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Flexible laser display is a critical component for an information output port in next-generation wearable devices. So far, the lack of appropriate display panels capable of providing sustained operation under rigorous mechanical conditions impedes the development of flexible laser displays with high reliability. Owing to the multiple scattering feedback mechanism, random lasers render high mechanical flexibility to withstand deformation, thus making them promising candidates for flexible display planes. However, the inability to obtain pixelated random laser arrays with highly ordered emissive geometries hinders the application of flexible laser displays in the wearable device. Here, for the first time, we demonstrate a mass fabrication strategy of full-color random laser arrays for flexible display panels. The feedback closed loops can be easily fulfilled in the pixels by multiple scatterings to generate durative random lasing. Due to the sustained operation of random laser, the display performance was well-maintained under mechanical deformations, and as a result, a flexible laser display panel was achieved. Our finding will provide a guidance for the development of flexible laser displays and laser illumination devices.

Short-term traffic flow prediction is an effective means for intelligent transportation system (ITS) to mitigate traffic congestion. However, traffic flow data with temporal features and periodic characteristics are vulnerable to weather effects, making short-term traffic flow prediction a challenging issue. However, the existing models do not consider the influence of weather changes on traffic flow, leading to poor performance under some extreme conditions. In view of the rich features of traffic data and the characteristic of being vulnerable to external weather conditions, the prediction model based on traffic data has certain limitations, so it is necessary to conduct research studies on traffic flow prediction driven by both the traffic data and weather data. This paper proposes a combined framework of stacked autoencoder (SAE) and radial basis function (RBF) neural network to predict traffic flow, which can effectively capture the temporal correlation and periodicity of traffic flow data and disturbance of weather factors. Firstly, SAE is used to process the traffic flow data in multiple time slices to acquire a preliminary prediction. Then, RBF is used to capture the relation between weather disturbance and periodicity of traffic flow so as to gain another prediction. Finally, another RBF is used for the fusion of the above two predictions on decision level, obtaining a reconstructed prediction with higher accuracy. The effectiveness and robustness of the proposed model are verified by experiments.

The characterization and correction of lens distortion is an important part of optical measurement. This work analyzes the formation mechanism of color fringes and multiplication moire, and discusses modification of the color CCD moire method for correcting lens distortion. A demosaicing algorithm was used to simulate the color fringes in a CCD moire pattern. We then performed a detailed analysis of the carrier field, and adopted a universal polynomial distortion model to characterize lens distortion, which increased the accuracy of distortion correction. Comparison experiments verified the feasibility of the modified method and the correctness of the formation mechanism for color CCD moire. The modified method was then applied to lens distortion correction in the DIC measurement process, effectively reducing errors in displacement measurement.

Is there a Muslim disadvantage in economic integration to the Chinese economy? Do political mandates from the government help reduce disparities? To answer these questions, we conducted a large-scale audit study and submitted over 4000 resumes of fictitious male candidates to job advertisements for accounting and administrative positions posted by private firms, state-owned firms and foreign firms. We randomized the ethnic identities of job applicants, their academic merit, and requested salaries. Our results show that a Muslim job seeker is more than 50% less likely to receive a callback than a Han job seeker, and higher academic merit does not compensate for this bias. Importantly, we find that state-owned enterprises are equally likely to discriminate against Muslim job seekers, despite their political mandate to increase diversity. Interview evidence suggests that besides productivity concerns and outright hostility towards outgroups, bias is also driven by employer concerns over the operational costs of accommodating a diverse workforce.

PD-1 blockade has transformed the management of advanced clear cell renal cell carcinoma (ccRCC), but the drivers and resistors of the PD-1 response remain incompletely elucidated. Here, we analyzed 592 tumors from patients with advanced ccRCC enrolled in prospective clinical trials of treatment with PD-1 blockade by whole-exome and RNA sequencing, integrated with immunofluorescence analysis, to uncover the immunogenomic determinants of the therapeutic response. Although conventional genomic markers (such as tumor mutation burden and neoantigen load) and the degree of CD8+ T cell infiltration were not associated with clinical response, we discovered numerous chromosomal alterations associated with response or resistance to PD-1 blockade. These advanced ccRCC tumors were highly CD8+ T cell infiltrated, with only 27% having a non-infiltrated phenotype. Our analysis revealed that infiltrated tumors are depleted of favorable PBRM1 mutations and enriched for unfavorable chromosomal losses of 9p21.3, as compared with non-infiltrated tumors, demonstrating how the potential interplay of immunophenotypes with somatic alterations impacts therapeutic efficacy. A pooled genetic, transcriptomic and immunopathologic analysis of over 500 tumors from patients with advanced renal cell cancer suggests that response to PD-1 blockade depends on both CD8+ T cell infiltration and enrichment of tumor-intrinsic somatic alterations.

Photonic barcodes have attracted extensive attention due to their promising applications in multiplexed high throughput bioassays, item tracking, information security, etc. Organic luminescent materials, capable of assembling into various micro/nanostructures as a result of their outstanding processability, afford a fundamental model for designing novel micro/nanoscale photonic barcodes. In this highlight, we review recent advances in micro/nanoscale photonic barcodes based on organic materials. This highlight starts by introducing the significance of tiny photonic barcodes and discussing why organics have become dominant. Then we present the research progress on organic photonic barcodes in terms of a series of strategies including graphical encoding, spectroscopic encoding and a combination of them both. In the following part, we focus on the construction of covert photonic barcodes based on near-infrared luminescence and responsive excited state processes, which have shown great potential in advanced anti-counterfeiting. Finally, we present our views on the current challenges and the future development of organic micro/nanoscale photonic barcodes. We believe that a comprehensive understanding on this topic would significantly contribute to the advancement of organic photonic barcodes for a broad range of applications.

Ischemic stroke is a severe neurological disease without known effective therapy. Microglia-mediated neuroinflammation plays an important role in ischemic stroke. Therefore, finding a safe and effective microglial activation inhibitor might lead to an effective therapeutic strategy against ischemic stroke. In this project, our goal was to explore both the mechanism and effect of pterostilbene in MCAO/R rats. The potential effect of pterostilbene on ischemic stroke was tested using MCAO/R rats and its effect on microglial activation was tested in LPS-stimulated BV-2 cells. In vivo, pterostilbene decreased the neurological scores, brain water content and infarct volume in MCAO/R rats. Pterostilbene increased the number of mature neurons, decreased the number of activated microglia, and reduced iNOS and IL-1β mRNA expression. Pterostilbene inhibited phosphorylated-IκBα expression, thus promoting IκBα expression and inhibiting ROS overexpression. In vitro, pterostilbene inhibited the expression of inflammatory cytokines and suppressed NAPDH activity as well as activation of both the NF-κB pathway and ROS production. To our knowledge, our study is the first to demonstrate that pterostilbene-mediated alleviation of cerebral ischemia and reperfusion injury in rats may be correlated with the inhibition of the ROS/NF-κB-mediated inflammatory pathway in microglia, indicating the potential for the use of pterostilbene as a candidate therapeutic compound for ischemic stroke.

Journal of traffic and transportation engineering : JTTE 8(6), 815-999 (2021). doi:10.1016/j.jtte.2021.10.001, Published by Periodical Offices of Chang��an University, [S.I.]

