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1. Abstracts of the Spring Anaesthetic Research Society Meeting (ARS)

Author

N. Goodfellow, A Arthur, A. Koh, J. McKenna, P. Phillips, B. A. McGrath, M. Al-Hashimi, P. Shiels, B. Horley, R. Thomas, D. Atkinson, Andrew Archbold, C. Y. Wang, L. Jolly, M. Bown, G. Davies, John Kinsella, M. Sanders, C. Small, M. Hards, C. Doherty, S. Ruane, K. Zealley, Philip McCall, Wadhah Mahbuba, R. Neal, B. Casadei, Andrew Wragg, A. Harada, G. Calo, H. Zhao, S. Munirama, M. Pullman, M. Wyatt, M. Babar, J. Andrzejowski, T. D. Abbott, P.J. Bickford Smith, R. Baker, Daqing Ma, L. Dorn, M. Hua Zhang, Cordula M. Stover, J. P. Thompson, C. Allen, Alan Kirk, Ben Shelley, A. Guleria, B. Shelley, James A. Russell, R.M. Pearse, R. Jayaram, W. Manning, M. Bird, Remo Guerrini, David G. Lambert, J. Cooke, A. Wilkes, L. Bowes, R. De Silva, Gareth L. Ackland, J. Riddell, C. Thomas, Alistair Macfie, Joyce Yeung, A. Ravalia, J. O'Doherty, H. Curley, C. Hirst, S. Harwell, Iain A. Bruce, George Corner, J. McDonald, Graeme McLeod, Helen F. Galley, J. Patel, N. Bateman, A. Verissimo, D. Celnik, R. Perkins, W. Wiles, S. Allen, S. Thomas, G. Wang, Rana Sayeed, D. McGuinness, Philip J. Devereaux, Tara Quasim, E. Whetton, and I. Neville

Subjects
medicine.medical_specialty, Creatinine, business.industry, medicine.medical_treatment, Intensive care unit, Telomere, law.invention, Surgery, Cardiac surgery, chemistry.chemical_compound, Anesthesiology and Pain Medicine, chemistry, Ageing, law, Internal medicine, medicine, Biomarker (medicine), Rifle, Renal replacement therapy, business
Abstract

Biological age is a better measure of functional capacity than chronological age.1 One of the measures of biological age is telomere length. Telomeres are nucleoprotein complexes that protect chromosome ends from damage. The DNA component of telomeres progressively shortens as biological age increases and thus acts as a read out for ‘miles on the biological clock’. 2 Telomere length progressively shortens as biological age increases. Within health care, ageing is almost exclusively described in terms of chronological age. Recent studies explored using biological age to stratify patients and predict outcomes.3 This project acts as a pilot study to investigate whether biological age is related to intensive care unit (ICU) outcomes and whether ICU patients age biologically at an accelerated rate. This project used blood samples from a previous study where patients underwent cardiac surgery and were admitted to the ICU. Blood samples were obtained before surgery and on days 1, 2, and 3 after surgery. The database contained the following physiological parameters: haemoglobin, urea, creatinine, RIFLE score, length of ICU stay, and whether renal replacement therapy was required. Information on co-morbidities and medication was also provided. DNA was isolated using a Maxwell machine and telomere length determined via quantitative PCR. One hundred and fifty-five blood samples from 46 patients underwent analysis. Telomere length did not differ significantly over the 4 days (P=0.662). No relationship was found between telomere length and any physiological parameter, co-morbidity, or medication. There was a trend towards significance with RIFLE score at day 3 increasing as telomere length decreased, although this was not statistically significant (P=0.09). No relationship between telomere length and the available physiological parameters, comorbidities, or medication was found. Telomere length did not vary during ICU stay. This study was limited by its small sample size. Future studies would benefit from a larger sample size; in addition, blood samples could also be obtained at 6 months after discharge to allow gradual alterations in biological age to be determined. Recent studies give evidence that telomere length is a weak biomarker of ageing,3 and that more meaningful data might be obtained using superior markers, such as CDKN2A expression or expression levels of non-coding RNAs.3

Published
2015
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2. Poster session 1

