449 results on '"Chen Dong"'
Search Results
2. An improved degree evaluation method of NFSR-based cryptosystems
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Tian Tian and Chen-Dong Ye
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Discrete mathematics ,Degree (graph theory) ,business.industry ,Applied Mathematics ,Initialization ,Cryptography ,Function (mathematics) ,Computer Science Applications ,Cryptosystem ,Trivium (cipher) ,Cube ,Algebraic number ,business ,Mathematics - Abstract
In this paper, we study the algebraic degree evaluation of NFSR-based cryptosystems. The degree evaluation method based on the numeric mapping proposed by Liu at CRYPTO 2017 is very fast and could be applied to a cube of any size. The numeric degree of $$f_1(\varvec{x},\varvec{v})\times f_2(\varvec{x},\varvec{v})$$ is estimated as $$D_1+D_2$$ , where $$D_1$$ and $$D_2$$ are the numeric degrees of $$f_1$$ and $$f_2$$ respectively and the algebraic degree of a function is no more than its numeric degree. It can be observed that some variables may be counted twice in $$D_1+D_2$$ and the precise of the numerical mapping heavily depends on how many variables are counted redundantly. When applied to an iterative cryptosystem, such redundances will accumulate during iteratively computing numeric degrees. This is an important factor accounting for the difference between the numeric degree and the algebraic degree of a cryptosystem. To reduce this difference, a new framework on the degree evaluation algorithm based on the numeric mapping is proposed. The main idea is to identify variables which are repeatedly counted in the numeric mapping and eliminate the redundant degrees on these variables. As illustrations, a concrete algorithm on Trivium-like ciphers is given which is shown to be useful in correlation cube attacks and the zero-sum distinguisher search. For correlation cube attacks on 835-round Trivium, we find some more useful cubes so that we could recover about 1.5 more bits at a cost of $$2^{40.7}$$ . Furthermore, we find several cubes leading to zero-sum distinguishers for Kreyvium variants with from 875 to 880 initialization rounds.
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- 2021
3. Analysis of the Clinical Features and Surgical Outcomes of First Branchial Cleft Anomalies
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Changming Zhang, Yang Chen, Yu Han, Yubin Lai, Runqin Yang, Dingjun Zha, Chen Dong, and Hongsheng Liu
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medicine.medical_specialty ,business.industry ,Incidence (epidemiology) ,Fistula ,Facial Paralysis ,Microtia ,Pharyngeal Diseases ,medicine.disease ,Facial nerve ,Facial paralysis ,Surgery ,Craniofacial Abnormalities ,Branchial Region ,Treatment Outcome ,Otitis ,Otorhinolaryngology ,Superficial Parotidectomy ,medicine ,Humans ,First branchial cleft ,medicine.symptom ,business ,Retrospective Studies - Abstract
OBJECTIVES To analyze the clinical features and otologic manifestations of first branchial cleft anomalies (FBCAs) and the disparity between Work's classification, and to explore the relationships between postoperative facial paralysis and features of FBCAs. STUDY DESIGN Retrospective clinical study. METHODS A retrospective analysis of 109 patients with FBCAs was conducted, including clinical characteristics and otologic features. Pearson chi-square tests and Fisher's exact tests were used to compare disparity between Work's classification, and the impact factors of postoperative facial paralysis among 86 patients who were explored in follow-up. RESULTS Patients with FBCAs presented with otologic symptoms, including cysts or fistula in the external auditory canal (EAC) and periauricular (43.2%), microtia (3.7%), EAC web (1.8%), otitis media (1.8%), and otorrhea (4.6%). Eighty-five cases (78.0%) were type I FBCAs and 24 (22.0%) were type II. Compared to type I FBCAs, type II (58.3%) was more likely to be located deep to the facial nerve (FN) and to have superficial parotidectomy on them (79.2%). This difference was statistically significant (P
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- 2021
4. Research on 'Internet+' third-party participation model and method of coal mine safety supervision
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Li Xiangchun, Nie Baisheng, Chunli Yang, Chen Dong, and Fanfan Guo
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Third party ,Renewable Energy, Sustainability and the Environment ,business.industry ,technology, industry, and agriculture ,Coal mining ,Energy Engineering and Power Technology ,respiratory system ,Environmental economics ,complex mixtures ,respiratory tract diseases ,Fuel Technology ,Nuclear Energy and Engineering ,otorhinolaryngologic diseases ,Production (economics) ,The Internet ,Coal ,business - Abstract
Coal mine safety supervision is essential in the production of coal. In the current “national monitoring, local supervision, enterprise responsibility” model of coal mine safety supervision, the th...
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- 2021
5. Ginkgolide B protects against cognitive impairment in senescence-accelerated P8 mice by mitigating oxidative stress, inflammation and ferroptosis
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Chen Dong, Qing He, Yu Shi, Deqin Geng, and Li Shao
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Senescence ,Biophysics ,Morris water navigation task ,Mice, Inbred Strains ,Inflammation ,Pharmacology ,GPX4 ,medicine.disease_cause ,Biochemistry ,Neuroprotection ,Lactones ,Mice ,medicine ,Animals ,Ferroptosis ,Molecular Biology ,Neuroinflammation ,biology ,business.industry ,Ginkgo biloba ,Cell Biology ,biology.organism_classification ,Oxidative Stress ,Ginkgolides ,Neuroprotective Agents ,medicine.symptom ,business ,Oxidative stress - Abstract
Alzheimer's disease (AD) is a destructive neurodegenerative disease that currently has no effective treatment option available. Ginkgolide B (GB) is a terpene lactone derivative of Ginkgo biloba that possesses neuroprotective effects in various diseases. The aim of the present study was to investigate whether GB protects against cognitive impairment in AD by mitigating oxidative stress, inflammation and ferroptosis using senescence-accelerated P8 (SAMP8) mice. The results showed that GB improved the cognitive dysfunction of SAMP8 mice in the Morris water maze and novel object recognition test, which was associated with the attenuation of oxidative stress, inflammation and nuclear factor erythroid 2-related factor 2/glutathione peroxidase 4 (GPX4) pathway-mediated ferroptosis. Furthermore, Ras-selective lethal small molecule 3, a GPX4 inhibitor and ferroptosis inducer, compromised GB-induced cognitive performance in SAMP8 mice. These findings suggested that GB alleviated AD-induced cognitive defects by mitigating oxidative stress, neuroinflammation and ferroptosis, and that the inhibition of ferroptosis is required for GB to have beneficial effects in AD.
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- 2021
6. Metabolite Biomarkers of Response (BoRs): Towards a fingerprint for the evolution of metastatic breast cancer
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Elizabeth M. O'Day, Josephine Wolf, and Chen Dong
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Oncology ,medicine.medical_specialty ,business.industry ,Metabolite ,Metabolic reprogramming ,Biophysics ,Cancer ,Breast Neoplasms ,Disease ,Precision medicine ,medicine.disease ,Metastatic breast cancer ,chemistry.chemical_compound ,Breast cancer ,chemistry ,Internal medicine ,medicine ,Humans ,Female ,skin and connective tissue diseases ,business ,Molecular Biology ,Biomarkers ,Cause of death - Abstract
Breast cancer is the most common cancer in women worldwide and despite improved treatment strategies, it persists as the second leading cause of death of women globally. Overall prognosis drops drastically once the cancer has metastasized, which is also associated with resistance to therapy. The evolution from a localized breast cancer to metastatic disease is complex and multifactorial. Metabolic reprogramming is a pre-requisite for this transition. In this graphical review, we provide an overview of altered metabolic pathways observed in metastatic breast cancer (mBC) and detail how metabolite biomarkers could serve as a novel class of precision medicine tools to improve the diagnosis, monitoring, and treatment of mBC.
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- 2021
7. Health-related quality of life in osteoarthritis patients: a systematic review and meta-analysis
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Jiaxin Guo, Wei Zhou, Jun Liu, Chen Dong, and Hongsheng Yan
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Health related quality of life ,Gerontology ,business.industry ,Osteoarthritis ,medicine.disease ,Health Surveys ,Psychiatry and Mental health ,Clinical Psychology ,Mental Health ,Quality of life (healthcare) ,Meta-analysis ,Outcome Assessment, Health Care ,Quality of Life ,Humans ,Medicine ,business ,Applied Psychology ,Systematic search - Abstract
The aim of this meta-analysis was to compare health-related quality of life (HRQoL) of Osteoarthritis (OA) patients and controls. A systematic literature search was performed on PubMed, Web of Science and EMBASE from database inception to 7 January 2020. Random effect model was performed to summarize the scores of each domain and the forest plot was used to compare the scores of OA patients with healthy controls. Subgroup analyses were conducted to explore the source of heterogeneity. Statistical analyses were executed using Review Manager (version 5.1). In total, six studies were included in this study, including 7094 patients with OA and 12 100 healthy controls, which were all reliable to summarize the scores of the Medical Outcomes Study 36-item Short-Form Health Survey (SF-36). Meta-analyses found that pooled mean HRQoL score for the SF-36 each domain (physical function, physical role function, body pain, general health, vitality, social function, emotional role function, mental health) was lower in patients with OA than in healthy controls, especially the score in the dimension of physical role function. OA have a substantial impact HRQoL. HRQoL is a significant component of measuring overall health, which contributes to formulate successful self-disease management plan, patient-centered care, and develop effective interventions target confidence.
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- 2021
8. Therapeutic effects of bone marrow mesenchymal stem cells‐derived exosomes on osteoarthritis
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Chen Dong, Yake Liu, Min Xu, Hai Zhu, Zhifeng Gu, Juan Ji, Aidong Deng, and Yi Jin
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Senescence ,Anterior cruciate ligament ,MSCs ,Apoptosis ,exosomes ,Osteoarthritis ,Chemical Fractionation ,Injections, Intra-Articular ,Chondrocytes ,medicine ,Animals ,Cellular Senescence ,business.industry ,MEG‐3 ,Mesenchymal stem cell ,Therapeutic effect ,In vitro toxicology ,Mesenchymal Stem Cells ,Original Articles ,X-Ray Microtomography ,Cell Biology ,medicine.disease ,Immunohistochemistry ,Microvesicles ,Rats ,Biological Therapy ,osteoarthritis ,Disease Models, Animal ,medicine.anatomical_structure ,Cancer research ,Cytokines ,Molecular Medicine ,Original Article ,RNA, Long Noncoding ,Inflammation Mediators ,business - Abstract
Mesenchymal stem cells (MSCs) have shown chondroprotective effects in clinical models of osteoarthritis (OA). However, effects of MSC‐derived exosomes on OA remain unclear. The study aimed to investigate the therapeutic potential of exosomes from human bone marrow MSCs (BM‐MSCs) in alleviating OA. The anterior cruciate ligament transection (ACLT) and destabilization of the medial meniscus (DMM) surgery were performed on the knee joints of a rat OA model, followed by intra‐articular injection of BM‐MSCs or their exosomes. In addition, BM‐MSC‐derived exosomes were administrated to primary human chondrocytes to observe the functional and molecular alterations. Both of BM‐MSCs and BM‐MSC‐derived exosomes alleviated cartilage destruction and subchondral bone remodelling in OA rat model. Administration of BM‐MSCs and exosomes could reduce joint damage and restore the trabecular bone volume fraction, trabecular number and connectivity density of OA rats. In addition, in vitro assays showed that BM‐MSCs‐exosomes could maintain the chondrocyte phenotype by increasing collagen type II synthesis and inhibiting IL‐1β–induced senescence and apoptosis. Furthermore, exosomal lncRNA MEG‐3 also reduced the senescence and apoptosis of chondrocytes induced by IL‐1β, indicating that lncRNA MEG‐3 might partially account the anti‐OA effects of BM‐MSC exosomes. The exosomes from BM‐MSCs exerted beneficial therapeutic effects on OA by reducing the senescence and apoptosis of chondrocytes, suggesting that MSC‐derived exosomes might provide a candidate therapy for OA treatment.