There are several causes of chronic kidney disease, but all of these patients have renal fibrosis. Although many studies have examined the pathogenesis of renal fibrosis, there are still no effective treatments. A healthy and balanced metabolism is necessary for normal cell growth, proliferation, and function, but metabolic abnormalities can lead to pathological changes. Normal energy metabolism is particularly important for maintaining the structure and function of the kidneys because they consume large amounts of energy. We describe the metabolic reprogramming that occurs during renal fibrosis, which includes changes in fatty acid metabolism and glucose metabolism, and the relationship of these changes with renal fibrosis. We also describe the potential role of novel drugs that disrupt this metabolic reprogramming and the development of fibrosis, and current and future challenges in the treatment of fibrosis.

Frontiers in Materials 8, 745392 (2021). doi:10.3389/fmats.2021.745392, Published by Frontiers Media, Lausanne

Background: Estrogen deficiency contributes to the development of Alzheimer’s disease (AD) in menopausal women. In the current study, we examined the impact of estrogen deficiency on mitochondrial function and cognition using a postmenopausal mouse model.Methods: Bilateral ovariectomy was conducted in adult females C57BL/6J. Cognitive function was examined using the Morris water maze (MWM) test at 2 weeks, 1, 2, and 3 months after ovariectomy. Neurodegeneration was assessed using an immunofluorescence assay of microtubule-associated protein 2 (MAP2) in the hippocampus and immunoblotting against postsynaptic density-95 (PSD95). Mitochondrial function in the hippocampus was assessed using immunoblotting for NDUFB8, SDHB, UQCRC2, MTCO1, and ATP5A1. Mitochondrial biogenesis was examined using immunoblotting for PGC-1α, NRF1, and mtTFA. Mitochondrion fission was assessed with immunoblotting for Drp1, whereas mitochondrion fusion was analyzed with immunoblotting for OPA1 and Mfn2. Mitophagy was examined with immunoblotting for PINK1 and LC3B. Mice receiving sham surgery were used as controls.Results: Ovariectomy resulted in significant learning and memory deficits in the MWM test at 3 months, but not at any earlier time points. At 2 weeks after ovariectomy, levels of Drp1 phosphorylated at Ser637 decreased in the hippocampus. At 1 month after ovariectomy, hippocampal levels of NDUFB8, SDHB, PGC-1α, mtTFA, OPA1, and Mfn2 were significantly reduced. At 2 months after ovariectomy, hippocampal levels of MAP2, PSD95, MTCO1, NRF1, and Pink1 were also reduced. At 3 months, levels of LC3B-II were reduced.Conclusions: The cognitive decline associated with estrogen deficiency is preceded by mitochondrial dysfunction, abnormal mitochondrial biogenesis, irregular mitochondrial dynamics, and decreased mitophagy. Thus, mitochondrial damage may contribute to cognitive impairment associated with estrogen deficiency.

Anticounterfeiting labels based on physical unclonable functions (PUFs) exhibit high security with unreplicable code outputs, making them an ideal platform to realize unbreakable anticounterfeiting. Although various schemes are proposed for PUF labels, the utilization of natural randomness suffers from unpredictable signal extraction sites, which poses a challenge to efficient and convenient authentication for practical anticounterfeiting applications. Here, a covert optical PUF-based cryptographic protocol from silk protein-based microlaser (SML) arrays that possess hidden randomness of lasers for unclonable lasing signals as well as a defined location for efficient identification is proposed. The initial SMLs are patterned by casting laser dye-doped regenerated silk fibroin solution, resulting in a uniform microlaser array with regulated positions. With the SML array as substrate, random methanol microdroplets are stochastically sprayed on the SML array, which eventually induces uneven lasing signal changes of the patterned microlasers. The treated SML array possesses the deterministic readout sites of laser signals and unrepeatable signal distribution characteristics, which can guarantee efficient authentication and high security when serving as an anticounterfeiting label.

The pharmaceutical tablet manufacturing process (PTMP) via wet granulation holds a critical position in pharmaceutical industry. The interest in integrating mechanistic process modeling into the pharmaceutical development has been increased because simulation model is a prerequisite for process design, analysis, control, and optimization. So the simulation modeling for PTMP via wet granulation is very necessary and significant. This study aims at proposing a simulation modeling framework for PTMP via spray fluidized bed granulation (SFBG), which is one of the most widely used wet granulation techniques in pharmaceutical industry. For SFBG, a simulation model that simultaneously involves the influences of operating variables and material attributes on average particle size (APS) is firstly developed, and then a drying model to determine the particle moisture content is introduced to be coupled with the established model predicting APS. For PTMP, considering the important effect of porosity on tablet qualities, a model describing the changes in tablet porosity is developed based on a promoted form of the Heckel equation, and then several recognized models that are all related to porosity are introduced or constructed to calculate important tablet quality indexes. The feasibility and effectiveness of the developed simulation models are validated by performing a computational experimental study to explore the scientific understanding of process and process quality control.

Irrigated agriculture consumes a large amount of groundwater resources with a huge energy requirement, and this has seriously restricted the development of green and efficient agriculture in China. However, recent studies on energy consumption for irrigation focus mainly on individual irrigation systems or single wells, and few spatial-temporal energy assessments have been carried out at regional scale. This is needed for effective management of regional energy consumption for groundwater utilization. Based on single-well pumping method, a distributed energy consumption model for groundwater irrigation (DPE_GI) was proposed in this study. The North China Plain (NCP) was selected as the research area, which is a typical groundwater irrigated area and has severe issues with aquifer depletion. The results showed that the average annual energy consumption for groundwater pumping was 13.67 billion kW h, and the energy consumption per area was 1122.4 kW h hm−2 under the winter wheat - summer maize rotation system in NCP. Current groundwater pumping energy consumption in the NCP is 2.9 times of the initial value in 1986, and the NCP has already become the world's largest energy consumer for groundwater irrigation. Due to the uncertainty of precipitation, energy consumption for irrigation fluctuates per growing season. Groundwater level also impacts energy consumption. Popularizing water-saving irrigation technology such as drip or sprinkler irrigation, changing cropping systems and habits can effectively reduce energy consumption for irrigation.

Background: Chronic progressive external ophthalmoplegia (CPEO) is a mitochondrial encephalomyopathy caused by multiple mtDNA abnormalities. There is little information about the changes of ocular fundus with CPEO. The aim of this work was to measure and evaluate changes in the macular retinal thickness and optic nerve head in patients with CPEO using spectral-domain optical coherence tomography and to compare the findings with those of healthy individuals. Methods: Totally, 18 CPEO patients were enrolled in this study. Healthy volunteers matched for gender, age, and diopter settings were included as a control group. The retinal thickness of macular central fovea, inner and outer retinal layer thickness of perifoveal macular, optic nerve head parameters, and peripapillay retinal nerve fiber layer thickness (pRNFLT) for all included cases were measured using spectral-domain optical coherence tomography. A paired t test was used to compare the differences in the studied parameters between the two groups. The correlations between macular retinal thickness, pRNFLT, disease duration, and age of onset were also analyzed. Results: Among the macular parameters, retinal thickness of macular central fovea (t = -2.135, P < 0.05) and outer retinal layer thickness (t = -1.994, P < 0.05) of patients in the CPEO group were statistically significant lower than those of patients in the normal control group. For the optic nerve head parameters, the patients in the CPEO group showed a larger rim volume (t = -2.499, P < 0.05) and nerve head volume (t = -2.103, P < 0.05). The overall pRNFLT of patients in the CPEO group was statistically significant lower than that of patients in the control group (t = -4.125, P < 0.05). The comparison of pRNFLT in eight sectors showed that the pRNFLT of patients in the CPEO group was statistically significant lower than that of the control group mainly in the inferior and temporal sectors. The degree of pRNFL defect negatively correlated with the disease duration (r = -0.583, P < 0.05). Conclusions: The retinal thickness of patients with CPEO was significantly thinner, which was mostly the outer retina. The patients’ optic discs had a low volume and the loss of the retinal nerve fiber layer was obvious. With the extension of the disease duration, the retinal nerve fiber layer defect was even more significant. Key words: Optical coherence tomography; Chronic progressive external ophthalmoplegia; Retina; Nerve fiber layer

Portal vein thrombosis (PVT) is a common complication of liver cirrhosis. The association between endoscopic injection sclerotherapy (EIS) and PVT is unclear. In this paper, we reported that a male cirrhotic patient developed acute mesenteric vein thrombosis after EIS for secondary prophylaxis of esophageal variceal bleeding. Immediate anticoagulation therapy was effective and safe in this patient.