Author

J. Schlueter, T. Brand, D. J. Henderson, V. Boczonadi, P. Humbert, B. Chaudhry, D. Sedmera, J. Svatunkova, R. Kockova, B. Sankova, C. Lopez Sanchez, D. Franco, A. Aranega, V. Garcia-Martinez, E. Demina, V. Miroshikova, A. Denisenko, A. Schwarzman, F. Sanchez-Cabo, C. Torroja, A. Benguria, R. Buchan, P. Srivastava, F. Martinez, P. Barton, S. Cook, A. Dopazo, E. Lara-Pezzi, H. Rai, S. Kumar, A. K. Sharma, S. Mastana, A. Kapoor, C. M. Pandey, S. Agrawal, N. Sinha, J. Lipkova, M. Goldbergova, J. Parenica, J. Bienertova Vasku, A. Vasku, P. Kala, J. Spinar, L. Perez-Cabornero, D. Cantalapiedra, A. Forteza, R. Saez-Villaverde, J. Zumalde, V. Fernandez-Pedrosa, S. Zuniga-Trejos, M. Gil-Borja, M. Lazaro, S. Santillan, M. Costa, N. Cortez-Dias, P. Carrilho-Ferreira, D. Silva, C. Jorge, R. Placido, C. Calisto, M. Fiuza, A. Nunes Diogo, F. J. Enguita, H. H. W. Sillje, B. Lu, H. Yu, M. Zwartbol, W. P. Ruifrok, W. H. Van Gilst, R. A. De Boer, D. Zaliaduonyte-Peksiene, S. Simonyte, V. Lesauskaite, J. Vaskelyte, V. Mizariene, R. Zaliunas, W. Tigchelaar, E. Barlaka, A. Lazou, C. Del Giudice, E. Cipolletta, A. Anastasio, G. Santulli, M. Rusciano, A. S. Maione, P. Campiglia, M. Illario, B. Trimarco, G. Iaccarino, G. A. Frentzou, M. J. Drinkhill, N. A. Turner, S. G. Ball, J. F. X. Ainscough, L. Bertrand, F. Mailleux, J. Hammond, A. Ginion, L. Hue, J. L. Balligand, S. Horman, J. L. Vanoverschelde, C. Beauloye, B. Demeulder, S. L. Puhl, A. Mueller, Y. Devaux, D. R. Wagner, K. Roemer, M. Boehm, C. Maack, D. Miranda-Silva, I. Falcao-Pires, N. Goncalves, D. Moreira-Goncalves, A. F. Leite-Moreira, F. Mraiche, L. Fliegel, J. Xue, G. G. Haddad, L. C. Hsiao, C. Carr, Z. F. Cui, K. Clarke, M. A. D'amico, P. Izzicupo, A. Di Fonso, A. Bascelli, S. Gallina, A. Di Baldassarre, C. Silvestre, P. Fernandez, O. M. Pello, C. Indolfi, F. Civeira, R. Hutter, B. Ibanez, J. Chaves, J. Martinez-Gonzalez, V. Andres Garcia, A. Zabirnik, N. Smolina, A. Malashicheva, E. Omelchenko, T. Sejersen, A. Kostareva, C. Noack, M. P. Zafiriou, A. Renger, R. Dietz, H. J. Schaeffer, M. B. Bergmann, C. Zelarayan, S. Van Linthout, K. Miteva, M. P. Becher, M. Haag, J. Ringe, H.-P. schultheiss, M. Sittinger, C. Tschoepe, T. Kakuchaya, L. Bockeria, E. Golukhova, M. Eremeeva, N. Chigogidze, I. Aslanidi, I. Shurupova, A. Svobodov, A. A. Ramkisoensing, D. A. Pijnappels, J. Swildens, M. J. Goumans, M. J. Schalij, A. A. F. De Vries, D. E. Atsma, A. Gomes, G. M. Costa, C. A. Cordeiro, A. Matsuada, L. B. Rosario, A. P. Freire, M. Bousquenaud, M. Rolland-Turner, F. Maskali, L. Zhang, P. Y. Marie, F. Azuaje, A. J. Smith, G. M. Ellison, C. D. Waring, S. Purushothaman, D. Torella, B. Nadal-Ginard, M. H. Van Marion, D. W. J. Van Der Schaft, M.-J. Goumans, F. P. T. Baaijens, C. V. C. Bouten, N. Kraenkel, K. Kuschnerus, M. Mueller, T. Speer, S. Briand, M. Bader, P. Madeddu, T. F. Luescher, U. Landmesser, A. Papalamprou, C. Vicinanza, D. F. Goldspink, M. Noseda, S. J. Mcsweeney, T. Leja, E. Belian, I. Macaulay, F. Al-Beidh, S. Koenemann, M. S. Abreu Pavia, S. E. Jacobsen, M. D. Schneider, G. Foldes, Z. Bagyura, Z. Lendvai, D. Mathe, T. Nemeth, J. Skopal, I. Foldes, B. Merkely, S. E. Harding, A. J. Candasamy, R. S. Haworth, A. Boguslavsky, F. Cuello, M. J. Shattock, M. Mayr, M. Gautel, M. Avkiran, P. Leszek, B. Sochanowicz, M. Szperl, P. Kolsut, K. Brzoska, W. Piotrowski, T. Rywik, B. Danko, J. Rozanski, M. Kruszewski, N. Bouteldja, R. J. Woodman, C. L. Hewitson, E. Domingo, J. A. Barbara, A. A. Mangoni, R. Carnicer Hijazo, A. B. Hale, X. Liu, S. Suffredini, J. K. Bendall, G. B. S. Lim, N. J. Alp, K. M. Channon, B. Casadei, L. R. Moltzau, J. M. Aronsen, S. Meier, I. Sjaastad, T. Skomedal, J.-B. Osnes, F. O. Levy, E. Qvigstad, P. T. Wright, L. M. K. Pannell, A. R. Lyon, J. Gorelik, A. Guellich, S. F. Vatner, R. Fischmeister, B. Manoury, E. Dubois, J. Hamelet, A. Vanderper, P. Herijgers, D. Langin, F. Gartner, J. Gummert, H. Milting, G. Euler, M. Priess, J. Heger, T. Noll, R. Schulz, T. Doi, T. Akagami, T. Naka, T. Masuyama, M. Ohyanagi, M. Massaro, E. Scoditti, M. Pellegrino, M. A. Carluccio, C. Martines, C. Storelli, R. De Caterina, M. Falck-Hansen, M. E. Goddard, J. E. Cole, N. Astola, A. J. Cross, R. Krams, C. Monaco, M. F. Corsten, W. Verhesen, A. P. Papageorgiou, P. Carai, M. Lindow, S. Obad, G. Summer, L. De Rijck, S. Coort, M. Hazebroek, R. Van Leeuwen, M. Gijbels, M. P. J. De Winther, F. R. M. Stassen, S. Kauppinen, B. Schroen, S. Heymans, Z. Husti, V. Juhasz, L. Virag, A. Kristof, I. Koncz, T. Szel, I. Baczko, N. Jost, J. G. Y. Papp, A. Varro, A. Ghigo, A. Perino, F. Damilano, J. Leroy, V. O. Nikolaev, W. Richter, M. Conti, G. Vandecasteele, E. Hirsch, R. Ang, S. Sebastian, A. Ludwig, L. Birnbaumer, A. Tinker, E. A. Ertel, R. Sube, A. Opel, C. L-H Huang, A. Grace, N. Tribulova, J. Radosinska, B. Bacova, T. Benova, V. Knezl, J. Slezak, T. A. Matsuyama, T. Tanaka, T. Adachi, Y. Jiang, H. Ishibashi-Ueda, T. Takamatsu, J. Kornej, C. Reihardt, J. Kosiuk, A. Arya, G. Hindricks, V. Adams, D. Husser, A. Bollmann, S. Severi, M. Fantini, E. Ravagli, L. A. Charawi, D. Difrancesco, C. Poulet, L. Lu, U. R. Ravens, M. Hoch, T. Koenig, A. Gardiwal, B. Stapel, S. Erschow, A. Froese, B. Weinhold, R. Gerardy-Schahn, G. Klein, D. Hilfiker-Kleiner, K. Chinda, S. Palee, S. Surinkaew, M. Phornphutkul, S. Chattipakorn, N. Chattipakorn, B. Tuana, Z. Kohajda, A. A. Kristof, C. Corici, F. Fulop, N. L. Jost, V. Szuts, D. Menesi, G. L. Puskas, A. Zvara, N. Houshmand, J. G. Papp, N. Al-Shanti, M. Hancock, A. Venturini, C. Stewart, R. Ascione, G. Angelini, M.