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- 2021
9. High stearic acid diet modulates gut microbiota and aggravates acute graft-versus-host disease
- Author
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Shoubao Ma, Huanle Gong, Haiyan Liu, Yuhui Huang, Bingyu Yang, Xianfeng Zhang, Chen Dong, Depei Wu, Xiaojin Wu, and Chang Wang
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Cancer Research ,Letter ,QH301-705.5 ,Graft vs Host Disease ,Gut flora ,Mice ,chemistry.chemical_compound ,Acute graft versus host disease ,Genetics ,Animals ,Medicine ,Biology (General) ,Immunological disorders ,Haematological cancer ,biology ,business.industry ,biology.organism_classification ,Dietary Fats ,Gastrointestinal Microbiome ,Disease Models, Animal ,chemistry ,Acute Disease ,Immunology ,Stearic acid ,business ,Stearic Acids - Published
- 2021
10. An Escherichia coli isolate from hospital sewage carries blaNDM-1 and blaoxa-10
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Si Qin, Chen Dong, Zimeng Hu, Yun Shen, Weiye Chen, Genglin Guo, Wei Zhang, and Long Chen
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Serotype ,0303 health sciences ,030306 microbiology ,business.industry ,Sewage ,General Medicine ,Drug resistance ,Biology ,medicine.disease_cause ,biology.organism_classification ,Biochemistry ,Microbiology ,Enterobacteriaceae ,Multiple drug resistance ,03 medical and health sciences ,Genetics ,medicine ,Multilocus sequence typing ,business ,Molecular Biology ,Escherichia coli ,Bacteria ,030304 developmental biology - Abstract
Carbapenems, as the "last line of defense" against Gram-negative bacteria, are increasingly being challenged by drug-resistant bacteria, especially Enterobacteriaceae. In this study, a carbapenem-resistant Gram-negative bacterium, named AH001, was isolated from hospital sewage, and a modified Hodge test confirmed that this bacterium can produce carbapenemase. Further analysis revealed that this bacterium exhibits multidrug resistance against an additional seven antibiotics. Whole-genome sequencing and analysis showed that AH001 could not be classified by existing MLST, and its serotype could not be distinguished among O9, O89 or O168 according to O antigen prediction. More attention should be given to the role of environmental sources of Escherichia coli in the development and transfer of drug resistance in the hospital environment.
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- 2021
11. Perovskite Solar Cells with Polyaniline Hole Transport Layers Surpassing a 20% Power Conversion Efficiency
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Shan Pang, Gentian Yue, Emma Dennis, Zhitao Shen, Furui Tan, Chen Dong, Yueyue Gao, Yantao Mei, Rong Liu, Soumya Kundu, Weifeng Zhang, and Makhsud I. Saidaminov
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chemistry.chemical_compound ,Materials science ,chemistry ,business.industry ,General Chemical Engineering ,Polyaniline ,Energy conversion efficiency ,Materials Chemistry ,Optoelectronics ,General Chemistry ,business ,Perovskite (structure) - Published
- 2021
12. Case study of gas drainage well location optimization in abandoned coal mine based on reservoir simulation model
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Zhendong Zhang, Chen Dong, Gao Tianxin, Jiaye Han, Guiqiang Zheng, and Fengyun Sang
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TK1001-1841 ,Computer simulation ,Renewable Energy, Sustainability and the Environment ,business.industry ,Coal mining ,TJ807-830 ,Energy Engineering and Power Technology ,Excavation ,Renewable energy sources ,Reservoir simulation ,Production of electric energy or power. Powerplants. Central stations ,Fuel Technology ,Nuclear Energy and Engineering ,Mining engineering ,Environmental science ,Drainage ,business - Abstract
The development of abandoned coal mine gas has multiple advantages in terms of safety, economy, environment, and society. Due to previous excavations, the gas distribution is heterogeneous, thereby hindering well location optimization. In this study, considering the Shenbei abandoned coal mine as an example, the authors developed a workflow for well location optimization through simulation. The workflow includes: (1) the setup of an initial reservoir simulation model with the preliminary well location designed by experience; (2) the optimization of the well location based on the flowline distribution, and it is preferred that the well connect a large number of flowlines; (3) the simulation based on the optimized well location, and (4) repetition of the steps until the optimized well locations are determined. Moreover, the role of fracturing is also examined through simulation scenarios. The simulation results show that the locations of the two originally designed wells (1# and 4#) should be optimized due to the relatively low gas production without fracturing. The two wells are optimized according to the flow streamlines, demonstrating performance improvement. Moreover, the simulation results also show that there is no need to optimize the well 4# location if the fracturing technology is applied. An additional well is suggested based on the flow streamline analysis and gas production performance simulation. The main conclusions drawn from this study are as follows. (1) Five optimized well locations are determined for the Shenbei abandoned coal mine, and they should be located within the “O” ring, a high permeability region nearby the previous excavation zone; (2) Fracturing is an effective method for stimulating gas production; however, the extent of fracturing varies from well to well; (3) The workflow applied in this study is effective for the well location optimization in abandoned coal mines.
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- 2021
13. Research on effective jamming style of projectile-carried communication for FH communication radio under common modulation systems
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Qian Lizhi, LI Shaoqiang, Chen Dong, Zhang Jie, and Ning Quanli
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business.industry ,Computer science ,Cognitive Neuroscience ,ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS ,Transmitter ,Jamming ,Minimum-shift keying ,Mathematics (miscellaneous) ,Artificial Intelligence ,Modulation ,Electronic engineering ,Bit error rate ,Wireless ,Frequency-hopping spread spectrum ,Computer Vision and Pattern Recognition ,business ,Frequency modulation - Abstract
This work addresses the effective jamming style of projectile-carried communication for frequency hopping radio with different modulation by applying simulation verification via OPNET platform to construct the projectile-carried communication jamming system model. A general projectile-carried communication jamming style based on the signal combination of sweep saw-tooth wave and noise frequency modulation is proposed and analyzed. The network model of projectile-carried communication jamming system is constructed, and then the model building process of frequency hopping radio from the two aspects of transmitter model and receiver model is deeply elaborated. We demonstrate that the general projectile-carried communication jamming style has good jamming effect on the frequency hopping radio receivers with five modulation modes of 2FSK, 2PSK, 2DPSK, MSK and GMSK by comparing the simulation results, including receiving throughput, end-to-end delay, time delay of wireless channel access, delivery rate of synchronized header message, signal-to-noise ratio, bit error rate, packet loss rate, remaining power of jammer. Among them, the bit error rate of radio receiver with five modulation modes is more than 20%.
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- 2021
14. SiamCPN: Visual tracking with the Siamese center-prediction network
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Hanxing Yao, Fan Tang, Weiming Dong, Chen Dong, and Changsheng Xu
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Computer science ,business.industry ,Frame (networking) ,02 engineering and technology ,Tracking (particle physics) ,Object (computer science) ,Computer Graphics and Computer-Aided Design ,Object detection ,Artificial Intelligence ,Minimum bounding box ,020204 information systems ,Video tracking ,0202 electrical engineering, electronic engineering, information engineering ,Eye tracking ,020201 artificial intelligence & image processing ,Computer vision ,Segmentation ,Computer Vision and Pattern Recognition ,Artificial intelligence ,business - Abstract
Object detection is widely used in object tracking; anchor-free object tracking provides an end-to-end single-object-tracking approach. In this study, we propose a new anchor-free network, the Siamese center-prediction network (SiamCPN). Given the presence of referenced object features in the initial frame, we directly predict the center point and size of the object in subsequent frames in a Siamese-structure network without the need for perframe post-processing operations. Unlike other anchor-free tracking approaches that are based on semantic segmentation and achieve anchor-free tracking by pixel-level prediction, SiamCPN directly obtains all information required for tracking, greatly simplifying the model. A center-prediction sub-network is applied to multiple stages of the backbone to adaptively learn from the experience of different branches of the Siamese net. The model can accurately predict object location, implement appropriate corrections, and regress the size of the target bounding box. Compared to other leading Siamese networks, SiamCPN is simpler, faster, and more efficient as it uses fewer hyperparameters. Experiments demonstrate that our method outperforms other leading Siamese networks on GOT-10K and UAV123 benchmarks, and is comparable to other excellent trackers on LaSOT, VOT2016, and OTB-100 while improving inference speed 1.5 to 2 times.
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- 2021
15. Self-passivated hybrid perovskite films for improved photovoltaic performance of solar cells
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Xingnan Qi, Gentian Yue, Rong Liu, Yantao Mei, Furui Tan, Yueyue Gao, Tingting Zhang, Chen Dong, Weifeng Zhang, Lisheng Zhang, and Junyi Huang
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Materials science ,Fabrication ,Passivation ,business.industry ,020502 materials ,Mechanical Engineering ,Photovoltaic system ,02 engineering and technology ,0205 materials engineering ,Mechanics of Materials ,Phase (matter) ,Trap density ,Optoelectronics ,General Materials Science ,Spontaneous emission ,business ,Perovskite (structure) - Abstract
Defect passivation management of perovskite films is of great importance in improving the performance of perovskite solar cells. Various in situ or post-passivation strategies were adopted to modify the optoelectric properties of perovskite films. However, these modifications increased the fabrication complexity and cost of the devices. Here, we developed a facile self-passivation strategy to effectively decrease charge trap states and suppress the non-radiative recombination loss in perovskite films. By simply aging the precursor solution, we found that the fabricated perovskite films possess residual PbI2 phase that could decrease trap density, enhance the radiative recombination intensity, and facilitate charge transfer and collection. Therefore, the solar cells with this self-passivated perovskite film generated an increased efficiency of 21.1% compared to that of 19.9% for the control devices from fresh precursor solution.
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- 2021
16. The precursor-compensation strategy boosts the photoresponse performance of air-stable, self-powered Cs2SnI6 photodetectors
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Furui Tan, Junyi Huang, Weifeng Zhang, Yantao Mei, Gentian Yue, Xiayao Lu, Rong Liu, Yueyue Gao, and Chen Dong
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Photocurrent ,Fabrication ,Materials science ,business.industry ,Photodetector ,General Chemistry ,Conductivity ,Evaporation (deposition) ,Responsivity ,Semiconductor ,Materials Chemistry ,Optoelectronics ,Thin film ,business - Abstract
Lead-free metal halide perovskites have attracted extensive attention as promising optoelectronic semiconductors with environmental friendliness. Cs2SnI6, a double perovskite with both a good phase and composition stability, is an appealing candidate for potential application in optoelectronic devices. To date, few reports have focused on the facile fabrication of dense and uniform Cs2SnI6 films that are key components for optoelectronic devices. Herein, a simple and low-cost solution method is reported to prepare densely packed Cs2SnI6 thin films. It was found that strategic precursor-compensation treatment (PCT) of the as-prepared spin-coated Cs2SnI6 thin films compensates the evaporation loss of volatile SnI4 and thus allows for pinhole-free and pure-phase double perovskite. The modified n-type Cs2SnI6 double perovskite shows enhanced conductivity and mobility with decreased charge recombination loss. As a result, the applied photodetectors show an enhanced photocurrent gain of 151 compared to that of 88 for the control sample. The responsivity (control 0.0059 mA W−1 to target 1.07 mA W−1) and detectivity (control 2.94 × 1010 Jones to target 6.03 × 1010 Jones) of the device were significantly improved in the self-powered mode. In addition, the PCT-Cs2SnI6 photodetectors show excellent long-time stability with 98% initial detectivity retained after storing in ambient environment for 28 days. This study paves the way for the preparation of high-quality Cs2SnI6 films for application in efficient optoelectronic devices.
