Author: "Cheng, Jun" / Topic: business.industry - Searchworks@Jio Institute Digital Library Search Results

363 results on '"Cheng, Jun"'

1. Prognostic value of gamma‐interferon‐inducible lysosomal thiol reductase expression in female patients diagnosed with breast cancer

Author: Man Feng, Chunmiao Ye, Yujuan Xiang, Zhong-Cheng Gao, Fei Wang, Shuya Huang, Zhigang Yu, Cheng-Jun Zhou, Wenzhong Zhou, Chao Zheng, Mingming Guo, Liyuan Liu, Xiaoxia Zhang, Gengshen Yin, Ling-Yu Kong, Dianshui Sun, and Lei Wang
Subjects: Adult, Oncology, Cancer Research, medicine.medical_specialty, Breast Neoplasms, Reductase, Breast cancer, Cell Movement, In vivo, Cell Line, Tumor, Internal medicine, Autophagy, medicine, Humans, Oxidoreductases Acting on Sulfur Group Donors, skin and connective tissue diseases, Aged, Cell Proliferation, Aged, 80 and over, chemistry.chemical_classification, Reactive oxygen species, business.industry, Standard treatment, Hazard ratio, Middle Aged, Prognosis, medicine.disease, In vitro, chemistry, Female, Reactive Oxygen Species, business
Abstract: Because of the high heterogeneity of breast cancer outcome, identification of novel prognostic biomarkers is critical to improve patient stratification and guide precise treatment. We examined the prognostic value of gamma-interferon-inducible lysosomal thiol reductase (GILT) expression in a training set of 416 breast cancer patients and a validation set of 210 patients, and performed functional studies to investigate the functions and underlying mechanisms of GILT on breast cancer prognosis. Our results indicated that high GILT expression in breast cancer cells was associated with improved disease-free survival (DFS; hazard ratio [HR] = 0.189, 95% confidence interval [CI]: 0.099-0.361) and breast cancer-specific survival (BCSS; HR = 0.187, 95% CI: 0.080-0.437) of breast cancer patients both in the training set and the external validation set (HR = 0.453, 95% CI: 0.235-0.873 for DFS, HR = 0.488, 95% CI: 0.245-0.970 for BCSS). In vitro and in vivo studies showed that GILT overexpression inhibited breast cancer cells proliferation, invasion, migration and tumor formation in nude mice and increased sensitivity of breast cancer cells to standard treatment. Proteomics analysis indicated that GILT inhibited reactive oxygen species (ROS) and autophagy activation in breast cancer cells, and GILT overexpression-mediated tumor growth was further enhanced in the presence of autophagy or ROS inhibitors. Our results demonstrate that GILT expression can be effectively used to predict the prognosis and guide treatment strategies of breast cancer patients.
Published: 2021

2. Predictive models for adverse clinical outcomes in Chinese patients with atrial fibrillation undergoing percutaneous coronary intervention with stenting

Author: Dong-Tao Li, Li Zhao, Zhi-Bo Hong, Yi-Xiong Huang, Zhi-Min Ma, Cheng-Jun Guo, Jian-Yong Zheng, Yu Chen, Zheng-Ming Xu, Yi-Da Tang, Yong-Quan Wu, Tian-Chang Li, Yi-Gang Qiu, and Yi Cao
Subjects: Male, medicine.medical_specialty, medicine.medical_treatment, Myocardial Infarction, Hemorrhage, Brain Ischemia, Percutaneous Coronary Intervention, Risk Factors, Thromboembolism, Internal medicine, Atrial Fibrillation, Humans, Medicine, In patient, cardiovascular diseases, Renal Insufficiency, Chronic, Aged, Ischemic Stroke, Retrospective Studies, Heart Failure, business.industry, Percutaneous coronary intervention, Atrial fibrillation, General Medicine, medicine.disease, humanities, Stroke, body regions, Treatment Outcome, Cardiology, ST Elevation Myocardial Infarction, Female, Cardiology and Cardiovascular Medicine, business, Cardiovascular outcomes
Abstract: This study aimed to evaluate predictors for adverse cardiovascular outcomes in patients with atrial fibrillation (AF) undergoing coronary stenting.We retrospectively recruited consecutive patients with previously documented non-valvular AF who underwent coronary stenting between January 2010 and June 2015 in 12 hospitals of Beijing, China. Major adverse cardiac/cerebrovascular events (MACCE) were a composite of all-cause death, non-fatal myocardial infarction, repeat revascularization, and ischaemic stroke/systemic thromboembolism (IS/STE). Major bleeding referred to grade 2 or higher of Bleeding Academic Research Consortium criteria.A total of 2394 patients (men: 72.3%Chinese patients with AF and coronary stenting had high mortality and incidence of MACCE. We compiled separate predictive models for all-cause death, IS/STE, MACCE, and major bleeding.
Published: 2021

3. Talaromyces Marneffei Infection in an HIV-Negative Child with a CARD9 Mutation in China: A Case Report and Review of the Literature

Author: Feng Xu, Si-wei Lu, Cheng-Jun Liu, Cheng-Yan You, Dan-Dan Pi, Yue-qiang Fu, and Fang Hu
Subjects: CARD9 mutation, China, medicine.medical_specialty, Antifungal Agents, Tuberculosis, Veterinary (miscellaneous), HIV Infections, Gene mutation, HIV-negative, medicine.disease_cause, Applied Microbiology and Biotechnology, Microbiology, Medical microbiology, Ascites, Humans, Medicine, Child, Genetic testing, Mutation, biology, medicine.diagnostic_test, business.industry, Bone Marrow Smear, Talaromyces marneffei, medicine.disease, CARD Signaling Adaptor Proteins, Mycoses, Talaromyces, Immunology, biology.protein, Original Article, medicine.symptom, Antibody, business, Agronomy and Crop Science
Abstract: Background Talaromyces marneffei (T. marneffei) is a thermally dimorphic fungus causing systemic mycosis. Due to the atypical symptoms and diverse imaging findings, T. marneffei-infected patients may be misdiagnosed thus preventing timely antifungal therapy. Moreover, HIV-negative patients with T. marneffei infection may be congenitally immunocompromised because of the mutation of immune-related genes. Case presentation We describe a case of an HIV-negative child who developed disseminated T. marneffei infection in a nonendemic area. Chest CT showed similar imaging changes of miliary pulmonary tuberculosis, while there was no other evidence of tuberculosis infection, and empirical antituberculosis treatment was not effective. Lymphocyte subset analysis showed reduced natural killer cells, and the immunoglobulin profile showed low levels of IgM, C3 and C4. A bone marrow smear revealed T. marneffei infection, and ascites culture also proved T. marneffei infection. Despite antifungal treatment, the child died of multiple organ failure. Two gene mutations in caspase recruitment domain-containing protein 9 (CARD9) were detected, which had not been reported previously in T. marneffei-infected patients. Conclusions HIV-negative patients with CARD9 mutations may be potential hosts of T. marneffei. Abnormalities in the immunoglobin profile and lymphocyte subset may provide clues for immunocompromised patients, and further genetic testing is advised to identify gene mutations in HIV-negative patients with T. marneffei infection.
Published: 2021

4. Visceral myopathy diagnosed by a de novo ACTG2 mutation in a patient with chronic intestinal pseudo-obstruction—a case report

Author: Jing Li, Feng Xu, Xiaoyu Xiong, and Cheng-Jun Liu
Subjects: 0301 basic medicine, Intestinal pseudo-obstruction, medicine.medical_specialty, medicine.diagnostic_test, business.industry, Genetic disorder, Case Report, medicine.disease, Gastroenterology, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Parenteral nutrition, medicine.anatomical_structure, Internal medicine, Pediatrics, Perinatology and Child Health, Mutation (genetic algorithm), Biopsy, medicine, Missense mutation, Abdomen, 030211 gastroenterology & hepatology, business, Hypoperistalsis
Abstract: Visceral myopathy is a rare genetic disorder that commonly affects the digestive and renal systems. Manifestations include a clinical spectrum covering chronic intestinal pseudo-obstruction (CIPO) and megacystis-microcolon-intestinal hypoperistalsis syndrome (MMIHS). The smooth muscle actin γ-2 gene (ACTG2) is one of the most common disease-causing genes. Here, we present a case of pediatric intestinal pseudo-obstruction associated with a novel missense ACTG2 mutation, c.588G>C/p.E196D. His parents had no this mutation, which suggested the possibility of spontaneous mutation. Amino acid conservation analysis of γ-2 actin showed replacement of glutamate at position 196 by aspartate. The patient suffered from recurrent episodes of abdominal bloating, undergone repeated gastrointestinal surgery, had feeding difficulties, and required long-term parenteral nutrition support. The patient had no other specific symptoms or underlying diseases. X-ray of the abdomen showed dilation of the intestine as well as an air-fluid pattern. The manifestations of biopsy were various. All biochemical tests were normal, and the possibility of secondary intestinal pseudo-obstruction was excluded. The mutation site of ACTG2 in the present study has not been previously described in patients with visceral myopathy, and thus, our study reveals a novel mutation of ACTG2-associated visceral myopathy in a patient with CIPO. This report can serve as a reference for future research and further expands the map of genetic variation for visceral myopathy.
Published: 2021

5. Underwater Image Enhancement Method Combining color and Luminance

Author: Guo Yong-cun, Wang Cheng-jun, Jia Xiaofen, Wang Feng, and Zhao Baiting
Subjects: business.industry, Computer science, Computer vision, Artificial intelligence, Electrical and Electronic Engineering, Image enhancement, Underwater, business, Luminance, Electronic, Optical and Magnetic Materials
Abstract: Background:: Aiming at the problems of color distortion, low clarity and poor visibility of underwater image caused by complex underwater environment, a wavelet fusion method UIPWF for underwater image enhancement is proposed. Methods:: First of all, an improved NCB color balance method is designed to identify and cut the abnormal pixels, and balance the color of R, G and B channels by affine transformation. Then, the color correction map is converted to CIELab color space, and the L component is equalized with contrast limited adaptive histogram to obtain the brightness enhancement map. Finally, different fusion rules are designed for low-frequency and high-frequency components, the pixel level wavelet fusion of color balance image and brightness enhancement image is realized to improve the edge detail contrast on the basis of protecting the underwater image contour. Results:: The experiments demonstrate that compared with the existing underwater image processing methods, UIPWF is highly effective in the underwater image enhancement task, improves the objective indicators greatly, and produces visually pleasing enhancement images with clear edges and reasonable color information. Conclusion:: The UIPWF method can effectively mitigate the color distortion, improve the clarity and contrast, which is applicable for underwater image enhancement in different environments.
Published: 2021

6. Transient temperature field analysis of steel-plate composite (SC) floor under standard fire

Author: Cheng-Jun Huang, Chen-Hui Qian, Si-Jia Chen, and Xiaobing Song
Subjects: Materials science, Yield (engineering), business.industry, Composite number, 0211 other engineering and technologies, 020101 civil engineering, 02 engineering and technology, Building and Construction, Structural engineering, Finite element method, 0201 civil engineering, Cross section (physics), Properties of concrete, 021105 building & construction, Architecture, Thermal, Heat transfer, Safety, Risk, Reliability and Quality, business, Civil and Structural Engineering, Test data
Abstract: To evaluate the fire resistance of a structural member, the temperature profile in the cross section of the member needs to be obtained first. Full-scale fire tests have not been conducted on floor systems with steel-plate composite structures, termed SC floors. The traditional finite element analysis does not yield reliable temperature predictions in the steel and concrete of the SC floor under a standard fire. In this paper, the effective thermal properties of concrete in an SC floor are proposed for evaluating the transient temperature field according to the special heat transfer mechanism found by test data. The validity of these effective thermal properties is established by incorporating them into a finite element model and comparing the temperature predictions with data from fire tests. It is shown that the proposed effective thermal properties of concrete provide a good prediction of the temperature field in an SC floor under fire. The derivation process of the effective thermal properties based on the heat transfer analysis makes it possible to expand the scope of its application when the situation is similar to an SC floor.
Published: 2021