Background Sarcoglycanopathies comprise four subtypes of autosomal recessive limb-girdle muscular dystrophy (LGMD2C, LGMD2D, LGMD2E, and LGMD2F) that are caused, respectively, by mutations in the SGCG, SGCA, SGCB, and SGCD genes. Knowledge about the clinical and genetic features of sarcoglycanopathies in Chinese patients is limited. The aims of this study were to investigate in detail the clinical manifestations, sarcoglycan expression, and gene mutations in Chinese patients with sarcoglycanopathies and to identify possible correlations between them. Results Of 3638 patients for suspected neuromuscular diseases (1733 with inherited myopathies, 1557 with acquired myopathies, and 348 unknown), 756 patients had next-generation sequencing (NGS) diagnostic panel. Twenty-five patients with sarcoglycanopathies (11.5%) were identified from 218 confirmed LGMDs, comprising 18 with LGMD2D, 6 with LGMD2E, and one with LGMD2C. One patient with LGMD2D also had Charcot-Marie-Tooth 1A. The clinical phenotypes of the patients with LGMD2D or LGMD2E were markedly heterogeneous. Muscle biopsy showed a dystrophic pattern in 19 patients and mild myopathic changes in 6. The percentage of correct prediction of genotype based on expression of sarcoglycan was 36.0% (4 LGMD2D, 4 LGMD2E, and one LGMD2C). There was a statistically significant positive correlation between reduction of α-sarcoglycan level and disease severity in LGMD2D. Thirty-five mutations were identified in SGCA, SGCB, SGCG, and PMP22, 16 of which were novel. Exon 3 of SGCA was a hotspot region for mutations in LGMD2D. The missense mutation c.662G > A (p.R221H) was the most common mutation in SGCA. Missense mutations in both alleles of SGCA were associated with a relative benign disease course. No obvious clinical, sarcoglycan expression, and genetic correlation was found in LGMD2E. Conclusions This study expands the clinical and genetic spectrum of sarcoglycanopathies in Chinese patients and provides evidence that disease severity of LGMD2D may be predicted by α-sarcoglycan expression and SGCA mutation. Electronic supplementary material The online version of this article (10.1186/s13023-019-1021-9) contains supplementary material, which is available to authorized users.

In spite of the relatively high incidence rate, the etiology and pathogenesis of restless legs syndrome (RLS) are still unclear. Long-term drug treatments fail to achieve satisfying curative effects, which is reflected by rebound and augmentation of related symptoms. An electrophysiological endophenotype experiment was done to investigate the mechanism of somatosensory disorder among RLS patients. Together with 15 normal subjects as the control group, with comparable ages and genders to the RLS patients, 15 primitive RLS patients were scanned by Magnetoencephalography (MEG) under natural conditions; furthermore, the somatosensory evoked magnetic field (SEF) with single and paired stimuli, was also measured. Compared to the control group, the SEF intensities of RLS patients’ lower limbs were higher, and the paired-pulse depression (PPD) for SEF in RLS patients was attenuated. It was also revealed by time-frequency analysis of somatosensory induced oscillation (SIO) in RLS patients, that 93.3% of somatosensory induced Alpha (8–12 Hz) oscillations were successfully elicited, while 0% somatosensory induced Gamma (30–55 Hz) oscillations were elicited; which was significantly different from the control group. Additionally, in RLS patients exhibit increased excitability of the sensorimotor cortex, a remarkable abnormality existing in early somatosensory gating control (GC) and an attenuated inhibitory interneuron network, which consequently results in a compensatory mechanism through which RLS patients increase their attention-driven lower limb sensory gating control via somatosensory-induced Alpha (8–12 Hz) oscillation. This hyperexcitability, partially due to an electrocortical disinhibition, may have an important therapeutical implication, and become an important target of neuromodulatory interventions.

How do individuals respond to internal security threats in non-democracies? Does violence make individuals more supportive of a strong state? Are the effects of violence on individual attitudes uniform, or are they heterogeneous with respect to the identity of the perpetrators? We field an online survey experiment on a national sample of Chinese citizens, in which respondents were randomly selected to view reports on violent acts in China. We show that exposure to violence makes individuals more supportive of a strong state: respondents randomly exposed to violence are more likely to approve police use of lethal force, and this effect is particularly strong among the less wealthy Han Chinese. We also find suggestive evidence that individuals exhibit intergroup biases in their reaction to violence.

We report the synthesis and photoluminescence (PL) behavior of a new molecular system, which is composed of three positional isomers. They exhibit isomeric effects on both aggregation-induced emission (AIE) and intramolecular charge transfer (ICT) mechanisms. Furthermore, one of them, i.e., (E)-5-methoxy-2-(((6-methylbenzo [d]thiazol-2- yl)imino)methyl)phenol (MTP3), shows unique mechanochromic fluorescence (MCF) phenomenon. Unlike most MCF materials that would function immediately after applying mechanical force, the MCF character of this material is however recessive with mechanical force, but becomes visible upon fumigation treatment. Given that the MCF is activated under specific conditions, it is termed as conditional mechanochromic fluorescence (CMCF) in this study. In light of the CMCF property of MTP3, a new data encryption-decryption technique was developed. Binary data and complex patterns can be recorded by mechanical force and concealed on the tailor-made data storage. The encoded data cannot be read unless it is fumed by organic vapour, demonstrating a successful encryption-decryption technique. The CMCF offers great potential to be the alternative to encryption algorithms and may contribute greatly to data security and cybercrime prevention.

Recent studies have shown that approximately 50% of patients with chronic myeloid leukemia (CML) receiving tyrosine kinase inhibitor (TKI) therapy with a sustained deep molecular response (DMR) (BCR-ABL1IS ≤ 0.01%) can achieve treatment-free remission (TFR, stopping TKI without relapse) and that prior interferon (IFN)-α therapy and higher NK cell counts at and after TKI discontinuation are associated with TFR. We recently reported that post-TKI discontinuation of IFN-α therapy could prevent molecular relapse (MR, BCR-ABL1IS > 0.1%). Here, we evaluated whether NK cells are associated with MR and investigated the effects of post-TKI discontinuation IFN-α therapy on lymphocyte subsets. A total of 34 patients measuring blood lymphocyte subclasses were included. In the 22 patients who did not receive IFN-α therapy, at 1 month after TKI discontinuation, the nonrelapsed patients showed a significantly higher proportion and count of NK cells than the relapsed patients. In particular, the proportion and count of CD56dim NK cells were significantly higher in the nonrelapsed patients than in the relapsed patients. In the 12 patients who received IFN-α therapy, the level of CD56bright NK cells increased significantly after 3 and 6 months of IFN-α therapy. In summary, NK cells, in particular CD56dim NK cells, were associated with MR after TKI discontinuation in patients with CML. Additionally, IFN-α therapy gradually increased the level of CD56bright NK cells in patients with CML.