-S. Suleiman, A. Gonzalez-Tendero, I. Torre, F. Crispi, E. Gratacos, T. Tzanavari, E. Varela, A. Economides, S. Theocharis, C. Pantos, D. V. Cokkinos, A. Karalis, P. Hecker, V. Lionetti, W. C. Stanley, C. Ferrara, N. Piroddi, B. Scellini, C. Ferrantini, V. Sequiera, C. Remedios, L. Carrier, C. Tesi, J. Van Der Velden, C. Poggesi, V. Kooij, G. J. M. Stienen, D. Dooijes, s. Marston, C. Redwood, C. Dos Remedios, I. Diakonov, S. Tokar, M. Sikkel, S. Schlossarek, M. Sauer, A. Papageorgiou, S. Velthuis, E. Lutgens, M. Swinnen, N. Van Rooijen, J. Kzhyshkowska, P. Carmeliet, P. Garcia-Canadilla, F. Garcia-Garcia, I. Iruretagoiena, J. Dopazo, I. Amat-Roldan, M. H. Zhang, Y. H. Zhang, C. E. Sears, B. Wojtas, A. Llach, L. Hove-Madsen, V. Spinelli, L. Sartiani, M. Bucciantini, R. Coppini, E. Russo, A. Mugelli, E. Cerbai, M. Stefani, M. Ibrahim, P. Kukadia, M. Navaratnarajah, U. Siedlecka, C. Van Doorn, M. Yacoub, C. Terracciano, W. Song, N. Curtin, R. Woledge, S. Marston, M. Balteau, N. Tajeddine, G. Behets-Wydemans, C. Dessy, P. Gailly, W. J. Van Der Laarse, S. J. P. Bogaards, D. Van Groen, Y. Y. Wong, I. Schalij, A. Vonk Noordegraaf, F. M. Faz, B. Littlejohns, P. Pasdois, A. P. Halestrap, G. D. Angelini, S. Lemoine, V. Jaspard-Vinassa, F. Vigneron, P. Dos Santos, M. Popescu, A. Vlad, G. Isvoranu, L. Suciu, B. Marinescu, D. Dimulescu, L. Zagrean, P. W. M. Kleikers, K. Wingler, K. Radermacher, A. Sydykov, H. A. Ghofrani, N. Weissmann, H. H. W. Schmidt, A. Poddubnaya, K. E. M. Khurs, S. O. G. Smolenskaya, G. Szucs, Z. Murlasits, S. Torok, G. F. Kocsis, T. Csont, C. Csonka, P. Ferdinandy, R. Dongworth, D. M. Yellon, D. J. Hausenloy, Y. Y. Chen, W. S. Lian, C. F. Cheng, K. H. Khoo, T. C. Meng, G. Youcef, E. Belaidi, L. Fazal, M. P. Vinvent, D. De Paulis, G. Zadigue, C. Richer-Giudicelli, F. Alhenc-Gelas, M. Ovize, A. Pizard, R. Cal, J. Castellano, J. Farre, G. Vilahur, L. Badimon, V. Llorente-Cortes, H. Naz, M. Gharanei, C. Mee, H. Maddock, A. Hussain, O. Pisarenko, V. Shulzhenko, L. Serebryakova, I. Studneva, Y. Pelogeykina, D. Khatri, O. Tskitishvili, E. Barnucz, G. Veres, P. Hegedus, T. Radovits, S. Korkmaz, S. Klein, R. Zoller, M. Karck, G. Szabo, S. Morel, M. A. Frias, C. Rosker, R. W. James, S. Rohr, B. R. Kwak, V. Braunersreuther, B. Foglia, F. Mach, E. Shantsila, S. Montoro-Garcia, L. D. Tapp, S. Apostolakis, B. J. Wrigley, G. Y. H. Lip, E. Sokolowska, K. Przyborowski, K. Kramkowski, W. Buczko, A. Mogielnicki, U. Simonsen, E. R. Hedegaard, B. D. Nielsen, A. Kun, A. Hughes, C. Kroigaard, S. Mogensen, O. Frobert, K. Ait Aissa, J. P. Max, D. Wahl, T. Lecompte, P. Lacolley, V. Regnault, A. Novakovic, M. Pavlovic, A. Vranic, P. Milojevic, I. Stojanovic, M. Jovic, D. Nenezic, N. Ugresic, Q. Yang, G. W. He, L. Calvier, P. Reboul, B. Martin-Fernandez, V. Lahera, F. Zannad, V. Cachofeiro, P. Rossignol, N. Lopez-Andres, V. K. Pulakazhi Venu, R. Baetta, A. Bonomo, A. F. Muro, A. Corsini, A. L. Catapano, G. D. Norata, L. E. Viiri, L. E. Full, T. J. Navin, A. Didangelos, I. Seppala, T. Lehtimaki, A. H. Davies, R. Wait, D. Sedding, P. Stieger, C. Thoelen, S. Fischer, J. M. Daniel, R. Widmer-Teske, K. T. Preissner, N. Alenina, L. A. Rabelo, M. Todiras, V. N. Souza, J. M. Penninger, R. A. Santos, I. A. Leonova, S. A. Boldueva, V. S. Feoktistova, O. V. Sirotkina, M. G. Kolesnichenko, Z. Springo, P. Toth, P. Cseplo, G. Szijjarto, A. Koller, S. Puthenkalam, M. K. Frey, I. M. Lang, R. Madonna, H. Shelat, Y. J. Geng, T. Ziegler, V. Pfetsch, J. Horstkotte, C. Schwab, I. Rohwedde, R. Hinkel, Q. Di, S. Dietzel, U. Deutsch, C. Kupatt, I. Ernens, B. Lenoir, O. Fortunato, A. Caporali, E. Sangalli, D. Cordella, M. Marchetti, G. Spinetti, C. Emanueli, G. Arderiu, E. Pena, M. J. Forteza, V. Bodi, S. Novella, C. Alguero, I. Trapero, I. Benet, C. Hermenegildo, J. Sanchis, F. J. Chorro, A. Nemeth, S. Szabados, A. Cziraki, E. Sulyok, I. G. Horvath, M. Rauh, W. Rascher, I. Sikharulidze, I. B. Bakhlishvili, J. T. T. Laitinen, J. P. Hytonen, O. Leppanen, J. Taavitsainen, A. Partanen, P. Korpisalo, S. Yla-Herttuala, J. Lonn, J. Hallstrom, T. Bengtsson, M. C. Guisasola, E. Dulin, S. Stojkovic, C. Kaun, G. Maurer, K. Huber, J. Wojta, S. Demyanets, T. B. Opstad, A. Pettersen, S. Aakra, H. Arnesen, I. Seljeflot, M. Borrell-Pages, C. Romero, A. Toso, M. Leoncini, L. Tanini, T. Pizzetti, F. Tropeano, M. Maioli, P. Casprini, F. Bellandi, R. F. Antunes, J. C. Kaski, I. E. Dumitriu, E. Wu, A. A. L. Tareen, M. Udovychenko, I. Rudyk, K. Riches, L. Franklin, A. Maqbool, J. Bond, M. L. Koschinsky, D. J. O'regan, K. E. Porter, I. R. Parepa, A. I. Suceveanu, A. Suceveanu, L. Mazilu, L. Cojocaru, A. Rusali, L. A. Tuta, E. Craiu, D. Lindner, C. Zietsch, H.-P. Schultheiss, C. Tschope, D. Westermann, M. Miana, E. Martinez, R. Jurado, C. Delgado, N. Gomez-Hurtado, A. Briones, J. Young, T. J. Geng, A. Brodehl, T. Schmidt, O. Smolenskaya, C. Stegemann, D. Byzov, I. Mikhaylova, N. Chizh, E. Pushkova, O. Synchykova, B. Sandomirsky, O. Freylikhman, O. Rotar, N. Chromova, E. Moguchaya, V. Ivanenko, E. Kolesova, A. Erina, M. Boyarinova, A. Konradi, S. D. Preston, D. Baskaran, A. M. Plonczak, K. Norita, S. V. De Noronha, M. N. Sheppard, A. Haghikia, S. F. Hill, M. Hoepfner, B. Nitzsche, M. Schrader, F. Zengerling, B. Hoffmann, A. Pries, S. Gao, J. T. Laitinen, S. Laidinen, H. Markkanen, H. Karvinen, V. Marjomaki, I. Vajanto, T. T. Rissanen, K. Alitalo, P. Mello Ferrao, M. C. Waghabi, L. R. Garzoni, J. Ritterhoff, C. Weidenhammer, M. Voelkers, W. H. Zimmermann, J. Rabinowitz, P. Most, S. C. Gordts, I. Muthuramu, F. Jacobs, E. Van Craeyveld, E. Nefyodova, B. De Geest, D. R. Tribuddharat, D. R. Sathitkarnmanee, M. R. Buddhisa, M. S. Suwannasaen, D. R. Silarat, D. R. Ngamsangsirisup, D. R. Hawrylowicz, D. R. Lertmemongkolchai, S. Rain, M. L. Handoko, N. Westerhof, A. Vonk-Noordegraaf, F. S. De Man, A. S. Iakovleva, O. A. Mirolyubova, A. Berezin, T. A. Samura, Suwannasaen, Tippayawat, Ngamsangsirisup, D. R. Sutra, Hawrylowicz, Lertmemongkolchai, L. M. Lima, M. G. Carvalho, D. R. G. Junqueira, M. O. Sousa, A. Zampetaki, P. Willeit, L. Tilling, I. Drozdov, M. Prokopi, A. Shah, C. Boulanger, P. Chowienczyk, S. Kiechl, S. H. V. Oliveira, V. Kirillova, E. Prosviryakov, C. T. M. Van Der Pouw Kraan, F. J. P. Bernink, J. M. Baggen, L. Timmers, A. M. Beek, M. Diamant, A. C. Van Rossum, N. Van Royen, A. J. G. Horrevoets, J. E. A. Appelman, A. Zyatenkov, L. S. Kokov, Y. U. D. Volynskiy, M. Krestjyaninov, V. I. Ruzov, A. V. Villar, E. Martinez-Laorden, A. Almela, M. A. Hurle, M. L. Laorden, N. Apaijai, M. K. Mcmullen, J. M. Whitehouse, G. Shine, and A. Towell