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- 2021
17. Effects of circadian rhythm disorder on body composition in women aged 31–40 years
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Mengshu Han, Zengkun Yang, Yidan Cao, Yong Kong, Yingying Jia, Ran Meng, Haiyun Duan, Chen Dong, and Kai Wang
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Adult ,medicine.medical_specialty ,medicine.medical_treatment ,Body water ,Blood Pressure ,Chronobiology Disorders ,Melatonin ,Insulin resistance ,Internal medicine ,Diabetes mellitus ,medicine ,Humans ,Circadian rhythm ,Advanced and Specialized Nursing ,business.industry ,Insulin ,medicine.disease ,Circadian Rhythm ,Anesthesiology and Pain Medicine ,Endocrinology ,Blood pressure ,Body Composition ,Female ,business ,Bioelectrical impedance analysis ,medicine.drug - Abstract
Background Circadian rhythm disorder caused by lack of sleep, day-night reversal, or staying up late, can cause irreparable damage to the body, a significant increase in both the systolic and diastolic blood pressure of women in this age bracket. The purpose of this study was to investigate the effects of circadian disruption on body composition and insulin resistance in women aged 31-40 years. Methods Thirty female with circadian rhythm disorder and employed of the Foot Bath Club in Qufu city were selected as the research subjects, and a body composition analyzer was used to test the subjects' body composition using bioelectrical impedance analysis. Serum melatonin (MT) levels were determined by enzyme-linked immunosorbent assay (ELISA), and blood glucose and insulin levels were detected by glucose oxidase and chemiluminescence assays, respectively. Results The results showed that circadian rhythm disorder caused a rise in blood pressure, whereas body water, especially lower limb water and intra- and extracellular fluid, decreased significantly. Circadian disruption also resulted in decreased muscle mass, protein quality, and melatonin production, but increased visceral fat levels and insulin resistance. Conclusions This study has demonstrated that circadian rhythm disorders are responsible for changes in body composition, melatonin levels, and insulin resistance in women aged 31-40 years and may be a risk factor for cardiovascular disease and diabetes.
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- 2021
18. A Novel PCR Method for Detecting ACE Gene Insertion/Deletion Polymorphisms and its Clinical Application
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Xue-Min Yang, Xiang-Rong Wang, Yang Sun, Yali Cui, Xiao-Juan Huang, Wenli Hui, Jian-Ping Liang, and Chen Dong
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Insertion/deletion polymorphisms ,Rapid detection ,Ace gene ,Computational biology ,030204 cardiovascular system & hematology ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,0302 clinical medicine ,Genotype ,Medicine ,Insertion deletion ,Genotyping ,Gene ,lcsh:QH301-705.5 ,lcsh:R5-920 ,business.industry ,Research ,Repeatability ,DNA extraction ,Direct-polymerase chain reaction (direct-PCR) ,lcsh:Biology (General) ,030220 oncology & carcinogenesis ,Gold magnetic nanoparticle lateral flow assay ,Pcr method ,business ,lcsh:Medicine (General) - Abstract
Background Angiotensin-converting enzyme (ACE) plays a major role in blood pressure regulation and cardiovascular homeostasis. The wide distribution and multifunctional properties of ACE suggest it’s involvement in various pathophysiological conditions. Results In this study, a novel visual detection method for ACE I/D polymorphisms was designed by integrating direct PCR without the need for DNA extraction using gold magnetic nanoparticles (GMNPs)-based lateral flow assay (LFA) biosensor. The entire detection procedure could enable the genotyping of clinical samples in about 80 min. The detection limit was 0.75 ng and results could be obtained in 5 min using the LFA device. Three hundred peripheral blood samples were analyzed using the direct PCR-LFA system and then verified by sequencing to determine accuracy and repeatability. A clinical preliminary study was then performed to analyze a total of 633 clinical samples. Conclusions After grouping based on age, we found a significant difference between the genotypes and the age of patients in the CHD group. The introduction of this method into clinical practice may be helpful for the diagnosis of diseases caused by large fragment gene insertions/deletions.
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- 2021
19. Evaluation of the 0 h/1 h high-sensitivity cardiac troponin T algorithm in diagnosis of non-ST-segment elevation myocardial infarction (NSTEMI) in Han population
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Gu Guorong, Guo Wei, Wang Kouqiong, Zhou Yannan, Chen Dong-xu, Tong Chaoyang, Yao Chenling, Yang Yilin, Shi Dong-wei, and Song Zhenju
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Cardiac troponin ,Clinical Biochemistry ,Myocardial Infarction ,030204 cardiovascular system & hematology ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Chinese han population ,Troponin T ,medicine ,Humans ,ST segment ,Prospective Studies ,030212 general & internal medicine ,Myocardial infarction ,Han population ,Non-ST Elevated Myocardial Infarction ,business.industry ,Biochemistry (medical) ,General Medicine ,Emergency department ,medicine.disease ,ST Elevation Myocardial Infarction ,business ,Algorithm ,Algorithms ,Biomarkers ,Mace ,Cohort study - Abstract
Objectives A rapid 0 h/1 h algorithm using high-sensitivity cardiac troponin T (hs-cTnT) for rule-out and rule-in of non-ST-segment elevation myocardial infarction (NSTEMI) is recommended by the European Society of Cardiology. We aim to prospectively evaluate the diagnostic performance of the algorithm in Chinese Han patients with suspected NSTEMI. Methods In this prospective diagnostic cohort study, 577 patients presenting to the emergency department with suspected NSTEMI and recent ( Results Among 577 enrolled patients, NSTEMI was the final diagnosis for 106 (18.4%) patients. Based on the hs-cTnT 0 h/1 h algorithm, 148 patients (25.6%) were classified as rule-out, 278 patients (48.2%) as rule-in and 151 patients (26.2%) were assigned to the observe group. The rule-out approach resulted in a sensitivity of 100% and negative predictive value of 100%. The rule-in approach resulted in a specificity of 62.9% [95% CI (58.5–67.2%)] and positive predictive value of 37.1% [95%CI (31.3–42.8%)]. No MACE was observed in the rule-out group within 30-day follow-up. Conclusions The hs-cTnT 0 h/1 h algorithm is a safe tool for early rule-out of NSTEMI, while probably not an effective strategy for accurate rule-in of NSTEMI in Chinese Han population.
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- 2020
20. Health-related quality of life assessed by Gout Impact Scale (GIS) in Chinese patients with gout
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Chen Dong, Jiaxin Guo, Jinjin Zhu, Huamao Chen, Zhifeng Gu, Fengyan Zhou, Wei Zhou, and Xiaomei Zhang
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Adult ,Male ,musculoskeletal diseases ,Gerontology ,China ,congenital, hereditary, and neonatal diseases and abnormalities ,Gout ,Scale (ratio) ,Anxiety ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Asian People ,Quality of life ,Surveys and Questionnaires ,Humans ,Medicine ,Patient Reported Outcome Measures ,030212 general & internal medicine ,Fatigue ,Aged ,Health related quality of life ,Depression ,business.industry ,nutritional and metabolic diseases ,General Medicine ,Middle Aged ,medicine.disease ,Cross-Sectional Studies ,Patient Satisfaction ,Quality of Life ,Female ,business - Abstract
The Gout Impact Scale (GIS) is a disease-specific health-related quality of life (HR-QoL) measurement for patients with gout. This study aimed to investigate the quality of life in Chinese patients with gout and potential risk factors for poorer HR-QoL by GIS.Adults with gout from February 2017 to February 2019 were invited to complete a questionnaire containing the GIS, social demographic characteristics, clinical information and gout-specific questions. Pearson/Spearman correlation and linear regression were used to analyze the data.A total of 413 patients were included in the analysis (mean age, 51.85 years; 96.4% male). The mean (SD) score of GIS total was 56.79 ± 15.45. Worse gout-specific HR-QoL was associated with anxiety (Gout-specific HR-QoL is impaired by social demographic and clinical characteristics, highlighting the importance of psychological factors (fatigue and depression) and patient-reported outcomes (patients' satisfaction and confidence in gout treatment). These findings suggest that more studies should focus on disease-specific HR-QoL.
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- 2020
21. Endoscopy-assisted versus open tissue expander placement in plastic and reconstructive surgery: a meta-analysis
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Liwei Dong, Zhou Yu, Xianjie Ma, and Chen Dong
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Tissue expander ,Reconstructive surgery ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,medicine ,Surgery ,business ,Endoscopy - Abstract
Tissue expansion can be used to overcome challenges due to tissue deficiency in plastic and reconstructive surgery; however, the long expansion process is often accompanied by numerous complications. This meta-analysis aimed to determine whether endoscopy-assisted expander placement could decrease complications and shorten treatment time. This study followed the principles of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and was registered in PROSPERO (CRD42021226116). A literature search was performed in eight databases from their inception dates up to 25 August 2021, to identify clinical studies on endoscopy-assisted and/or open tissue expander placement in plastic and reconstructive surgery. Seven studies met the inclusion criteria. In seven studies, 194 underwent endoscopy-assisted expander placement, and 565 underwent open expander placement. The overall complication rate in the endoscopy-assisted group was significantly lower than that in the open group (risk difference (RD) −0.28, 95% confidence interval (CI), −0.38, −0.18, p < .001). Subgroup analysis showed significantly lower incidence rates of hematoma, infection and dehiscence in the endoscopy-assisted group. The complication rate in the head/neck was lower with low heterogeneity (RD, −0.18; 95% CI, −0.26 to −0.09, p < .001; I2 = 0%). The endoscopy-assisted group had shorter surgery time, hospital stay and time to full expansion (weighted mean difference (WMD), −13.97 min, −16.88 h, −27.54 days; 95% CI, −15.85, −12.08 min, −24.36, −9.40 h, −38.85, −16.24 days; both p < .001, respectively). Endoscopy-assisted expander placement may help lower the risk of complications, especially in the head/neck, and reduce surgery time, hospital stay, and time to full expansion. Abbreviations: CI: confidence interval; CNKI: China National Knowledge Infrastructure Database; CSTJ, China Science and Technology Journal Database; NOS: the Newcastle–Ottawa Scale; PRISMA: preferred reporting items for systematic reviews and meta-analyses; RCT: randomized controlled trial; RoB: the cochrane risk-of-bias; RD: risk difference; WMD: weighted mean difference; SE: standard error; SND: standard normal deviate
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- 2022
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22. Influence of diabetes mellitus on the severity and fatality of SARS‐CoV‐2 (COVID‐19) infection
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Chen Dong, Xingxiang Liu, Jingqi Zhang, Jing Wu, Xiaohua Sun, Lijuan Wang, Yunfang Xu, and Yuanyuan Zhang
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medicine.medical_specialty ,2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,business.industry ,Endocrinology, Diabetes and Metabolism ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Medical record ,030209 endocrinology & metabolism ,macromolecular substances ,030204 cardiovascular system & hematology ,medicine.disease ,Logistic regression ,Age and gender ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Internal medicine ,Diabetes mellitus ,Severity of illness ,Internal Medicine ,medicine ,business - Abstract
Aims Diabetes mellitus is one of the most common comorbidities in Coronavirus disease 2019 (COVID-19) patients The objective of this study was to evaluate the influences of diabetes mellitus on the severity and fatality of SARS-CoV-2 infection Materials and Methods Medical records of 66 hospitalized COVID-19 patients were collected and classified into non-severe (mild/moderate cases) and severe (severe/critical cases) groups, respectively Logistic regression analysis was used to estimate the risk of severe COVID-19 (severe/critical infection) In addition, a meta-analysis including published studies reported the impacts of diabetes mellitus on severity and fatality of COVID-19, and our current study was conducted using fixed-effects models Results There were 22 diabetic and 44 non-diabetic cases among the 66 hospitalized COVID-19 patients As the results shown, seven cases (31 82%) were diagnosed as severe COVID-19 in diabetic patients, which was significantly higher than that in non-diabetic group (4/44, 9 09%, P = 0 033) After adjustment for age and gender, the results showed that diabetes mellitus was significantly associated with COVID-19 severity (OR: 5 29, 95% CI: 1 07?26 02) A meta-analysis further confirmed the positive association between diabetes mellitus and COVID-19 severity (pooled OR = 2 58, 95% CI: 1 93?3 45) Moreover, the diabetic patients infected with SARS-CoV-2 showed to have 2 95-fold higher risk of fatality compared to those patients without diabetes mellitus (95% CI: 1 93?4 53) Conclusions Our findings provide new evidences that diabetes mellitus is associated with a higher risk of severity and fatality of COVID-19 Therefore, intensive monitoring and antidiabetic therapy should be considered in diabetic patients with SARS-CoV-2 infection This article is protected by copyright All rights reserved
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- 2020
23. Algebraic method to recover superpolies in cube attacks
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Chen-Dong Ye and Tian Tian
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Computer Networks and Communications ,business.industry ,Computer science ,020206 networking & telecommunications ,Cube (algebra) ,Cryptography ,0102 computer and information sciences ,02 engineering and technology ,Algebraic normal form ,01 natural sciences ,Nonlinear feedback shift register ,Brute-force attack ,010201 computation theory & mathematics ,0202 electrical engineering, electronic engineering, information engineering ,Cryptosystem ,Trivium (cipher) ,business ,Time complexity ,Algorithm ,Software ,Information Systems - Abstract
Cube attacks are an important type of key recovery attacks against nonlinear feedback shift register (NFSR)-based cryptosystems. The key step in cube attacks closely related to key recovery is recovering superpolies. However, in the previous cube attacks including original, division property based and correlation cube attacks, the algebraic normal form of superpolies could hardly be shown to be exact due to an unavoidable failure probability or a requirement of large time complexity. In this study, the authors propose an algebraic method aiming at recovering the exact algebraic normal forms of superpolies practically. The proposed method is developed based on the degree of evaluation method proposed by Liu in Crypto 2017. As an illustration, the authors apply the proposed method to Trivium. As a result, they recover the algebraic normal forms of some superpolies for the 818-, 835-, 837- and 838-round Trivium. Based on these superpolies, the authors could mount key-recovery attacks on 818-, 835-, 837- and 838-round Trivium with the worst complexity slightly lower than a brute-force attack. Besides, for the cube proposed by Liu in Crypto 2017 as a zero-sum distinguisher for the 838-round Trivium, it is proved that its superpoly is not zero-constant. Hopefully, the proposed method would provide some new insights on cube attacks against NFSR-based ciphers.