Purpose Leptin and adiponectin are adipokines which have been commonly implicated in carcinogenesis. As such, many studies have investigated the association of circulating leptin and adiponectin levels with colorectal cancer (CRC) risk. However, the results remained inconsistent. Methods In this work, we performed a systematic review and meta-analysis to precisely examine the association between circulating levels of leptin and adiponectin and CRC risk. A systematic literature search was performed in PubMed/MEDLINE, Scopus, Web of Science, and EMBASE databases from inception until October 2020. The pooled effect size was then estimated by calculating the odds ratio (OR). Results A total of 23 records (comprising 26 studies) were included in the meta-analysis. The overall analysis found that circulating levels of leptin and adiponectin were not significantly associated with CRC risk (P > 0.05). Interestingly, subgroup analysis revealed that a higher level of adiponectin was significantly associated with an increased CRC risk among overweight individuals (OR = 1.16; 95 % CI: 1.02, 1.32), and a decreased CRC risk among normal weight individuals (OR = 0.76; 95 % CI: 0.62, 0.92). Besides, a higher level of adiponectin was also significantly associated with a decreased risk of CRC in men (OR = 0.76; 95 % CI: 0.59, 0.98). Conclusions In conclusion, circulating leptin level was not associated with CRC risk, but that of adiponectin was associated with CRC risk only in specific subgroups.

In modern transportation, pavement is one of the most important civil infrastructures for the movement of vehicles and pedestrians. Pavement service quality and service life are of great importance for civil engineers as they directly affect the regular service for the users. Therefore, monitoring the health status of pavement before irreversible damage occurs is essential for timely maintenance, which in turn ensures public transportation safety. Many pavement damages can be detected and analyzed by monitoring the structure dynamic responses and evaluating road surface conditions. Advanced technologies can be employed for the collection and analysis of such data, including various intrusive sensing techniques, image processing techniques, and machine learning methods. This review summarizes the state-of-the-art of these three technologies in pavement engineering in recent years and suggests possible developments for future pavement monitoring and analysis based on these approaches.

One of the key steps in pavement maintenance is the fast and accurate identification of the distresses, defects, and pavement markings and ability to conduct the maintenance before the irre...

Objective To investigate the effectiveness of alpha activity neurofeedback training over the parietal lobe in GAD patients. Methods Twenty‐six female patients who had been diagnosed as GAD according to the Diagnostic and Statistical Manual of Mental Disorders (5th edition, DSM‐V) criteria were included in this study. Patients were randomized into two groups: the left parietal lobe training group (LPL group, n = 13) and the right parietal lobe training group (RPL group, n = 13), and then received ten 40‐minute alpha training sessions in the relevant area. Evaluations included severity of anxiety (by State‐Trait Anxiety Inventory, STAI) and depression (by Beck Depression Inventory, BDI‐II) after the fifth training session and the last training session. Results The scores of STAI‐S decreased significantly two weeks after the fifth training session in both groups (LPL group: from 47.15 ± 10.65 to 38.69 ± 8.78, p, Neurofeedback training of alpha activity over the parietal lobe is effective in GAD patients. Especially on the improvement of GAD patients’ anxiety trait and depressive symptoms.

BackgroundTo build a novel and simple model to predict iatrogenic preterm birth in pregnant women with scarred uteri.MethodsIn this retrospective, observational, single-centre cohort study, data from 2315 patients with scarred uteri were collected. Multiple logistic regression analysis and mathematical modelling were used to develop a risk evaluation tool for iatrogenic preterm birth. After modelling, the calibration and discrimination of the model along with decision curve analysis were checked and performed to ensure clinical applicability.ResultsAmong the 2315 patients, 417 (18.0%) had iatrogenic preterm births. The following variables were included in the model: interpregnancy interval (0 to P = 0.003; 13 to P = 0.068; ≥ 60 months, OR 1.60 (95% Cl 0.86–2.97),P = 0.14), height (OR 0.95, (95% CI 0.92–0.98),P = 0.003), parity (parity ≤1 (reference), parity = 2, OR 2.92 (95% CI 1.71–4.96),P P = 0.001), number of vaginal bleeding (OR 1.81, (95% Cl 1.36–2.41),P P P ConclusionsIn this study, we built a model to predict iatrogenic preterm birth for pregnant women with scarred uteri. The nomogram we created can assist doctors in evaluating the risk of iatrogenic preterm birth and help in making referrals; thus, better medical care can be given to improve the prognosis of patients and foetuses.

Purpose: We sought to validate levels of CD8+ tumor-infiltrating cells (TIC) expressing PD-1 but not TIM-3 and LAG-3 (IF biomarker; Pignon and colleagues, 2019) and to investigate human endogenous retroviruses (hERV) as predictors of response to anti–PD-1 in a randomized trial of nivolumab (nivo) versus everolimus (evero) in patients with metastatic clear cell renal cell carcinoma (mccRCC; CheckMate-025). Experimental Design: Tumor tissues (nivo: n = 116, evero: n = 107) were analyzed by multiparametric immunofluorescence (IF) and qRT-PCR. Genomic/transcriptomic analyses were performed in a subset of samples. Clinical endpoints included objective response rate (ORR), progression-free survival (PFS), overall survival (OS), and durable response rate (DRR, defined as complete response or partial response with a PFS ≥ 12 months). Results: In the nivo (but not evero) arm, patients with high-IF biomarker density (24/116, 20.7%) had higher ORR (45.8% vs. 19.6%, P = 0.01) and DRR (33.3% vs. 14.1%, P = 0.03) and longer median PFS (9.6 vs. 3.7 months, P = 0.03) than patients with low-IF biomarker. By RNA sequencing, several inflammatory pathways (q < 0.1) and immune-related gene signature scores (q < 0.05) were enriched in the high-IF biomarker group. When combined with the IF biomarker, tumor cell (TC) PD-L1 expression (≥1%) further separated clinical outcomes in the nivo arm. ERVE-4 expression was associated with increased DRR and longer PFS in nivo-treated patients. Conclusions: High levels of CD8+ TIC expressing PD-1 but not TIM-3 and LAG-3 and ERVE-4 expression predicted response to nivo (but not to evero) in patients with mccRCC. Combination of the IF biomarker with TC PD-L1 improved its predictive value, confirming our previous findings.

With the rapid development of wireless communication, the channel transmission is close to the Shannon–Hartley theorem, so the birth of new technologies is urgently needed. At the same time, the discovery and development of orbital angular momentum (OAM) provides new ideas for wireless communications. Due to the mutual orthogonality of OAM wave modes, spatial multiplexing becomes possible, beams of the same frequency with OAM can travel simultaneously, and the channel capacity efficiency can be greatly improved.

