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1. Factores de riesgo cardiovascular en una cohorte de mujeres de edad media

Author

Salvador Sarrá C, María Ema Roncagliolo M., Juan Enrique Blümel M, Camil Castelo Branco F, and Lorena Binfa E

Subjects
medicine.medical_specialty, medicine.diagnostic_test, business.industry, medicine.medical_treatment, Hormone replacement therapy (menopause), General Medicine, medicine.disease, Obesity, Surgery, Menopause, Cardiovascular diseases, Hyperlipidemia, Blood pressure, Hormone replacement therapy, Internal medicine, Diabetes mellitus, Cohort, medicine, Lipid profile, business, Dyslipidemia
Abstract

It is generally accepted that menopause significantly modifies cardiovascular risk. The effects of hormone replacement therapy (HRT) on this risk remain controversial. Aim: To study the prevalence of cardiovascular risk factors (RF) in middle-aged women and their changes with aging, menopause and hormone replacement therapy (HRT). Material and methods: cardiovascular risk factors were assessed in 576 women aged 40 to 59 years in 1991-92. Five years later, 467 of these women were reassessed. Results: Sedentarism (87.2%), dyslipidemias (71.5%), high blood pressure (13.5%), obesity (13.1%), smoking (12.4%) and diabetes (2.8%) were the most prevalent RF. Five years later, the prevalence of hypertension increased to 20.9%, the prevalence of obesity increased to 27.3%, smoking increased to 20.8% and diabetes to 5.9%. The prevalence of dyslipidemia did not change, although triglycerides levels rose from 125.9±56.4 to 136.8±63.5 mg/dl (p

Published
2003
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2. Assessing the impact of COVID-19 on liver cancer management (CERO-19)

Author

Manuel Delgado, Mar Lozano, Alejandro Forner, Bruno Sangro, Alessandro Granito, Margarita Sala, Monica Ronzoni, Giuseppe Cabibbo, Frederik J H Hoogwater, José Luis Lledó, Rosanna Villani, Alessandra Elvevi, Lorenza Rimassa, Juan Acevedo, Mariona Calvo, Mercedes Vergara, Sergio Muñoz-Martínez, Jean-Charles Nault, Juan C. Bandi, Markus Peck-Radosavljevic, Brandon M. Meyers, Marco Sanduzzi-Zamparelli, Rogerio Alves, Saleh A. Alqahtani, Alberto E. Muñoz, Sonia Pascual, Alberto Lué, Josepmaria Argemi, Beatriz Minguez, Henning Wege, Giovan Giuseppe Di Costanzo, David J. Pinato, Victor Sapena, Maria Guarino, Stefano Okolicsanyi, Vivianne Mello, Martina Gambato, Susanna Coll, Carlos Benítez, Dhanny Gomez, Christoph Roderburg, Peter R. Galle, Bristi Basu, Federico Piñero, Cassia Leal, Frank Tacke, Christie Perelló, Tudor Mocan, Massimiliano Salati, Helen L. Reeves, Jörg Trojan, Vincenzo Cardinale, Mohamed El Kassas, Tom Lüdde, John Bridgewater, Mário Reis Álvares-da-Silva, Anja Lachenmayer, Giovanni Brandi, Alex Vianey Callado França, Mohamed Bouattour, Tim Meyer, Gerda Elisabeth Villadsen, M. Varela, Jordi Bruix, Dalia Morales-Arraez, Carlos Rodríguez-Lope, Christian Toso, Wacław Hołówko, Philippe Merle, Manuel Romero-Gómez, Ignacio García-Juárez, Fernanda Branco, Gonzalo Sapisochin, Chiara Braconi, Emmanouil Giorgakis, Hidenori Toyoda, Lorraine Blaise, Ana María Matilla Peña, Andrea Casadei-Gardini, Leonardo G Da Fonseca, Alexander Siebenhüner, Maria Reig, Gustavo Pereira, Massimo Iavarone, Maria Margarita Anders, Munoz-Martinez S., Sapena V., Forner A., Nault J.-C., Sapisochin G., Rimassa L., Sangro B., Bruix J., Sanduzzi-Zamparelli M., Holowko W., El Kassas M., Mocan T., Bouattour M., Merle P., Hoogwater F.J.H., Alqahtani S.A., Reeves H.L., Pinato D.J., Giorgakis E., Meyer T., Villadsen G.E., Wege H., Salati M., Minguez B., Di Costanzo G.G., Roderburg C., Tacke F., Varela M., Galle P.R., Alvares-da-Silva M.R., Trojan J., Bridgewater J., Cabibbo G., Toso C., Lachenmayer A., Casadei-Gardini A., Toyoda H., Ludde T., Villani R., Matilla Pena A.M., Guedes Leal C.R., Ronzoni M., Delgado M., Perello C., Pascual S., Lledo J.L., Argemi J., Basu B., da Fonseca L., Acevedo J., Siebenhuner A.R., Braconi C., Meyers B.M., Granito A., Sala M., Rodriguez-Lope C., Blaise L., Romero-Gomez M., Pinero F., Gomez D., Mello V., Pinheiro Alves R.C., Franca A., Branco F., Brandi G., Pereira G., Coll S., Guarino M., Benitez C., Anders M.M., Bandi J.C., Vergara M., Calvo M., Peck-Radosavljevic M., Garcia-Juarez I., Cardinale V., Lozano M., Gambato M., Okolicsanyi S., Morales-Arraez D., Elvevi A., Munoz A.E., Lue A., Iavarone M., Reig M., Basu, Bristi [0000-0002-3562-2868], Apollo - University of Cambridge Repository, Institut Català de la Salut, [Muñoz-Martínez S, Sapena V, Forner A] BCLC group, Liver Unit, Hospital Clinic Barcelona, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain. [Nault JC] Service d’hépatologie, Hôpital Avicenne, Hôpitaux Universitaires Paris-Seine-Saint-Denis, Assistance-Publique Hôpitaux de Paris, Bobigny, France. Unité de Formation et de Recherche Santé Médecine et Biologie Humaine, Université Paris Nord, Paris, France. Centre de Recherche des Cordeliers, Inserm, Sorbonne Université, Université Paris, INSERM UMR 1138 Functional Genomics of Solid Tumors Laboratory, Paris, France. [Sapisochin G] Abdominal Transplant & HPB Surgical Oncology, University Health Network, Toronto General Hospital, University of Toronto, Toronto, Canada. [Rimassa L] Medical Oncology and Hematology Unit, Humanitas Cancer Center, Humanitas Clinical and Research Center – IRCCS, Rozzano, Milan, Italy. Department of Biomedical Sciences, Humanitas University, Milan, Italy. [Mínguez B] Unitat del Fetge, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Grup de Recerca en Malalties hepàtiques, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain, and Vall d'Hebron Barcelona Hospital Campus