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- 2020
24. Dysregulation of gut microbiome is linked to disease activity of rheumatic diseases
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Zhifeng Gu, Juan Ji, Chen Dong, and Yanfeng Bao
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medicine.medical_specialty ,Flora ,Disease ,Gut flora ,Disease activity ,03 medical and health sciences ,0302 clinical medicine ,Rheumatology ,Rheumatic Diseases ,Internal medicine ,medicine ,Humans ,030212 general & internal medicine ,030203 arthritis & rheumatology ,biology ,business.industry ,General Medicine ,medicine.disease ,biology.organism_classification ,Gastrointestinal Microbiome ,Immunology ,Etiology ,business ,Dysbiosis ,Rheumatism - Abstract
Objective rheumatism refers to a large group of diseases with different etiology, mainly characterized by autoimmune disorder. Intestinal flora combines with the digestive organs of the human body to synthesize and secrete the key substances of growth. Several studies have reported abnormal intestinal flora in rheumatic diseases. The purposes of this research were to review the primary studies and figure out the relationship between intestinal flora and rheumatic disease activity. The article search was based on the database of PubMed (MEDLINE), EMBASE, Cochrane to collect English language studies that were published from 1985 to 2019. The articles concerning the intestinal flora and disease activities of rheumatic diseases were classified by disease types, and the relationship between disease activities and intestinal flora was summarized. Eight rheumatic diseases were included in the study. It was found that the changes of intestinal flora were significantly correlated with the activities of rheumatic diseases. There were significant differences in the classification of disease activity and the composition of intestinal flora. Interfering with the composition of intestinal flora can apparently modulate the development of disease. But how to apply such findings is rarely reported. The study finds out that intestinal flora disorder is linked to the activity of rheumatic diseases. But which specific gut flora is connected to the disease activity needs further researches. More discussion is needed on how to apply the results to clinical treatment.
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- 2020
25. RETRACTED ARTICLE: Optimization analysis of sport pattern driven by machine learning and multi-agent
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Hao Wang, Chen Dong, and Yuming Fu
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0209 industrial biotechnology ,Computer science ,business.industry ,Work (physics) ,02 engineering and technology ,Space (commercial competition) ,Machine learning ,computer.software_genre ,020901 industrial engineering & automation ,Artificial Intelligence ,Learning disability ,0202 electrical engineering, electronic engineering, information engineering ,medicine ,020201 artificial intelligence & image processing ,Artificial intelligence ,medicine.symptom ,business ,computer ,Software - Abstract
The intelligent simulation of Sports can match the actual game and is of great significance to the development of Sports. Sports is a system in which multiple agents work together. Compared with a single agent, the learning space of multiple agents increases sharply as the number of agents increases, so the learning difficulty increases. Therefore, based on machine learning technology, this study combines with the actual situation to build a Sports simulation system. Moreover, after establishing a more reasonable team defensive formation and strategy, the overall movement of the agent is optimized, and the corresponding structural model has been established in combination with various actions. In addition, this study designs a controlled trial to analyze the performance of the model. The research shows that the proposed method has certain effects and can provide theoretical reference for subsequent related research.
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- 2020
26. Effects of glucocorticoids on osteoporosis in rheumatoid arthritis: a systematic review and meta-analysis
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Chen Dong, Rui Zhao, Yilin Wang, Zhifeng Gu, Liren Li, and G. Guo
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musculoskeletal diseases ,0301 basic medicine ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Osteoporosis ,030209 endocrinology & metabolism ,Arthritis, Rheumatoid ,03 medical and health sciences ,0302 clinical medicine ,Bone Density ,Internal medicine ,medicine ,Humans ,Femur ,Glucocorticoids ,Femoral neck ,Bone mineral ,Femur Neck ,business.industry ,medicine.disease ,Rheumatology ,medicine.anatomical_structure ,Meta-analysis ,Rheumatoid arthritis ,Orthopedic surgery ,030101 anatomy & morphology ,business - Abstract
We evaluated the effects of glucocorticoids on bone mineral density (BMD), and prevalence of osteoporosis and fracture in rheumatoid arthritis (RA) by meta-analysis. Until June 26, 2019, we conducted a systematic literature search in EMBASE, Web of science, PubMed, and Cochrane Library to obtain BMD and the prevalence of osteoporosis and fracture in glucocorticoid-treated subjects with RA. The BMD of the treatment and control groups were analyzed by meta-analysis (Stata. version 15), and the 95% confidence interval (CI) was calculated. We identified 15 observational studies, including 46,711 RA subjects and 857 healthy controls. The BMD of the lumbar spine (− 0.038 g/cm2; CI, − 0.052, − 0.024) and femoral neck (− 0.017 g/cm2; − 0.030, − 0.003) in RA treated with glucocorticoids were significantly lower than those in RA controls. Compared with healthy control group, the BMD of the lumbar spine (− 0.094 g/cm2; − 0.126, − 0.061) and femoral neck (− 0.097 g/cm2, − 0.109, − 0.085) of RA treated with glucocorticoids decreased more significantly. The prevalence of osteoporosis in whole body, spine, and femur was 38.6% (0.305, 0.466), 32.9% (0.277, 0.381), and 21.7% (0.106, 0.328), respectively. And the prevalence of vertebral fracture was 13.0% (0.058, 0.203). Glucocorticoids may lead to a decline in skeletal health in subjects with RA, especially in vertebral and femoral BMD, compared with normal people or RA without glucocorticoid therapy. Meanwhile, osteoporosis and fractures were also common. Therapeutic measures should be targeted at individuals, which needs further study. Through meta-analysis, we found that glucocorticoids have some negative effects on the bone health of subjects with rheumatoid arthritis. Therefore, when using glucocorticoids to treat rheumatoid arthritis, we should take strategic measures to prevent the decline of bone quality.
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- 2020
27. CORONA VIRUS INFECTION IN BROILERS (INFECTIOUS BRONCHITIS) VS OSTRICH EGGS ANTIBODIES: MINI REVIEW
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Guo Songchang and Chen Dong
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Corona (optical phenomenon) ,biology ,Infectious bronchitis ,business.industry ,biology.protein ,Medicine ,Antibody ,business ,Virology ,Virus ,Mini review - Published
- 2020
28. Multimedia access control with secure provenance in fog-cloud computing networks
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Ximeng Liu, Zhiquan Liu, Yang Yang, Chen Dong, Wenzhong Guo, and Xianghan Zheng
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Multimedia ,Computer Networks and Communications ,business.industry ,Computer science ,Access control ,Cloud computing ,computer.software_genre ,Encryption ,Hardware and Architecture ,Media Technology ,Attribute-based encryption ,Chosen-plaintext attack ,business ,computer ,Software ,Anonymity - Abstract
Multimedia data, ranging from text, audio, video to animation, undergoes intellectual property protection or has high sensitivity. To deal with privacy leakage during multimedia sharing and dissemination, it is crucial to trace the origin and transformation history of multimedia data, which is called multimedia provenance. In this paper, we construct a multimedia access control system with secure provenance in fog-cloud computing networks, which is designed based on attribute based encryption (ABE) and zero of knowledge technologies. The proposed scheme realizes confidentiality of multimedia big data that is outsourced to the cloud, anonymity of data provider, fine-grained access control of encrypted data, irrefutable of the provenance data, and traceability of data provider. We utilize the fog server to reduce user’s decryption burden and transfer partial decryption tasks. The suggested system is formally proved indistinguishable against chosen plaintext attack (IND-CPA). The simulation and experimental results indicate that our system has low communication overhead and low computation cost.