Objective To explore the neurophysiological mechanism of clinically effective transcutaneous spinal cord direct current stimulation (tsDCS) on idiopathic restless legs syndrome (RLS), structural magnetic resonance imaging (sMRI), and resting-state functional MRI (rs-fMRI) were applied to reveal the structural and functional changes in idiopathic RLS patients after tsDCS. Methods Thirty idiopathic RLS patients and 20 gender- and age-matched healthy controls (HC) were enrolled. All patients were randomly divided into anodal treatment group and sham treatment group and were treated with tsDCS for 2 weeks. The international RLS Rating Scale (IRLS-RS) and Pittsburgh Sleep Quality Index (PSQI) were used to evaluate the severity of RLS and sleep quality respectively. The sMRI and rs-fMRI data of anodal treatment group and HC were collected. Voxel-based morphology (VBM) and resting-state functional connectivity analysis were used to assess the change of cortical gray matter volume (GMV) and corresponding functional connectivity (FC) respectively in anodal treatment group after tsDCS treatment. Results Sham treatment group showed no significant change in IRLS-RS and PSQI scores after tsDCS, while significant decrease scores were observed in anodal treatment group, and the improvement sustained up to 2 weeks. Anodal treatment group showed significant regional decrease of GMV in bilateral cuneus compared to the HC. After tsDCS treatment, the GMV in the bilateral cuneus and left ventral post central gyrus (PoCG_L) decreased significantly. The FC between bilateral cuneus and left primary visual cortex (V1_L), and between right cuneus (Cune_R) and right lingual gyrus (LG_R) increased significantly after tsDCS, whereas the FC between PoCG_L and supplementary motor area (SMA) decreased significantly. The changed FC between PoCG_L and SMA, between Cune_R and V1_L were correlated with the changed IRLS-RS. Conclusion Disturbance of sensorimotor network and visual processing network may be involved in the pathogenesis of RLS. tsDCS probably can regulate FC in the sensorimotor cortex and visual processing cortex to relieve the symptom of RLS. Continuous tsDCS may improve the symptoms of RLS patients for a long time. tsDCS probably could provide a potential non-pharmacologic treatment for idiopathic RLS patients.

Aim To develop nomograms predicting the risk of postpartum hemorrhage (PPH) in cesarean delivery for singleton pregnant women with a scarred uterus in the north of China. Methods A retrospective cohort study was conducted. Totally 3722 singleton pregnant women with a scarred uterus who underwent a cesarean delivery in a large teaching hospital of north China between January 2013 and December 2017 were enrolled. Nomograms, a kind of user-friendly tool, were developed to predict PPH (blood loss ≥1000 mL or accompanied by signs or symptoms of hypovolemia within 24 h after the birth process) based on the model generated by logistic regression analysis. The discrimination and calibration of models were evaluated, and decision curve analysis was developed. Results Among 3722 enrolled women, 243 (6.53%) had PPH. There are six identified factors associated with PPH: maternal age, placental location, placenta previa, hypertensive disorders of pregnancy, fetal position and placenta accreta spectrum (PAS). The model achieved a good calibration (Hosmer-Lemeshow test P value 0.77) and discrimination (area under curve c-statistics 0.90, 95% confidence interval 0.86-0.93). Decision curve analysis showed the threshold probability by using our model is between 1.0% and 85.7%. A nomogram was developed accordingly. And another nomogram for women without placenta previa and PAS was also developed. Conclusion Two nomograms were first generated to predict PPH, respectively, for women with a scarred uterus and for women with a scarred uterus who do not have placenta previa or PAS. Placental location and fetal position were found to be closely related to PPH.

Problem To determine whether patients with unexplained recurrent pregnancy loss (URPL) can benefit from pre-conception immunotherapy or on the early phase of the first trimester. Method of study The prospective follow-up study which involved pre-conception patients diagnosed with URPL following rigorous etiology screening in the medical center of recurrent pregnancy loss. In this study, pre-conception immunotherapy included lymphocyte immunotherapy (pre-LIT). Post-conception immunotherapy (post-IM) included LIT or intravenous immunoglobulin (IVIG). Patients were recommended to undergo post-IM immediately from human chorionic gonadotrophin (hCG) elevation. Autoimmune antibodies (AIA) and anti-paternal lymphocytotoxic antibodies (APLA) were tested before and after pre-LIT. Favorable outcome was defined as pregnancy over 14 weeks. Unfavorable outcomes included biochemical pregnancy loss (BPL) and pregnancy loss with clear implantation location (PLCIL). Results In this study, URPL accounted for 12.9% of recurrent pregnancy loss (217/1682). Frequency of BPL was significantly lower in patients with post-IM than that without post-IM [2.8% vs 28.2%; adjusted relative risk (aRR), 0.06; 95% confidence interval (CI), 0.01-0.24]. There was a significant positive conversion in the AIA induced by pre-LIT (0.0% vs 31.0%). Frequency of PLCIL in patients with positive iatrogenic AIA conversion induced by pre-LIT was higher than that in patients without AIA conversion [30.4% vs 5.8%; aRR, 7.53; 95% CI, 1.31-43.34]. Conclusion Pre-LIT of patients with URPL contributed to a positive iatrogenic AIA conversion, which was associated with an increased risk of PLCIL. Post-IM immediately initiated from the time of hCG elevation can reduce the incidence of BPL.

Mitochondrial chronic progressive external ophthalmoplegia (CPEO) is a major manifestation of human mitochondrial encephalomyopathies. Previous studies have shown cognitive deficits in patients with mitochondrial diseases. However, these studies often included patients with heterogeneous subtypes of mitochondrial diseases. Here, we aimed to provide a better cognitive profile of patients with CPEO by applying a comprehensive battery of neuropsychological assessments in a pure sample of patients with CPEO. We recruited 28 patients with CPEO (19 women, age 16-62 years) and 38 age- and education-matched healthy control subjects (25 women, age 16-60 years). The neuropsychological assessments covered global cognition and five cognitive domains (executive functions, language, working memory, memory, and visuospatial functions). We found that the patients were impaired in global cognition [Montreal Cognitive Assessment (MoCA)], executive functions [Trail Making Test Part B (TMT-B)], and language [Boston Naming Test (BNT)], but not in working memory, memory or visuospatial functions. Moreover, individual patients' performances in the TMT-B (completion time) were predicted by the severity of non-ophthalmoplegia mitochondrial symptoms/signs [Newcastle Mitochondrial Disease Adult Scale (NMDAS)] and duration of the mitochondrial disease (years). Namely, patients with more severe non-ophthalmoplegia mitochondrial symptoms/signs and a longer disease duration took a longer time to complete the TMT-B. No clinical measures predicted individual patients' performances in the BNT.

How do new politicians distribute government resources in regimes with no electoral considerations? We argue that when the payoffs are not immediately clear in a low information environment, politicians use heuristics to make decisions that minimize political risks. We propose that for new local politicians, firm ownership types serve as a useful source of informational shortcuts to evaluating political importance, and this decision making process benefits state-owned firms. Using firm-level subsidies data in China combined with leadership turnover data at the provincial level from 2007 to 2015, we find that new provincial governors, immediately after taking office, distribute a significantly smaller proportion of subsidies to private firms relative to state-owned enterprises. The effect gradually attenuates as new governors understand local conditions and establish connections with local private firms. This strategy also proves to be politically effective, with governors who adopt such a strategy more likely to be promoted at the end of their tenure.

This study proposes a lens distortion characterization technique based on a colour charge coupled device (CCD) moire method. The colour CCD imaging lattice unit can be considered as three sets of parallel integrated reference gratings. An image formed from the reflected light of a physical grating through a lens was selected as a specimen grating. High-contrast colour moire stripes were formed by superimposing the three sets of reference gratings and the specimen grating under specific conditions. The mechanism of colour CCD moire formation was further studied and illustrated. The specimen grating image is modulated by lens distortion, and thus the formed moire stripes carry amplified lens distortion information. The principle of lens distortion extraction was described in detail. During moire image processing, a high-contrast image could be obtained by extracting the blue or red values of the original fringe pattern, which were determined by the distribution of the three colour filter arrays on the filter. Because the ultimate resolution of the camera is fully utilised, this method has a high sensitivity and accuracy in the distortion measurement. It not only very intuitively reflects all features of the lens distortion field, but is also very convenient for obtaining the distortion parameters of the lens distortion field. Finally, the distortion and deformation of two types of lens were characterized and analysed using the colour CCD moire method.