Subjects
Hepatocellular carcinoma, LC, medicine.medical_treatment, diagnóstico::toma de decisiones clínicas [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Nurses, RC799-869, Liver transplantation, Cholangiocarcinoma, Clinical trials, ENS-CCA, Interquartile range, Decisió, Presa de, Pandemic, Other subheadings::/diagnosis [Other subheadings], virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus [ENFERMEDADES], CERO-19, Pandèmia de COVID-19, 2020, Immunology and Allergy, iCCA, intrahepatic cholangiocarcinoma, COVID-19, coronavirus disease 2019, Liver Cancer Outcome in the COVID-19-pandemic Project, Settore MED/12 - Gastroenterologia, ddc:617, IQR, Gastroenterology, BCLC, Barcelona Clinic Liver Cancer, Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [DISEASES], neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias hepáticas [ENFERMEDADES], Diseases of the digestive system. Gastroenterology, Management, Clinical Practice, Clinical trial, European Network for the Study of Cholangiocarcinoma, Diagnosis::Clinical Decision-Making [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], Fetge - Malalties - Diagnòstic, Liver cancer, PROGRESSION-FREE SURVIVAL, Liver Cancer, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Otros calificadores::/diagnóstico [Otros calificadores], 610 Medicine & health, Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Liver Neoplasms [DISEASES], LT, liver transplantation, Article, Barcelona Clinic Liver Cancer, Internal Medicine, medicine, ENS-CCA, European Network for the Study of Cholangiocarcinoma, Hepatology, business.industry, CERO-19, Liver Cancer Outcome in the COVID-19-pandemic Project, COVID-19, IQR, Interquartile range, medicine.disease, BCLC, Emergency medicine, Observational study, 610 Medizin und Gesundheit, business, HCC, hepatocellular carcinoma, LC, liver cancer, SARS-CoV-2, severe acute respiratory syndrome coronavirus-2
Abstract

[Background & Aims] The coronavirus disease 2019 (COVID-19) pandemic has posed unprecedented challenges to healthcare systems and it may have heavily impacted patients with liver cancer (LC). Herein, we evaluated whether the schedule of LC screening or procedures has been interrupted or delayed because of the COVID-19 pandemic., [Methods] An international survey evaluated the impact of the COVID-19 pandemic on clinical practice and clinical trials from March 2020 to June 2020, as the first phase of a multicentre, international, and observational project. The focus was on patients with hepatocellular carcinoma or intrahepatic cholangiocarcinoma, cared for around the world during the first COVID-19 pandemic wave., [Results] Ninety-one centres expressed interest to participate and 76 were included in the analysis, from Europe, South America, North America, Asia, and Africa (73.7%, 17.1%, 5.3%, 2.6%, and 1.3% per continent, respectively). Eighty-seven percent of the centres modified their clinical practice: 40.8% the diagnostic procedures, 80.9% the screening programme, 50% cancelled curative and/or palliative treatments for LC, and 41.7% modified the liver transplantation programme. Forty-five out of 69 (65.2%) centres in which clinical trials were running modified their treatments in that setting, but 58.1% were able to recruit new patients. The phone call service was modified in 51.4% of centres which had this service before the COVID-19 pandemic (n = 19/37)., [Conclusions] The first wave of the COVID-19 pandemic had a tremendous impact on the routine care of patients with liver cancer. Modifications in screening, diagnostic, and treatment algorithms may have significantly impaired the outcome of patients. Ongoing data collection and future analyses will report the benefits and disadvantages of the strategies implemented, aiding future decision-making., [Lay summary] The coronavirus disease 2019 (COVID-19) pandemic has posed unprecedented challenges to healthcare systems globally. Herein, we assessed the impact of the first wave pandemic on patients with liver cancer and found that routine care for these patients has been majorly disrupted, which could have a significant impact on outcomes.

