1. A urinary peptidomic profile predicts outcome in SARS-CoV-2-infected patients
- Author
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Jan A. Staessen, Emmanuel Dudoignon, Barbara Neuhaus, Lutgarde Thijs, Joachim Beige, K Rothfuss, Beata Czerwieńska, Åsa Nilsson, Alexandre Mebazaa, Jochen Metzger, Christoph Lübbert, Justyna Siwy, Goce Spasovski, Andrzej Wiecek, Heiko von der Leyen, Mimoza Milenkova, Julia Raad, Aleksandra Canevska-Talevska, Björn Peters, Harald Mischak, Sven Kalbitz, Matthias Schwab, and Ralph Wendt
- Subjects
medicine.medical_specialty ,Urinary system ,Logistic regression ,01 natural sciences ,03 medical and health sciences ,0302 clinical medicine ,Urinary proteomics ,Internal medicine ,Medicine ,030212 general & internal medicine ,0101 mathematics ,Disease severity ,Framingham Risk Score ,Receiver operating characteristic ,business.industry ,SARS-CoV-2 ,010102 general mathematics ,Area under the curve ,COVID-19 ,General Medicine ,Odds ratio ,Biomarker (medicine) ,Risk score ,business ,Body mass index ,Research Paper - Abstract
BACKGROUND: COVID-19 prediction models based on clinical characteristics, routine biochemistry and imaging, have been developed, but little is known on proteomic markers reflecting the molecular pathophysiology of disease progression. METHODS: The multicentre (six European study sites) Prospective Validation of a Proteomic Urine Test for Early and Accurate Prognosis of Critical Course Complications in Patients with SARS-CoV-2 Infection Study (Crit-COV-U) is recruiting consecutive patients (≥ 18 years) with PCR-confirmed SARS-CoV-2 infection. A urinary proteomic biomarker (COV50) developed by capillary-electrophoresis-mass spectrometry (CE-MS) technology, comprising 50 sequenced peptides and identifying the parental proteins, was evaluated in 228 patients (derivation cohort) with replication in 99 patients (validation cohort). Death and progression along the World Health Organization (WHO) Clinical Progression Scale were assessed up to 21 days after the initial PCR test. Statistical methods included logistic regression, receiver operating curve (ROC) analysis and comparison of the area under the curve (AUC). FINDINGS: In the derivation cohort, 23 patients died, and 48 developed worse WHO scores. The odds ratios (OR) for death per 1 standard deviation (SD) increment in COV50 were 3·52 (95% CI, 2·02-6·13, p
- Published
- 2021