Mortar is one of the most widely used civil infrastructure materials, where the mortar fracture properties will significantly affect the structure service performance and life. In this paper, the fracture toughness of mortar specimen with respect to different thickness is investigated by conducting the three point bending test. The Extended Finite Element Method (XFEM) is also employed to model the crack propagation and failure process in the mortar specimen. It is found that the thickness of mortar specimen will affect the mortar cracking performance and the new emerged numerical tool XFEM is able to characterize the fracture properties of mortar specimen. Keywords: Fracture toughness, Mortar, Crack propagation, XFEM

Fundamental understandings of the pavement-tire friction are vital to improve the design of asphalt pavements. Most of the current research on pavement-tire friction is based on Finite Element Meth...

An Internet of things (IOT) based wireless sensor system, solely using wireless accelerometers, is developed for traffic volume and vehicle classification monitoring in this paper. A series of laboratory tests, field tests as well as numerical simulation were performed to validate the feasibility and accuracy of the monitoring system. Besides, in order to eliminate the impacts of noises in the output signals, an advanced algorithm is developed to analyze the test data. The findings based on the test results indicate that the system is capable of reliably detecting axles and calculating axle spacing in both laboratory and field tests. In addition, compared with the actual measurements, the numerical simulation further validates the feasibility of the integrated wireless sensor system for traffic information monitoring. Keywords: Wireless sensor, Accelerometer, Traffic volume, Vehicle classification

Particle shape was one of the most important factors which affects the gravel aggregate’s properties. It was also one of the important factors that directly affects the performance of asphalt pavements. In this paper, the gravel aggregate of quartzite was studied by using the industrial CT instrument. MATLAB was used to capture the aggregate slice properties including reverse color, median filtering, noise reduction, binarization and so on. The 3D aggregate model was reconstructed by using the software of MIMICS. The three-dimensional model of the aggregate was further optimized. The best fitting cuboid, cylinder, cone and sphere information of the aggregate were obtained by using the characteristics analysis function. Keywords: CT scanning, 3D reconstruction, Watershed transform, Particle shape, Gravel aggregate

Flexible thermoelectric generators (f‐TEGs) have demonstrated great potential in wearable self‐powered health monitoring devices. However, the existing wearable f‐TEGs are neither flexible enough to bend and stretch while maintaining the device's integrity with a good TE performance nor directly compatible with clothes materials. Here, ultraflexible fabric‐based thermoelectric generators (uf‐TEGs) are proposed with conductive cloth electrodes and elastic fabric substrate. The patterned elastic fabric substrate fits the rigid cuboids well, together with serpentine structured cloth electrodes, rendering uf‐TEG with excellent integrity and flexibility, thereby achieving a highly functional TE performance when strain reaches 30% or on arbitrarily shaped heat sources. The uf‐TEGs show a large peak power of 64.10 μW for a temperature difference of 33.24 K with a high voltage output of 111.49 mV, which is superior compared to previously reported fabric‐based TEG devices, and it is still functional after the water immersion test. Besides the energy harvesting function, with both the temperature sensing ability and the touch perception, this uf‐TEG is demonstrated as the electrical skin when mounted on a robot. Moreover, due to the wind‐sensitive performance and self‐power ability, the uf‐TEGs are assembled on cloth as wearable health and motion monitoring devices., An ultraflexible whole‐fabric assisted thermoelectric generator (uf‐TEG) with thermoelectric cuboids, elastic fabric as assembling material, and conductive flexible cloth‐based electrodes is presented here. The uf‐TEG can be applied in different applications such as electrical skin (temperature sensing and touch perception) and human health and motion monitoring (respiration rate, finger gesture, and steps counting).

Background: Management of CML with TKIs is constrained by treatment resistance, which portends a poor prognosis particularly in pts failing 2 nd-generation TKIs. Cells with BCR-ABL1 T315I mutations are insensitive to 1 st- and 2 nd -generation TKIs, and compound BCR-ABL1 mutations complicate management with all TKIs (including 3 rd-generation ponatinib). Olverembatinib is a novel, potent, 3 rd-generation, orally active BCR-ABL1 TKI with promising activity against CML , largely irrespective of genotype and has a preliminary favorable safety profile. Methods: HQP1351-CC201 and HQP1351-CC202 are Chinese open, single-arm, multicenter phase 2 trials evaluating the safety and efficacy of olverembatinib in adults with TKI-resistant (BCR-ABL1 T351-mutated) CML-CP and CML-CP, respectively. Olverembatinib was administered at 40 mg orally on alternate days for 28-day cycles. The primary outcome measure is major cytogenetic response (MCyR) and major hematologic response (MaHR) by the end of Cycle 12 in CML-CP and CML-AP, respectively. Secondary study endpoints include : complete CyR (CCyR), complete hematologic response (CHR), major molecular response (MMR), progression-free survival (PFS), overall survival (OS), and safety, including treatment-related adverse events (TRAEs) and serious AEs (SAEs). Results: Baseline characteristics Study CC201 （CML-CP ） On the study cutoff date of August 25,2020, 41 pts were enrolled, of whom 32 (78%) completed ≥ 12 cycles and 21 (51.2%) were male. The median (range) follow-up was 13 (3.1-16.3) months, age was 47 (22-70) years, and interval from CML diagnosis to first olverembatinib dose was 5.31 (0.6-23.2) years. In all, 32 (78.1%) pts had received ≥ 2 prior TKIs and 9 pts withdrew because of progressive disease (PD), intolerance, or consent withdrawal before Cycle 12. Study CC202 （CML-AP ） On the cut-off date of July 27, 2020, 23 pts were enrolled, of whom 14 (61%) had completed ≥ 12 cycles and 18 (78.3%) were male. The median (range) follow-up was 13.5 (1.4-15.2) months, age was 41 (21-74) years, and interval from CML diagnosis to first olverembatinib dose was 4.96 (0.4-10.2) years. In all, 18 (78.3%) pts had received ≥ 2 prior TKIs, and 11 pts withdrew because of PD or intolerance before Cycle 12. Efficacy Study CC201 （CML-CP ） After ≥ 12 treatment cycles in pts without responses at baseline, all 31 (100%) experienced CHR (10 other pts had CHR at baseline); 31/41 (75.6%) MCyR; 28/41 (68.3%) CCyR; and 23/41 (56.1%) MMR (Figure 1). The median time to CHR was 1 (95% CI = 1.0-1.9) month, the median time to MCyR was 2.8 (95% CI = 2.8-5.6) months, and the median time to MMR was 6.5 (95% CI = 2.8 to not reached [NR]) months. At 12 months, the PFS rate was 89.3% (95% CI = 73.9%-95.8%), and the OS was 100% (95% CI = 100%-100%). Study CC202 （CML-AP ） After ≥ 12 treatment cycles in pts without responses at baseline, 17/23 (73.9%) experienced MaHR (65.2% CHR and 8.7% no evidence of leukemia [NEL]); 12/23 (52.2%) MCyR; 11/23 (47.8%) CCyR; and 9/23 (39.1%) MMR (Figure 1). The median time to MaHR was 2.8 (95% CI = 1.0-4.7) months, the median time to MCyR was 5.6 (95% CI = 2.00-NR) months, and the median time to MMR was 13.1 (95% CI = 5.6-NR) months. At 12 months, the PFS rate was 74.1% (95% CI = 48.2%-88.4%), and the OS was 91.3% (95% CI = 69.5%-97.8%). Safety Study CC201 （CML-CP ） Frequent TRAEs (all grades; grade 3-4; SAEs) included thrombocytopenia (70.7%; 48.8%; 7.3%), followed by anemia (61%; 26.8%; 2.4%), leukopenia (43.9%; 17.1%; 0), and neutropenia (36.6%; 19.5%; 0). Common nonhematologic TRAEs (all grades; G3-4) included skin pigmentation (56.1%, 0%) and elevations in creatine kinase (51.2%, 14.6%), ALT (39%, 2.4%) and AST (34.1%, 0) (Table 1). No deaths occurred. Study CC202 （CML-AP ） Common TRAEs (all grades; G3-4; SAEs) included thrombocytopenia (73.9%; 56.5%; 17.4%), anemia (60.9%; 34.8%; 13.0%), leukopenia (56.5%; 30.4%; 0), and neutropenia (26.1%; 21.7%; 0). Common nonhematologic AEs included skin pigmentation (69.6%), hypocalcemia (52.2%), proteinuria (47.8%), hypertriglyceridemia (56.5%), hyperphosphatemia (47.8%), hyperuricemia (21.7%), and arthralgia (34.8%), of which most were grade 1-2 (Table 2). Conclusions: Olverembatinib was efficacious and well tolerated when administered as monotherapy in pts with TKI-resistant CP-CML and AP-CML and the BCR-ABL1 T315Imutation. Internal study identifiers: HQP1351-CC201-CC202. ClinicalTrials.gov identifiers: NCT03883087 and NCT03883100. Figure 1 Figure 1. Disclosures Chen: Ascentage Pharma (Suzhou) Co., Ltd: Current Employment, Current equity holder in publicly-traded company. Niu: Ascentage Pharma (Suzhou) Co., Ltd: Current Employment, Current equity holder in publicly-traded company. Men: Ascentage Pharma (Suzhou) Co., Ltd.: Current Employment, Current equity holder in publicly-traded company. Yang: Ascentage Pharma (Suzhou) Co., Ltd: Current Employment, Current equity holder in publicly-traded company, Other: Leadership and other ownership interests, Patents & Royalties, Research Funding. Zhai: Ascentage Pharma Group Inc.: Current Employment, Current equity holder in publicly-traded company, Other: Leadership and other ownership interests, Patents & Royalties, Research Funding; Ascentage Pharma (Suzhou) Co., Ltd.: Current Employment, Current equity holder in publicly-traded company, Other: Leadership and other ownership interests, Patents & Royalties, Research Funding.

