric energy. It’s efficiency of 10 % to 40 % so that it can be calculated as a component of GHG emission reductions whose value is 4.6 t CO2 yr–1 to 18.7 t CO2 yr–1 per plant. With this reduction, each of the GHG emission and emission factors per plant dropped to 93 442 t CO2 yr–1 and 0.16 CO2 t-pull–1.
- Published
- 2021
49. The Evolution from Life Insurance to Financial Engineering
- Author
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Motohiro Yogo and Ralph S. J. Koijen
- Subjects
Financial engineering ,Equity risk ,Actuarial science ,Download ,Life insurance ,Tax advantage ,Net worth ,Longevity insurance ,Business ,Stock (geology) - Abstract
Since the mid-1980s, the share of household net worth intermediated by US financial institutions has shifted from defined benefit plans to life insurers and defined contribution plans. Life insurers have primarily grown through variable annuities, which are mutual funds with longevity insurance, a potential tax advantage, and minimum return guarantees. The minimum return guarantees change the primary function of life insurers from traditional insurance to financial engineering. Variable annuity insurers are exposed to interest and equity risk mismatch and suffered especially low stock returns during the COVID-19 crisis. We consider regulatory changes, such as more detailed financial disclosure and standardized stress tests, to monitor potential risk mismatch and to ensure stability of the insurance sector. Institutional subscribers to the NBER working paper series, and residents of developing countries may download this paper without additional charge at www.nber.org.
- Published
- 2021
50. The Technical Design Concept of Hi-Tech Cook Stove for Urban Communities using Non-Wood Agricultural Waste as Fuel Sources
- Author
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Kamaruddin Abdullah, Yogo Adhi Nugroho, Fridolini Fridolini, Erkata Yandri, Washington Purba, Satriyo Krido Wahono, Bangun Novianto, Haryo Wibowo, and Roy Hendroko Setyabudi
- Subjects
lcsh:GE1-350 ,Briquette ,Cook stove ,business.product_category ,Waste management ,020209 energy ,Biomass ,Overheating (economics) ,02 engineering and technology ,010501 environmental sciences ,Combustion ,01 natural sciences ,Biogas ,energy efficient building ,Stove ,renewable energy integration ,pellet ,0202 electrical engineering, electronic engineering, information engineering ,Fuel efficiency ,Environmental science ,briquette ,business ,rural development ,lcsh:Environmental sciences ,0105 earth and related environmental sciences - Abstract
The purpose of this study is to conceptualize an urban Hi-Tech Cook-Stove (HTCS) design using agricultural waste. Several steps need to be carried out. First, determine the cooking activities depend on the family size and food categories. Second, calculate the energy required for cooking. Third, determine the mass of biomass fuel required. Fourth, calculate the fuel consumption rate. Fifth, design the dimensions of the stove by considering the ergonomics, easy in manufacturing, installation, etc. Sixth, estimate the volume of each component. The result shows that the fuel supply must adjust the flow rate of fuel, air to fuel ratio controlled by a simple mechanical-electric compressor, monitor the combustion chamber visually/automatically, and the dust must be collected/disposed of automatically/mechanically. HTCS must consider the pellets from the higher heating value and faster of biomass with a certain composition of chopped and fibre, also the safety and comfort, such as overheating control, air exhaust control, combustion control, cooling control. For the future, the HTCS technical design concept must be integrated with the electricity and hot water from solar energy by using a hybrid photovoltaic-thermal (PVT) collector and urban biogas digester in the development of smart grids and smart cities.
- Published
- 2021
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