Published
2021
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3. Higher Fluid Balance Increases the Risk of Death From Sepsis: Results From a Large International Audit

Author

Sakr Y., Rubatto Birri P. N., Kotfis K., Nanchal R., Shah B., Kluge S., Schroeder M. E., Marshall J. C., Vincent J. -L, E Tomas, E Amisi Bibonge, B Charra, M Faroudy, L Doedens, Z Farina, D Adler, C Balkema, A Kok, S Alaya, H Gharsallah, D Muzha, A Temelkov, G Georgiev, G Simeonov, G Tsaryanski, S Georgiev, A Seliman, S Vrankovic, Z Vucicevic, I Gornik, B Barsic, I Husedzinovic, P Pavlik, J Manak, E Kieslichova, R Turek, M Fischer, R Valkova, L Dadak, P Dostal, J Malaska, R Hajek, A Židková, P Lavicka, J Starkopf, Z Kheladze, M Chkhaidze, V Kaloiani, L Medve, A Sarkany, I Kremer, Z Marjanek, P Tamasi, I Krupnova, I Vanags, V Liguts, V Pilvinis, S Vosylius, G Kekstas, M Balciunas, J Kolbusz, A Kübler, B Mielczarek, M Mikaszewska-Sokolewicz, K Kotfis, B Tamowicz, W Sulkowski, P Smuszkiewicz, A Pihowicz, E Trejnowska, N Hagau, D Filipescu, G Droc, M Lupu, A Nica, R Stoica, D Tomescu, D Constantinescu, G Valcoreanu Zbaganu, A Slavcovici, V Bagin, D Belsky, S Palyutin, S Shlyapnikov, D Bikkulova, A Gritsan, G Natalia, E Makarenko, V Kokhno, A Tolkach, E Kokarev, B Belotserkovskiy, K Zolotukhin, V Kulabukhov, L Soskic, I Palibrk, R Jankovic, B Jovanovic, M Pandurovic, V Bumbasirevic, B Uljarevic, M Surbatovic, N Ladjevic, G Slobodianiuk, V Sobona, A Cikova, A Gebhardtova, C Jun, S Yunbo, J Dong, S Feng, M Duan, Y Xu, X Xue, T Gao, X Xing, X Zhao, C Li, G Gengxihua, H Tan, J Xu, L Jiang, Q Tiehe, Q Bingyu, Q Shi, Z Lv, L Zhang, L Jingtao, Z Zhen, Z Wang, T Wang, L Yuhong, Q Zhai, Y Chen, C Wang, W Jiang, W Ruilan, Y Chenv, H Xiaobo, H Ge, T Yan, C Yuhui, J Zhang, F Jian-Hong, H Zhu, F Huo, Y Wang, M Zhuang, Z Ma, J Sun, L Liuqingyue, M Yang, J Meng, S Ma, Y Kang, L Yu, Q Peng, Y Wei, W Zhang, R Sun, A Yeung, W Wan, K Sin, K Lee, M Wijanti, U Widodo, H Samsirun, T Sugiman, C Wisudarti, T Maskoen, N Hata, Y Kobe, O Nishida, D Miyazaki, S Nunomiya, S Uchino, N Kitamura, K Yamashita, S Hashimoto, H Fukushima, N Nik Adib, L Tai, B Tony, R Bigornia, J Palo, S Chatterjee, B Tan, A Kong, S Goh, C Lee, C Pothirat, B Khwannimit, P Theerawit, P Pornsuriyasak, A Piriyapatsom, A Mukhtar, A Nabil Hamdy, H Hosny, A Ashraf, M Mokhtari, S Nowruzinia, A Lotfi, F Zand, R Nikandish, O Moradi Moghaddam, J Cohen, O Sold, T Sfeir, A Hasan, D Abugaber, H Ahmad, T Tantawy, S Baharoom, H Algethamy, A Amr, G Almekhlafi, R Coskun, M Sungur, A Cosar, B Güçyetmez, O Demirkiran, E Senturk, H Ulusoy, H Atalan, S Serin, I Kati, Z Alnassrawi, A Almemari, K Krishnareddy, S Kashef, A Alsabbah, G Poirier, J Marshall, M Herridge, R Fernandez-Medero, G Fulda, S Banschbach, J Quintero, E Schroeder, C Sicoutris, R Gueret, R Kashyap, P Bauer, R Nanchal, R Wunderink, E Jimenez, A Ryan, D Prince, J Edington, F Van Haren, A Bersten, D J Hawkins, M Kilminster, D Sturgess, M Ziegenfuss, S O' Connor, J Lipman, L Campbell, R Mcallister, B Roberts, P Williams, R Parke, P Seigne, R Freebairn, D Nistor, C Oxley, P Young, R Valentini, N Wainsztein, P Comignani, M Casaretto, G Sutton, P Villegas, C Galletti, J Neira, D Rovira, J Hidalgo, F Sandi, E Caser, M Thompson, M D'agostino Dias, L Fontes, M Lunardi, N Youssef, S Lobo, R Silva, J Sales Jr, L Madeira Campos Melo, M Oliveira, M Fonte, C Grion, C Feijo, V Rezende, M Assuncao, A Neves, P Gusman, D Dalcomune, C Teixeira, K Kaefer, I Maia, V Souza Dantas, R Costa Filho, F Amorim, M Assef, P Schiavetto, J Houly, F Bianchi, F Dias, C Avila, J Gomez, L Rego, P Castro, J Passos, C Mendes, G Colozza Mecatti, M Ferrreira, V Irineu, M Guerreiro, S Ugarte, V Tomicic, C Godoy, W Samaniego, I Escamilla, L Castro Castro, G Libreros Duque, D Diaz-Guio, F Benítez, A Guerra Urrego, R Buitrago, G Ortiz, M Villalba Gaviria, D Salas, J Ramirez-Arce, E Salgado, D Morocho, J Vergara, M Chung Sang, C Orellana-Jimenez, L Garrido, O Diaz, D Resiere, C Osorio, A De La Vega, R Carrillo, V Sanchez, A Villagomez, R Martinez Zubieta, M Sandia, M Zalatiel, M Poblano, D Rodriguez Gonzalez, F Arrazola, L Juan Francisco, S A Ñamendys-Silva, M Hernandez, D Rodriguez Cadena, I