7. Measuring serum melatonin concentrations to predict clinical outcome after aneurysmal subarachnoid hemorrhage

Author: Xin-Jiang Yan, Wei-Min Dai, Cheng-Jun Zhuge, Guo-Feng Yu, and Cheng-Peng Zhan
Subjects: 0301 basic medicine, medicine.medical_specialty, Poor prognosis, Subarachnoid hemorrhage, Clinical Biochemistry, Independent predictor, medicine.disease_cause, Biochemistry, Gastroenterology, Melatonin, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Prospective Studies, Good outcome, business.industry, Glasgow Outcome Scale, Biochemistry (medical), General Medicine, Subarachnoid Hemorrhage, Prognosis, medicine.disease, 030104 developmental biology, 030220 oncology & carcinogenesis, business, hormones, hormone substitutes, and hormone antagonists, Oxidative stress, medicine.drug
Abstract: Oxidative stress has a key role in brain injury and melatonin possesses antioxidant effects. We aimed to ascertain the potential relationship between serum melatonin concentrations and functional outcome following aneurysmal subarachnoid hemorrhage (aSAH).This prospective and observational study was conducted of 169 aSAH patients. Baseline serum melatonin concentrations were determined. A worse 6-month functional outcome was defined as a Glasgow Outcome Scale score of 1-3.Patients with a worse outcome (56 cases) compared to those with a good outcome (113 cases) exhibited significantly higher concentrations of serum melatonin (P 0.001). An area under the receiver operating curve of 0.819 was revealed for the prediction of 6-month worse outcome by serum melatonin concentrations. Multiple logistic regression analysis showed an independent association of serum melatonin concentrations with 6-month worse outcome (odds ratio = 1.204). An intimate correlation existed between serum melatonin concentrations and World Federation of Neurological Surgeons subarachnoid hemorrhage scale scores as well as between serum melatonin concentrations and modified Fisher scores (P 0.001).Patients with higher serum melatonin concentrations are more likely to have a poor prognosis. Serum melatonin can be considered as an independent predictor of functional outcome after aSAH.
Published: 2021

8. Application value analysis of magnetic resonance imaging and computed tomography in the diagnosis of intracranial infection after craniocerebral surgery

Author: Lan Gu, Cheng-Jun Geng, Hui-Kang Yin, Xiao-Liang Yang, and Ze-Hua Lu
Subjects: medicine.medical_specialty, Intracranial infection, Diagnostic efficacy, medicine.diagnostic_test, business.industry, Magnetic resonance imaging, Computed tomography, General Medicine, equipment and supplies, Surgery, 03 medical and health sciences, 0302 clinical medicine, Craniocerebral surgery, Retrospective Study, 030220 oncology & carcinogenesis, medicine, 030211 gastroenterology & hepatology, Comparative study, business, human activities, Value (mathematics), Diagnosis of intracranial infection
Abstract: BACKGROUND Intracranial infection is a common clinical disease. Computed tomography (CT) and magnetic resonance imaging (MRI) have certain sensitivity and have good diagnostic efficacy. AIM To study the application value of MRI and CT in the diagnosis of intracranial infection after craniocerebral surgery. METHODS We selected 82 patients who underwent craniocerebral surgery (including 40 patients with intracranial infection and 42 patients without infection) during the period from April 2016 to June 2019 in our hospital. All 82 patients received CT and MRI examinations, and their clinical data were reviewed. A retrospective analysis was performed, and the coincidence rate of positive diagnosis and the overall diagnosis coincidence rate of different pathogenic infection types were measured with the two examination methods. The diagnostic sensitivity and specificity as well as the positive and negative predictive values of the two examination methods were compared. RESULTS For all types of pathogenic infections (Staphylococcus aureus, Staphylococcus hemolyticus, Staphylococcus epidermidis, and others), MRI scans had higher positive diagnostic coincidence rates than CT scans; the overall diagnostic coincidence rate, sensitivity, specificity, positive predictive value, and negative predictive values were significantly higher with MRI examinations than with CT examinations, and the differences were statistically significant (P < 0.05). CONCLUSION MRI examination can accurately diagnose intracranial infection after clinical craniocerebral surgery. Compared with CT, MRI had higher diagnostic efficiency. The diagnostic sensitivity and specificity, the diagnostic coincidence rate, and the positive and negative predictive values were significantly higher with MRI than with conventional CT, which can be actively promoted.
Published: 2020

9. Adult-onset Still’s disease successfully treated with Chinese herbal medicine: A case report with 15-month follow-up

Author: Shao-zhong Zhou, Cheng-jun Ban, Jun Yan, Ming-sheng Lyu, and De-ying Li
Subjects: Adult, Male, myalgia, China, medicine.medical_specialty, 0211 other engineering and technologies, Hepatosplenomegaly, 02 engineering and technology, Disease, 03 medical and health sciences, 0302 clinical medicine, 021105 building & construction, medicine, Sore throat, Humans, Fever of unknown origin, Prospective cohort study, business.industry, General Medicine, medicine.disease, Dermatology, Rash, 030205 complementary & alternative medicine, Chills, medicine.symptom, business, Still's Disease, Adult-Onset, Drugs, Chinese Herbal, Follow-Up Studies
Abstract: Adult-onset Still's disease (AOSD) is a rare but clinically well-known, polygenic, and systemic autoinflammatory disease, which is characterized by spiking fever, evanescent skin rash, arthralgia, and sore throat. The application of non-steroidal anti-inflammatory drugs and glucocorticoids, which are first-line therapies of AOSD, is limited due to their side effects such as liver injury or disorder of blood glucose. Therefore, patients who suffer from systemic diseases in China prefer to seek help from Chinese herbal medicine (CHM), which is an important part of complementary and alternative medicine. In this case, we report a 28-year-old male badminton coach presenting with a 15-day history of fever and skin rash, accompanied by sore throat, fatigue, myalgia and chills. Additionally, hepatosplenomegaly, multiple lymphadenopathies, aminotransferase abnormality, and elevated inflammatory factor levels were observed during hospitalization. Infectious diseases, solid tumors, hematological diseases, and common autoimmune diseases were excluded. Not benefitting from antibiotic therapy, the patient was finally diagnosed with AOSD, after a careful examination, then showed rapid remission after a six-week treatment with CHM granules based on Xiaochaihu Decoction and Yinqiao Powder. After stopping the treatment, there was no relapse within a 15-month follow-up period. To the best of our knowledge, this is the first well-documented case of this successful treatment. The present case report suggests that CHM is a reliable choice for complementary and alternative therapy for AOSD, but confirming the utility of CHM for AOSD requires further support from prospective studies.
Published: 2020

10. Hypoglossal Nerve Lesions: The Role of a 3D IR‐Prepped Fast SPGR High‐Resolution 3T MRI Sequence

Author: Xia Xiaoliang, Wei Chu, Cheng-Jun Geng, Liyue Yang, Hui-Kang Yin, Ze-Hua Lu, Lulu Xuan, and Xiao-Liang Yang
Subjects: Adult, Male, Hypoglossal Nerve, High resolution, Hypoglossal canal, Signal-To-Noise Ratio, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Imaging, Three-Dimensional, 0302 clinical medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, Retrospective Studies, Sequence (medicine), medicine.diagnostic_test, business.industry, Magnetic resonance imaging, Middle Aged, Magnetic Resonance Imaging, medicine.anatomical_structure, Neurology (clinical), Nuclear medicine, business, Hypoglossal nerve, 030217 neurology & neurosurgery
Abstract: BACKGROUND AND PURPOSE To assess a 3D high-resolution IR-prepped fast SPGR high-resolution MRI sequence for evaluating hypoglossal nerve lesions. METHODS The clinical data of 8 patients with hypoglossal nerve lesions admitted from December 2011 to February 2016 were retrospectively analyzed. MRI included contrast-enhanced conventional sequences and a 3D IR-prepped fast SPGR high-resolution T1-weighted (BRAVO) MRI sequence at 3T. RESULTS Eight patients had hypoglossal lesions detected by MRI. Conventional enhanced scanning could not clearly display the hypoglossal nerve and canal, while the enhanced 3D high-resolution sequence could. In addition, multiple planar reconstruction clearly displayed the hypoglossal nerve, hypoglossal canal, and lesions in multiple planes. CONCLUSIONS Compared with conventional MRI, we show superior results from an advanced sequence to improve image quality in characterizing hypoglossal nerve lesions.
Published: 2020

11. The Board Size and Board Composition Impact on Financial Performance: An Evidence from the Pakistani and Chinese’s Listed Banking Sector

Author: Muhammad Mohsin, Muhammad Zeeshan Rafiq, Ji Cheng Jun, Muhammad Kashif Majeed, and Muhammad Zia-ur-Rehman
Subjects: Economics and Econometrics, Board structure, Financial performance, business.industry, Accounting, business, Composition (language), Finance, Banking sector, Management Information Systems
Published: 2020

12. Antibody responses to SARS-CoV-2 in patients with COVID-19

Author: Hua Wen Liu, Jun Yuan, Jin Jing Li, Hai Jun Deng, Shao Bo Wu, Xiao Ping Cui, Man Man Zhu, Fang Gong, Juan Chen, Jie Li Hu, Xiao He Luo, Zhi Jie Li, Xiao Feng Li, Wen Guang Tian, Li Hu, Liu Ping, Chun Hui Lang, Jing Wang, Kun Deng, Yuan Hu, Kun Wang, Li Hua Yu, Jing Fu Qiu, Deqiang Wang, Cheng Jun Xue, Yong Zhang, Bai Zhong Liu, Xiao-li Zhang, Yin Yin Xu, Yong Lin, Qing Jun Yang, Fan Zhang, Xian Xiang Zhang, Zhan Mo, Xue Fei Cai, Yao Kai Chen, Qin Li, Ailong Huang, Ji Hua Ren, Xia Mao Liu, De Chun Zhang, Ni Tang, Quanxin Long, Gui Cheng Wu, Jiang Lin Xiang, Li Wang, Pu Liao, Xiaojun Tang, Hong Xin Du, Zheng Zhou, and Chang Chun Niu
Subjects: Adult, Male, 0301 basic medicine, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Pneumonia, Viral, Antibodies, Viral, Antiviral Agents, Asymptomatic, General Biochemistry, Genetics and Molecular Biology, Serology, Betacoronavirus, 03 medical and health sciences, 0302 clinical medicine, Humans, Medicine, Seroconversion, Pandemics, Aged, biology, SARS-CoV-2, business.industry, COVID-19, General Medicine, Middle Aged, medicine.disease, Pneumonia, Titer, 030104 developmental biology, Immunoglobulin M, Immunoglobulin G, 030220 oncology & carcinogenesis, Antibody Formation, Immunology, biology.protein, Female, Antibody, medicine.symptom, Coronavirus Infections, business
Abstract: We report acute antibody responses to SARS-CoV-2 in 285 patients with COVID-19. Within 19 days after symptom onset, 100% of patients tested positive for antiviral immunoglobulin-G (IgG). Seroconversion for IgG and IgM occurred simultaneously or sequentially. Both IgG and IgM titers plateaued within 6 days after seroconversion. Serological testing may be helpful for the diagnosis of suspected patients with negative RT-PCR results and for the identification of asymptomatic infections.
Published: 2020

13. Aging-related liver degeneration is associated with increased bacterial endotoxin and lipopolysaccharide binding protein levels

Author: Marianne Hege, Anna Janina Engstler, Annika Höhn, Richard Kehm, Cheng Jun Jin, Otto W. Witte, Annette Brandt, Anika Nier, Christian Schmeer, Anja Baumann, Ina Bergheim, and Tilman Grune
Subjects: Liver Cirrhosis, Male, Senescence, Aging, medicine.medical_specialty, Physiology, Apoptosis, Inflammation, Mice, Insulin resistance, Malate Dehydrogenase, Fibrosis, Physiology (medical), Internal medicine, Animals, Medicine, RNA, Messenger, Risk factor, Receptor, Mice, Knockout, Membrane Glycoproteins, Hepatology, biology, business.industry, Gastroenterology, medicine.disease, Receptor, Insulin, Endotoxins, Mice, Inbred C57BL, Toll-Like Receptor 4, Glucose, Endocrinology, Gene Expression Regulation, Liver, Insulin Receptor Substrate Proteins, biology.protein, Female, medicine.symptom, Carrier Proteins, business, Lipopolysaccharide binding protein, Biomarkers, Acute-Phase Proteins
Abstract: Aging is a risk factor in the development of many diseases, including liver-related diseases. The two aims of the present study were 1) to determine how aging affects liver health in mice in the absence of any interventions and 2) if degenerations observed in relation to blood endotoxin levels are critical in aging-associated liver degeneration. Endotoxin levels and markers of liver damage, mitochondrial dysfunction, insulin resistance, and apoptosis as well as the Toll-like receptor 4 (Tlr-4) signaling cascade were studied in liver tissue and blood, respectively, of 3- and 24-mo-old male C57BL/6J mice. In a second set of experiments, 3- to 4-mo-old and 14-mo-old female lipopolysaccharide-binding protein (LBP)−/− mice and littermates fed standard chow, markers of liver damage, insulin resistance, and mitochondrial dysfunction were assessed. Plasma activity of aspartate aminotransferase and histological signs of hepatic inflammation and fibrosis were significantly higher in old C57BL/6J mice than in young animals. The number of neutrophils, CD8α-positive cells, and mRNA expression of markers of apoptosis were also significantly higher in livers of old C57BL/6J mice compared with young animals, being also associated with a significant induction of hepatic Tlr-4 and LBP expression as well as higher endotoxin levels in peripheral blood. Compared with age-matched littermates, LBP−/− mice display less signs of senescence in liver. Taken together, our data suggest that, despite being fed standard chow, old mice developed liver inflammation and beginning fibrosis and that bacterial endotoxin may play a critical role herein. NEW & NOTEWORTHY Old age in mice is associated with marked signs of liver degeneration, hepatic inflammation, and fibrosis. Aging-associated liver degeneration is associated with elevated bacterial endotoxin levels and an induction of lipopolysaccharide-binding protein (LBP) and Toll-like receptor 4-dependent signaling cascades in liver tissue. Furthermore, in old aged LBP−/− mice, markers of senescence seem to be lessened, supporting the hypothesis that bacterial endotoxin levels might be critical in aging-associated decline of liver.
Published: 2020

