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BACKGROUND Probable unresectable Glioblastomas (GB) diagnosed by imaging techniques withouth anatomo-pathological (ap) confirmation could be treated under standard treatment. We reported the outcomes from this strategy in our center after tumor board evaluation. MATERIAL AND METHODS From January/10 to September/16, 303 patients (pt) with GB were assessed by tumor board, during the same period 66 patients were consecutive analyzed with suspected GB by radiological criteria without histological diagnosis. We focus in the last group and analyzed the demographic/radiological data, non-biopsy causes, treatment type (concomitant Radio-Chemotherapy (RT/Ch), exclusive RT or Ch or Best supportive care (BSC)), Karnofsky index (KI) and degree of comorbidity (Charlson index (CI)). RESULTS Sixty six patients, 17.88% of the total GB cases (with/without ap). Average age: 77 years (33–91). Biopsy: non-diagnostic in 4pt. No biopsy: 62pt; due to non medical indication (71%), localization (22.7%), voluntary (4.5%). Treatment Type: Active: 43.93%, without biopsy due to non-medical indication (44.8%) and localization (41.37%). BSC: 53.03%, without biopsy due to non-medical indication 82.85%, localization 8.5%, voluntary 5.7%. Overall survival: 11.65 months in patients with active treatment and 4.8 months in BSC, greater benefit in CONCLUSION The diagnosis of GB by radiological criteria with the new imaging techniques has a good diagnostic-therapeutic correlation. In cases where surgical intervention is not possible, standard treatment offers good results. Age and KPS are variables that allow predicting a better evolution course. Although it was not possible to obtain a histological diagnosis, in this type of cases liquid biopsy could contribute to diagnosis this type of lesions inaccessible to biopsy.

Face localization is the first step in several applications such as face tracking, person identification, expression recog- nition and eye tracking. Face localization can be performed by segmentation using the color of the skin. Color images can be represented in several color models. This work presents a performance comparison between several color models including RGB, HSI, CIELab and YCbCr. The best performance in terms of classification error is achieved by the HSI and YCbCr models. However, due to the fact that all images are capture in the RGB color model, a transformation be- tween this model and the other models must be performed. The best performance in terms of execution time is achieved by the YCbCr model. An important speed-up can be achieved by downscaling the original image. Results show that, in the case of the HSI model, a downscale factor can speed up the process up to a 28% while a factor of 4 can speed up the process as much as 68%.

In this work, we showed experimental and theoretical results of the characterization of a spatial light modulator based in a nematic liquid crystal display Sony model LCX038ARA with electric field excitation. The parameters: effective molecular twist and equivalent retardation are determinated using the retarder-rotor technique in the amplitude-coupled regime.

An 18-year-old girl presented with a headache and behavioural changes. She was found to have a frontal mass. Neuroimaging revealed an intra-axial mass, located at the left frontal cortical/subcortical region approximately 6×7, 5×7, 5 cm (TxApxL), having a heterogeneous density with cysts and calcification. She had total gross excision of the neoplasm. Histopathological examination revealed an anaplastic ependymoma. Fluorescence in situ hybridisation, a molecular cytogenetic test, reported deletion of 1p without deletion of 19q. The patient had a good postoperative improvement.

This work shows experimental and theoretical results of the characterization of a nematic liquid-crystal spatial light modulator Sony model LCX038ARA for the parameters angle of molecular rotation, the birefringence and angle of the molecular axis, using the retarder-rotor model without electric field applied in the amplitude regime-coupled.

Background Younger age at onset and higher frequency of severe gout has been reported in some countries (1-3), when compared to previous reports. It seems that these patterns could be changing in the last years. Objectives To compare the clinical pattern of gout patients attended for the first time, in the same Rheumatology department, during the last 15 years. Methods Our Gout clinic receives 6-8/new patients each month, they had been evaluated by the same investigators in the last 15 years. We analyzed 568 gout patients from 3 groups: G1: n=316, (1995-2000) (3), G2: n=133m (2006-2007), G3: n=119 (2010-22). Variables: Demographic, clinical, biochemical and functional data regarding gout and associated diseases. Socioeconomic level according to Giuscaffre index; low educational level ( 10 tophi); renal failure (Creatinine clearance: Results Data from the 3 groups: Males: 97%, age at evaluation: 50.01±12.93 and age at onset: 37.6±13.1 years. In the last 15 years, several demographic, clinical variables and previous treatment had significant changes. Main characteristics are shown in the table as percentages. Conclusions Although some social and clinical characteristics improved in the last 15 years (socioeconomic and educational level, severe tophaceous gout, renal failure and obesity). We attend now patients younger at onset, with higher frequency of familial gout, hypertension and functional impairment. References Tanaka E, Yamanaka H, Shoji A, et al. Recent trend in the onset age of gouty arthritis in Japan. Gout and Nucleic Acid Metabolism 2004; 28:7–11. Chen SY, Chen CL, Shen ML, Kamatani N. Trends in the manifestations of gout in Taiwan. Rheumatology (Oxford) 2003; 42:1529–1533. Vazquez-Mellado J, Cruz J, Guzman S, Casasola Vargas J, Lino L, Burgos Vargas R. Severe tophaceous gout. Characterization of low socioeconomic patients from Mexico. Clin Exp Rheumatol 2006;24:233-238. Disclosure of Interest None Declared

Introduccion. Desde el comienzo de la epidemia del virus de inmunodeficiencia humana (VIH)/sida en 1981 hasta finales de 2003, han muerto 580.000 ninos por esta enfermedad. Se calcula que entre 2,1 y 2,9 millones sufren el VIH/sida. En este articulo revisamos las caracteristicas de la infeccion por el VIH en lactantes, ninos y adolescentes desde una perspectiva neuropsicologica. Asimismo, revisamos las pruebas neuropsicologicas que se utilizan para evaluar las alteraciones cognitivas y psicomotrices asociadas con la infeccion en lactantes, ninos y adolescentes. Desarrollo. La mayoria de los ninos infectados morira antes de llegar a la adolescencia. Los ninos seropositivos sufren alteraciones tanto neurologicas como neuropsicologicas, pero la evolucion y los deficit concretos varian mucho de un nino a otro. La principal enfermedad neurologica asociada con el VIH en ninos es la encefalopatia progresiva de la infancia asociada con el VIH, que puede ser la presentacion clinica inicial del sida hasta en el 18% de los casos y afecta al 30-60% de los ninos y adolescentes seropositivos en algun momento de la enfermedad. Produce deficit neuropsicologicos en areas cognitivas y motoras muy variadas, y puede afectar muy negativamente al desarrollo evolutivo normal del nino y a su rendimiento escolar y social. Conclusiones. Es importante determinar como el VIH afecta al desarrollo de estos ninos y que tipo de intervenciones les ayudaran a mejorar. Ademas, es necesario determinar la influencia de las variables de confusion que pueden afectar al desarrollo neuropsicologico para determinar asi los efectos evolutivos directos e indirectos de la infeccion. Buscar en PubMed Por autor Millana-Cuevas LC Portellano JA Martinez-Arias R Por palabra clave AIDS. Cognitive impairment. HIV. Neuropsychological assessment. Neuropsychological tests. Progressive encephalopathy. Ver en PubMed Este articulo Articulos relacionados