Lopez Islas, C Ballesteros Zarzavilla, A Matos, I Oyanguren, J Cerna, R Quispe Sierra, R Jimenez, L Castillo, R Ocal, A Sencan, S Mareque Gianoni, A Deicas, J Hurtado, G Burghi, A Martinelli, I Von Der Osten, C Du Maine, M Bhattacharyya, S Bandyopadhyay, S Yanamala, P Gopal, S Sahu, M Ibrahim, D Rathod, N Mukundan, A Dewan, P Amin, S Samavedam, B Shah, D Gurupal, B Lahkar, A Mandal, M Sircar, S Ghosh, V Balasubramani, F Kapadia, S Vadi, K Nair, S Tripathy, S Nandakumar, J Sharma, A Kar, S Jha, K Zirpe-Gurav, M Patel, A Bhavsar, D Samaddar, A Kulkarni, M Hashmi, W Ali, S Nadeem, K Indraratna, A Margarit, P Urbanek, J Schlieber, J Reisinger, J Auer, A Hartjes, A Lerche, T Janous, E Kink, W Krahulec, K Smolle, M Van Der Schueren, P Thibo, M Vanhoof, I Ahmet, G Philippe, P Dufaye, O Jacobs, V Fraipont, P Biston, A Dive, Y Bouckaert, E Gilbert, B Gressens, E Pinck, V Collin, J L Vincent, J De Waele, R Rimachi, D Gusu, K De Decker, K Mandianga, L Heytens, X Wittebole, S Herbert, V Olivier, W Vandenheede, P Rogiers, P Kolodzeike, M Kruse, T Andersen, V Harjola, K Saarinen, M Leone, A Durocher, S Moulront, A Lepape, M Losser, P Cabaret, E Kalaitzis, E Zogheib, P Charve, B Francois, J Y Lefrant, B Beilouny, X Forceville, B Misset, F Jacobs, F Bernard, D Payen, A Wynckel, V Castelain, A Faure, P Lavagne, L Thierry, M Moussa, A Vieillard-Baron, M Durand, M Gainnier, C Ichai, S Arens, C Hoffmann, M Kaffarnik, C Scharnofske, I Voigt, C Peckelsen, M Weber, J Gille, A Lange, G Schoser, A Sablotzki, U Jaschinski, A Bluethgen, F Vogel, A Tscheu, T Fuchs, M Wattenberg, T Helmes, S Scieszka, M Heintz, S Sakka, J Kohler, F Fiedler, M Danz, Y Sakr, R Riessen, T Kerz, A Kersten, F Tacke, G Marx, T Volkert, A Schmutz, A Nierhaus, S Kluge, P Abel, R Janosi, S Utzolino, H Bracht, S Toussaint, M Giannakou Peftoulidou, P Myrianthefs, A Armaganidis, C Routsi, A Xini, E Mouloudi, I Kokoris, G Kyriazopoulos, S Vlachos, A Lavrentieva, P Partala, G Nakos, A Moller, S Stefansson, J Barry, R O'Leary, C Motherway, M Faheem, E Dunne, M Donnelly, T Konrad, E Bonora, C Achilli, S Rossi, G Castiglione, A Peris, D Albanese, N Stocchetti, G Citerio, L Mozzoni, E Sisillo, P De Negri, M Savioli, P Vecchiarelli, F Puflea, V Stankovic, G Minoja, S Montibeller, P Calligaro, R Sorrentino, M Feri, M Zambon, E Colombaroli, A Giarratano, T Pellis, C Capra, M Antonelli, A Gullo, C Chelazzi, A De Capraris, N Patroniti, M Girardis, F Franchi, G Berlot, M Buttigieg, H Ponssen, J Ten Cate, L Bormans, S Husada, M Buise, B Van Der Hoven, A Reidinga, M Kuiper, P Pickkers, G Kluge, S Den Boer, J Kesecioglu, H Van Leeuwen, H Flaatten, S Mo, V Branco, F Rua, E Lafuente, M Sousa, N Catorze, M Barros, L Pereira, A Vintém De Oliveira, J Gomes, I Gaspar, M Pereira, M Cymbron, A Dias, E Almeida, S Beirao, I Serra, R Ribeiro, P Povoa, F Faria, Z Costa-E-Silva, J Nóbrega, F Fernandes, J Gabriel, G Voga, E Rupnik, L Kosec, M Kerin Povšic, I Osojnik, V Tomic, A Sinkovic, J González, E Zavala, J Pérez Valenzuela, L Marina, P Vidal-Cortés, P Posada, A Ignacio Martin-Loeches, N Muñoz Guillén, M Palomar, J Sole-Violan, A Torres, M Gonzalez Gallego, G Aguilar, R Montoiro Alluév, M Argüeso, M Parejo, M Palomo Navarro, A Jose, N Nin, F Alvarez Lerma, O Martinez, E Tenza Lozano, S Arenal López, M Perez Granda, S Moreno, C Llubia, C De La Fuente Martos, P Gonzalez-Arenas, N Llamas Fernández, B Gil Rueda, I Estruch Pons, N Cruza, F Maroto, A Estella, A Ferrer, L Iglesias Fraile, B Quindos, A Quintano, M Tebar, P Cardinal, A Reyes, A Rodríguez, A Abella, S García Del Valle, S Yus, E Maseda, J Berezo, A Tejero Pedregosa, C Laplaza, R Ferrer, J Rico-Feijoo, M Rodríguez, P Monedero, K Eriksson, D Lind, D Chabanel, H Zender, K Heer, B Frankenberger, S Jakob, A Haller, S Mathew, R Downes, C Barrera Groba, A Johnston, R Meacher, R Keays, P Haji-Michael, C Tyler, A Ferguson, S Jones, D Tyl, A Ball, J Vogel, M Booth, P Downie, M Watters, S Brett, M Garfield, L Everett, S Heenen, S Dhir, Z Beardow, M Mostert, S Brosnan, N Pinto, S Harris, A Summors, N Andrew, A Rose, R Appelboam, O Davies, E Vickers, B Agarwal, T Szakmany, S Wimbush, I Welters, R Pearse, R Hollands, J Kirk-Bayley, N Fletcher, B Bray, D Brealey, Sakr, Y, Rubatto Birri, P, Kotfis, K, Nanchal, R, Shah, B, Kluge, S, Schroeder, M, Marshall, J, Vincent, J, Citerio, G, Sakr Y., Rubatto Birri P.N., Kotfis K., Nanchal R., Shah B., Kluge S., Schroeder M.E., Marshall J.C., and Vincent J.