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- 2020
29. Abstract P4-10-25: Pretreatment serum metabolome predicts PFS in first-line trastuzumab-treated metastatic breast cancer
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Suhail M. Ali, Hyma Polimera, Kim Leitzel, Walter P. Carney, Elizabeth O’Day, W. Koestler, Leah Cream, Ashok Maddukuri, Bo Zhang, Allan Lipton, Chen Dong, Harry Menon, Vinod Nagabhairu, Prashanth Reddy Moku, Joseph J. Drabick, Neha Pancholy, Xiajian Shi, Monali Vasekar, and Haiwei Gu
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0301 basic medicine ,Oncology ,Cancer Research ,medicine.medical_specialty ,Chemotherapy ,business.industry ,medicine.medical_treatment ,Retrospective cohort study ,Palbociclib ,medicine.disease ,Metastatic breast cancer ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Breast cancer ,Trastuzumab ,030220 oncology & carcinogenesis ,Internal medicine ,Cancer cell ,medicine ,Metabolome ,skin and connective tissue diseases ,business ,medicine.drug - Abstract
Background: Cancer cells have altered metabolism, which contributes to their ability to proliferate, survive in unusual microenvironments, and invade other tissues. Measuring the complete set of metabolites in an individual (i.e. the metabolome) provides a functional readout for cellular pathways. Further, changes in the metabolome can be correlated with disease status, prognosis and progression. Using a metabolomics platform and machine learning algorithms, biomarker signatures can be identified to predict response to therapy. Metabolite analysis of pretreatment plasma has shown promise for predicting response in a small retrospective study of the CDK 4/6 inhibitors palbociclib and ribociclib in hormone receptor-positive metastatic breast cancer (Zhang B et al, ASCO 2019 Abstr 3043). HER2-positive metastatic breast cancer patients have significant heterogeneity in response and progression-free survival (PFS) to HER2-targeted therapy. Here we retrospectively evaluated the pretreatment serum metabolome for association with PFS in a cohort of trastuzumab-treated metastatic breast cancer patients from a single institution. Methods: Pretreatment serum from 26 HER2-positive trastuzumab-naive metastatic breast cancer patients who were treated with first-line trastuzumab and chemotherapy were included in this exploratory analysis. Metabolites were extracted from previously frozen serum (1 mL) using ice-cold methanol and chloroform. The resulting metabolites were isolated and quantified using an unbiased, non-destructive, nuclear magnetic resonance (NMR)-based profiling platform (Olaris, Inc., Cambridge, MA). The serum was analyzed via 1D 1H NMR and 2D 13C-1H heteronuclear single quantum coherence spectroscopy (HSQC) using customized non-uniform sampling (NUS) techniques and processed with proprietary Olaris software. Supervised and unsupervised machine learning algorithms were used to identify patients with shorter and longer PFS to trastuzumab-based therapy. Results: The median PFS for this cohort was 301 days. Patients were subdivided into early progressors (PFS < 301 days) and late progressors (PFS ≥ 301 days). 23 metabolite resonance levels were statistically different between the two groups (KW test p Citation Format: Elizabeth O'Day, Kim Leitzel, Suhail M Ali, Bo Zhang, Chen Dong, Haiwei Gu, Xiajian Shi, Joseph J Drabick, Leah Cream, Monali Vasekar, Hyma V Polimera, Vinod Nagabhairu, Prashanth Moku, Ashok Maddukuri, Harry Menon, Neha Pancholy, Walter P Carney, Wolfgang Koestler, Allan Lipton. Pretreatment serum metabolome predicts PFS in first-line trastuzumab-treated metastatic breast cancer [abstract]. In: Proceedings of the 2019 San Antonio Breast Cancer Symposium; 2019 Dec 10-14; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2020;80(4 Suppl):Abstract nr P4-10-25.
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- 2020
30. Lycopene attenuates chronic prostatitis/chronic pelvic pain syndrome by inhibiting oxidative stress and inflammation via the interaction of NF‐κB, MAPKs, and Nrf2 signaling pathways in rats
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Xinxing Lu, Mingshuai Wang, Nianzeng Xing, Qinxin Zhao, Feiya Yang, Dexi Chen, Meng Lingquan, Chen Dong, and Yongguang Jiang
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Male ,antioxidant ,MAP Kinase Signaling System ,NF-E2-Related Factor 2 ,Urology ,Endocrinology, Diabetes and Metabolism ,Anti-Inflammatory Agents ,Prostatitis ,Inflammation ,Pharmacology ,anti‐inflammation ,chronic pelvic pain syndrome ,Pelvic Pain ,medicine.disease_cause ,Rats, Sprague-Dawley ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Endocrinology ,Chronic prostatitis/chronic pelvic pain syndrome ,medicine ,Animals ,030219 obstetrics & reproductive medicine ,business.industry ,NF-kappa B ,Prostate ,NF-κB ,Original Articles ,Syndrome ,lycopene ,medicine.disease ,Malondialdehyde ,signaling pathways ,Lycopene ,Rats ,Oxidative Stress ,Reproductive Medicine ,chemistry ,Original Article ,Tumor necrosis factor alpha ,Chronic Pain ,medicine.symptom ,business ,chronic prostatitis ,Oxidative stress ,Signal Transduction - Abstract
Background Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is identified as a urinary andrological diseases that afflict men due to various discomforts. It is urgent and meaningful to develop the novel and effective treatments as a result of the unclear etiology and dismal therapeutic effect of CP/CPPS. Lycopene exerts a crucial role in numerous chronic inflammatory diseases owing to its potent antioxidant capacity. Objective This study aimed to observe the effect of lycopene on CP/CPPS and to explore the underlying mechanisms. Materials and Methods A CP/CPPS model with complete Freund's adjuvant was established in this study. Afterward, intragastric lycopene or corn oil was administered daily for 4 consecutive weeks. Finally, the cardiac blood and prostate tissue samples were collected from rats to carry out related evaluation and testing. Results It was found in this study that lycopene alleviated changes in prostate histopathology compared with those in the complete Freund's adjuvant‐induced CP/CPPS model rats without lycopene treatment. Furthermore, lycopene was suggested to reduce the levels of chemokines MCP1 and MIP‐1α, down‐regulate the expression levels of cytokines (such as TNFα, IL‐1β, IL‐2, and IL‐6), and up‐regulate those of CAT, GSH‐PX, and T‐SOD, decrease that of malondialdehyde. Moreover, it also inhibited the phosphorylation of MAPKs, NF‐κB, and enhanced phosphorylation of the Nrf2 in the CP/CPPS rat model. Discussion and Conclusions The findings in this study suggest that lycopene exerts potent anti‐ CP/CPPS Seffects through alleviating inflammatory response and oxidative stress, which is probably attributed to the interaction of NF‐κB, MAPKs, and Nrf2 signaling pathways in rats. As a natural antioxidant, lycopene may serve as a promising pharmaceutical preparation for treating CP/CPPS.
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- 2020
31. Research on Inception Module Incorporated Siamese Convolutional Neural Networks to Realize Face Recognition
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Yong Lu, Xian-Feng Xu, Li Zhang, and Chen-Dong Duan
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General Computer Science ,Biometrics ,business.industry ,Computer science ,ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION ,General Engineering ,Pattern recognition ,Facial recognition system ,Convolutional neural network ,Support vector machine ,Robustness (computer science) ,Siamese convolutional neural networks ,inception module ,General Materials Science ,lcsh:Electrical engineering. Electronics. Nuclear engineering ,Artificial intelligence ,Cyclical learning rate ,business ,lcsh:TK1-9971 ,face recognition - Abstract
Face recognition is an active research subject of biometrics due to its significant research and application prospects. The performance of face recognition can be affected by a series of uncontrollable factors, such as illumination, expression, posture and occlusion, which restricts its real-world applications. Therefore, improving the robustness of face recognition to environmental changes became an urgent problem. In this paper, a simplified deep convolutional neural network structure having high robustness under unlimited conditions is designed for face recognition. This structure can improve training speed and face recognition accuracy, and be suitable for small-scale data sets. Inception Module Incorporated Siamese Convolutional Neural Networks (IMISCNN) is developed based on effective reduction of external interference and better features extraction by adopting the Siamese network structure. A cyclical learning rate strategy is also introduced in IMISCNN for better model convergence. Compared to classical face recognition algorithms, such as PCA, PCA and SVM, CNN, PCANet, and the original SNN et al. The accuracy of IMISCNN in CASIA-webface and Extended Yale B standard face database is 99.36% and 99.21%, respectively. Its feasibility and effectiveness have been verified in our experiments.
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- 2020
32. Significance of Neutrophil Gelatinase-Associated Lipocalin as a Biomarker for the Diagnosis of Diabetic Kidney Disease: A Systematic Review and Meta-Analysis
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Chen Dong, Jin-Ping Hu, Ming Bai, Chen Huang, Shiren Sun, and Peng He
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lcsh:Diseases of the circulatory (Cardiovascular) system ,medicine.medical_specialty ,Subgroup analysis ,lcsh:RC870-923 ,Sensitivity and Specificity ,Gastroenterology ,Likelihood ratios in diagnostic testing ,Lipocalin-2 ,Diabetes mellitus ,Internal medicine ,lcsh:Dermatology ,medicine ,Humans ,Diabetic Nephropathies ,Prospective cohort study ,Likelihood Functions ,business.industry ,neutrophil gelatinase-associated lipocalin ,General Medicine ,lcsh:RL1-803 ,lcsh:Diseases of the genitourinary system. Urology ,medicine.disease ,diabetic kidney disease ,meta-analysis ,lcsh:RC666-701 ,Nephrology ,Meta-analysis ,Diagnostic odds ratio ,Biomarker (medicine) ,Cardiology and Cardiovascular Medicine ,business ,Biomarkers ,Kidney disease - Abstract
Background: Neutrophil gelatinase-associated lipocalin (NGAL) is a promising marker for the diagnosis of diabetic kidney disease (DKD), but its utility is currently debated. This meta-analysis aims to evaluate the diagnostic value of NGAL for DKD. Method: MEDLINE, Embase, Cochrane Library, CNKI, and CBM databases were searched up to April 13, 2019. In bivariate random-effect models, the diagnostic performance of NGAL for DKD was assessed using pooled estimates of sensitivity, specificity, likelihood ratio, diagnostic odds ratio, and hierarchical summary receiver-operating characteristic analysis. Results: Nineteen studies were eligible for the meta-analysis. Serum NGAL had a pooled sensitivity and specificity of 0.79 (95% confidence intervals [CI] 0.60–0.91) and 0.87 (0.75–0.93) (7 studies, 1,238 patients). The pooled positive likelihood ratio (LR+) and negative likelihood ratio (LR–) were 5.97 (3.03–11.76) and 0.24 (0.11–0.51). For urine NGAL, the pooled sensitivity, specificity, LR+, and LR– were 0.85 (0.74–0.91), 0.74 (0.57–0.86), 3.26 (1.87–5.67), and 0.21 (0.12–0.35), respectively (10 studies, 1,369 patients). The pooled sensitivity and specificity for kidney disease in normoalbuminuric patients with diabetes was 0.90 (0.82–0.95) and 0.97 (0.90–0.99) for both serum NGAL and 0.94 (0.87–0.98) and 0.90 (0.81–0.96) for urine NGAL (4 studies, 221 patients). NGAL appeared to perform similarly in subgroup analysis. Conclusion: The meta-analysis has shown that NGAL may be useful for DKD classification and also has a potential diagnostic value for normoalbuminuric kidney disease. Large-scale prospective studies are required to clarify its role in the diagnosis and risk stratification of patients with DKD.
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- 2020
33. An Unsupervised Detection Approach for Hardware Trojans
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Chen Yuzhong, Ximeng Liu, Wenzhong Guo, Chen Jinghui, Chen Dong, and Yulin Liu
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General Computer Science ,Computer science ,0507 social and economic geography ,02 engineering and technology ,Software ,Hardware security ,hardware Trojan detection ,0202 electrical engineering, electronic engineering, information engineering ,General Materials Science ,LOF ,Local outlier factor ,business.industry ,05 social sciences ,Supervised learning ,integrated circuit ,General Engineering ,Process (computing) ,020202 computer hardware & architecture ,Trojan ,Outlier ,Key (cryptography) ,lcsh:Electrical engineering. Electronics. Nuclear engineering ,business ,unsupervised machine learning ,lcsh:TK1-9971 ,050703 geography ,Host (network) ,Computer hardware - Abstract
With the booming development of the cyber-physical system, human society is much more dependent on information technology. Unfortunately, like software, hardware is not trusted at all, due to so many third parties involved in the separated integrated circuit's (IC) design and manufacturing stages for the high profit. The malicious circuits (named Hardware Trojans) can be implanted during any stage of the ICs' design and manufacturing process. However, the existing pre-silicon approaches based on machine learning theory have good performance, they all belong to supervised learning methods, which have a key prerequisite that is numerous already known information. Meanwhile, hardware Trojans are even more unimaginable because today's ICs are becoming more complicated. The known information is even harder to gain. Furthermore, the training process for supervised learning methods tends to be time-consuming and generally requires a huge amount of balanced training data. Therefore, this paper proposes an unsupervised hardware Trojans detection approach by combined the principal component analysis (PCA) and local outlier factor (LOF) algorithm, called PL-HTD. We firstly visualize the distribution features of normal nets and Trojan nets, and then reveal the differences between the two types of nets to reduce the dimension of the feature set. According to the outliers of each net, the abnormal nets are selected and verified by professionals later to confirm whether it is a true Trojan relative to the host circuit to realize the detection. The experiments show that the proposed method can detect hardware Trojans effectively and reduce the cost of manual secondary detection. For the Trust-HUB benchmarks, the PL-HTD achieves up to 73.08% TPR and 97.52% average TNR, moreover, it achieves average 96.00% accuracy, which shows the feasibility and efficiency of hardware Trojans detecting by employing a method without the guidance of class label information.