Background Studies on the association of abnormal serum phosphorus level with all-cause mortality in patients with end-stage renal disease (ESRD) have yielded inconsistent results. Objective To evaluate the association of abnormal serum phosphorus level with all-cause mortality in patients with ESRD requiring dialysis by conducting a meta-analysis. Methods Pubmed and Embase databases were searched through March 2017 to identify all observational studies that assessed the association between abnormal serum phosphorus level and all-cause mortality risk in patients with ESRD requiring dialysis. Pooled hazard risk (HR) with 95% confidence interval (CI) was calculated for the highest versus referent phosphorus category and lower versus referent phosphorus category, separately. Results Nine cohort studies were eligible for analysis. During 12 to 97.6 months follow-up duration, 24,463 death events occurred among 1,992,869 ESRD patients. Meta-analysis showed that the pooled HR of all-cause mortality was 1.16 (95% CI 1.06–1.28) for the lower versus referent serum phosphorus category. Similarly, patients with highest serum phosphorus levels were associated with an increased risk of all-cause mortality (HR 1.39; 95% CI 1.31–1.47) compared with those in the referent phosphorus category. Subgroup analyses revealed that the effect of phosphorus on the all-cause mortality risk appeared to be stronger within 2 years follow-up. Conclusions Both very high and very low values of phosphorus are independently associated with an increased risk for all-cause mortality in ESRD patients requiring dialysis. This meta-analysis highlighted a non-linear association of serum phosphorus with all-cause mortality among dialysis-dependent ESRD patients.

The mechanical performance evaluation on bridge deck pavement has always been a critical issue for pavement engineers since it directly bears the loadings from vehicles and environment. Due to the complex service conditions including composite structure design, massive vehicle loadings, serious environmental conditions, large vibration and large deflection deformation, the service life of bridge pavement structure is usually much shorter than the common pavement structures. To evaluate the pavement structure stress state comprehensively, a combined static-and-dynamics analysis is conducted in this paper, combining with the sites tests in the cross-sea bridge pavement deck in Caofeidian District, China. The finite element software ANSYS is employed to study both the static and dynamics stress of bridge pavement. Simulation results show that the suggested thickness for the upper layer pavement thickness is 3.5 cm–4.5 cm and the lower layer is 5 cm ∼ 7 cm. And the suggested modulus for the pavement upper structure is 1600–1900 MPa and 900–1000 MPa for the lower structure. It is found that, along with the approaching of the load, the vertical displacement of each layer of the bridge deck pavement increases, and the vertical displacement decreases with the leaving of load. During the loading cycle, with the increase of speed, the maximum vertical displacement of bridge deck pavement decreases.

The effect of laser doping of Al on the gas sensing behavior of nanocrystalline ZnO thin films is reported. The doping of Al was carried out by the spin-coating of Al-precursors on nanocrystalline ZnO films followed by a pulsed laser irradiation. The laser-doped films were characterized as a function of laser power density by measuring the optical, structural, electrical, morphological and gas sensing properties of ZnO films. It was found that the laser doping process resulted in an increase of electrical conductivity of ZnO films. The performance of gas sensor was investigated for different concentrations of H2 and NH3 in the air. The results indicate that the laser doping process can be utilized to improve the sensor characteristics such as sensitivity and response time by optimization of laser power density. The optimum laser power is interpreted as the critical power level required to compete the effective doping versus developing the effective grain boundaries. Also, the selectivity of laser-doped ZnO sensors for H2 was studied for a likelihood practical gas mixture composed of H2, NH3 and CH4. It is found that these films can be optimized to develop H2 and NH3 sensors in PPM level with a higher selectivity over other reducing gases.

Transportation infrastructure professionals have been striving for innovations in highway pavements and materials to keep the transportation systems working smoothly, safely, and efficiently (Huang...

In this study, we devised a promising method to harvest the clean power from vehicle vibrations. We tested the electrical response of stacked piezoelectric units at different temperatures and loadings by using indoor laboratory tests. It is also discovered that ambient temperature has a great influence on the piezoelectric power generation. The generated electric energy of piezoelectric unit increased with increase in the loading and their relationship follow the cubic polynomial. It is demonstrated that there is a linear correlation between the open-circuit voltage and the amount of charge generated of the piezoelectric unit. The output energy increases with an increase in the frequency and the load.

Ettringite, as one of the hydration products of cement paste, has attracted the attention of pavement engineers recently. In this paper, a concise and comprehensive multi-scale modelling approach is presented to study the Mode I fracture based on the continuum level tool Phase-field Theory (PFT) and the atomistic level tool Molecular Dynamics (MD) Simulation. The PFT is a new modelling and computational tool used to predict the crack propagation using a phase-field variable, which assumes to be positive one in the intact solid and negative one in the crack region. Realising the fact that at the crack tip, the PFT is unable to deal with the singularity of stress and strain, and thus we use the MD Simulation to further investigate mechanical performances at a finer level. By the energy coupling the two different approaches at the crack tip, we present the two-way multi-scale coupling simulation of ettringite to simulate Mode I cracking fracture. The comparison between our multi-scale results with results fr...