-L, E Tomas, E Amisi Bibonge, B Charra, M Faroudy, L Doedens, Z Farina, D Adler, C Balkema, A Kok, S Alaya, H Gharsallah, D Muzha, A Temelkov, G Georgiev, G Simeonov, G Tsaryanski, S Georgiev, A Seliman, S Vrankovic, Z Vucicevic, I Gornik, B Barsic, I Husedzinovic, P Pavlik, J Manak, E Kieslichova, R Turek, M Fischer, R Valkova, L Dadak, P Dostal, J Malaska, R Hajek, A Židková, P Lavicka, J Starkopf, Z Kheladze, M Chkhaidze, V Kaloiani, L Medve, A Sarkany, I Kremer, Z Marjanek, P Tamasi, I Krupnova, I Vanags, V Liguts, V Pilvinis, S Vosylius, G Kekstas, M Balciunas, J Kolbusz, A Kübler, B Mielczarek, M Mikaszewska-Sokolewicz, K Kotfis, B Tamowicz, W Sulkowski, P Smuszkiewicz, A Pihowicz, E Trejnowska, N Hagau, D Filipescu, G Droc, M Lupu, A Nica, R Stoica, D Tomescu, D Constantinescu, G Valcoreanu Zbaganu, A Slavcovici, V Bagin, D Belsky, S Palyutin, S Shlyapnikov, D Bikkulova, A Gritsan, G Natalia, E Makarenko, V Kokhno, A Tolkach, E Kokarev, B Belotserkovskiy, K Zolotukhin, V Kulabukhov, L Soskic, I Palibrk, R Jankovic, B Jovanovic, M Pandurovic, V Bumbasirevic, B Uljarevic, M Surbatovic, N Ladjevic, G Slobodianiuk, V Sobona, A Cikova, A Gebhardtova, C Jun, S Yunbo, J Dong, S Feng, M Duan, Y Xu, X Xue, T Gao, X Xing, X Zhao, C Li, G Gengxihua, H Tan, J Xu, L Jiang, Q Tiehe, Q Bingyu, Q Shi, Z Lv, L Zhang, L Jingtao, Z Zhen, Z Wang, T Wang, L Yuhong, Q Zhai, Y Chen, C Wang, W Jiang, W Ruilan, Y Chenv, H Xiaobo, H Ge, T Yan, C Yuhui, J Zhang, F Jian-Hong, H Zhu, F Huo, Y Wang, C Li, M Zhuang, Z Ma, J Sun, L Liuqingyue, M Yang, J Meng, S Ma, Y Kang, L Yu, Q Peng, Y Wei, W Zhang, R Sun, A Yeung, W Wan, K Sin, K Lee, M Wijanti, U Widodo, H Samsirun, T Sugiman, C Wisudarti, T Maskoen, N Hata, Y Kobe, O Nishida, D Miyazaki, S Nunomiya, S Uchino, N Kitamura, K Yamashita, S Hashimoto, H Fukushima, N Nik Adib, L Tai, B Tony, R Bigornia, R Bigornia, R Bigornia, J Palo, S Chatterjee, B Tan, A Kong, S Goh, C Lee, C Pothirat, B Khwannimit, P Theerawit, P Pornsuriyasak, A Piriyapatsom, A Mukhtar, A Nabil Hamdy, H Hosny, A Ashraf, M Mokhtari, S Nowruzinia, A Lotfi, F Zand, R Nikandish, O Moradi Moghaddam, J Cohen, O Sold, T Sfeir, A Hasan, D Abugaber, H Ahmad, T Tantawy, S Baharoom, H Algethamy, A Amr, G Almekhlafi, R Coskun, M Sungur, A Cosar, B Güçyetmez, O Demirkiran, E Senturk, H Ulusoy, H Atalan, S Serin, I Kati, Z Alnassrawi, A Almemari, K Krishnareddy, S Kashef, A Alsabbah, G Poirier, J Marshall, M Herridge, M Herridge, R Fernandez-Medero, G Fulda, S Banschbach, J Quintero, E Schroeder, C Sicoutris, R Gueret, R Kashyap, P Bauer, R Nanchal, R Wunderink, E Jimenez, A Ryan, D Prince, J Edington, F Van Haren, A Bersten, D J Hawkins, M Kilminster, D Sturgess, M Ziegenfuss, S O' Connor, J Lipman, L Campbell, R Mcallister, B Roberts, P Williams, R Parke, P Seigne, R Freebairn, D Nistor, C Oxley, P Young, R Valentini, N Wainsztein, P Comignani, M Casaretto, G Sutton, P Villegas, C Galletti, J Neira, D Rovira, J Hidalgo, F Sandi, E Caser, M Thompson, M D'agostino Dias, L Fontes, M Lunardi, N Youssef, S Lobo, R Silva, J Sales Jr, L Madeira Campos Melo, M Oliveira, M Fonte, C Grion, C Feijo, V Rezende, M Assuncao, A Neves, P Gusman, D Dalcomune, C Teixeira, K Kaefer, I Maia, V Souza Dantas, R Costa Filho, F Amorim, M Assef, P Schiavetto, J Houly, F Bianchi, F Dias, C Avila, J Gomez, L Rego, P Castro, J Passos, C Mendes, C Grion, G Colozza Mecatti, M Ferrreira, V Irineu, M Guerreiro, S Ugarte, V Tomicic, C Godoy, W Samaniego, I Escamilla, L Castro Castro, G Libreros Duque, D Diaz-Guio, F Benítez, A Guerra Urrego, R Buitrago, G Ortiz, M Villalba Gaviria, D Salas, J Ramirez-Arce, E Salgado, D Morocho, J Vergara, M Chung Sang, C Orellana-Jimenez, L Garrido, O Diaz, D Resiere, C Osorio, A De La Vega, R Carrillo, V Sanchez, A Villagomez, R Martinez Zubieta, M Sandia, M Zalatiel, M Poblano, D Rodriguez Gonzalez, F Arrazola, L Juan Francisco, S A Ñamendys-Silva, M Hernandez, D Rodriguez Cadena, I Lopez