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- 2020
34. Prevention of uneven color for TFT-LCD TN curve panel
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Chen Dong-chuan, Xin Lan, LI Xiao-ji, Gong Peng-cheng, LI Zhe, HU Jing-yong, Piao Zheng-hao, Zhu Wei, Min Tai-ye, Li Peng, and Yang Jun
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Liquid-crystal display ,Materials science ,law ,business.industry ,Thin-film transistor ,Signal Processing ,Optoelectronics ,business ,Instrumentation ,Electronic, Optical and Magnetic Materials ,law.invention - Abstract
薄膜晶体管液晶显示器(TFT-LCD)扭曲向列型(TN)液晶曲面显示器搭配宽视角偏光片暗态时会发生色不均现象,推测色不均现象的发生机理为:曲面状态时,玻璃基板受应力发生形变,面板中应力不均,加之液晶双折射,暗态时上视角观察显示屏上下两侧边缘发蓝。本文模拟了不同改善措施对色不均现象的影响,同时对有改善的模拟结果进行了实验测试。测试结果表明,可以通过两种方式改善色不均现象:第一种是增加暗态亮度,掩盖暗态时色不均现象,如调整电路、偏光片吸收轴角度等。实验结果表明调整电路使显示器暗态亮度从0.18 cd/m2提升至0.25 cd/m2,色不均面积由显示器面积的30%减小至10%,吸收轴角度从135°调整至134.5°,色不均面积减小至10%,但电路调整使显示器响应时间增加2.5倍,吸收轴角度调整0.5°会使对比度下降20%,对产品性能均有不利影响;第二种是改善曲面状态下显示屏内部应力均一性,如增加液晶盒盒厚、高温老化、降低显示器玻璃基板厚度等。实验结果表明:降低玻璃厚度至0.2 mm以及高温60℃老化72 h均能使色不均现象消失,且对产品性能无不利影响。
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- 2020
35. Gout and risk of diabetes mellitus: meta-analysis of observational studies
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Jiaxin Guo, Xiaoqi Sha, Xingyu Ge, Yilin Wang, Wei Zhou, Genkai Guo, Rui Zhao, Chen Dong, and Ting Fu
- Subjects
musculoskeletal diseases ,congenital, hereditary, and neonatal diseases and abnormalities ,medicine.medical_specialty ,Gout ,Population ,Subgroup analysis ,Comorbidity ,03 medical and health sciences ,Sex Factors ,0302 clinical medicine ,Diabetes mellitus ,Internal medicine ,Epidemiology ,Diabetes Mellitus ,medicine ,Humans ,030212 general & internal medicine ,education ,Applied Psychology ,education.field_of_study ,business.industry ,Incidence (epidemiology) ,Age Factors ,nutritional and metabolic diseases ,medicine.disease ,030227 psychiatry ,Observational Studies as Topic ,Psychiatry and Mental health ,Clinical Psychology ,Meta-analysis ,Cohort ,business - Abstract
To determine the prevalence of diabetes mellitus (DM) in people with gout, and investigate the relationship between gout and the occurrence of DM. Systematic review and meta-analysis of epidemiological studies. Data sources: MEDLINE, Web of Science, EMBASE and CINAHL databases, hand-searched reference lists, citation history and contact with authors. Eligibility criteria: cohort, case-control or cross-sectional studies which examined the occurrence of DM amongst adults with gout (with or without gout group) in primary care or general population samples. Prevalence and risk estimate meta-analyses were performed using a random-effects model. A total of 23 identified studies matched the inclusion criteria, reporting on a total of 575 284 gout patients. Meta-analyses revealed that the prevalence of DM in gout patients was 16% (95% CI, 14-18%, I2 = 99.8%) according to clinical interviews. In the subgroup analysis, the prevalence of DM was higher in the female population (18%, 95%CI 2.7-33.3%) than the male population (12.6%, 95%CI 8.2-17.1%). As age increased, the incidence of diabetes in gout population increased. DM is commonly found among patients with gout. Patients with gout should be actively screened for DM and its consequences.
- Published
- 2019
36. Serum urate goal attainment and associated factors in Chinese gout patients
- Author
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Wei Zhou, Genkai Guo, Rui Zhao, Rulan Yin, Chen Dong, Guoyuan Lu, Ying Yang, Yilin Wang, and Jiaxin Guo
- Subjects
Adult ,Male ,China ,medicine.medical_specialty ,Gout ,Visual analogue scale ,Disease ,Logistic regression ,Gout Suppressants ,03 medical and health sciences ,0302 clinical medicine ,Waist–hip ratio ,Internal medicine ,medicine ,Humans ,030212 general & internal medicine ,Family history ,Applied Psychology ,Aged ,Univariate analysis ,business.industry ,Middle Aged ,medicine.disease ,Uric Acid ,030227 psychiatry ,Serum urate ,Psychiatry and Mental health ,Clinical Psychology ,Cross-Sectional Studies ,Female ,business ,Goals - Abstract
We conducted a cross-sectional study with 350 gout patients to investigate serum urate acid (sUA) goal attainment (sUA < 360 μmol/L) and associated factors in Chinese gout patients in the Affiliated Hospital of Nantong University from August 2015 to September 2017. Descriptive statistics, health assessment questionnaire, global visual analog scale for general health and Gout Knowledge Questionnaire were calculated comparing patients at sUA goal or not at sUA goal. Univariate analysis and logistic regression models were applied to analyze data. The proportion of urate-lowering therapy (ULT) use was 61.2% (211/350). The mean ± standard deviation sUA of the participants was 475.07 ± 121.53 μmol/L. Only 17.4% of gout patients attain the serum urate goal, which also means 289(82.6%) patients cannot keep their sUA below the target of 360 μmol/L. The factors associated with sUA goal attainment including age, education level and ULT use. Among these, age, waist hip ratio, ULT, family history of cardiovascular disease was the predictor of sUA goal attainment. In conclusion, more than 80% of gout patients did not achieve sUA goal. Younger and fatter patients were more difficult to control the serum urate level.
- Published
- 2019
37. Assessment of changes in oasis scale and water management in the arid Manas River Basin, north western China
- Author
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Lianqing Xue, Aihua Long, Guang Yang, Fadong Li, Chen Dong, and Xinlin He
- Subjects
geography ,Irrigation ,Environmental Engineering ,geography.geographical_feature_category ,010504 meteorology & atmospheric sciences ,business.industry ,Drainage basin ,010501 environmental sciences ,01 natural sciences ,Pollution ,Arid ,Water resources ,Remote sensing (archaeology) ,Agriculture ,Environmental Chemistry ,Environmental science ,Water resource management ,Scale (map) ,business ,China ,Waste Management and Disposal ,0105 earth and related environmental sciences - Abstract
Modern water-saving irrigation technology has expanded the scale of agricultural oases in arid and semi-arid regions of China. In this study, we used Landsat MSS and Landsat TM/ETM remote sensing data to assess changes in oasis scale and water availability with reference to differing water management practices in the Manas River Basin of north-western China from 1975 to 2015. We used the water-heat balance index H0 to determine oasis stability over time and constructed a suitable-scale calculation model for arid and semi-arid regions to assess the suitable development scale and cultivated land area in the study area. The implementation of water-saving technology in 2000 effectively improved the utilization efficiency of water resources and accelerated the formation of artificial oases; these expanded by 3873.3 km2 while natural oasis area was reduced by 3485.0 km2. The oasis stability index H0 was less than the critical stability index of 0.5 throughout the study period, implying that these areas were in a metastable state and unsuitable for further development. Therefore, in order to improve oasis stability, both scale and agricultural area should be further controlled. At present, actual oasis scale exceeds appropriate scale by 1.1 times and agricultural area exceeds suitable area by 2.5 times. To ensure the stability of the oasis, its area should be maintained at 3942.28–4481.06 km2 and the cultivated land should be maintained at 1576.91–1792.42 km2.
- Published
- 2019
38. Associated factors with interstitial lung disease and health-related quality of life in Chinese patients with primary Sjögren’s syndrome
- Author
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Zhifeng Gu, Jiaxin Guo, Chen Dong, Ping Li, M. He, Yilin Wang, Rui Zhao, Jianlin Gao, and Wei Zhou
- Subjects
Adult ,Male ,China ,medicine.medical_specialty ,Hospital Anxiety and Depression Scale ,Severity of Illness Index ,behavioral disciplines and activities ,Pittsburgh Sleep Quality Index ,03 medical and health sciences ,0302 clinical medicine ,stomatognathic system ,Rheumatology ,Quality of life ,Surveys and Questionnaires ,Internal medicine ,Humans ,Medicine ,030212 general & internal medicine ,Fatigue ,Aged ,030203 arthritis & rheumatology ,Health related quality of life ,business.industry ,Interstitial lung disease ,General Medicine ,Middle Aged ,respiratory system ,medicine.disease ,respiratory tract diseases ,stomatognathic diseases ,Cross-Sectional Studies ,Sjogren's Syndrome ,Quality of Life ,Mann–Whitney U test ,Female ,Lung Diseases, Interstitial ,Sleep ,business ,Rheumatism - Abstract
The main purpose of this study was to investigate the current situation of primary Sjögren's syndrome (pSS) patients with interstitial lung disease (ILD) in China. The relationships between social demography, disease activity, psychological status, clinical variables, and ILD were analyzed. Besides that, the quality of life (QoL) in pSS with ILD was also analyzed.In the cross-sectional study, 101 pSS patients participated in this study. Under the guidance of the researchers, the European League Against Rheumatism Sjögren's Syndrome Disease Activity Index (ESSDAI), EULAR Sjögren's Syndrome Patient-Reported Index (ESSPRI), the Short-Form 36 health survey (SF-36), Hospital Anxiety and Depression Scale (HADS), Pittsburgh sleep quality index (PSQI), Summated Xerostomia Inventory (SXI), and other related questionnaires were completed. Independent sample t tests, Mann-Whitney U test, chi-square test, and correlational analysis were used.The data showed that 28 (30.1%) pSS people with ILD. The occurrence and development of ILD were associated with disease duration, fatigue, alanine aminotransferase (ALT), neutrophils, albumin, and use of hormone. The survey also found that the QoL of pSS-ILD was significantly lower than non-ILD, especially the score in the dimension of role physical function.ILD was very common in pSS. ILD had a significant negative impact on the QoL of patients. Therefore, it is of great significance to strengthen the early intervention and drug treatment of pSS patients to prevent ILD and improve their QoL.Key Points• This cross-sectional study finds that the incidence of ILD in patients with pSS is 30.1%.• The occurrence and development of ILD is associated with disease duration, fatigue, alanine aminotransferase (ALT), neutrophils, albumin, and use of hormone.•The study also finds that the QoL of pSS-ILD is significantly lower than in patients with non-ILD, especially the score in the dimension of role physical function.
