1. On the optimal temporal resolution for phase contrast cardiovascular magnetic resonance imaging: establishment of baseline values
- Author
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Tilman Schubert, Francesco Santini, Thomas Langenickel, Jens Bremerich, Oliver Bieri, Denise Yates, Michele Pansini, Maja Hrabak-Paar, University of Zurich, and Santini, Francesco
- Subjects
Male ,lcsh:Diseases of the circulatory (Cardiovascular) system ,Time Factors ,Femoral artery ,Frequency content ,030204 cardiovascular system & hematology ,01 natural sciences ,Doppler ultrasound ,010104 statistics & probability ,Temporal resolution ,0302 clinical medicine ,Aorta ,Aged, 80 and over ,education.field_of_study ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,Middle Aged ,Magnetic Resonance Imaging ,Femoral Artery ,Carotid Arteries ,Cardiovascular Diseases ,cardiovascular system ,Body region ,Female ,Cardiology and Cardiovascular Medicine ,Blood Flow Velocity ,Phase contrast MRI ,Adult ,medicine.medical_specialty ,Population ,610 Medicine & health ,2705 Cardiology and Cardiovascular Medicine ,03 medical and health sciences ,Young Adult ,Predictive Value of Tests ,10043 Clinic for Neuroradiology ,medicine.artery ,Ascending aorta ,medicine ,Humans ,2741 Radiology, Nuclear Medicine and Imaging ,Radiology, Nuclear Medicine and imaging ,0101 mathematics ,education ,3614 Radiological and Ultrasound Technology ,Angiology ,Aged ,Retrospective Studies ,business.industry ,Research ,Magnetic resonance imaging ,Ultrasonography, Doppler ,Phase contrast MRI, Doppler ultrasound, Frequency content, Temporal resolution ,Blood pressure ,Regional Blood Flow ,lcsh:RC666-701 ,business ,Nuclear medicine - Abstract
Background The aim of this study is to quantify the frequency content of the blood velocity waveform in different body regions by means of phase contrast (PC) cardiovascular magnetic resonance (CMR) and Doppler ultrasound. The highest frequency component of the spectrum is inversely proportional to the ideal temporal resolution to be used for the acquisition of flow-sensitive imaging (Shannon-Nyquist theorem). Methods Ten healthy subjects (median age 33y, range 24–40) were scanned with a high-temporal-resolution PC-CMR and with Doppler ultrasound on three body regions (carotid arteries, aorta and femoral arteries). Furthermore, 111 patients (median age 61y) with mild to moderate arterial hypertension and 58 patients with aortic aregurgitation, atrial septal defect, or repaired tetralogy of Fallot underwent aortic CMR scanning. The frequency power distribution was calculated for each location and the maximum frequency component, fmax, was extracted and expected limits for the general population were inferred. Results In the healthy subject cohort, significantly different fmax values were found across the different body locations, but they were nonsignificant across modalities. No significant correlation was found with heart rate. The measured fmax ranged from 7.7 ± 1.1 Hz in the ascending aorta, up to 12.3 ± 5.1 Hz in the femoral artery (considering PC-CMR data). The calculated upper boundary for the general population ranged from 11.0 Hz to 27.5 Hz, corresponding to optimal temporal resolutions of 45 ms and 18 ms, respectively. The patient cohort exhibited similar values for the frequencies in the aorta, with no correlation between blood pressure and frequency content. Conclusions The temporal resolution of PC-CMR acquisitions can be adapted based on the scanned body region and in the adult population, should approach approximately 20 ms in the peripheral arteries and 40 ms in the aorta. Trial registration This study presents results from a restrospective analysis of the clinical study NCT01870739 (ClinicalTrials.gov).
- Published
- 2020
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