Subjects
Gerontology, Physiology, business.industry, Physiology (medical), Cancer research, Medicine, SCRIB gene, Cardiology and Cardiovascular Medicine, business
Published
2012
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3. Oral abstract presentations & Young Investigators Competition

Author

A. Leone, I. Aquila, C. Vicinanza, C. Iaconetti, A. Bochicchio, S. Ottolenghi, C. Indolfi, B. Nadal-Ginard, G. M. Ellison, D. Torella, C. Mias, G. Genet, C. Guilbeau-Frugier, A. Pathak, J. M. Senard, C. Gales, A. D. Egorova, P. S. J. Khedoe, M. T. H. Goumans, S. M. Nauli, P. Ten Dijke, R. E. Poelmann, B. P. Hierck, M. Miragoli, M. J. Lab, A. Singh, M. Sikkel, A. Lyon, J. Gorelik, C. Cheung, A. S. Bernardo, M. W. Trotter, R. A. Pedersen, S. Sinha, M. Mioulane, G. Foldes, S. E. Harding, B. Reglin, T. W. Secomb, A. R. Pries, M. Buckingham, F. Lescroart, S. Meilhac, J.-F. Le Garrec, N. Rozmaritsa, T. Christ, E. Wettwer, M. Knaut, U. Ravens, S. Tokar, S. Schobesberger, P. T. Wright, A. R. Lyon, A. Van Mil, S. Grundmann, M.-J. Goumans, S. Jaksani, P. A. Doevendans, J. P. Sluijter, A. J. Tijsen, A. S. Amin, J. R. Giudicessi, M. W. Tanck, C. R. Bezzina, E. E. Creemers, A. M. Wilde, M. J. Ackerman, Y. M. Pinto, C. Gedicke-Hornung, V. Behrens-Gawlik, D. Khajetoorians, G. Mearini, S. Reischmann, B. Geertz, T. Voit, P. Dreyfus, T. Eschenhagen, L. Carrier, G. D. Duerr, J. C. Heinemann, D. Wenzel, A. Ghanem, J. C. Alferink, A. Zimmer, B. Lutz, A. Welz, B. K. Fleischmann, O. Dewald, M. Sbroggio', A. Bertero, L. Giuliano, M. Brancaccio, G. Tarone, M. Meiser, M. Kohlhaas, Y. Chen, G. Csordas, G. Dorn, C. Maack, B. Stapel, M. Hoch, A. Haghikia, P. Fischer, D. Hilfiker-Kleiner, B. Schroen, M. Corsten, W. Verhesen, L. De Windt, S. Zacchigna, T. Thum, P. Carmeliet, A. Papageorgiou, S. Heymans, I. G. Lunde, A. V. Finsen, G. Florholmen, B. Skrbic, H. Kvaloy, H. O. Jarstadmarken, I. Sjaastad, T. Tonnessen, C. R. Carlson, G. Christensen, J. Paavola, S. Schliffke, S. Rossetti, I. Kuo, S. Yuan, Z. Sun, P. Harris, V. Torres, B. Ehrlich, P. Robinson, K. Adams, Y.-H. Zhang, B. Casadei, H. Watkins, C. Redwood, A. N. Seneviratne, J. E. Cole, M. E. Goddard, Z. Mohri, A. J. Cross, R. Krams, C. Monaco, B. R. Everaert, S. J. Van Laere, V. Y. Hoymans, J. P. Timmermans, and C. J. Vrints