14. Ultrasonic Chinese herbal medication penetration therapy at Tiānshū (天枢 ST25) for opioid-induced constipation with liver stagnation and spleen deficiency

Author: Na Song, Hong-jian Xu, Cheng Jun, Meng Lingzhan, Xin Zhou, Zong-lang Lai, Ying Li, Xuan Gao, and Jing Wang
Subjects: medicine.medical_specialty, Constipation, business.industry, Therapeutic effect, 0211 other engineering and technologies, Spleen, 02 engineering and technology, 030226 pharmacology & pharmacy, Gastroenterology, 03 medical and health sciences, Diarrhea, 0302 clinical medicine, medicine.anatomical_structure, Opioid induced constipation, Complementary and alternative medicine, Oral administration, Statistical significance, Internal medicine, 021105 building & construction, medicine, Polyethylene glycol electrolyte powder, medicine.symptom, business
Abstract: Objectives To observe the clinical effect on opioid-induced constipation of liver stagnation and spleen deficiency treated with the ultrasonic penetration of the No.1 constipation herbal formula at Tiānshū (天枢 ST25). Methods A total of 126 patients that were in compliance with the inclusion criteria were randomized into an acupoint group (41 cases), a Chinese medication group (42 cases) and a western medication group (43 cases). In the acupoint group, the ultrasonic penetration of the No.1 constipation herbal formula at bilateral Tiānshū (天枢 ST25) were given. In the Chinese herbal medication group, the No.1 constipation herbal formula was prescribed for oral administration. In the western medication group, polyethylene glycol electrolyte powder was prescribed for oral administration. The treatment was given once a day, for 14 days totally. Before and after treatment, the constipation symptom score, the score of the patient assessment of constipation quality of life (PAC-QOL), the situation of nitric oxide synthetase (NOS) in serum were observed in each group. The safety indicators in the observation included diarrhea, allergic reaction, liver dysfunction, skin lesions, etc. Results A total of 122 cases accomplished the trial. The total effective rate was 82.5% in the acupoint group, 80.48% in the Chinese medication group and 78.04% in the western medication group. The constipation symptoms were all relieved in the three groups, indicating the statistical significance as compared with those before treatment (P Conclusion The ultrasonic penetration of the No.1 constipation herbal formula at Tiānshū (天枢 ST25) is effective on opioid-induced constipation of liver stagnation and spleen deficiency. This therapy achieves the significant therapeutic effect and presents the good compliance in treatment. Hence, it deserves to be further promoted in clinical application.
Published: 2020

15. Broadband Tunable Mid-infrared Plasmon Resonances in Cadmium Oxide Nanocrystals Induced by Size-Dependent Nonstoichiometry

Author: Zeke Liu, Cheng-Jun Sun, Yaxu Zhong, Xingchen Ye, Hoai T Nguyen, Yaroslav Losovyj, Jun Chen, Soojin Jeong, Wanli Ma, Tao Li, Liguang Wang, Ibrahim Shafei, Xinfeng Gao, and Lei Chen
Subjects: Free electron model, Materials science, business.industry, Mechanical Engineering, Doping, Bioengineering, 02 engineering and technology, General Chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Wavelength, chemistry.chemical_compound, Nanocrystal, chemistry, Cadmium oxide, Optoelectronics, General Materials Science, 0210 nano-technology, business, Plasmon, Stoichiometry, Localized surface plasmon
Abstract: A central theme of nanocrystal (NC) research involves synthesis of dimension-controlled NCs and studyof size-dependent scaling laws governing their optical, electrical, magnetic, and thermodynamic properties. Here, we describe the synthesis of monodisperse CdO NCs that exhibit high quality-factor (up to 5.5) mid-infrared (MIR) localized surface plasmon resonances (LSPR) and elucidate the inverse scaling relationship between carrier concentration and NC size. The LSPR wavelength is readily tunable between 2.4 and ∼6.0 μm by controlling the size of CdO NCs. Structural and spectroscopic characterization provide strong evidence that free electrons primarily originate from self-doping due to NC surface-induced nonstoichiometry. The ability to probe and to control NC stoichiometry and intrinsic defects will pave the way toward predictive synthesis of doped NCs with desirable LSPR characteristics.
Published: 2020

16. A Review of Research on Pulsar Candidate Recognition Based on Machine Learning

Author: Cheng Jun Zhang, Xiang Hua Miao, Zhen Hong Shang, Liu Xie, and Wan Min Chen
Subjects: business.industry, Computer science, Gravitational wave, Astrophysics::High Energy Astrophysical Phenomena, Astrophysics::Instrumentation and Methods for Astrophysics, 020206 networking & telecommunications, 02 engineering and technology, Machine learning, computer.software_genre, Sextant (astronomical), law.invention, Identification (information), Neutron star, Pulsar, law, 0202 electrical engineering, electronic engineering, information engineering, General Earth and Planetary Sciences, 020201 artificial intelligence & image processing, Artificial intelligence, business, computer, General Environmental Science
Abstract: The pulsar is a highly magnetized rotating neutron star that provides the first indirect evidence for the existence of gravitational waves and also provides the possibility to reveal extreme phenomena in neutron star astrophysics. Therefore, the identification of pulsars in the universe is a prerequisite for the study of pulsars and gravitational waves. At present, a large number of pulsar searches have produced millions of pulsar candidates. In the face of these large-scale data, if only relying on manual visual classification by experts in related fields, it will be a huge project. Since the emergence of machine learning, its theory and technology have become increasingly mature, and has been successfully applied to astronomical research fields such as pulsar candidate screening. This paper introduces the related machine learning theory of pulsar candidate recognition firstly, and then reviews the research status of pulsar candidate recognition based on machine learning in recent years. Finally, we discuss and prospect the identification of pulsars in the future.
Published: 2020

17. An Improved Initialization Method for Monocular Visual-Inertial SLAM

Author: Zhang Liyan, Chen Qihong, and Cheng Jun
Subjects: Monocular, Inertial frame of reference, initialization, TK7800-8360, business.industry, Computer science, Computer Networks and Communications, Initialization, VI-SLAM, localization, optimization, Hardware and Architecture, Control and Systems Engineering, Signal Processing, Computer vision, Artificial intelligence, Electrical and Electronic Engineering, Electronics, business, automotive_engineering
Abstract: In the aim of improving the positioning accuracy of the monocular visual-inertial simultaneous localization and mapping (VI-SLAM) system, an improved initialization method with faster convergence is proposed. This approach is classified into three parts: Firstly, in the initial stage, the pure vision measurement model of ORB-SLAM is employed to make all the variables visible. Secondly, the frequency of the IMU and camera was aligned by IMU pre-integration technology. Thirdly, an improved iterative method is put forward for estimating the initial parameters of IMU faster. The estimation of IMU initial parameters is divided into several simpler sub-problems, containing direction refinement gravity estimation, gyroscope deviation estimation, accelerometer bias, and scale estimation. The experimental results on the self-built robot platform show that our method can up-regulate the initialization convergence speed, simultaneously improve the positioning accuracy of the entire VI-SLAM system.
Published: 2021

18. Prospective Explore of Clinical-Pathological Shrinkage Modes After Neoadjuvant Therapy in Breast Cancer

Author: Tong Zhao, Cheng-Jun Xu, Zhao-Peng Zhang, Zhao Bi, Peng-fei Qiu, Yong-Sheng Wang, and Peng Chen
Subjects: Oncology, medicine.medical_specialty, Breast cancer, business.industry, medicine.medical_treatment, Internal medicine, Medicine, business, medicine.disease, Pathological, Neoadjuvant therapy, Shrinkage
Abstract: Purpose: The aim was to explore the clinical-pathological shrinkage modes which oriented by breast conserving surgery (BCS) purpose after neoadjuvant therapy (NAT) using three-dimensional (3D) MRI and pathology reconstruction, in order to guide the individualized selection of BCS candidates and scope of resection after NAT. Methods: From April 2014 to 2018, 104 breast cancer patients underwent operation after NAT were included in this prospective study. All patients underwent MRI examinations before and after NAT. Breast residual tumors were prepared with sub-serial section. The 3D MRI and pathology models were reconstructed with 3D-DOCTOR software. The association and correlation between 3D MRI and pathology models were assessed. The traditional shrinkage modes included the surgical pathology complete response, solitary lesions without surrounding lesions, multinodular lesions, solitary lesions with adjacent spotty lesions and diffuse lesions. Combined with the MD Anderson Cancer Center BCS indications after NAT and traditional shrinkage modes, we derived clinical-pathological shrinkage modes which oriented by BCS purpose: clinical pathological-concentric shrinkage modes (CP-CSM) and clinical pathological-non concentric shrinkage modes (CP-NCSM). The CP-CSM means the longest diameter of residual tumor was less than 50% and ≤2cm in comparison with the primary tumor before NAT. Other shrinkage modes were classified as CP-NCSM. Univariate and multivariate logistic regression analysis was conducted to identify the independent predictive factors of clinical-pathological shrinkage modes. A nomogram was developed based on variables in the final model with pResults: Based on the gold standard of 3D pathology reconstruction model-measured shrinkage modes, the accuracy, sensitivity and specificity of 3D MRI reconstruction for predicting the traditional shrinkage modes were 84.6%, 61.9% and 90.4%, respectively (Kappa value=0.497). The accuracy, sensitivity and specificity of 3D MRI reconstruction in predicting clinical-pathological shrinkage modes were 93.3%, 97.0% and 86.5%, respectively (Kappa value=0.850). Multivariate analysis showed that primary tumor stage (OR=2.059, 95%CI: 1.187-3.574), mammographic malignant calcification (OR=3.424, 95%CI: 1.437-8.161), molecular subtypes (OR=0.530, 95%CI: 0.364-0.772) and nodal down-staging after NAT (OR=0.183, 95%CI: 0.067-0.497) were independent predictors of clinical-pathological shrinkage modes (all pp=0.002). Patients with CP-CSM had a better overall survival and disease-free survival (all pConclusion: The 3D MRI reconstruction after NAT could accurately predict the extent of residual tumor. Combining clinical, imaging, molecular subtypes and NAT efficacy, the nomogram of clinical-pathological shrinkage modes showed sufficient predicting accuracy. And it could help to guide the individualized selection of BCS candidates and scope of resection after NAT, thereby achieve the minimum and effective treatment. However, the applicability of the nomogram still needs to be externally validated. Patients with CP-NCSM after NAT had a worse prognosis.
Published: 2021

19. Serum Albumin Levels are a Predictor of COVID-19 Patient Prognosis: Evidence from a Single Cohort in Chongqing, China

Author: Cheng-jun Xue, Jing Wang, Huan Yang, Yuan Xu, Chang-chun Niu, Xiaoying Li, and Pu Liao
Subjects: medicine.medical_specialty, Lymphocyte, Serum albumin, International Journal of General Medicine, Gastroenterology, Internal medicine, medicine, Hypoalbuminemia, albumin, Original Research, biology, business.industry, SARS-CoV-2, Albumin, COVID-19, General Medicine, medicine.disease, Comorbidity, Transthyretin, medicine.anatomical_structure, liver function, Cohort, biology.protein, Liver function, prognosis, business
Abstract: Yuan Xu,1â 4 Huan Yang,2,5 Jing Wang,6 Xiaoying Li,2,5 Chengjun Xue,6 Changchun Niu,2 Pu Liao1,2 1Chongqing Medical University, Chongqing, 400014, Peopleâs Republic of China; 2Department of Clinical Laboratory, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing, 400014, Peopleâs Republic of China; 3Chongqing College, University of Chinese Academy of Sciences, Chongqing, 400014, Peopleâs Republic of China; 4Department of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, Peopleâs Republic of China; 5Southwest Medical University, Luzhou, 646000, Peopleâs Republic of China; 6Department of Clinical Laboratory, Chongqing Public Health Medical Center, Chongqing, 400036, Peopleâs Republic of ChinaCorrespondence: Pu Liao Email liaopu@ucas.ac.cnBackground: COVID-19 infections are still at pandemic levels globally and there are currently no specific drugs to treat these infections. Previous studies have demonstrated that serum albumin levels were abnormally low in COVID-19 patients and might be used as a prognosis biomarker. Supplemental albumin has been used as an experimental therapeutic method. However, dynamic evaluation of albumin in patients with COVID-19 was limited and whether serum albumin could predict the prognosis of these patients is unknown.Methods: We enrolled 79 COVID-19 patients in the present study and reviewed electronic medical laboratory records. Data was processed using SPSS software (Version 20.0) and correlation analysis was performed between serum albumin and other clinical and laboratory findings.Results: Serum albumin levels were gradually decreased both in severe and non-severe COVID-19 patients. Moreover, 17.7% of the patients presented with hypoalbuminemia at least one time during 3 consecutive weekly time points. The hypoalbuminemia group displayed more severe disease and comorbidity that included fever, fatigue, headache, and dizziness on admission. Moreover, serum albumin levels were positively correlated with lymphocyte and RBC numbers, Hb and prealbumin levels as well as with total T cell numbers and the presence of CD4+ and CD8+ T cells. In contrast, there was a negative correlation with C-reactive protein levels and this was an indicator of patient recovery.Conclusion: Our results demonstrated that hypoalbuminemia was common in COVID-19 patients and its levels were linked to disease severity. Patients with fever, fatigue and headache or dizziness on admission were more likely to experience hypoalbuminemia. Dynamic monitoring of serum albumin is therefore necessary and should be performed during COVID-19 patient treatments as a tool for evaluating the prognosis of COVID-19 infections.Keywords: COVID-19, SARS-CoV-2, albumin, liver function, prognosis
Published: 2021