Islas, C Ballesteros Zarzavilla, A Matos, I Oyanguren, J Cerna, R Quispe Sierra, R Jimenez, L Castillo, R Ocal, A Sencan, S Mareque Gianoni, A Deicas, J Hurtado, G Burghi, A Martinelli, I Von Der Osten, C Du Maine, M Bhattacharyya, S Bandyopadhyay, S Yanamala, P Gopal, S Sahu, M Ibrahim, D Rathod, N Mukundan, A Dewan, P Amin, S Samavedam, B Shah, D Gurupal, B Lahkar, A Mandal, M Sircar, S Ghosh, V Balasubramani, F Kapadia, S Vadi, K Nair, S Tripathy, S Nandakumar, J Sharma, A Kar, S Jha, K Zirpe-Gurav, M Patel, A Bhavsar, D Samaddar, A Kulkarni, M Hashmi, W Ali, S Nadeem, K Indraratna, A Margarit, P Urbanek, J Schlieber, J Reisinger, J Auer, A Hartjes, A Lerche, T Janous, E Kink, W Krahulec, K Smolle, M Van Der Schueren, P Thibo, M Vanhoof, I Ahmet, G Philippe, P Dufaye, O Jacobs, V Fraipont, P Biston, A Dive, Y Bouckaert, E Gilbert, B Gressens, E Pinck, V Collin, J L Vincent, J De Waele, R Rimachi, D Gusu, K De Decker, K Mandianga, L Heytens, X Wittebole, S Herbert, V Olivier, W Vandenheede, P Rogiers, P Kolodzeike, M Kruse, T Andersen, V Harjola, K Saarinen, M Leone, A Durocher, S Moulront, A Lepape, M Losser, P Cabaret, E Kalaitzis, E Zogheib, P Charve, B Francois, J Y Lefrant, B Beilouny, X Forceville, B Misset, F Jacobs, F Bernard, D Payen, A Wynckel, V Castelain, A Faure, P Lavagne, L Thierry, M Moussa, A Vieillard-Baron, M Durand, M Gainnier, C Ichai, S Arens, C Hoffmann, M Kaffarnik, C Scharnofske, I Voigt, C Peckelsen, M Weber, J Gille, A Lange, G Schoser, A Sablotzki, U Jaschinski, A Bluethgen, F Vogel, A Tscheu, T Fuchs, M Wattenberg, T Helmes, S Scieszka, M Heintz, S Sakka, J Kohler, F Fiedler, M Danz, Y Sakr, R Riessen, T Kerz, A Kersten, F Tacke, G Marx, T Volkert, A Schmutz, A Nierhaus, S Kluge, P Abel, R Janosi, S Utzolino, H Bracht, S Toussaint, M Giannakou Peftoulidou, P Myrianthefs, A Armaganidis, C Routsi, A Xini, E Mouloudi, I Kokoris, G Kyriazopoulos, S Vlachos, A Lavrentieva, P Partala, G Nakos, A Moller, S Stefansson, J Barry, R O'Leary, C Motherway, M Faheem, E Dunne, M Donnelly, T Konrad, E Bonora, C Achilli, S Rossi, G Castiglione, A Peris, D Albanese, N Stocchetti, G Citerio, L Mozzoni, E Sisillo, P De Negri, M Savioli, P Vecchiarelli, F Puflea, V Stankovic, G Minoja, S Montibeller, P Calligaro, R Sorrentino, M Feri, M Zambon, E Colombaroli, A Giarratano, T Pellis, C Capra, M Antonelli, A Gullo, C Chelazzi, A De Capraris, N Patroniti, M Girardis, F Franchi, G Berlot, M Buttigieg, H Ponssen, J Ten Cate, L Bormans, S Husada, M Buise, B Van Der Hoven, A Reidinga, M Kuiper, P Pickkers, G Kluge, S Den Boer, J Kesecioglu, H Van Leeuwen, H Flaatten, S Mo, V Branco, F Rua, E Lafuente, M Sousa, N Catorze, M Barros, L Pereira, A Vintém De Oliveira, J Gomes, I Gaspar, M Pereira, M Cymbron, A Dias, E Almeida, S Beirao, I Serra, R Ribeiro, P Povoa, F Faria, Z Costa-E-Silva, J Nóbrega, F Fernandes, J Gabriel, G Voga, E Rupnik, L Kosec, M Kerin Povšic, I Osojnik, V Tomic, A Sinkovic, J González, E Zavala, J Pérez Valenzuela, L Marina, P Vidal-Cortés, P Posada, A Ignacio Martin-Loeches, N Muñoz Guillén, M Palomar, J Sole-Violan, A Torres, M Gonzalez Gallego, G Aguilar, R Montoiro Alluév, M Argüeso, M Parejo, M Palomo Navarro, A Jose, N Nin, F Alvarez Lerma, O Martinez, E Tenza Lozano, S Arenal López, M Perez Granda, S Moreno, C Llubia, C De La Fuente Martos, P Gonzalez-Arenas, N Llamas Fernández, B Gil Rueda, I Estruch Pons, N Cruza, F Maroto, A Estella, A Ferrer, L Iglesias Fraile, B Quindos, A Quintano, M Tebar, P Cardinal, A Reyes, A Rodríguez, A Abella, S García Del Valle, S Yus, E Maseda, J Berezo, A Tejero Pedregosa, C Laplaza, R Ferrer, J Rico-Feijoo, M Rodríguez, P Monedero, K Eriksson, D Lind, D Chabanel, H Zender, K Heer, B Frankenberger, S Jakob, A Haller, S Mathew, R Downes, C Barrera Groba, A Johnston, R Meacher, R Keays, P Haji-Michael, C Tyler, A Ferguson, S Jones, D Tyl, A Ball, J Vogel, M Booth, P Downie, M Watters, S Brett, M Garfield, L Everett, S Heenen, S Dhir, Z Beardow, M Mostert, S Brosnan, N Pinto, S Harris, A Summors, N Andrew, A Rose, R Appelboam, O Davies, E Vickers, B Agarwal, T Szakmany, S Wimbush, I Welters, R Pearse, R Hollands, J Kirk-Bayley, N Fletcher, B Bray, D Brealey