Subjects
Competition (economics), medicine.medical_specialty, Pathology, Physiology, business.industry, Physiology (medical), Family medicine, medicine, Cardiology and Cardiovascular Medicine, business
Published
2012
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4. Design and characterization of a fast cmos multiple linear array imager for nanosecond light pulse detections

Author

Bernard Cunin, B. Casadei, J. P. Le Normand, and Yann Hu

Subjects
Physics, Pixel, business.industry, ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, Shot noise, Chip, Noise (electronics), Optics, CMOS, Electronic engineering, Miniaturization, Flicker noise, Electrical and Electronic Engineering, Image sensor, business, Instrumentation
Abstract

Active pixel sensors (APS) technology offers performance competitive with charge-coupled device technology, and it offers advantages in on-chip functionality, system power reduction, cost, and miniaturization. In this paper, we present the design and characterization of a fast CMOS APS imager for high-speed laser detections, which can replace streak cameras. It produces intensity information as a function of one spatial dimension and time (I=f(x,t)) from a pixel array with two spatial dimensions. The time information is obtained for the first prototype camera by delaying successively the integration phase for each pixel of the same row. The different noise sources of the APS sensors, such as shot noise due to the photo sensor, thermal noise, and flicker noise due to the readout transistors, and the photon shot noise are presented in order to determine the fundamental limits of the image sensor. The first prototype fast MOS imager (FAMOSI) consists of 64/spl times/64 active pixels. The simulation and experimental results show that a conversion gain of 6.73/spl plusmn/0.25 /spl mu/ V/e/sup -/ has been obtained with a noise level of 87/spl plusmn/3 e/sup -/ rms. The power consumption of the chip is 25 mW at 50 frames/s. The time resolution is 0.8 ns for this new concept camera.

Published
2003
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5. A monolithic active pixel sensor for charged particle tracking and imaging using standard VLSI CMOS technology

Author

C. Colledani, Marc Winter, D. Husson, Gilles Claus, Yann Hu, J. P. Le Normand, Renato Turchetta, W. Dulinski, B. Casadei, J.L. Riester, J.D. Berst, Ulrich Goerlach, Grzegorz Deptuch, S. Higueret, Institut de Recherches Subatomiques (IReS), and Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Cancéropôle du Grand Est-Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)

Subjects
Physics, Nuclear and High Energy Physics, CMOS sensor, Pixel, Physics::Instrumentation and Detectors, business.industry, Detector, Integrated circuit, Tracking (particle physics), Photodiode, law.invention, CMOS, law, Optoelectronics, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Particle physics experiments, business, Instrumentation
Abstract

A novel Monolithic Active Pixel Sensor (MAPS) for charged particle tracking made in a standard CMOS technology is proposed. The sensor is a photodiode, which is readily available in a CMOS technology. The diode has a special structure, which allows the high detection efficiency required for tracking applications. The partially depleted thin epitaxial silicon layer is used as a sensitive detector volume. Semiconductor device simulation, using either ToSCA based or 3-D ISE-TCAD software packages shows that the charge collection is efficient, reasonably fast (order of 100 ns), and the charge spreading limited to a few pixels only. A first prototype has been designed, fabricated and tested. It is made of four arrays each containing 64×64 pixels, with a readout pitch of 20 μm in both directions. The device is fabricated using standard submicron 0.6 μm CMOS process, which features twin-tub implanted in a p-type epitaxial layer, a characteristic common to many modern CMOS VLSI processes. Extensive tests made with soft X-ray source ( 55 Fe) and minimum ionising particles (15 GeV/ c pions) fully demonstrate the predicted performances, with the individual pixel noise (ENC) below 20 electrons and the Signal-to-Noise ratio for both 5.9 keV X-rays and Minimum Ionising Particles (MIP) of the order of 30. This novel device opens new perspectives in high-precision vertex detectors in Particle Physics experiments, as well as in other application, like low-energy beta particle imaging, visible light single photon imaging (using the Hybrid Photon Detector approach) and high-precision slow neutron imaging.

Published
2001
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6. A fast, high resolution CMOS imager for nanosecond light pulse detections

Author

J.P. Le Normand, B. Casadei, and Yann Hu

Subjects
Physics, CMOS sensor, Optics, Pixel, CMOS, business.industry, ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, Shot noise, Image noise, Flicker noise, Image sensor, business, Noise (electronics)
Abstract

In this paper, we present design and characterisation of a fast CMOS APS (active pixel sensor) imager for high-speed laser detection, which can replace streak cameras. It produces the intensity information as a function of one spatial dimension and time (I=f (x, t)) from a two spatial dimensions frame. The time information is obtained for the first prototype camera by delaying successively the integration phase for each pixel of the same row. The different noise sources of the APS sensors; such as shot noise due to the photo sensor, thermal noise and flicker noise due to the readout transistors, and the photon shot noise, are presented in order to determine the fundamental limits of the image sensor. The first prototype FAMOSI (fast MOS imager) consists of 64/spl times/64 active pixels. The simulation and experimental results show that a conversion gain of 6.73/spl plusmn/0.25 /spl mu/V/e has been obtained with a noise level of 87/spl plusmn/ 3 electrons rms. The power consumption of the chip is 25 mW at 50 frames/sec. The time resolution is 0.8 ns for this new concept of camera.

Published
2005
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7. Model for electrical simulation of photogate active pixel sensor

Author

Y. Hu, C. Dufaza, L. Martin, and B. Casadei

Subjects
Very-large-scale integration, Engineering, CMOS sensor, Pixel, business.industry, Hardware description language, Design tool, Description model, CMOS, Electronic engineering, Cadence, business, computer, computer.programming_language
Abstract

A new electrical simulation model for photogate active pixel sensor in CMOS imagers is proposed. Review of three conventional models is done and shows lack of accuracy. Therefore photoelectric mechanisms and charges transfer of photogate pixel are analysed and lead to the definition of a Verilog-A description model. This model is then simulated into the Cadence design tool environment and simulation results show great improvements in simulation accuracy of the proposed model versus others ones.