20. Engineering of Exciton Spatial Distribution in CdS Nanoplatelets

Author: Xiaogang Peng, Haibing Zhang, Zheng Li, Yan Zhang, Jian-Hui Jiang, Cheng-Jun Sun, Yang Ren, Dongdong Chen, and Linjun Wang
Subjects: Diffraction, Materials science, business.industry, Band gap, Mechanical Engineering, Exciton, Bioengineering, 02 engineering and technology, General Chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Cadmium sulfide, chemistry.chemical_compound, chemistry, Transmission electron microscopy, Quantum dot, Optoelectronics, General Materials Science, 0210 nano-technology, business, Spectroscopy, Absorption (electromagnetic radiation)
Abstract: Zinc-blende CdS nanoplatelets with atomically flat and very large {100} basal planes terminated solely by one type of element (either Cd or S atoms) are synthesized. Optical spectroscopy, X-ray diffraction, X-ray absorption, and transmission electron microscopy confirm that the surface structures of newly developed S-terminated CdS nanoplatelets are at least as well-defined as the original Cd-terminated nanoplatelets. Band gaps of the nanoplatelets are found to depend on not only the quantum-confined dimension (thickness) but also the nature of the surface termination. The facet structure dictates the packing of the ligands (carboxylate for Cd-terminated nanoplatelets and alkyl for S-terminated nanoplatelets), which causes a difference in the lattice strain and significantly affects the optical spectral width. Experimental and theoretical results reveal that engineering the exciton spatial distribution by the tailored synthesis of semiconductor nanocrystals with a precisely controlled surface structure is fully possible, which should open a new door for delivering the long-promised potential of semiconductor nanocrystals.
Published: 2021

21. Humanized Deviation and Its Revert in China Based on METLAB

Author: Xiang Cheng-Jun
Subjects: Actuarial science, Higher education, business.industry, Status quo, media_common.quotation_subject, Social issues, Order (exchange), Vocational education, China, business, Psychology, Normality, Qualitative research, media_common
Abstract: In educational practice in Chinese basic, general higher and higher vocational education, there are many cases of deviations from educational humanization. In order to find out the status quo of humanization in Chinese basic, general higher and vocational higher education, and what may cause the deviations, and how to revert it to normality, a survey is carried out via internet. The data from 181 subjects are collected and analyzed through comparative study, aiming to highlight the status quo, the possible causes and countermeasures and suggestions accordingly for the reversion of humanization in Chinese basic, general higher and higher vocational education. To make it more concise, coherent, and persuasive, many METLAB-based charts are used first to illustrate the situations, and some theory-based analyses are employed later as well to further explain the situations. The paper finds that in Chinese basic, general higher and higher vocational education, humanized deviation does exist to different extents, with different causes, thus relevant countermeasures are put forward accordingly. The paper not only serves as a good example in the qualitative study of some social problems which are not easy to do through quantitative study, but also a good way in the study of humanization in other countries.
Published: 2021

22. Design of intelligent parking lot vehicle identification system based on radio frequency technology

Author: Cheng Jun Liu, Kun Jiang, and Qun Yue
Subjects: Identification (information), Software, business.industry, Computer science, Power module, Real-time computing, Parking lot, Radio-frequency identification, Wireless, Radio frequency, business, Automation
Abstract: In order to solve the problem of low recognition accuracy and efficiency in traditional vehicle identification system, an intelligent parking lot vehicle identification system based on radio frequency technology is proposed and designed. The hardware structure of the system includes radio frequency identification module, electronic tag module, power module, wireless trigger circuit to complete the vehicle information identification, transmission and system power supply design. The software part of the system calculates the weight of the RFID tag identification results, so as to obtain the horizontal and vertical coordinates of the vehicle and complete the identification of the vehicle position. The experimental results show that the vehicle position recognition results of the designed system are basically consistent with the actual results, and the recognition time is lower than the traditional vehicle recognition system, and the maximum recognition time of the designed system is less than 0.2S. Therefore, it fully shows that the designed system has good practical application performance.
Published: 2021

23. Direct medical costs of hospitalized patients with idiopathic pulmonary fibrosis in a tertiary hospital in China

Author: Dingyuan Jiang, Ming Zhu, Xiao-Fen Zheng, Cheng-Jun Ban, Chen Wang, Huaping Dai, Shu Zhang, Yan Liu, Bingbing Xie, Yanhong Ren, and Jing Geng
Subjects: Clinical Observations, China, Pediatrics, medicine.medical_specialty, business.industry, Hospitalized patients, lcsh:R, MEDLINE, lcsh:Medicine, Health Care Costs, General Medicine, medicine.disease, Idiopathic Pulmonary Fibrosis, Hospitalization, Tertiary Care Centers, Idiopathic pulmonary fibrosis, medicine, Humans, business, Medical costs, Retrospective Studies
Published: 2020

24. Non-Cirrhotic Liver is Associated with Poor Prognosis of Hepatocellular Carcinoma: A Literature Review

Author: Cheng-Jun Luo, Jianping Gong, Hao Li, Ye-Yu Hu, Hao Wu, Nan Ye, and Yan Liu
Subjects: Liver Cirrhosis, medicine.medical_specialty, Cirrhosis, Carcinoma, Hepatocellular, Epidemiologic Factors, Disease, 030204 cardiovascular system & hematology, Chronic liver disease, Malignancy, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Carcinoma, Biomarkers, Tumor, Humans, neoplasms, Review Articles, business.industry, Fatty liver, Liver Neoplasms, General Medicine, medicine.disease, Prognosis, digestive system diseases, 030220 oncology & carcinogenesis, Hepatocellular carcinoma, Etiology, business
Abstract: Primary hepatocellular carcinoma (HCC) is the fifth most frequently reported malignancy, and it is also the second most common cause of cancer-related deaths worldwide. Although most HCC cases have been reported to develop from cirrhosis, accumulating data suggest that HCC is also closely related to non-cirrhotic chronic liver disease. Traditionally, HCC was thought to develop mostly from cirrhosis; however, an increasing number of reports have found that HCC can develop directly from inflammation without cirrhosis. The incidence of HCC in non-cirrhotic liver (HCC-NCL) is high, especially in developed countries. Studies have found that the most common cause of HCC-NCL is neglected fatty liver disease. This type of HCC has unique clinical characteristics and is closely related to metabolic disorders. Unfortunately, the prevention of HCC-NCL has not received enough attention worldwide, and there is also a lack of specific screening methods and clinical guidelines. This article mainly reviews the etiology, incidence, clinical characteristics, and screening markers of HCC-NCL to improve the understanding and prevention of this disease.
Published: 2019

25. Phase evolution of conversion-type electrode for lithium ion batteries

Author: Eric A. Stach, Dong Su, Ke Sun, Shuang Li, Ronghui Kou, Hong Gan, Jing Li, Fangming Guo, Sooyeon Hwang, Hua Zhou, Aiping Yu, Cheng-Jun Sun, and Zhongwei Chen
Subjects: 0301 basic medicine, Materials science, Passivation, Diffusion barrier, Science, General Physics and Astronomy, chemistry.chemical_element, 02 engineering and technology, Electrolyte, General Biochemistry, Genetics and Molecular Biology, Energy storage, Article, 03 medical and health sciences, Batteries, Phase (matter), lcsh:Science, Multidisciplinary, business.industry, General Chemistry, Current collector, 021001 nanoscience & nanotechnology, 030104 developmental biology, chemistry, Electrode, Optoelectronics, Lithium, lcsh:Q, 0210 nano-technology, business, Transmission electron microscopy
Abstract: Batteries with conversion-type electrodes exhibit higher energy storage density but suffer much severer capacity fading than those with the intercalation-type electrodes. The capacity fading has been considered as the result of contact failure between the active material and the current collector, or the breakdown of solid electrolyte interphase layer. Here, using a combination of synchrotron X-ray absorption spectroscopy and in situ transmission electron microscopy, we investigate the capacity fading issue of conversion-type materials by studying phase evolution of iron oxide composited structure during later-stage cycles, which is found completely different from its initial lithiation. The accumulative internal passivation phase and the surface layer over cycling enforce a rate−limiting diffusion barrier for the electron transport, which is responsible for the capacity degradation and poor rate capability. This work directly links the performance with the microscopic phase evolution in cycled electrode materials and provides insights into designing conversion-type electrode materials for applications., Conversion electrodes possess high energy density but suffer a rapid capacity loss over cycling compared to their intercalation equivalents. Here the authors reveal the microscopic origin of the fading behavior, showing that the formation and augmentation of passivation layers are responsible.
Published: 2019

26. A Large Chinese Text Dataset in the Wild

Author: Tai-Ling Yuan, Zhe Zhu, Kun Xu, Tai-Jiang Mu, Shi-Min Hu, and Cheng-Jun Li
Subjects: Source code, business.industry, Computer science, media_common.quotation_subject, Deep learning, 020207 software engineering, Character encoding, 02 engineering and technology, Optical character recognition, computer.software_genre, Computer Science Applications, Theoretical Computer Science, Character (mathematics), Computational Theory and Mathematics, Hardware and Architecture, Minimum bounding box, 0202 electrical engineering, electronic engineering, information engineering, Artificial intelligence, Chinese characters, Line (text file), business, computer, Software, Natural language processing, media_common
Abstract: In this paper, we introduce a very large Chinese text dataset in the wild. While optical character recognition (OCR) in document images is well studied and many commercial tools are available, the detection and recognition of text in natural images is still a challenging problem, especially for some more complicated character sets such as Chinese text. Lack of training data has always been a problem, especially for deep learning methods which require massive training data. In this paper, we provide details of a newly created dataset of Chinese text with about 1 million Chinese characters from 3 850 unique ones annotated by experts in over 30 000 street view images. This is a challenging dataset with good diversity containing planar text, raised text, text under poor illumination, distant text, partially occluded text, etc. For each character, the annotation includes its underlying character, bounding box, and six attributes. The attributes indicate the character’s background complexity, appearance, style, etc. Besides the dataset, we give baseline results using state-of-the-art methods for three tasks: character recognition (top-1 accuracy of 80.5%), character detection (AP of 70.9%), and text line detection (AED of 22.1). The dataset, source code, and trained models are publicly available.
Published: 2019

27. Response of abundance distribution of five species of Quercus to climate change in northern China

Author: Feng Zhang, Xue-Jiao Zhang, Zhiyao Tang, Cheng-Jun Ji, Ming Yue, Mu-Yi Kang, Ren-Qing Wang, and Xian-Ming Gao
Subjects: Generalized linear model, Ecology, business.industry, Abundance (ecology), Generalized additive model, Distribution (economics), Environmental science, Climate change, Plant Science, business, Atmospheric sciences, China, Ecology, Evolution, Behavior and Systematics
Published: 2019

28. Distribution, community structures and species diversity of larch forests in North China

Author: Qiong Cai, Jingyun Fang, Cheng-Jun Ji, Xian-Ming Gao, Wenjing Fang, Feng Zhang, Ming Yue, Zhiyao Tang, Jiang-Ling Zhu, and Wei-Hua Guo
Subjects: Ecology, biology, business.industry, Community structure, North china, Species diversity, Distribution (economics), Plant Science, biology.organism_classification, Geography, Larix kaempferi, Larch forest, Larch, business, Ecology, Evolution, Behavior and Systematics
Published: 2019

