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To effectively manage the automated warehouse, aiming at the optimization of goods location assignment, an optimization function for the assignment of storage location was established with the shelf stability and access efficiency as the goal according to the principle of storage space allocation. To optimize the picking location of the roadway stacker when exiting the warehouse, a mathematical function model was established by analyzing the picking strategy of the warehouse delivery operation. The research results showed that the optimization of the cargo space and the optimization of the stacker crane operation route can improve the overall operating efficiency. It is concluded that the model can reduce the cost of goods handling and storage, the time lost in the storage process and handling process, thereby decreasing logistics costs and increasing revenue. [ABSTRACT FROM AUTHOR]