Published
2005
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8. A fast CMOS array imager for nanosecond light pulse detection in accumulation mode

Author

B. Casadei, Jean-P. Le Normand, Frédéric Morel, Yann Hu, Wilfried Uhring, Chantal-V. Zint, Jung, Marie-Anne, Institut d'Electronique du Solide et des Systèmes (InESS), and Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)

Subjects
Physics, business.industry, Streak camera, Noise (signal processing), Nanosecond, Laser, Signal, Photodiode, law.invention, Optics, Signal-to-noise ratio, law, Temporal resolution, business, ComputingMilieux_MISCELLANEOUS
Abstract

We designed a camera based on a fast CMOS APS imager for high speed optical detection which produces images simi-larly as a streak camera. This imager produces the intensity information I as function of one spatial dimension and time (I=f(x,t)) from one frame with two spatial dimensions. The time sweeping is obtained by delaying successively the integration phase for each pixel of the same row. For the first FAMOSI (Fast MOs Imager) prototype the start of in-tegration is given by the camera itself. This signal is injected to a laser trigger. This laser emits a 10 nanoseconds light pulse onto the sensor. The temporal evolution of the light pulse is then resolved by the camera with a resolution of 800 ps. In single shot, the maximum dynamic of the camera is estimated to 64 dB and is limited by the readout noise. We decide to work in accumulation mode in order to increase the signal to noise ratio of the camera. But the high laser trigger (about 20 ns rms) does not allow accumulation of several optical events without a large spreading. The camera has been modified in order to be triggered by an external signal delivered by a trigger unit. In this new configuration the laser emit pulses at a repetition rate of 50 Hz. A photodiode detect a part of the laser pulse and generate the trigger signal for FAMOSI. The laser pulse is delayed with an optical fibre before being directed to the camera. The trigger jitter obtained is then less than 100 ps and allows accumulation without significant loss of the temporal resolution. With accumulation the readout noise is attenuated by a √N factor. Then with N = 1000 accumulations, the dynamics approach 93 dB. This allows the camera to work similarly as a synchroscan streak camera and then to observe weak signal.

Published
2004
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9. Characterization of a fast CMOS imaging sensor for high-speed laser detection

Author

J. P. Le Normand, Bernard Cunin, Yann Hu, and B. Casadei

Subjects
Physics, CMOS sensor, Signal-to-noise ratio, Optics, business.industry, Relative intensity noise, ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, Shot noise, Image noise, Flicker noise, Image sensor, business, Noise (electronics)
Abstract

CMOS active pixel sensors (APS) have performances competitive with charge-coupled device (CCD) technology, and offer advantages in on-chip functionality, system power reduction, cost and miniaturization. In this paper, we present characterization of a fast CMOS APS used in an imager for high-speed laser detections, which can replace the streak cameras. It produces the intensity information in function of one spatial dimension and time [I = f(x,t)] from one frame in two spatial dimensions. The time information is obtained for the first prototype camera to delay successively the integration phase in each pixel of the same row. The different noise sources of the APS sensors such as shot noise due to the photo sensor, the thermal noise and flicker noise due to the readout transistors and the photon shot noise are presented to determine the fundamental limits on image sensor. The first prototype FAMOSI (FAst MOS Imager) is composed of 64 x 64 active pixels. The simulation and experimental results show that a conversion gain of 6.73 ± 0.25 μV/e - has been obtained with a noise level of 87 ± 3e - rms. The power consumption of the chip is 25 mW at 50 images/sec.

Published
2003
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10. Design and characterisation of a fast CMOS APS imager for high speed laser detection

Author

Y. Hu, B. Casadei, B. Cunin, and J.P. Lenormand

Subjects
Very-large-scale integration, Engineering, Pixel, business.industry, ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, Shot noise, Streak, Chip, Laser, law.invention, CMOS, law, Low-power electronics, Electronic engineering, Optoelectronics, business
Abstract

CMOS active pixel sensors (APS) have performances competitive with CCD technology, and offer advantages in on-chip functionality, system power reduction, cost and miniaturisation. We present design of a fast CMOS APS imager for high speed laser detections which can replace the streak cameras. This imager is composed of 64/spl times/64 active pixels. The simulation and experimental results show that a gain of 7.3 /spl mu//spl nu//e/sup -/ has been obtained with a noise level of 106 e rms. The power consumption of the chip is 30 mW at 50 images/sec.

Published
2002
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11. Design of a Fast CMOS APS Imager for High Speed Laser Detections

Author

Bernard Cunin, J. P. Le Normand, B. Casadei, and Yann Hu

Subjects
Physics, Streak camera, business.industry, Dynamic range, Fixed-pattern noise, ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, Shot noise, Noise (electronics), Optics, CMOS, Electronic engineering, Flicker noise, Image sensor, business
Abstract

In this paper, the results of the first temporal resolution imager CMOS for high-speed laser pulse characterisation are presented. This new imager can replace the conventional streak camera using a charge-coupled device (CCD) sensor for some applications. It produces the intensity information in function of time and one spatial dimension (Iph = f (x, t)). The time information is obtained for the prototype to delay successively the integration phase in each pixel of the same row. The different noise sources for an APS sensor such as the shot noise due to the photo sensor, the flicker noise and the thermal noise due to the transistors are studied to determine the fundamental limits on image sensor. The prototype imager named FAMOSI (FAst MOS Imager) consists of an array of 64 x 64 active pixel sensors that are integrated in AMS 0.6 μm CMOS technology. Each pixel size is 13 μm × 13 μm and has a fill factor of 28%. At 50 frames/s, theoretical and experimental results show a total noise of 95± 4 electrons, a fixed pattern noise of 2% (saturation voltage is 760 mV), a dynamic range of 64 dB and a power consumption of 25 mW. The conversion gain is 6.73 ± 0.25 μV/electrons and the time resolution is 0.8 ns.