29. MA11.01 Development of Novel EGFR Mutant NSCLC Mouse Models and Murine Cell Lines: New Tools for NSCLC Research

Author: Raphael A. Nemenoff, Cheng-Jun Hu, Mary C.M. Weiser-Evans, Lydia R. Heasley, Anh T. Le, and Emily K. Kleczko
Subjects: Pulmonary and Respiratory Medicine, Oncology, business.industry, Mutant, Cancer research, Medicine, business, Murine cell
Published: 2021

30. Implantation of an S-ICD in a Patient with a DDD Pacemaker and Congenitally Corrected Transposition of the Great Arteries

Author: Can-Can Lin, Cheng-Jun Guo, Qiaoyuan Li, Wen-Long Dai, and Yu Zhang
Subjects: lcsh:Diseases of the circulatory (Cardiovascular) system, medicine.medical_specialty, Atrioventricular valve, Ddd pacemaker, Heart disease, Defibrillation, business.industry, medicine.medical_treatment, General Medicine, medicine.disease, pacemaker, Sudden cardiac death, Congenitally corrected transposition, lcsh:RC666-701, Great arteries, subcutaneous implantable cardioverter-defibrillator, Internal medicine, medicine, Cardiology, business, congenitally corrected transposition of the great arteries, Atrioventricular block
Abstract: Subcutaneous implantable cardioverter-defibrillator (S-ICD) therapy has become a viable alternative to conventional transvenous ICD implantation. Patients with congenitally corrected transposition of the great arteries (ccTGA) have a high risk of sudden cardiac death due to malignant arrhythmia. The interaction between the S-ICD system and the transvenous pacemaker system is not fully understood. We report a case of S-ICD implantation in a patient with ccTGA and a DDD pacemaker. The patient was a 30-year-old man with a previously placed pacemaker with diagnoses of congenital heart disease, ccTGA (SLL), left atrioventricular valve insufficiency, and third-degree atrioventricular block. He presented with an out-of-hospital cardiac arrest, and an S-ICD was implanted to prevent sudden cardiac death. Defibrillation checks were performed successfully. We tested the compatibility of the DDD pacemaker with the S-ICD and found that there was no interference between them. In conclusion, an S-ICD system is a reasonable and safe option in patients with ccTGA.
Published: 2021

31. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1

Author: Klionsky, Daniel, Abdel-Aziz, Amal Kamal, Abdelfatah, Sara, Abdellatif, Mahmoud, Abdoli, Asghar, Abel, Steffen, Abeliovich, Hagai, Abildgaard, Marie, Abudu, Yakubu Princely, Acevedo-Arozena, Abraham, Adamopoulos, Iannis, Adeli, Khosrow, Adolph, Timon, Adornetto, Annagrazia, Aflaki, Elma, Agam, Galila, Agarwal, Anupam, Aggarwal, Bharat, Agnello, Maria, Agostinis, Patrizia, Agrewala, Javed, Agrotis, Alexander, Aguilar, Patricia, Ahmad, S Tariq, Ahmed, Zubair, Ahumada-Castro, Ulises, Aits, Sonja, Aizawa, Shu, Akkoc, Yunus, Akoumianaki, Tonia, Akpinar, Hafize Aysin, Al-Abd, Ahmed, Al-Akra, Lina, Al-Gharaibeh, Abeer, Alaoui-Jamali, Moulay, Alberti, Simon, Alcocer-Gómez, Elísabet, Alessandri, Cristiano, Ali, Muhammad, Alim Al-Bari, M Abdul, Aliwaini, Saeb, Alizadeh, Javad, Almacellas, Eugènia, Almasan, Alexandru, Alonso, Alicia, Alonso, Guillermo, Altan-Bonnet, Nihal, Altieri, Dario, Álvarez, Élida, Alves, Sara, Alves Da Costa, Cristine, Alzaharna, Mazen, Amadio, Marialaura, Amantini, Consuelo, Amaral, Cristina, Ambrosio, Susanna, Amer, Amal, Ammanathan, Veena, An, Zhenyi, Andersen, Stig, Andrabi, Shaida, Andrade-Silva, Magaiver, Andres, Allen, Angelini, Sabrina, Ann, David, Anozie, Uche, Ansari, Mohammad, Antas, Pedro, Antebi, Adam, Antón, Zuriñe, Anwar, Tahira, Apetoh, Lionel, Apostolova, Nadezda, Araki, Toshiyuki, Araki, Yasuhiro, Arasaki, Kohei, Araújo, Wagner, Araya, Jun, Arden, Catherine, Arévalo, Maria-Angeles, Arguelles, Sandro, Arias, Esperanza, Arikkath, Jyothi, Arimoto, Hirokazu, Ariosa, Aileen, Armstrong-James, Darius, Arnauné-Pelloquin, Laetitia, Aroca, Angeles, Arroyo, Daniela, Arsov, Ivica, Artero, Rubén, Asaro, Dalia Maria Lucia, Aschner, Michael, Ashrafizadeh, Milad, Ashur-Fabian, Osnat, Atanasov, Atanas, Au, Alicia, Auberger, Patrick, Auner, Holger, Aurelian, Laure, Autelli, Riccardo, Avagliano, Laura, Ávalos, Yenniffer, Aveic, Sanja, Aveleira, Célia Alexandra, Avin-Wittenberg, Tamar, Aydin, Yucel, Ayton, Scott, Ayyadevara, Srinivas, Azzopardi, Maria, Baba, Misuzu, Backer, Jonathan, Backues, Steven, Bae, Dong-Hun, Bae, Ok-Nam, Bae, Soo Han, Baehrecke, Eric, Baek, Ahruem, Baek, Seung-Hoon, Baek, Sung Hee, Bagetta, Giacinto, Bagniewska-Zadworna, Agnieszka, Bai, Hua, Bai, Jie, Bai, Xiyuan, Bai, Yidong, Bairagi, Nandadulal, Baksi, Shounak, Balbi, Teresa, Baldari, Cosima, Balduini, Walter, Ballabio, Andrea, Ballester, Maria, Balazadeh, Salma, Balzan, Rena, Bandopadhyay, Rina, Banerjee, Sreeparna, Banerjee, Sulagna, Bánréti, Ágnes, Bao, Yan, Baptista, Mauricio, Baracca, Alessandra, Barbati, Cristiana, Bargiela, Ariadna, Barilà, Daniela, Barlow, Peter, Barmada, Sami, Barreiro, Esther, Barreto, George, Bartek, Jiri, Bartel, Bonnie, Bartolome, Alberto, Barve, Gaurav, Basagoudanavar, Suresh, Bassham, Diane, Bast, Robert, Basu, Alakananda, Batoko, Henri, Batten, Isabella, Baulieu, Etienne, Baumgarner, Bradley, Bayry, Jagadeesh, Beale, Rupert, Beau, Isabelle, Beaumatin, Florian, Bechara, Luiz, Beck, George, Beers, Michael, Begun, Jakob, Behrends, Christian, Behrens, Georg, Bei, Roberto, Bejarano, Eloy, Bel, Shai, Behl, Christian, Belaid, Amine, Belgareh-Touzé, Naïma, Bellarosa, Cristina, Belleudi, Francesca, Belló Pérez, Melissa, Bello-Morales, Raquel, Beltran, Jackeline Soares de Oliveira, Beltran, Sebastián, Benbrook, Doris Mangiaracina, Bendorius, Mykolas, Benitez, Bruno, Benito-Cuesta, Irene, Bensalem, Julien, Berchtold, Martin, Berezowska, Sabina, Bergamaschi, Daniele, Bergami, Matteo, Bergmann, Andreas, Berliocchi, Laura, Berlioz-Torrent, Clarisse, Bernard, Amélie, Berthoux, Lionel, Besirli, Cagri, Besteiro, Sebastien, Betin, Virginie, Beyaert, Rudi, Bezbradica, Jelena, Bhaskar, Kiran, Bhatia-Kissova, Ingrid, Bhattacharya, Resham, Bhattacharya, Sujoy, Bhattacharyya, Shalmoli, Bhuiyan, Md Shenuarin, Bhutia, Sujit Kumar, Bi, Lanrong, Bi, Xiaolin, Biden, Trevor, Bijian, Krikor, Billes, Viktor, Binart, Nadine, Bincoletto, Claudia, Birgisdottir, Asa, Bjorkoy, Geir, Blanco, Gonzalo, Blas-Garcia, Ana, Blasiak, Janusz, Blomgran, Robert, Blomgren, Klas, Blum, Janice, Boada-Romero, Emilio, Boban, Mirta, Boesze-Battaglia, Kathleen, Boeuf, Philippe, Boland, Barry, Bomont, Pascale, Bonaldo, Paolo, Bonam, Srinivasa Reddy, Bonfili, Laura, Bonifacino, Juan, Boone, Brian, Bootman, Martin, Bordi, Matteo, Borner, Christoph, Bornhauser, Beat, Borthakur, Gautam, Bosch, Jürgen, Bose, Santanu, botana, luis, Botas, Juan, Boulanger, Chantal, Boulton, Michael, Bourdenx, Mathieu, Bourgeois, Benjamin, Bourke, Nollaig, Bousquet, Guilhem, Boya, Patricia, Bozhkov, Peter, Bozi, Luiz, Bozkurt, Tolga, Brackney, Doug, Brandts, Christian, Braun, Ralf, Braus, Gerhard, Bravo-Sagua, Roberto, Bravo-San Pedro, José, Brest, Patrick, Bringer, Marie-Agnès, Briones-Herrera, Alfredo, Broaddus, V Courtney, Brodersen, Peter, Brodsky, Jeffrey, Brody, Steven, Bronson, Paola, Bronstein, Jeff, Brown, Carolyn, Brown, Rhoderick, Brum, Patricia, Brumell, John, Brunetti-Pierri, Nicola, Bruno, Daniele, Bryson-Richardson, Robert, Bucci, Cecilia, Buchrieser, Carmen, Bueno, Marta, Buitrago-Molina, Laura Elisa, Buraschi, Simone, Buch, Shilpa, Buchan, J Ross, Buckingham, Erin, Budak, Hikmet, Budini, Mauricio, Bultynck, Geert, Burada, Florin, Burgoyne, Joseph, Burón, M Isabel, Bustos, Victor, Büttner, Sabrina, Butturini, Elena, Byrd, Aaron, Cabas, Isabel, Cabrera-Benitez, Sandra, Cadwell, Ken, Cai, Jingjing, Cai, Lu, Cai, Qian, Cairó, Montserrat, Calbet, Jose, Caldwell, Guy, Caldwell, Kim, Call, Jarrod, Calvani, Riccardo, Calvo, Ana, Calvo-Rubio Barrera, Miguel, Camara, Niels OS, Camonis, Jacques, Camougrand, Nadine, Campanella, Michelangelo, Campbell, Edward, Campbell-Valois, François-Xavier, Campello, Silvia, Campesi, Ilaria, Campos, Juliane, Camuzard, Olivier, Cancino, Jorge, Candido de Almeida, Danilo, Canesi, Laura, Caniggia, Isabella, Canonico, Barbara, Cantí, Carles, Cao, Bin, Caraglia, Michele, Caramés, Beatriz, Carchman, Evie, Cardenal-Muñoz, Elena, Cardenas, Cesar, Cardenas, Luis, Cardoso, Sandra, Carew, Jennifer, Carle, Georges, Carleton, Gillian, Carloni, Silvia, Carmona-Gutierrez, Didac, Carneiro, Leticia, Carnevali, Oliana, Carosi, Julian, Carra, Serena, Carrier, Alice, Carrier, Lucie, Carroll, Bernadette, Carter, A Brent, Carvalho, Andreia Neves, Casanova, Magali, Casas, Caty, Casas, Josefina, Cassioli, Chiara, Castillo, Eliseo, Castillo, Karen, Castillo-Lluva, Sonia, Castoldi, Francesca, Castori, Marco, Castro, Ariel, Castro-Caldas, Margarida, Castro-Hernandez, Javier, Castro-Obregon, Susana, Catz, Sergio, Cavadas, Claudia, Cavaliere, Federica, Cavallini, Gabriella, Cavinato, Maria, Cayuela, Maria, Cebollada Rica, Paula, Cecarini, Valentina, Cecconi, Francesco, Cechowska-Pasko, Marzanna, Cenci, Simone, Ceperuelo-Mallafré, Victòria, Cerqueira, João, Cerutti, Janete, Cervia, Davide, Cetintas, Vildan Bozok, Cetrullo, Silvia, Chae, Han-Jung, Chagin, Andrei, Chai, Chee-Yin, Chakrabarti, Gopal, Chakrabarti, Oishee, Chakraborty, Tapas, Chakraborty, Trinad, Chami, mounia, Chamilos, Georgios, Chan, David, Chan, Edmond, Chan, Edward, Chan, H.Y. Edwin, Chan, Helen, Chan, Hung, Chan, Matthew, Chan, Yau Sang, Chandra, Partha, Chang, Chih-Peng, Chang, Chunmei, Chang, Hao-Chun, Chang, Kai, Chao, Jie, Chapman, Tracey, Charlet-Berguerand, Nicolas, Chatterjee, Samrat, Chaube, Shail, Chaudhary, Anu, Chauhan, Santosh, Chaum, Edward, Checler, Frédéric, Cheetham, Michael, Chen, Chang-Shi, Chen, Guang-Chao, Chen, Jian-Fu, Chen, Liam, Chen, Leilei, Chen, Lin, Chen, Mingliang, Chen, Mu-Kuan, Chen, Ning, Chen, Quan, Chen, Ruey-Hwa, Chen, Shi, Chen, Wei, Chen, Weiqiang, Chen, Xin-Ming, Chen, Xiong-Wen, Chen, Xu, Chen, Yan, Chen, Ye-Guang, Chen, Yingyu, Chen, Yongqiang, Chen, Yu-Jen, Chen, Yue-Qin, Chen, Zhefan Stephen, Chen, Zhi, Chen, Zhi-Hua, Chen, Zhijian, Chen, Zhixiang, Cheng, Hanhua, Cheng, Jun, Cheng, Shi-Yuan, Cheng, Wei, Cheng, Xiaodong, Cheng, Xiu-Tang, Cheng, Yiyun, Cheng, Zhiyong, Chen, Zhong, Cheong, Heesun, Cheong, Jit Kong, Chernyak, Boris, Cherry, Sara, Cheung, Chi Fai Randy, Cheung, Chun Hei Antonio, Cheung, King-Ho, Chevet, Eric, Chi, Richard, Chiang, Alan Kwok Shing, Chiaradonna, Ferdinando, Chiarelli, Roberto, Chiariello, Mario, Chica, Nathalia, Chiocca, Susanna, Chiong, Mario, Chiou, Shih-Hwa, Chiramel, Abhilash, Chiurchiù, Valerio, Cho, Dong-Hyung, Choe, Seong-Kyu, Choi, Augustine, Choi, Mary, Choudhury, Kamalika Roy, Chow, Norman, Chu, Charleen, Chua, Jason, Chua, John Jia En, Chung, Hyewon, Chung, Kin Pan, Chung, Seockhoon, Chung, So-Hyang, Chung, Yuen-Li, Cianfanelli, Valentina, Ciechomska, Iwona, Cifuentes, Mariana, Cinque, Laura, Cirak, Sebahattin, Cirone, Mara, Clague, Michael, Clarke, Robert, Clementi, Emilio, Coccia, Eliana, Codogno, Patrice, Cohen, Ehud, Cohen, Mickael, Colasanti, Tania, Colasuonno, Fiorella, Colbert, Robert, Colell, Anna, Čolić, Miodrag, Coll, Nuria, Collins, Mark, Colombo, María, Colón-Ramos, Daniel, Combaret, Lydie, Comincini, Sergio, Cominetti, Márcia, Consiglio, Antonella, Conte, Andrea, Conti, Fabrizio, Contu, Viorica Raluca, Cookson, Mark, Coombs, Kevin, Coppens, Isabelle, Corasaniti, Maria Tiziana, Corkery, Dale, Cordes, Nils, Cortese, Katia, Costa, Maria do Carmo, Costantino, Sarah, Costelli, Paola, Coto-Montes, Ana, Crack, Peter, Crespo, Jose, Criollo, Alfredo, Crippa, Valeria, Cristofani, Riccardo, Csizmadia, Tamas, Cuadrado, Antonio, Cui, Bing, Cui, Jun, Cui, Yixian, Cui, Yong, Culetto, Emmanuel, Cumino, Andrea, Cybulsky, Andrey, Czaja, Mark, Czuczwar, Stanislaw, D'Adamo, Stefania, D'Amelio, Marcello, D'Arcangelo, Daniela, D'Lugos, Andrew, D'Orazi, Gabriella, da Silva, James, Dafsari, Hormos Salimi, Dagda, Ruben, Dagdas, Yasin, Daglia, Maria, Dai, Xiaoxia, Dai, Yun, Dai, Yuyuan, Dal Col, Jessica, Dalhaimer, Paul, Dalla Valle, Luisa, Dallenga, Tobias, Dalmasso, Guillaume, Damme, Markus, Dando, Ilaria, Dantuma, Nico, Darling, April, Das, Hiranmoy, Dasarathy, Srinivasan, Dasari, Santosh, Dash, Srikanta, Daumke, Oliver, Dauphinee, Adrian, Davies, Jeffrey, Dávila, Valeria, Davis, Roger, Davis, Tanja, Dayalan Naidu, Sharadha, De Amicis, Francesca, De Bosscher, Karolien, De Felice, Francesca, De Franceschi, Lucia, De Leonibus, Chiara, de Mattos Barbosa, Mayara, De Meyer, Guido, De Milito, Angelo, De Nunzio, Cosimo, De Palma, Clara, De Santi, Mauro, De Virgilio, Claudio, De Zio, Daniela, Debnath, Jayanta, DeBosch, Brian, Decuypere, Jean-Paul, Deehan, Mark, Deflorian, Gianluca, DeGregori, James, Dehay, Benjamin, Del