Subjects
Internationality, Time Factors, Databases, Factual, medicine.medical_treatment, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], Settore MED/41 - Anestesiologia, Critical Care and Intensive Care Medicine, law.invention, 0302 clinical medicine, law, Risk Factors, 80 and over, 030212 general & internal medicine, Hospital Mortality, 610 Medicine & health, Aged, 80 and over, Medical Audit, fluid output, Middle Aged, Water-Electrolyte Balance, fluid administration, Intensive care unit, outcome, septic shock, Adult, Aged, Humans, Intensive Care Units, Sepsis, Fluid Therapy, Cohort, Human, Cohort study, medicine.medical_specialty, Time Factor, Sepsi, Intensive Care Unit, Observational Study, 03 medical and health sciences, Databases, Hemofiltration, medicine, Journal Article, Risk factor, Intensive care medicine, Factual, Hetastarch, business.industry, Septic shock, Risk Factor, 030208 emergency & critical care medicine, fluid administration, fluid output, outcome, septic shock, medicine.disease, business
Abstract

Contains fulltext : 177598.pdf (Publisher’s version ) (Closed access) OBJECTIVES: Excessive fluid therapy in patients with sepsis may be associated with risks that outweigh any benefit. We investigated the possible influence of early fluid balance on outcome in a large international database of ICU patients with sepsis. DESIGN: Observational cohort study. SETTING: Seven hundred and thirty ICUs in 84 countries. PATIENTS: All adult patients admitted between May 8 and May 18, 2012, except admissions for routine postoperative surveillance. For this analysis, we included only the 1,808 patients with an admission diagnosis of sepsis. Patients were stratified according to quartiles of cumulative fluid balance 24 hours and 3 days after ICU admission. MEASUREMENTS AND MAIN RESULTS: ICU and hospital mortality rates were 27.6% and 37.3%, respectively. The cumulative fluid balance increased from 1,217 mL (-90 to 2,783 mL) in the first 24 hours after ICU admission to 1,794 mL (-951 to 5,108 mL) on day 3 and decreased thereafter. The cumulative fluid intake was similar in survivors and nonsurvivors, but fluid balance was less positive in survivors because of higher fluid output in these patients. Fluid balances became negative after the third ICU day in survivors but remained positive in nonsurvivors. After adjustment for possible confounders in multivariable analysis, the 24-hour cumulative fluid balance was not associated with an increased hazard of 28-day in-hospital death. However, there was a stepwise increase in the hazard of death with higher quartiles of 3-day cumulative fluid balance in the whole population and after stratification according to the presence of septic shock. CONCLUSIONS: In this large cohort of patients with sepsis, higher cumulative fluid balance at day 3 but not in the first 24 hours after ICU admission was independently associated with an increase in the hazard of death.