- Published
- 2019
39. Associations of visit-to-visit variabilities and trajectories of serum lipids with the future probability of type 2 diabetes mellitus
- Author
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Lei Wu, Hui Zhou, Yang Jing, Chen Dong, Qian Sun, Yue Sun, Jianrong Jin, Jingchao Liu, Sudan Wang, and Jing Wu
- Subjects
Male ,medicine.medical_specialty ,RC620-627 ,endocrine system diseases ,Endocrinology, Diabetes and Metabolism ,Clinical Biochemistry ,Trajectory ,Blood lipids ,Association ,Endocrinology ,Risk Factors ,Internal medicine ,Type 2 diabetes mellitus ,medicine ,Humans ,Serum lipids ,Prediabetes ,Risk factor ,Nutritional diseases. Deficiency diseases ,Triglycerides ,Probability ,Proportional Hazards Models ,business.industry ,Proportional hazards model ,Incidence (epidemiology) ,Research ,Biochemistry (medical) ,Hazard ratio ,nutritional and metabolic diseases ,Middle Aged ,medicine.disease ,Lipids ,Confidence interval ,Lipoproteins, LDL ,Cholesterol ,Quartile ,Diabetes Mellitus, Type 2 ,Female ,Visit-to-visit variability ,business ,Lipoproteins, HDL - Abstract
Background Serum lipid abnormalities are generally considered as a major risk factor for type 2 diabetes mellitus (T2DM). However, evidence for the effect of long-term serum lipid fluctuations on future T2DM probability remains limited. Methods A total of 4475 nondiabetic participants who underwent annual health examinations between 2010 and 2013 were followed for the subsequent 5-year risk of T2DM. The Cox proportional hazards model was performed to evaluate the associations of visit-to-visit variabilities and trajectories of triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c) and low-density lipoprotein cholesterol (LDL-c) with T2DM probability. Results During the five-year follow-up, 223 newly developed T2DM cases were identified. Compared with the “Low” TG trajectory, “Moderate” and “Moderate-High” TG trajectories were significantly associated with T2DM incidence, with adjusted hazard ratios (HRs) and 95 % confidence intervals (CIs) of 1.51 (1.12-2.03) and 2.55 (1.62-4.03), respectively. Additionally, participants in the third and fourth quartiles of TG/standard deviation (SD) were associated with increased T2DM probability when compared with those in the lowest quartile. After excluding individuals with prediabetes, participants with “Moderate-High” TG trajectory still had a 2.43-fold greater risk of T2DM compared with those with “Low” TG trajectory (95 % CI: 1.28-4.63). In addition, compared with participants in “Low” HDL-c trajectory, the future T2DM probability was significantly reduced in those with “Moderate” and “High” HDL-c trajectories, with HR (95 % CI) of 0.52 (0.37-0.72) and 0.38 (0.18-0.80), respectively. After excluding individuals with prediabetes, the “Moderate” HDL-c trajectory remained associated with decreased T2DM probability when compared with “Low” HDL-c trajectory (HR: 0.55, 95 % CI: 0.35-0.88). However, the incidence of T2DM was not associated with the long-term fluctuations of TC and LDL-c. Conclusions Long-term visit-to-visit variability of TG, and the change trajectories of TG and HDL-c were significantly associated with future T2DM probability. Moreover, these associations were not affected after excluding individuals with prediabetes.
- Published
- 2021
40. SOCS3 Gene Polymorphism and Hypertension Susceptibility in Chinese Population: A Two-Center Case-Control Study
- Author
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Lingyun Liu, Yuanlin Xie, Meiling Zuo, Dabin Kuang, Zhousheng Yang, Li-Chen Dong, and Tao-Ming Li
- Subjects
Adult ,Male ,China ,Article Subject ,Adolescent ,Genotype ,Inflammation ,Polymorphism, Single Nucleotide ,General Biochemistry, Genetics and Molecular Biology ,Young Adult ,Asian People ,Gene Frequency ,Polymorphism (computer science) ,Risk Factors ,Medicine ,Humans ,Genetic Predisposition to Disease ,SOCS3 ,RNA, Messenger ,Allele ,Genetic Association Studies ,Aged ,Aged, 80 and over ,General Immunology and Microbiology ,business.industry ,digestive, oral, and skin physiology ,Case-control study ,General Medicine ,Middle Aged ,medicine.disease ,Obesity ,Logistic Models ,Suppressor of Cytokine Signaling 3 Protein ,Case-Control Studies ,Immunology ,Hypertension ,Female ,Gene polymorphism ,medicine.symptom ,business ,Research Article - Abstract
Endothelial inflammation and vascular damage are essential risk factors contributing to hypertension. Suppressor of cytokine signaling 3 (SOCS3) is involved in the regulation of multiple inflammatory pathways. A large number of studies have shown that the anti-inflammatory effect of SOCS3 in hypertension, obesity, and allergic reactions has brought more insights into the inhibition of inflammation. Therefore, we selected a tagSNP of SOCS3 (rs8064821) to investigate whether they are contributing to the risk of hypertension in the Chinese population. In total, 532 patients with hypertension and 569 healthy controls were enrolled for two central of China. SOCS3 rs8064821 C>A polymorphism was genotyped using TaqMan assay. SOCS3 rs8064821 CA genotype was associated with an increased risk of hypertension ( OR = 1.821 , 95 % CI = 1.276 -2.600, P = 0.001 ). Rs8064821 A allele was associated with higher SOCS3 mRNA level in PBMCs from healthy donors. SOCS3 rs8064821 C>A polymorphism may contribute to the risk of hypertension in the Chinese population by regulating the expression of SOCS3.
- Published
- 2021
41. Factors associated with blood lead levels in children in Shenyang, China: a cross-sectional study
- Author
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Shuang-Shuang Zhang, Xiao-Jun Cheng, Ying Liu, Guang-Bo Li, Xue-Ning Li, and Yi-Chen Dong
- Subjects
Male ,China ,business.industry ,Cross-sectional study ,Infant ,Environmental Exposure ,Lead Poisoning ,Cross-Sectional Studies ,Lead ,Environmental health ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Prevalence ,Medicine ,Humans ,Female ,business ,Lead (electronics) ,Child - Abstract
Background Although blood lead levels (BLLs) in children are gradually decreasing, low-concentration lead exposure can still exert adverse effects. We studied the factors that affect BLLs in children in Shenyang, China. Methods We conducted a cross-sectional study by administering structured questionnaires on family demographics and food intake. The concentrations of lead in venous blood were determined by graphite furnace atomic absorption spectrometry. Results A total of 273 children aged 1–6 years were enrolled. The geometric mean (geometric standard deviation) of BLLs was 24.94 (12.70) μg/L in boys and 23.75 (11.34) μg/L in girls. The prevalence of BLLs of ≥35 μg/L was 22.7% and was mainly observed in children aged under 3 years. Often hand washing before meals was protective against BLLs ≥20 μg/L (adjusted OR: 0.427, 95%CI: 0.238–0.767, p = 0.004). Consumption of puffed grains and eggs had an adjusted OR (95%CI) for BLLs ≥20 μg/L of 1.714 (1.012–2.901) (p = 0.045) and 1.787 (1.000–3.192) (p = 0.050), respectively. Conclusions BLLs of children in Shenyang are still higher than in developed countries. Consumption of puffed grains and eggs is associated with higher BLLs. Often hand washing before meals may be protective against high BLLs.
- Published
- 2021
42. The enhanced terahertz absorption of metal gratings/Si-based blocked-impurity-band (BIB) hybrid structures
- Author
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Bingbing Wang, Xiaodong Wang, Lin Wang, Wulin Tong, Liu Wenhui, Yongshan Hu, Wanlong Guo, Yulu Chen, and Chen Dong
- Subjects
Materials science ,business.industry ,Terahertz radiation ,Detector ,Finite-difference time-domain method ,Molar absorptivity ,Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials ,Responsivity ,Wavelength ,Impurity ,Optoelectronics ,Electrical and Electronic Engineering ,business ,Absorption (electromagnetic radiation) - Abstract
Terahertz (THz) detecting technology has attracted many attentions. In this work, a novel THz detector based on a metal gratings/Si-based blocked-impurity-band (BIB) hybrid structure was designed and theoretically calculated. The highly integrated hybrid structure was found useful for modulating the response wavelength and improving the responsivity of Si-based BIB detector. The enhanced THz absorption of the hybrid device structure of metal gratings and Si-based BIB absorption layer was carefully investigated by finite difference time domain. The peak wavelength can be moved from 26.9 to 36.53 μm when metal gratings (period: 32 μm) were added on the Si-based BIB. The peak absorptivity of the hybrid detector was increased by 87.3 % with the metal gratings, compared with that of conventional Si-based BIB detector. Our results indicate that a highly integrated hybrid device structure can replace the divided band filters, and realize selective resonant enhanced absorption and tunable THz spectral response.
- Published
- 2021
43. Determinants of Vaccine Acceptance against COVID-19 in China: Perspectives on Knowledge and DrVac-COVID19S Scale
- Author
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Jian Feng, Jun Gu, Min Shuai, Tanao Ji, Rui Zhao, Qian Liang, Chen Dong, Zhifeng Gu, and Xiaoming Zhang
- Subjects
medicine.medical_specialty ,China ,knowledge ,COVID-19 Vaccines ,Isolation (health care) ,Nausea ,Cross-sectional study ,Health, Toxicology and Mutagenesis ,media_common.quotation_subject ,Article ,vaccine ,parasitic diseases ,Medicine ,Humans ,media_common ,business.industry ,SARS-CoV-2 ,Public Health, Environmental and Occupational Health ,Panic ,COVID-19 ,Chinese people ,Test (assessment) ,Vaccination ,Cross-Sectional Studies ,Family medicine ,attitude ,medicine.symptom ,business ,Autonomy ,acceptance - Abstract
Background: This study determined the knowledge and attitudes regarding COVID-19 and assessed the acceptance of the COVID-19 vaccine among the Chinese population. Methods: An online and offline cross-sectional study was conducted from 1 to 18 June 2021 among the Chinese population. Demographic characteristics, attitudes, knowledge, values, impact, and autonomy regarding the COVID-19 vaccine were collected using questionnaire. The variables in our study were analyzed by Mann-Whitney test and chi-square test. Results: A total of 93.8% participants were willing to be vaccinated, 2.7% refused, and 3.5% hesitated. In regards to knowledge about the COVID-19 vaccine, 94.3% citizens surveyed knew about the spread of droplets and 65% had knowledge about surfaces touched by an infected person. In addition, 93.8% of participants had knowledge of the common symptoms related to COVID-19, such as fever and cough (93.8%), shortness of breath/anorexia/fatigue/nausea/vomiting/diarrhea (80.2%), and panic and chest tightness (69.4%). Most participants had a strong self-prevention awareness, such as washing hands regularly (92.1%) and wearing a facemask (94.1%). Besides, over ninety percent of respondents would report exposure to SARS-CoV-2 (96.6%) and exposure to symptoms possibility related to COVID-19 (92.9%). If necessary, most respondents would agree to isolate at home (93.5%) or an isolation in hospital (96.3%). Knowledge of COVID-19, including transmission, symptoms, protective measures, and vaccines itself, is associated with vaccination attitude. Values, perceived impacts, knowledge, and autonomy, assessed by the scale of DrVac-COVID19S, have also been revealed as important determinants to vaccine acceptance. Conclusions: Almost 93% of Chinese people surveyed in this study showed a willing attitude toward COVID-19 vaccination. Based on the above results, government and social workers can take measures from these perspectives to improve the vaccination attitude, so as to increase vaccine immunization rates.