Rio, Gabriel, Delaney, Joe, Delbridge, Lea, Delorme-Axford, Elizabeth, Delpino, M Victoria, Demarchi, Francesca, Dembitz, Vilma, Demers, Nicholas, Deng, Hongbin, Deng, Zhiqiang, Dengjel, Joern, Dent, Paul, Denton, Donna, DePamphilis, Melvin, Der, Channing, Deretic, Vojo, Descoteaux, Albert, Devis, Laura, Devkota, Sushil, Devuyst, Olivier, Dewson, Grant, Dharmasivam, Mahendiran, Dhiman, Rohan, di Bernardo, Diego, Di Cristina, Manlio, Di Domenico, Fabio, Di Fazio, Pietro, Di Fonzo, Alessio, Di Guardo, Giovanni, Di Guglielmo, Gianni, Di Leo, Luca, Di Malta, Chiara, Di Nardo, Alessia, Di Rienzo, Martina, Di Sano, Federica, Diallinas, George, Diao, Jiajie, Diaz-Araya, Guillermo, Díaz-Laviada, Inés, Dickinson, Jared, Diederich, Marc, Dieudé, Mélanie, Dikic, Ivan, Ding, Shiping, Ding, Wen-Xing, Dini, Luciana, Dinić, Jelena, Dinic, Miroslav, Dinkova-Kostova, Albena, Dionne, Marc, Distler, Jörg, Diwan, Abhinav, Dixon, Ian, Djavaheri-Mergny, Mojgan, Dobrinski, Ina, Dobrovinskaya, Oxana, Dobrowolski, Radek, Dobson, Renwick, Đokić, Jelena, Dokmeci Emre, Serap, Donadelli, Massimo, Dong, Bo, Dong, Xiaonan, Dong, Zhiwu, Dorn Ii, Gerald, Dotsch, Volker, Dou, Huan, Dou, Juan, Dowaidar, Moataz, Dridi, Sami, Drucker, Liat, Du, Ailian, Du, Caigan, Du, Guangwei, Du, Hai-Ning, Du, Li-Lin, du Toit, André, Duan, Shao-Bin, Duan, Xiaoqiong, Duarte, Sónia, Dubrovska, Anna, Dunlop, Elaine, Dupont, Nicolas, Durán, Raúl, Dwarakanath, Bilikere, Dyshlovoy, Sergey, Ebrahimi-Fakhari, Darius, Eckhart, Leopold, Edelstein, Charles, Efferth, Thomas, Eftekharpour, Eftekhar, Eichinger, Ludwig, Eid, Nabil, Eisenberg, Tobias, Eissa, N Tony, Eissa, Sanaa, Ejarque, Miriam, El Andaloussi, Abdeljabar, El-Hage, Nazira, El-Naggar, Shahenda, Eleuteri, Anna Maria, El-Shafey, Eman, Elgendy, Mohamed, Eliopoulos, Aristides, Elizalde, María, Elks, Philip, Elsasser, Hans-Peter, Elsherbiny, Eslam, Emerling, Brooke, Emre, N., Eng, Christina, Engedal, Nikolai, Engelbrecht, Anna-Mart, Engelsen, Agnete, Enserink, Jorrit, Escalante, Ricardo, Esclatine, Audrey, Escobar-Henriques, Mafalda, Eskelinen, Eeva-Liisa, Espert, Lucile, Eusebio, Makandjou-Ola, Fabrias, Gemma, Fabrizi, Cinzia, Facchiano, Antonio, Facchiano, Francesco, Fadeel, Bengt, Fader, Claudio, Faesen, Alex, Fairlie, W Douglas, Falcó, Alberto, Falkenburger, Bjorn, Fan, Daping, Fan, Jie, Fan, Yanbo, Fang, Evandro, Fang, Yanshan, Fang, Yognqi, Fanto, Manolis, Farfel-Becker, Tamar, Faure, Mathias, Fazeli, Gholamreza, Fedele, Anthony, Feldman, Arthur, Feng, Du, Feng, Jiachun, Feng, Lifeng, Feng, Yibin, Feng, Yuchen, Feng, Wei, Fenz Araujo, Thais, Ferguson, Thomas, Fernández, Álvaro, Fernandez-Checa, Jose, Fernández-Veledo, Sonia, Fernie, Alisdair, Ferrante, Anthony, Ferraresi, Alessandra, Ferrari, Merari, Ferreira, Julio, Ferro-Novick, Susan, Figueras, Antonio, Filadi, Riccardo, Filigheddu, Nicoletta, Filippi-Chiela, Eduardo, Filomeni, Giuseppe, Fimia, Gian Maria, Fineschi, Vittorio, Finetti, Francesca, Finkbeiner, Steven, Fisher, Edward, Fisher, Paul, Flamigni, Flavio, Fliesler, Steven, Flo, Trude, Florance, Ida, Florey, Oliver, Florio, Tullio, Fodor, Erika, Follo, Carlo, Fon, Edward, Forlino, Antonella, Fornai, Francesco, Fortini, Paola, Fracassi, Anna, Fraldi, Alessandro, Franco, Brunella, Franco, Rodrigo, Franconi, Flavia, Frankel, Lisa, Friedman, Scott, Fröhlich, Leopold, Frühbeck, Gema, Fuentes, Jose, Fujiki, Yukio, Fujita, Naonobu, Fujiwara, Yuuki, Fukuda, Mitsunori, Fulda, Simone, Furic, Luc, Furuya, Norihiko, Fusco, Carmela, Gack, Michaela, Gaffke, Lidia, Galadari, Sehamuddin, Galasso, Alessia, Galindo, Maria, Gallolu Kankanamalage, Sachith, Galluzzi, Lorenzo, Galy, Vincent, Gammoh, Noor, Gan, Boyi, Ganley, Ian, Gao, Feng, Gao, Hui, Gao, Minghui, Gao, Ping, Gao, Shou-Jiang, Gao, Wentao, Gao, Xiaobo, Garcera, Ana, Garcia, Maria Noé, Garcia, Verónica, García-del Portillo, Francisco, Garcia-Escudero, Vega, Garcia-Garcia, Aracely, Garcia-Macia, Marina, García-Moreno, Diana, Garcia-Ruiz, Carmen, García-Sanz, Patricia, Garg, Abhishek, Gargini, Ricardo, Garofalo, Tina, Garry, Robert, Gassen, Nils, Gatica, Damian, Ge, Liang, Ge, Wanzhong, Geiss-Friedlander, Ruth, Gelfi, Cecilia, Genschik, Pascal, Gentle, Ian, Gerbino, Valeria, Gerhardt, Christoph, Germain, Kyla, Germain, Marc, Gewirtz, David, Ghasemipour Afshar, Elham, Ghavami, Saeid, Ghigo, Alessandra, Ghosh, Manosij, Giamas, Georgios, Giampietri, Claudia, Giatromanolaki, Alexandra, Gibson, Gary, Gibson, Spencer, Ginet, Vanessa, Giniger, Edward, Giorgi, Carlotta, Girao, Henrique, Girardin, Stephen, Giridharan, Mridhula, Giuliano, Sandy, Giulivi, Cecilia, Giuriato, Sylvie, Giustiniani, Julien, Gluschko, Alexander, Goder, Veit, Goginashvili, Alexander, Golab, Jakub, Goldstone, David, Golebiewska, Anna, Gomes, Luciana, Gomez, Rodrigo, Gómez-Sánchez, Rubén, Gomez-Puerto, Maria Catalina, Gomez-Sintes, Raquel, Gong, Qingqiu, Goni, Felix, González-Gallego, Javier, Gonzalez-Hernandez, Tomas, Gonzalez-Polo, Rosa, Gonzalez-Reyes, Jose, González-Rodríguez, Patricia, Goping, Ing Swie, Gorbatyuk, Marina, Gorbunov, Nikolai, Görgülü, Kıvanç, Gorojod, Roxana, Gorski, Sharon, Goruppi, Sandro, Gotor, Cecilia, Gottlieb, Roberta, Gozes, Illana, Gozuacik, Devrim, Graef, Martin, Gräler, Markus, Granatiero, Veronica, Grasso, Daniel, Gray, Joshua, Green, Douglas, Greenhough, Alexander, Gregory, Stephen, Griffin, Edward, Grinstaff, Mark, Gros, Frederic, Grose, Charles, Gross, Angelina, Gruber, Florian, Grumati, Paolo, Grune, Tilman, Gu, Xueyan, Guan, Jun-Lin, Guardia, Carlos, Guda, Kishore, Guerra, Flora, Guerri, Consuelo, Guha, Prasun, Guillén, Carlos, Gujar, Shashi, Gukovskaya, Anna, Gukovsky, Ilya, Gunst, Jan, Günther, Andreas, Guntur, Anyonya, Guo, Chuanyong, Guo, Chun, Guo, Hongqing, Guo, Lian-Wang, Guo, Ming, Gupta, Pawan, Gupta, Shashi Kumar, Gupta, Swapnil, Gupta, Veer Bala, Gupta, Vivek, Gustafsson, Asa, Gutterman, David, H B, Ranjitha, Haapasalo, Annakaisa, Haber, James, Hać, Aleksandra, Hadano, Shinji, Hafrén, Anders, Haidar, Mansour, Hall, Belinda, Halldén, Gunnel, Hamacher-Brady, Anne, Hamann, Andrea, Hamasaki, Maho, Han, Weidong, Hansen, Malene, Hanson, Phyllis, Hao, Zijian, Harada, Masaru, Harhaji-Trajkovic, Ljubica, Hariharan, Nirmala, Haroon, Nigil, Harris, James, Hasegawa, Takafumi, Hasima Nagoor, Noor, Haspel, Jeffrey, Haucke, Volker, Hawkins, Wayne, Hay, Bruce, Haynes, Cole, Hayrabedyan, Soren, Hays, Thomas, He, Congcong, He, Qin, He, Rong-Rong, He, You-Wen, He, Yu-Ying, Heakal, Yasser, Heberle, Alexander, Hejtmancik, J Fielding, Helgason, Gudmundur Vignir, Henkel, Vanessa, Herb, Marc, Hergovich, Alexander, Herman-Antosiewicz, Anna, Hernández, Agustín, Hernandez, Carlos, Hernandez-Diaz, Sergio, Hernandez-Gea, Virginia, Herpin, Amaury, Herreros, Judit, Hervás, Javier, Hesselson, Daniel, Hetz, Claudio, Heussler, Volker, Higuchi, Yujiro, Hilfiker, Sabine, Hill, Joseph, Hlavacek, William, Ho, Emmanuel, Ho, Idy, Ho, Philip Wing-Lok, Ho, Shu-Leong, Ho, Wan Yun, Hobbs, G Aaron, Hochstrasser, Mark, Hoet, Peter, Hofius, Daniel, Hofman, Paul, Höhn, Annika, Holmberg, Carina, Hombrebueno, Jose, Yi-Ren Hong, Chang-Won Hong, Hooper, Lora, Hoppe, Thorsten, Horos, Rastislav, Hoshida, Yujin, Hsin, I-Lun, Hsu, Hsin-Yun, Hu, Bing, Hu, Dong, Hu, Li-Fang, Hu, Ming Chang, Hu, Ronggui, Hu, Wei, Hu, Yu-Chen, Hu, Zhuo-Wei, Hua, Fang, Hua, Jinlian, Hua, Yingqi, Huan, Chongmin, Huang, Canhua, Huang, Chuanshu, Huang, Chuanxin, Huang, Chunling, Huang, Haishan, Huang, Kun, Huang, Michael, Huang, Rui, Huang, Shan, Huang, Tianzhi, Huang, Xing, Huang, Yuxiang Jack, Huber, Tobias, Hubert, Virginie, Hubner, Christian, Hughes, Stephanie, Hughes, William, Humbert, Magali, Hummer, Gerhard, Hurley, James, Hussain, Sabah, Hussain, Salik, Hussey, Patrick, Hutabarat, Martina, Hwang, Hui-Yun, Hwang, Seungmin, Ieni, Antonio, Ikeda, Fumiyo, Imagawa, Yusuke, Imai, Yuzuru, Imbriano, Carol, Imoto, Masaya, Inman, Denise, Inoki, Ken, Iovanna, Juan, Iozzo, Renato, Ippolito, Giuseppe, Irazoqui, Javier, Iribarren, Pablo, Ishaq, Mohd, ISHIKAWA, Makoto, Ishimwe, Nestor, Isidoro, Ciro, Ismail, Nahed, Issazadeh-Navikas, Shohreh, Itakura, Eisuke, Ito, Daisuke, Ivankovic, Davor, Ivanova, Saška, Iyer, Anand Krishnan V, Izquierdo, José, Izumi, Masanori, Jäättelä, Marja, Jabir, Majid Sakhi, Jackson, William, Jacobo-Herrera, Nadia, Jacomin, Anne-Claire, Jacquin, Elise, Jadiya, Pooja, Jaeschke, Hartmut, Jagannath, Chinnaswamy, Jakobi, Arjen, Jakobsson, Johan, Janji, Bassam, Jansen-Dürr, Pidder, Jansson, Patric, Jantsch, Jonathan, Januszewski, Sławomir, Jassey, Alagie, Jean, Steve, Jeltsch-David, Hélène, Jendelova, Pavla, Jenny, Andreas, Jensen, Thomas, Jessen, Niels, Jewell, Jenna, Ji, Jing, Jia, Lijun, Jia, Rui, Jiang, Liwen, Jiang, Qing, Jiang, Richeng, Jiang, Teng, Jiang, Xuejun, Jiang, Yu, Jimenez-Sanchez, Maria, Jin, Eun-Jung, Jin, Fengyan, Jin, Hongchuan, Jin, Li, Jin, Luqi, Jin, Meiyan, Jin, Si, Jo, Eun-Kyeong, Joffre, Carine, Johansen, Terje, Johnson, Gail, Johnston, Simon, Jokitalo, Eija, Jolly, Mohit Kumar, Joosten, Leo, Jordan, Joaquin, Joseph, Bertrand, Ju, Dianwen, Ju, Jeong-Sun, Ju, Jingfang, Juárez, Esmeralda, Judith, Delphine, Juhász, Gábor, Jun, Youngsoo, Jung, Chang Hwa, Jung, Sung-Chul, Jung, Yong Keun, Jungbluth, Heinz, Jungverdorben, Johannes, Just, Steffen, Kaarniranta, Kai, Kaasik, Allen, Kabuta, Tomohiro, Kaganovich, Daniel, Kahana, Alon, Kain, Renate, Kajimura, Shinjo, Kalamvoki, Maria, Kalia, Manjula, Kalinowski, Danuta, Kaludercic, Nina, Kalvari, Ioanna, Kaminska, Joanna, Kaminskyy, Vitaliy, Kanamori, Hiromitsu, Kanasaki, Keizo, Kang, Chanhee, Kang, Rui, Kang, Sang Sun, Kaniyappan, Senthilvelrajan, Kanki, Tomotake, Kanneganti, Thirumala-Devi, Kanthasamy, Anumantha, Kanthasamy, Arthi, Kantorow, Marc, Kapuy, Orsolya, Karamouzis, Michalis, Karim, Md Razaul, Karmakar, Parimal, Katare, Rajesh, Kato, Masaru, Kaufmann, Stefan, Kauppinen, Anu, Kaushal, Gur, Kaushik, Susmita, Kawasaki, Kiyoshi, Kazan, Kemal, Ke, Po-Yuan, Keating, Damien, Keber, Ursula, Kehrl, John, Keller, Kate, Keller, Christian, Kemper, Jongsook Kim, Kenific, Candia, Kepp, Oliver, Kermorgant, Stephanie, Kern, Andreas, Ketteler, Robin, Keulers, Tom, Khalfin, Boris, Khalil, Hany, Khambu, Bilon, Khan, Shahid, Khandelwal, Vinoth Kumar Megraj, Khandia, Rekha, Kho, Widuri, Khobrekar, Noopur, Khuansuwan, Sataree, Khundadze, Mukhran, Killackey, Samuel, Kim, Dasol, Kim, Deok Ryong, Kim, Do-Hyung, Kim, Dong-Eun, Kim, Eun Young, Kim, Eun-Kyoung, Kim, Hak-Rim, Kim, Hee-Sik, Kim, Hyung Ryong, Kim, Jeong Hun, Kim, Jin Kyung, Kim, Jin-Hoi, Kim, Joungmok, Kim, Ju