Published
2017
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4. Contribution to the platoon distribution analysis in steady-state traffic conditions

Author

Raffaele Mauro, Marco Guerrieri, Federico Branco, MAURO, R, BRANCO, F, and GUERRIERI, M

Subjects
Engineering, Steady state (electronics), Stochastic process, business.industry, Poison control, Geotechnical Engineering and Engineering Geology, Traffic flow, Platoons statistical model steady-state time headway random function of tra c flow, Transport engineering, Flow (mathematics), Control theory, Platoon, business, Highway engineering, Civil and Structural Engineering, Traffic wave
Abstract

The traffic flow analysis and the relevant vehicle distribution (“free-moving” or “platooned” vehicles) on highway facilities at uninterrupted flow has always had fundamental importance in Highway Engineering, with special reference to topics like traffic operations, car accidents, road safety and air pollution emissions. In light of this, the study suggests a calculation algorithm as a random test generator to simulate a steady state traffic flow and to provide time headways. Thanks to the outcome produced by numerical simulations, we analysed platoon distributions within traffic flows in a steady-state regime and showed the results of numerical analyses carried out by traffic random process functions. The laws to determine “time headways” were obtained by the Pearson type III generalized distribution.

Published
2014

5. Transvesical peritoneoscopy with rigid scope: feasibility study in human male cadaver

Author

Estevão Lima, Jorge Correia-Pinto, Frederico Branco, Rui Versos, Victor Cavadas, Mário Gomes, Giovannalberto Pini, Riccardo Autorino, Luís Osório, Branco, F, Pini, G, Osório, L, Cavadas, V, Versos, R, Gomes, M, Autorino, Riccardo, Correia Pinto, J, Lima, E., and Universidade do Minho

Subjects
Adult, Male, Natural Orifice Endoscopic Surgery, medicine.medical_specialty, Endoscope, Abdominal cavity, Medicina Clínica [Ciências Médicas], Laparoscopia, Port (medical), Cadaver, Peritoneoscopy, medicine, Humans, Laparoscopy, Ciências Médicas::Medicina Clínica, Science & Technology, medicine.diagnostic_test, business.industry, NOTES, Endoscopy, Appendix, Surgery, medicine.anatomical_structure, Ureteroscopes, Feasibility Studies, business, Transvesical
Abstract

Transvesical port refers to the method of accessing the abdominal cavity through a natural orifice (i.e., urethra) under endoscopic visualization. Since its introduction in 2006, various reports have been published describing different surgical interventions using a rigid ureteroscope in a porcine model. The aim of this study was to test the access and feasibility of peritoneoscopy by using a rigid ureteroscope in a human male cadaver. Background Transvesical port refers to the method of accessing the abdominal cavity through a natural orifice (i.e., urethra) under endoscopic visualization. Since its introduction in 2006, various reports have been published describing different surgical interventions using a rigid ureteroscope in a porcine model. The aim of this study was to test the access and feasibility of peritoneoscopy by using a rigid ureteroscope in a human male cadaver. Methods Two adult male cadavers were used to perform the procedures. A rigid ureteroscope was used for the creation of transvesical access into the peritoneal cavity. Peritoneoscopy, liver biopsy, and identification and manipulation of the ileocecal appendix were performed. Results Transvesical access into the peritoneal cavity was quickly established. The rigid ureteroscope easily allowed visualization of the abdominal cavity with good image quality. Liver biopsy and manipulation of ileocecal appendix were carried out without difficulties. Conclusions Peritoneoscopy, liver biopsy, and ileocecal appendix manipulation using a rigid ureteroscope through a transvesical port is feasible in a cadaver model. The development of a specific rigid scope for the transvesical port might herald a promising future for this NOTES access. The craving for the discovery of new, minimally invasive surgical procedures allowed a new surgery concept to emerge: natural orifice transluminal endoscopic surgery (NOTES). The main challenge of this new concept is the execution of numerous surgical procedures through natural orifices, with the consequent advantages that may result, such as cosmetic benefits due to the absence of a surgical incision. The absence of a surgical incision also means less risk of wound infection and potentially less pain. In 2004, Kalloo et al. [1] described access to the peritoneal cavity through the transgastric port in a porcine model. Since then, several studies have been performed using transgastric access [2–6]. However, many limitations were described, particularly when singly performed by transgastric port. In 2006, Lima et al. [7] described the transvesical port going beyond the wall of bladder for access to the peritoneal cavity in a porcine model. Soon it became apparent that this access was not only a major shift in how the bladder was seen, but also a safe and fast means of access to the peritoneal cavity, with an excellent view of all the upper peritoneal structures [7]. This same group of researchers also described the execution of complex surgical procedures, including nephrectomy [8] and cholecystectomy [9, 10], which were carried out by an approach combining the transvesical port with the transgastric port. In both surgical procedures, the transvesical port represented not only a working port through which many instruments are used, but also a way of support and guidance in choosing the site of entry into the peritoneal cavity via the transgastric port [9, 10]. The transvesical port, although at the lower end of the abdomen, also allowed the execution of thoracic procedures in the porcine model [11]. Some critics question the feasibility and reproducibility of these procedures in the human being, particularly regarding the use of rigid instruments. The distance from the bladder to other organs in the abdominal cavity is larger than in the animal model, which could limit the imaging and manipulation of the organs of the upper abdominal cavity. Another questioned aspect is the possibility of obtaining images of the upper abdomen using rigid instruments without angulation, which might preclude the use of the scopes currently on the market in the transvesical approach in humans. Therefore, transvesical access to the peritoneal cavity might be a reality not only in the animal model, but also in the human model in the near future, especially if it is possible to use rigid instruments in this procedure. The aim of this study was to describe and test the feasibility of NOTES procedures performed in a human male cadaver, with access to the abdominal cavity made through the transvesical port and by using rigid instruments.

Published
2011

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