Stacked transition-metal dichalcogenides on hexagonal boron nitride (h-BN) are platforms for high-performance electronic devices. However, such vertical stacks are usually constructed by the layer-by-layer polymer-assisted transfer of mechanically exfoliated layers. This inevitably causes interfacial contamination and device performance degradation. Herein, we develop a two-step, low-pressure chemical vapor deposition synthetic strategy incorporating the direct growth of monolayer h-BN on Au foil with the subsequent growth of MoS2. In such vertical stacks, the interactions between MoS2 and Au are diminished by the intervening h-BN layer, as evidenced by the appearance of photoluminescence in MoS2. The weakened interfacial interactions facilitate the transfer of the MoS2/h-BN stacks from Au to arbitrary substrates by an electrochemical bubbling method. Scanning tunneling microscope/spectroscopy characterization shows that the central h-BN layer partially blocks the metal-induced gap states in MoS2/h-BN/Au ...

In this paper, a new type of aggregate-shape embedded piezoelectric sensor for health monitoring of civil infrastructures was developed. The sensor was designed by using piezoelectric ceramic chip as the functional phase, and a new composite material as packaging phase. 3D printing technology was also used for packaging system design and sensor fabrication. The frequency independence, linearity, sensitivity, response rate, and service performance of the sensor were tested by frequency scanning and amplitude scanning. Experimental results show that within the vibration frequency range of common civil engineering structures, the new aggregate-shape embedded piezoelectric sensor has good mechanical and workability properties. Test results also show that the new embedded sensors have very good mechanical-electrical coupling performance, which builds a solid foundation for further application in the civil engineering infrastructures.

INTRODUCTION HQP1351 (olverembatinib) is an orally active third-generation BCR-ABL TKI designed for treatment of the patients with CML, harboring T315I mutation, which confers resistance against all first- and second-generation TKIs. METHODS The TKI resistant CML patients harboring T315I mutations either in chronic-phase (CP), or in accelerated-phase (AP), were enrolled into two single-arm, multicenter, open-label pivotal studies: HQP1351-CC201 in and HQP1351-CC202, respectively. The HQP1351 was administered at 40 mg once every other day (QOD) for 28 consecutive days per cycle over 24 months. The primary objective was to evaluate efficacy by major cytogenetic response (MCyR) in patients with CML-CP and major hematologic response (MaHR) in CML-AP. Secondary objectives included safety, tolerability, and pharmacokinetics (PK). RESULTS Baseline characteristics Study CC201 (CML-CP) As of the study cut-off date of March 23, 2020, total 41 patients were enrolled, of whom 38 (92.7%) completed ≥ 6 cycles and 21 (51.2%) were male. Median (range) follow-up was 7.9 (3.1-11.1) months, median age was 47 (22-70) years old. Median (range) interval from CML diagnosis to first HQP1351 treatment was 5.31 (0.6-23.2) years, and 32 (78.1%) patients received ≥ 2 prior lines of TKI. Three patients withdrew from the study-due to progressive disease (PD), intolerance, or consent withdrawal. Study CC202 (CML-AP) As of the cut-off date of February 11, 2020, total 23 patients were enrolled, of whom 18 (78.3%) completed ≥ 6 cycles and 18 (78.3%) were male. Follow-up duration was 8.2 (1.4-9.6) months, median age was 41 (21-74) years old. Median interval from CML diagnosis to first dose of HQP1351 was 4.96 (0.4-10.2) years, and 18 (78.3%) patients received ≥ 2 prior TKIs. Five patients withdrew because of PD or intolerance before Cycle 6. Efficacy Study CC201 (CML-CP) Across a median follow-up of 7.9 months, the mean (95% CI) 3-month progression-free survival (PFS) was 100% (100-100%) and 6-month PFS 96.7% (78.6-99.5%) because of 1 PD. In 31 evaluable patients who did not have a complete hematologic response (CHR) at baseline, 30 (96.8%) achieved CHR. In 41 evaluable patients who did not have a complete CyR (CCyR) at baseline, 31 (75.6%) achieved MCyR, including 27 (65.9%) CCyR and 4 (9.8%) partial CyR (PCyR). Total 20 out of 41 (48.8%) evaluable patients achieved major molecular response (MMR; Figure 1). Study CC202 (CML-AP) Across a median follow-up of 8.2 months, the 3-month PFS was 100% (100-100%) and the 6- month PFS 95.5% (71.9-99.3%) because of 2 PDs. A total of 18 (78.3%) of 23 evaluable patients without MaHR at baseline achieved MaHR, including 14 (60.9%) with CHR. In the 23 evaluable patients without MCyR at baseline, 12 (52.2%) patients achieved MCyR, including 9 (39.1%) CCyR and 3 (13.1%) PCyR. A total of 6 out of 23 (26.1%) evaluable patients achieved MMR (Figure 1). HQP1351 was highly and durably efficacious in the CML patients with T315I mutation; the probability and depth of clinical response may increase with prolonged treatment period. Safety/tolerability Study CC201 Frequent treatment-related adverse events (TRAEs; all grades; G3-4) included thrombocytopenia (65.9%; 48.8%), followed by anemia (48.8%; 24.4%), leukopenia (46.3%; 12.2%), and neutropenia (36.6%; 19.5%). Common non-hematologic TRAEs of any grade included skin pigmentation (53.7%) as well as elevations in creatine kinase (48.8%), ALT (31.7%) and AST (26.8% which most were grade 1 - 2. No death occurred. Study CC202 Common TRAEs (all grades; G3-4; serious AE [SAE]) included thrombocytopenia (73.9%; 52.2%; 17.4%), anemia (65.2%; 39.1%; 13.0%), leukopenia (56.5%; 30.4%; 0%), and neutropenia (26.1%; 21.7%; 0%;). Common non-hematologic AEs included skin pigmentation (69.6%), hypocalcemia (52.2%), proteinuria (52.2%), hypertriglyceridemia (47.8%), hyperphosphatemia (43.5%), arthralgia (34.8%), and fatigue (26.1%), of which most were grade 1- 2. CONCLUSIONS HQP1351 has been shown highly efficacious in heavily TKI-pretreated patients with T315I-mutated CML-CP or CML-AP and was well tolerated. Registration: Clinicaltrials.gov identifier NCT03883087 (Study HQP1351-CC201) NCT03883100 (Study HQP1351-CC202). Disclosures Chen: Ascentage Pharma Group: Current Employment. Niu:Ascentage Pharma Group: Current Employment. Zeng:Ascentage Pharma Group: Current Employment. Men:Ascentage Pharma Group: Current Employment. Lu:Ascentage Pharma Group: Current Employment, Current equity holder in publicly-traded company. Wang:Ascentage Pharma Group: Current Employment. JI:Ascentage Pharma Group: Current Employment. Yue:Ascentage Pharma Group: Current Employment. Yang:Ascentage Pharma (SuZhou) Co., Ltd: Current Employment, Current equity holder in publicly-traded company, Other: Leadership and other ownership interests. Zhai:Ascentage Pharma (SuZhou) Co., Ltd: Current Employment, Current equity holder in publicly-traded company, Other: Leadership and other ownership interests.