Published
2002
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12. D: A DYSTROPHIN-DEPENDENT LOSS OF NEURONAL NITRIC OXIDE SYNTHASE IN ATRIAL FIBRILLATION (AF) PROMOTES ELECTRICALREMODELLING AND CREATES A SUBSTRATE FOR THE MAINTENANCE OF AF

Author

N C Surdo, R Jayaram, S Verheule, R Sayeed, R Carnicer, C Ratnatunga, B Casadei, X Liu, U Schotten, S N Reilly, and R de Silva

Subjects
medicine.medical_specialty, Arginine, biology, business.industry, Cardiac muscle, Atrial fibrillation, Tetrahydrobiopterin, medicine.disease, Nitric oxide, chemistry.chemical_compound, Endocrinology, medicine.anatomical_structure, chemistry, Internal medicine, cardiovascular system, medicine, biology.protein, Myocyte, Cardiology and Cardiovascular Medicine, business, Dystrophin, Syntrophin, medicine.drug
Abstract

Rationale Nitric oxide production in the heart is involved in the regulation of ion channels activity, myocardial perfusion and thrombogenesis. Atrial fibrillation (AF) has been associated with reduced myocardial nitric oxide (NO) bioavailability; however, the mechanisms and the consequences of this phenomenon remain to be elucidated. Methods and Results We evaluated the activity, protein content, and localization of constitutive NO synthases (NOS) in atrial tissue from 62 patients with permanent AF and 148 controls in normal sinus rhythm (SR), and in goats after 2 weeks (2W-AF, n=15) or 6 months (6M-AF, n=10) of pacing-induced AF ( vs. sham surgery & SR, n=14). NOS activity was uncoupled in right atrial (RA) tissue from AF patients and 6M-AF goats, both of which also exhibited an ipsilateral reduction in the NOS cofactor tetrahydrobiopterin (BH4) and an increase in arginase activity (HPLC). Although ex vivo BH4 and arginine supplementation reversed NOS uncoupling, atrial NOS activity remained profoundly suppressed in AF due to a progressive decrease in the “neuronal” isoform of NOS (nNOS) in atrial cardiomyocytes (by 65% in 2W-AF, 86% in 6M-AF goats and 62% in patients with AF). Atrial nNOS mRNA expression (qRT-PCR) did not differ between AF and SR; however, nNOS ubiquitination was increased in AF. Atrial nNOS protein content was partially restored by inhibition of proteasomal activity with MG132 but not by inhibiting the autophagy-lysosomal pathway with bafilomycin A1 or by pre-treatment with BH4. nNOS signalling and protein stability in the cardiac muscle depends on the enzyme9s anchoring to the dystrophin-syntrophin complex at the sarcolemmal membrane. In the fibrillating atrial myocardium we observed a significant reduction in dystrophin (by 56%) and its associated proteins, 1α syntrophin and caveolin-3; by contrast no difference in the dystrophin complex was observed in the atrial myocardium of nNOS -/- mice. Immunoprecipitation showed co-localisation of nNOS with dystrophin in SR, but not in AF. To assess whether loss of nNOS and reduced NO bioavailability played a role in the AF-induced atrial electrical remodelling; we evaluated the effect of nNOS inhibition or gene deletion in human and murine atrial myocytes. In RA myocytes from patients in SR (but not in patients with AF), nNOS inhibition shortened the action potential duration (APD) by 40%, and decreased the rate dependent-adaptation of APD (both of which are a hallmark of AF-induced electrical remodelling). These findings were recapitulated in murine right atrial myocytes in the presence of nNOS gene deletion or inhibition. In mice, nNOS gene deletion was sufficient to induce a 2-fold increase in the likelihood of developing AF in response to electrical stimulation. Conclusions - These data indicate that dystrophin-dependent loss of myocardial nNOS in AF is sufficient to produce an atrial electrical substrate that increases both inducibility and maintenance of this arrhythmia. Therapeutic strategies aimed at preserving or restoring the dystrophin complex may have a profound effect on NO bioavailability and the electrical substrate of AF.

Published
2013
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13. BAS/BSCR17 Myocardial xanthine oxidase regulates basal inotropy in murine left ventricular myocytes

Author

X H Sun, Y H Zhang, and B Casadei

Subjects
chemistry.chemical_classification, medicine.medical_specialty, Reactive oxygen species, Superoxide, business.industry, Allopurinol, Xanthine, Nitric oxide, chemistry.chemical_compound, Endocrinology, chemistry, Internal medicine, Apocynin, medicine, Lucigenin, Cardiology and Cardiovascular Medicine, Xanthine oxidase, business, medicine.drug
Abstract

Xanthine oxidase (XO) is a major source of reactive oxygen species in the cardiovascular system. Enhanced XO activity in the failing myocardium has been associated with a reduction in inotropy; however, whether this association is causal remains to be established. To test this hypothesis, the effect of XO inhibition (oxypurinol, 100 μmol/l and allopurinol, 100 μmol/l) or activation (xanthine, 100 or 500 μmol/l) on cell shortening (3 Hz, 35°) was evaluated in left ventricular (LV) myocytes isolated from C56BL/6–129j mice. Similarly, LV superoxide production in the absence and presence of inhibitors of XO, NADPH oxidases (apocynin, 100 μmol/l) or nitric oxide synthases (LNAME, 1 μmol/l) was measured by lucigenin (5 μmol/l)-enhanced chemiluminescence. Oxypurinol and allopurinol significantly suppressed basal superoxide production and cell shortening (by about 20%), whereas xanthine caused a dose-dependent increase in cell shortening and superoxide production. In contrast, apocynin had no effect on superoxide release or cell shortening. Taken together, our findings indicate that superoxide production by XO exerts a tonic positive inotropic effect on murine LV myocytes, suggesting that the increase in XO activity in heart failure may be, at least in part, adaptive.

Published
2010
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14. Effect of vagal stimulation by scopoderm TTS on exercise performance and R-R interval variability (RRV) in patients with chronic heart failure (CHF)

Author

B. Casadei, Peter Sleight, and James R.W. Conway

Subjects
medicine.medical_specialty, Vagal stimulation, Physiology, business.industry, General Neuroscience, medicine.disease, R-R Interval, Internal medicine, Heart failure, Anesthesia, Exercise performance, Cardiology, medicine, In patient, Neurology (clinical), Scopoderm TTS, business
Published
1993
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15. Vemurafenib mucosal side-effect

Author

Alessandro Pileri, Monica Cricca, Pier Luigi Zinzani, Annalisa Patrizi, Beatrice Casadei, Cosimo Misciali, Letizia Gandolfi, A. Pileri, M. Cricca, L. Gandolfi, C. Misciali, B. Casadei, P. L. Zinzani, and A. Patrizi

Subjects
Side effect, business.industry, Dermatology, Pharmacology, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Infectious Diseases, 030220 oncology & carcinogenesis, medicine, vemurafenib, Vemurafenib, business, medicine.drug
Abstract

No abstract available.