- Published
- 2021
44. Correspondence to proton pump inhibitors and risk of colorectal cancer
- Author
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Chen Dong, James Cheng-Chung Wei, Yun-Hsun Lee, Tzu-Yang Tan, and Chung-Chin Yao
- Subjects
Oncology ,medicine.medical_specialty ,Active Comparator ,medicine.drug_class ,Colorectal cancer ,business.industry ,Gastroenterology ,Proton-pump inhibitor ,Proton Pump Inhibitors ,Receptor antagonist ,medicine.disease ,Risk Factors ,Internal medicine ,medicine ,Humans ,business ,Colorectal Neoplasms - Abstract
We have read with interest the paper by Abrahami et al on the risk of colorectal cancer (CRC) with long-term proton pump inhibitor (PPI) usage with a new user and active comparator design (PPI users n=1 293 749 and histamine-2 receptor antagonist (H2RA) users n=292 387, from 1 January 1990 to 30 April 2018 with 1-year follow-up).1 The authors found that overall use of PPI did not increase the risk of CRC (HR 1.02, 95% CI 0.92 to 1.14). However, the HR increased by 2–4 years (HR 1.45, 95% CI 1.28 to 1.60) and more than 4 years (HR 1.60, 95% CI 1.42 to 1.80) with cumulative duration of PPI usage. Similar patterns were …
- Published
- 2021
45. RORα is critical for mTORC1 activity in T cell-mediated colitis
- Author
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Bing Su, Xiaohong Zhao, Qinli Sun, Xiaohu Wang, Xue Bai, Xuexian O. Yang, Chen Dong, Wei Jin, Xinxin Chi, Jing Shao, and Jiaqi Li
- Subjects
CD4-Positive T-Lymphocytes ,anti-TNF therapy ,Colon ,colitis ,QH301-705.5 ,T cell ,Apoptosis ,mTORC1 ,Drug resistance ,Mechanistic Target of Rapamycin Complex 1 ,Inflammatory bowel disease ,General Biochemistry, Genetics and Molecular Biology ,Transcriptome ,Mice ,Intestinal inflammation ,medicine ,Animals ,Humans ,Colitis ,Biology (General) ,RORα ,Mice, Knockout ,business.industry ,Interleukin-17 ,Nuclear Receptor Subfamily 1, Group F, Member 1 ,medicine.disease ,Infliximab ,CD4+ T cells ,Mice, Inbred C57BL ,Disease Models, Animal ,medicine.anatomical_structure ,Drug Resistance, Neoplasm ,Cancer research ,Th17 Cells ,Colitis, Ulcerative ,Female ,T-Box Domain Proteins ,business ,Signal Transduction - Abstract
Summary Inflammatory bowel disease (IBD) is multi-factorial chronic intestinal inflammation driven by pathogenic T cells, among which a large portion of patients are resistant to current anti-inflammatory regimes. The mechanisms underlying colitis pathogenicity and drug resistance are not fully understood. Here, we demonstrate that RORα is highly expressed in active UC patients, particularly in those non-responsive to anti-TNF treatment. Rorα deficiency in CD4+ T cells greatly reduced colitis development. Mechanistically, RORα regulated T cell infiltration in colon and inhibited T cell apoptosis. Meanwhile, genome-wide occupancy and transcriptome analysis revealed that RORα promoted mTORC1 activation. mTORC1 signaling, also hyperactivated in active UC patients, is necessary for T cell-mediated colitis. Our results thus demonstrate a crucial role of the RORα-mTORC1 axis in CD4+ T cells in promoting IBD, which may be targeted in human patients.
- Published
- 2021
46. A Cryogenic Readout Integrated Circuit Designed For the Blocked-Impurity-Band Terahertz Detector
- Author
-
Xiaowan Dai, Yulu Chen, Chen Dong, Xin Ge, Ying Li, Xinyu Cui, Hongbo Ma, and Yongshan Hu
- Subjects
Transimpedance amplifier ,Wire bonding ,Materials science ,Correlated double sampling ,Physics::Instrumentation and Detectors ,business.industry ,Terahertz radiation ,Circuit design ,Detector ,Astrophysics::Instrumentation and Methods for Astrophysics ,Cryogenics ,Computer Science::Hardware Architecture ,Computer Science::Emerging Technologies ,Readout integrated circuit ,Optoelectronics ,business - Abstract
This article proposes a cryogenic readout integrated circuit (ROIC) for the blocked-impurity-band (BIB) Terahertz detector. The cryogenic ROIC is composed of a capacitance transimpedance amplifier (CTIA) input-stage circuit, a correlated double sampling (CDS) circuit and an output-stage circuit. The circuit design is based on a cryogenic MOSFET model obtained by optimizing some parameters of BSIM4 according to previous cryogenic test results. The ROIC and BIB detector are interconnected by wire bonding, and the output characteristics are measured at 6K. Our result shows that the circuit has realized the design function under cryogenic conditions.
- Published
- 2021
47. Bi-directional and temporal relationship between elevated alanine aminotransferase and hypertension in a longitudinal study of Chinese adults
- Author
-
Hui Zhou, Chen Dong, Shaoyan Zhang, Guoxin Huang, Ruyu Xue, Chao Shen, and Yihui Sheng
- Subjects
Adult ,medicine.medical_specialty ,Longitudinal study ,China ,Physiology ,business.industry ,Chinese adults ,Alanine Transaminase ,Blood Pressure ,General Medicine ,Endocrinology ,Internal medicine ,Hypertension ,Internal Medicine ,medicine ,Humans ,Longitudinal Studies ,Alanine aminotransferase ,business - Abstract
Despite the strong correlation between elevated alanine aminotransferase (ALT) and hypertension, their bi-directional and temporal relationship are currently unclear. Our study aimed to explore the bi-directional and temporal association between elevated ALT (ALT40 U/L) and hypertension.Measurements of alanine aminotransferase and blood pressure were obtained twice from 2013 to 2017 in 3314 Chinese adults without cardiovascular disease at baseline. Bi-directional and cross-lagged panel analyses were performed to dissect the temporal relationship between elevated ALT and hypertension.Longitudinally, we found that baseline elevated ALT was strongly correlated with incident hypertension (odds ratios = 2.16,Our results provide evidence for the bi-directional association of elevated ALT and hypertension among Chinese adults, and elevated ALT probably antedates the development of hypertension.
- Published
- 2021
48. A Novel Second Order Boost Converter with High-Gain and Low Switch Tube Voltage Stress
- Author
-
Wei Wang, Chen Dong, Yang Zhou, Dianguo Xu, and Panbao Wang
- Subjects
Engineering ,business.industry ,Electrical engineering ,Topology (electrical circuits) ,Hardware_PERFORMANCEANDRELIABILITY ,Switched capacitor ,Inductor ,law.invention ,Capacitor ,law ,Boost converter ,Voltage spike ,Inverter ,business ,Voltage - Abstract
Aiming at the problem that the output voltage of the photovoltaic (PV) array is much lower than the voltage required by the grid-connected inverter in the grid-connected power generation system, a new type of second order boost converter with high-gain and low switching tube voltage stress is proposed. The proposed topology is based on the basic Boost circuit, including three switching capacitors and a boost inductor to increase the boost ratio. At the same time, the converter clamps the switching tube to suppress the voltage spike and greatly reduce the voltage stress of the switching tube. The converter circuit topology is simple, which reduces the cost and volume of the converter. The working principle of the converter is analyzed, and the boosting effect of the converter is verified by corresponding simulation and experiments, which proves the correctness of the theoretical analysis.
- Published
- 2021
49. Multidimensional Fatigue in Chinese Meningioma Patients Newly Diagnosed : Prevalence, Severity and Risk Factors
- Author
-
Dandan Zhang, Zhifeng Gu, Rong Li, X. Gu, Xiaomei Zhang, Liren Li, Zhi-Ying Zong, Qian Wu, and Chen Dong
- Subjects
Meningioma ,Pediatrics ,medicine.medical_specialty ,Text mining ,business.industry ,Medicine ,Newly diagnosed ,business ,medicine.disease - Abstract
Purpose Few studies have assessed fatigue of meningioma patients. The purpose of this study was to explore the prevalence, severity, and risk factors of multidimensional fatigue, as well as the impact on health-related quality of life (HRQoL) in Chinese meningioma patients newly diagnosed. Methods This cross-sectional study included 120 Chinese meningioma patients recruited from Affiliated Hospital of Nantong University from January 2020 to February 2021. Data were collected before surgery, including demographic, clinical and psychological characteristics, as well as fatigue scores, based on completion of the Multidimensional Fatigue Inventory (MFI-20). Spearman correlation and multiple linear regression were used to analyze the data. Results The results demonstrated that a high prevalence of severe fatigue for each dimension: general fatigue (33.3%), physical fatigue (27.5%), reduced activity (28.3%), reduced motivation (12.5%), mental fatigue (11.7%), and total fatigue (23.3%). Headache and anxiety were predictors of general fatigue. Depression was an independent predictor of physical fatigue. Karnofsky Performance Status (KPS) score and depression independently predicted reduced activity. Depression and Epworth Sleepiness Scale (ESS) score were risk factors predicting reduced motivation, while KPS score and anxiety predicted mental fatigue. Importantly, comorbidity, KPS score, headache, depression, sleep disturbances, and ESS score could predict total fatigue. Furthermore, MFI-20 scores in all dimensions were negatively correlated with Short Form 36 Health Survey (SF-36) scores in all dimensions. Conclusion Our findings indicate that meningioma patients newly diagnosed are frequently affected by fatigue, potentially contributing to impair HRQoL. For patients with risk factors of fatigue, targeted interventions are advised in order to decrease fatigue and improve HRQoL.
- Published
- 2021
50. MEDASec
- Author
-
Huangda Liu, null null, Lingqing Liu, Ximeng Liu, Sihuang Lian, and Chen Dong
- Subjects
Scheme (programming language) ,Structure (mathematical logic) ,0303 health sciences ,Focus (computing) ,business.industry ,Computer science ,Hardware_PERFORMANCEANDRELIABILITY ,02 engineering and technology ,Encryption ,020202 computer hardware & architecture ,03 medical and health sciences ,chemistry.chemical_compound ,chemistry ,Brute-force attack ,Embedded system ,Hardware_INTEGRATEDCIRCUITS ,0202 electrical engineering, electronic engineering, information engineering ,Key (cryptography) ,Hardware_ARITHMETICANDLOGICSTRUCTURES ,Biochip ,business ,computer ,030304 developmental biology ,computer.programming_language ,MEDA - Abstract
As the next generation of digital microfluidic biochips (DMFBs) platform, Micro-electrode-dot-array (MEDA) has sea-of-micro-electrodes that support fine-grained control of the droplet and constant real-time monitoring of droplet paths. As MEDA biochips are expected to be had a booming market in the near future, their security, especially the protection of intellectual property (IP), has become the focus of the academic community. In this paper, we first propose a logic encryption-based IP protection scheme for MEDA biochips, called MEDASec, which is without modifying the structure. Our scheme aims to hide the droplet mix-split operation in bioassay, making the IP akin to a black-box in the manufacturing process. Besides, increasing computing power has facilitated the threat of brute force attacks on the secret key. In response to the brute force attack, we propose security metrics for the first time, called RRA, to evaluate the ratio of reagents that result from biochemical reactions. Experimental results on multiple bioassays demonstrate the effectiveness of the proposed logical encryption strategy against the brute force attack.
- Published
- 2021
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