Published
2015
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16. Personalized management of atrial fibrillation: Proceedings from the fourth Atrial Fibrillation competence NETwork/European Heart Rhythm Association consensus conference

Author

Markus Mueller, Herbert Schaefer, van Isabelle Gelder, Lukasz Szumowski, Gerhard Steinbeck, Kenneth M. Stein, Michael Oeff, Guido Hack, Jeroen J. Bax, Hugh Calkins, Stéphane N. Hatem, Axel Brandes, Laurent M. Haegeli, Karl-Heinz Kuck, Michael D. Ezekowitz, Ali Oto, Wim Stegink, Alphons Vincent, Burkert Pieske, Lucas V.A. Boersma, Stephan Willems, Isabelle Richard-Lordereau, Ralf Meyer, Andreas Clemens, Christophe Bailleul, Ursula Ravens, Stavros Apostolakis, Guenter Breithardt, Thorsten Lewalter, David J. Werring, Ulrich Schotten, Jessica Hernandez-Brichis, James A. Reiffel, Ron Pisters, Dobromir Dobrev, Angelo Auricchio, J Kautzner, Anne M. Gillis, Karl Georg Haeusler, Lars Melholt Rasmussen, Andrea Gerth, Roland Derwand, Angelika Leute, Harry J.G.M. Crijns, Michele Massimo Gulizia, Deirdre A. Lane, Berndt von Stritzky, Helen Brown, A. John Camm, Pierre Jaïs, Barbara Casadei, Sana Al Khatib, Carina Blomström-Lundqvist, Tatjana S. Potpara, Lluís Mont, Michael Naebauer, Etienne Aliot, Gregory Moses, Lukas Kappenberger, Gregory Y.H. Lip, Sakis Themistoclakis, Martina Brueckmann, Felix Muenzel, Karen Thomitzek, Jens Cosedis Nielsen, Thomas Fetsch, Hein Heidbuechel, Paulus Kirchhof, Giuseppe Boriani, Steven Kim, Luigi Tavazzi, Gerlinde Benninger, Cardiologie, MUMC+: MA Cardiologie (9), Fysiologie, RS: CARIM School for Cardiovascular Diseases, Faculteit Medische Wetenschappen/UMCG, Cardiovascular Centre (CVC), Academic Medical Center, P. Kirchhof, G. Breithardt, E. Aliot, S. Al Khatib, S. Apostolaki, A. Auricchio, C. Bailleul, J. Bax, G. Benninger, C. Blomstrom-Lundqvist, L. Boersma, G. Boriani, A. Brande, H. Brown, M. Brueckmann, H. Calkin, B. Casadei, A. Clemen, H. Crijn, R. Derwand, D. Dobrev, M. Ezekowitz, T. Fetsch, A. Gerth, A. Gilli, M. Gulizia, G. Hack, L. Haegeli, S. Hatem, K. Georg Hausler, H. Heidbuchel, J. Hernandez-Brichi, P. Jai, L. Kappenberger, J. Kautzner, S. Kim, K.-H. Kuck, D. Lane, A. Leute, T. Lewalter, R. Meyer, L. Mont, G. Mose, M. Mueller, F. Munzel, M. Nabauer, J. C. Nielsen, M. Oeff, A. Oto, B. Pieske, R. Pister, T. Potpara, L. Rasmussen, U. Raven, J. Reiffel, I. Richard-Lordereau, H. Schafer, U. Schotten, W. Stegink, K. Stein, G. Steinbeck, L. Szumowski, L. Tavazzi, S. Themistoclaki, K. Thomitzek, I. C. Van Gelder, B. von Stritzky, A. Vincent, D. Werring, S. Willem, G. Y. H. Lip, and A. J. Camm

Subjects
Rate control, medicine.medical_treatment, Medizin, Management of atrial fibrillation, 030204 cardiovascular system & hematology, law.invention, Imaging, 0302 clinical medicine, SMALL VESSEL DISEASE, Randomized controlled trial, Risk Factors, law, RADIOFREQUENCY CATHETER ABLATION, Medicine, 030212 general & internal medicine, Precision Medicine, biology, BIOLOGICAL MARKERS, Brain, Disease Management, Atrial fibrillation, Canadian Cardiovascular Society, RANDOMIZED CONTROLLED-TRIAL, Implantable cardioverter-defibrillator, Magnetic Resonance Imaging, C-REACTIVE PROTEIN, 3. Good health, Treatment Outcome, Echocardiography, Cardiology, Rhythm control, Cardiology and Cardiovascular Medicine, medicine.medical_specialty, IMPLANTABLE CARDIOVERTER-DEFIBRILLATOR, VON-WILLEBRAND-FACTOR, ATRIAL FIBRILLATION, ELECTROCARDIOGRAPHY, Left ventricular mass, 03 medical and health sciences, Anticoagulation, Von Willebrand factor, LEFT-VENTRICULAR MASS, Physiology (medical), Internal medicine, Genetics, Humans, SILENT BRAIN INFARCTS, business.industry, C-reactive protein, medicine.disease, NATRIURETIC PEPTIDE LEVELS, Electrocardiogram, biology.protein, CANADIAN CARDIOVASCULAR SOCIETY, Personalised medicine, business, Biomarkers
Abstract

The management of atrial fibrillation (AF) has seen marked changes in past years, with the introduction of new oral anticoagulants, new antiarrhythmic drugs, and the emergence of catheter ablation as a common intervention for rhythm control. Furthermore, new technologies enhance our ability to detect AF. Most clinical management decisions in AF patients can be based on validated parameters that encompass type of presentation, clinical factors, electrocardiogram analysis, and cardiac imaging. Despite these advances, patients with AF are still at increased risk for death, stroke, heart failure, and hospitalizations. During the fourth Atrial Fibrillation competence NETwork/European Heart Rhythm Association (AFNET/EHRA) consensus conference, we identified the following opportunities to personalize management of AF in a better manner with a view to improve outcomes by integrating atrial morphology and damage, brain imaging, information on genetic predisposition, systemic or local inflammation, and markers for cardiac strain. Each of these promising avenues requires validation in the context of existing risk factors in patients. More importantly, a new taxonomy of AF may be needed based on the pathophysiological type of AF to allow personalized management of AF to come to full fruition. Continued translational research efforts are needed to personalize management of this prevalent disease in a better manner. All the efforts are expected to improve the management of patients with AF based on personalized therapy.

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