Hwan, Kim, Keun Il, Kim, Peter, Kim, Seong-Jun, Kimball, Scot, Kimchi, 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Kazuyuki, Kuenen, Sabine, Kuerschner, Lars, Kukar, Thomas, Kumar, Ajay, Kumar, Ashok, Kumar, Deepak, Kumar, Dhiraj, Kumar, Sharad, Kume, Shinji, Kumsta, Caroline, Kundu, Chanakya, Kundu, Mondira, Kunnumakkara, Ajaikumar, Kurgan, Lukasz, Kutateladze, Tatiana, Kutlu, Ozlem, Kwak, SeongAe, Kwon, Ho Jeong, Kwon, Taeg Kyu, Kwon, Yong Tae, Kyrmizi, Irene, La Spada, Albert, Labonté, Patrick, Ladoire, Sylvain, Laface, Ilaria, Lafont, Frank, Lagace, Diane, Lahiri, Vikramjit, Lai, Zhibing, Laird, Angela, Lakkaraju, Aparna, Lamark, Trond, Lan, Sheng-Hui, Landajuela, Ane, Lane, Darius, Lane, Jon, Lang, Charles, Lange, Carsten, Langel, Ülo, Langer, Rupert, Lapaquette, Pierre, Laporte, Jocelyn, LaRusso, Nicholas, Lastres-Becker, Isabel, Lau, Wilson Chun Yu, Laurie, Gordon, Lavandero, Sergio, Law, Betty Yuen Kwan, Law, Helen Ka-wai, Layfield, Rob, Le, Weidong, Le Stunff, Herve, Leary, Alexandre, Lebrun, Jean-Jacques, Leck, Lionel, Leduc-Gaudet, Jean-Philippe, Lee, Changwook, Lee, Chung-Pei, Lee, 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Chengyu, Liang, Qiangrong, Liang, Weicheng, Liang, Yongheng, Liang, YongTian, Liao, Guanghong, Liao, Lujian, Liao, Mingzhi, Liao, Yung-Feng, Librizzi, Mariangela, Lie, Pearl, Lilly, Mary, Lim, Hyunjung, Lima, Thania, Limana, Federica, Lin, Chao, Lin, Chih-Wen, Lin, Dar-Shong, Lin, Fu-Cheng, Lin, Jiandie, Lin, Kurt, Lin, Kwang-Huei, Lin, Liang-Tzung, LIN, Pei-Hui, Lin, Qiong, Lin, Shaofeng, Lin, Su-Ju, Lin, Wenyu, Lin, Xueying, Lin, Yao-Xin, Lin, Yee-Shin, Linden, Rafael, Lindner, Paula, Ling, Shuo-Chien, Lingor, Paul, Linnemann, Amelia, Liou, Yih-Cherng, Lipinski, Marta, Lipovšek, Saška, Lira, Vitor, Lisiak, Natalia, Liton, Paloma, Liu, Chao, Liu, Ching-Hsuan, Liu, Chun-Feng, Liu, Cui Hua, Liu, Fang, Liu, Hao, Liu, Hsiao-Sheng, Liu, Hua-feng, Liu, Huifang, Liu, Jia, Liu, Jing, Liu, Julia, Liu, Leyuan, Liu, Longhua, Liu, Meilian, Liu, Qin, Liu, Wei, Liu, Wende, Liu, Xiao-Hong, Liu, Xiaodong, Liu, Xingguo, Liu, Xu, Liu, Xuedong, Liu, Yanfen, Liu, Yang, Liu, Yueyang, Liu, Yule, 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Elena, Uchiyama, Yasuo, Ugun-Klusek, Aslihan, Uhlig, Holm, Ułamek-Kozioł, Marzena, Ulasov, Ilya, Umekawa, Midori, Ungermann, Christian, Unno, Rei, Urbe, Sylvie, Uribe-Carretero, Elisabet, Üstün, Suayib, Uversky, Vladimir, Vaccari, Thomas, Vaccaro, Maria, Vahsen, Björn, Vakifahmetoglu-Norberg, Helin, Valdor, Rut, Valente, Maria, Valko, Ayelén, Vallee, Richard, Valverde, Angela, Van Den Berghe, Greet, van der Veen, Stijn, Van Kaer, Luc, van Loosdregt, Jorg, van Wijk, Sjoerd, Vandenberghe, Wim, Vanhorebeek, Ilse, Vannier-Santos, Marcos, Vannini, Nicola, Vanrell, M Cristina, Vantaggiato, Chiara, Varano, Gabriele, Varela-Nieto, Isabel, Varga, Máté, Vasconcelos, M Helena, Vats, Somya, Vavvas, Demetrios, Vega-Naredo, Ignacio, Vega-Rubin-de-Celis, Silvia, Velasco, Guillermo, Velázquez, Ariadna, Vellai, Tibor, Vellenga, Edo, Velotti, Francesca, Verdier, Mireille, Verginis, Panayotis, Vergne, Isabelle, Verkade, Paul, Verma, Manish, Verstreken, Patrik, Vervliet, Tim, Vervoorts, Jörg, Vessoni, Alexandre, Victor, Victor, Vidal, Michel, Vidoni, Chiara, Vieira, Otilia, Vierstra, Richard, Viganó, Sonia, Vihinen, Helena, Vijayan, Vinoy, Vila, Miquel, Vilar, Marçal, Villalba, José, Villalobo, Antonio, Villarejo-Zori, Beatriz, Villarroya, Francesc, Villarroya, Joan, Vincent, Olivier, Vindis, Cecile, Viret, Christophe, Viscomi, Maria Teresa, Visnjic, Dora, Vitale, Ilio, Vocadlo, David, Voitsekhovskaja, Olga, Volonté, Cinzia, Volta, Mattia, Vomero, Marta, Von Haefen, Clarissa, Vooijs, Marc, Voos, Wolfgang, Vucicevic, Ljubica, Wade-Martins, Richard, Waguri, Satoshi, Waite, Kenrick, Wakatsuki, Shuji, Walker, David, Walker, Mark, Walker, Simon, Walter, Jochen, Wandosell, Francisco, Wang, Bo, Wang, Chao-Yung, Wang, Chen, Wang, Chenran, Wang, Chenwei, Wang, Cun-Yu, Wang, Dong, Wang, Fangyang, Wang, Feng, Wang, Fengming, Wang, Guansong, Wang, Han, Wang, Hao, Wang, Hexiang, Wang, Hong-Gang, Wang, Jianrong, Wang, Jigang, Wang, Jiou, Wang, Jundong, Wang, Kui, Wang, Lianrong, Wang, Liming, Wang, Maggie Haitian, Wang, Meiqing, Wang, Nanbu, Wang, PengWei, Wang, PeiPei, Wang, Ping, Wang, Qing Jun, Wang, Qing, Wang, Qing Kenneth, Wang, Qiong, Wang, Wen-Tao, Wang, Wuyang, Wang, Xinnan, Wang, Xuejun, Wang, Yan, Wang, Yanchang, Wang, Yanzhuang, Wang, Yen-Yun, Wang, Yihua, Wang, Yipeng, Wang, Yu, wang, yuqi, Wang, Zhe, Wang, Zhenyu, Wang, Zhouguang, Warnes, Gary, Warnsmann, Verena, Watada, Hirotaka, Watanabe, Eizo, Watchon, Maxinne, Wawrzyńska, Anna, Weaver, Timothy, Wegrzyn, Grzegorz, Wehman, Ann, Wei, Huafeng, Wei, Lei, Wei, Taotao, Wei, Yongjie, Weiergräber, Oliver, Weihl, Conrad, Weindl, Günther, Weiskirchen, Ralf, Wells, Alan, Wen, Runxia, Wen, Xin, Werner, Antonia, Weykopf, Beatrice, Wheatley, Sally, Whitton, J Lindsay, Whitworth, Alexander, Wiktorska, Katarzyna, Wildenberg, Manon, Wileman, Tom, Wilkinson, Simon, Willbold, Dieter, Williams, Brett, Williams, Robin, Williams, Roger, Williamson, Peter, Wilson, Richard, Winner, Beate, Winsor, Nathaniel, Witkin, Steven, Wodrich, Harald, Woehlbier, Ute, Wollert, Thomas, Wong, Esther, Wong, Jack Ho, Wong, Richard, Wong, Vincent Kam Wai, Wong, W Wei-Lynn, Wu, An-Guo, Wu, Chengbiao, Wu, Jian, Wu, Junfang, Wu, Kenneth, Wu, Min, Wu, Shan-Ying, Wu, Shengzhou, Wu, Shu-Yan, Wu, Shufang, Wu, William, Wu, Xiaohong, Wu, Xiaoqing, Wu, Yao-Wen, Wu, Yihua, Xavier, Ramnik, Xia, Hongguang, Xia, Lixin, Xia, Zhengyuan, Xiang, Ge, Xiang, Jin, Xiang, Mingliang, Xiang, Wei, Xiao, Bin, Xiao, Guozhi, Xiao, Hengyi, Xiao, Hong-tao, Xiao, Jian, Xiao, Lan, Xiao, Shi, Xiao, Yin, Xie, Baoming, Xie, Chuan-Ming, Xie, Min, Xie, Yuxiang, Xie, Zhiping, Xie, Zhonglin, Xilouri, Maria, Xu, Congfeng, Xu, En, Xu, Haoxing, Xu, Jing, Xu, Jinrong, Xu, Liang, Xu, Wen Wen, Xu, Xiulong, Xue, Yu, Yakhine-Diop, Sokhna, Yamaguchi, Masamitsu, Yamaguchi, Osamu, Yamamoto, Ai, Yamashina, Shunhei, Yan, Shengmin, Yan, Shian-Jang, Yan, Zhen, Yanagi, Yasuo, Yang, Chuanbin, Yang, Dun-Sheng, Yang, Huan, Yang, Huang-Tian, Yang, Hui, Yang, Jin-Ming, Yang, Jing, Yang, Jingyu, Yang, Ling, Yang, Liu, Yang, Ming, Yang, Pei-Ming, Yang, Qian, Yang, Seungwon, Yang, Shu, Yang, Shun-Fa, Yang, Wannian, Yang, Wei Yuan, Yang, Xiaoyong, Yang, Xuesong, Yang, Yi, Yang, Ying, Yao, Honghong, Yao, Shenggen, Yao, Xiaoqiang, Yao, Yong-Gang, Yao, Yong-Ming, Yasui, Takahiro, Yazdankhah, Meysam, Yen, Paul, Yi, Cong, Yin, Xiao-Ming, Yin, Yanhai, Yin, Zhangyuan, Yin, Ziyi, Ying, Meidan, Ying, Zheng, Yip, Calvin, Yiu, Stephanie Pei Tung, Yoo, Young, Yoshida, Kiyotsugu, Yoshii, Saori, Yoshimori, Tamotsu, Yousefi, Bahman, Yu, Boxuan, Yu, Haiyang, Yu, Jun, Yu, Li, Yu, Ming-Lung, Yu, Seong-Woon, Yu, Victor, Yu, W Haung, Yu, Zhengping, Yu, Zhou, Yuan, Junying, Yuan, Ling-Qing, Yuan, Shilin, Yuan, Shyng-Shiou, Yuan, Yanggang, Yuan, Zengqiang, Yue, Jianbo, Yue, Zhenyu, Yun, Jeanho, Yung, Raymond, Zacks, David, Zaffagnini, Gabriele, Zambelli, Vanessa, Zanella, Isabella, Zang, Qun, Zanivan, Sara, Zappavigna, Silvia, Zaragoza, Pilar, Zarbalis, Konstantinos, Zarebkohan, Amir, Zarrouk, Amira, Zeitlin, Scott, Zeng, Jialiu, Zeng, Ju-deng, Žerovnik, Eva, Zhan, Lixuan, Zhang, Bin, Zhang, Donna, Zhang, Hanlin, Zhang, Hong, Zhang, Honghe, Zhang, Huafeng, Zhang, Huaye, Zhang, Hui, Zhang, Hui-Ling, Zhang, Jianbin, Zhang, Jianhua, Zhang, Jing-Pu, Zhang, Kalin, Zhang, Leshuai, Zhang, Lin, Zhang, Lisheng, Zhang, Lu, Zhang, Luoying, Zhang, Menghuan, Zhang, Peng, Zhang, Sheng, Zhang, Wei, Zhang, Xiangnan, Zhang, Xiao-Wei, Zhang, Xiaolei, Zhang, Xiaoyan, Zhang, Xin, Zhang, Xinxin, Zhang, Xu Dong, Zhang, Yang, Zhang, Yanjin, Zhang, Yi, Zhang, Ying-Dong, Zhang, Yingmei, Zhang, Yuan-Yuan, Zhang, Yuchen, Zhang, Zhe, Zhang, Zhengguang, Zhang, Zhibing, Zhang, Zhihai, Zhang, Zhiyong, Zhang, Zili, Zhao, Haobin, Zhao, Lei, Zhao, Shuang, Zhao, Tongbiao, Zhao, Xiao-Fan, Zhao, Ying, Zhao, Yongchao, Zhao, Yongliang, Zhao, Yuting, Zheng, Guoping, Zheng, Kai, Zheng, Ling, Zheng, Shizhong, Zheng, Xi-Long, Zheng, Yi, Zheng, Zu-Guo, Zhivotovsky, Boris, Zhong, Qing, Zhou, Ao, Zhou, Ben, Zhou, Cefan, ZHOU, Gang, Zhou, Hao, Zhou, Hong, Zhou, Hongbo, Zhou, Jie, Zhou, Jing, Zhou, Jiyong, Zhou, Kailiang, Zhou, Rongjia, Zhou, Xu-jie, Zhou, Yanshuang, Zhou, Yinghong, Zhou, Yubin, Zhou, Zheng-Yu, Zhou, Zhou, Zhu, Binglin, Zhu, Changlian, Zhu, Guo-Qing, Zhu, Haining, Zhu, Hongxin, Zhu, Hua, Zhu, Wei-Guo, Zhu, Yanping, Zhu, Yushan, Zhuang, Haixia, Zhuang, Xiaohong, Zientara-Rytter, Katarzyna, Zimmermann, Christine, Ziviani, Elena, Zoladek, Teresa, Zong, Wei-Xing, Zorov, Dmitry, Zorzano, Antonio, Zou, Weiping, Zou, Zhen, Zou, Zhengzhi, Zuryn, Steven, Zwerschke, Werner, Brand-Saberi, Beate, Dong, X Charlie, Kenchappa, Chandra Shekar, Li, Zuguo, Lin, Yong, Oshima, Shigeru, Rong, Yueguang, Sluimer, Judith, Stallings, Christina, Tong, Chun-Kit, Ahmad, S. Tariq, Alim Al-Bari, M. Abdul, Bechara, Luiz R.G., Behrens, Georg M.N., Bhuiyan, Md. Shenuarin, Broaddus, V. Courtney, Buchan, J. Ross, Burón, M. Isabel, Carter, A. Brent, Chan, Matthew T.V., Choi, Augustine M.K., D’Adamo, Stefania, D’Amelio, Marcello, D’Arcangelo, Daniela, D’Lugos, Andrew, D’Orazi, Gabriella, De Meyer, Guido R.Y., Delpino, M. Victoria, Distler, Jörg H.W., Dixon, Ian M.C., Dobson, Renwick C.J., 2nd Dorn, Gerald, Eissa, N. Tony, Engelsen, Agnete S.T., Fairlie, W. Douglas, Ferreira, Julio C.B., H.B., Ranjitha, Hanson, Phyllis I., Hejtmancik, J. Fielding, Ho, Idy H.T., Hobbs, G. Aaron, Hoet, Peter H.M., Huang, Michael L.H., Iyer, Anand Krishnan V., Johnson, Gail V.W., Joosten, Leo A.B., Karim, Md. Razaul, Kaufmann, Stefan H.E., Ko, Ben C.B., Leck, Lionel Y.W., Lima, Thania R.R., Livingston, J. Andrew, Martin, Alexandre P.J., Montes, L. Ruth, Murphy, J. Patrick, Ng, Charlene C.W., Nicolao, M. Celeste, O’Donovan, Tracey, O’Leary, Seónadh, O’Rourke, Eyleen, O’Sullivan, Mary, O’Sullivan, Timothy, Omary, M. Bishr, Pereira, Gustavo J.S., Ratnayaka, J. Arjuna, Riazuddin, S. Amer, Rouschop, Kasper M.A., Sanderson, J. Thomas, Scaglione, K. Matthew, Schapira, Anthony H.V., Scovassi, A. Ivana, St. Clair, Daret, Sunahara, Karen K.S., Symons, J. David, Triola, Gemma, van Wijk, Sjoerd J.L., Vanrell, M. Cristina, Vasconcelos, M. Helena, Whitton, J. Lindsay, Williams, Robin S.B., Wong, W. Wei-Lynn, Wu, William K.K., Yakhine-Diop, Sokhna M.S., Yu, W. Haung, Zhang, Kalin Y.B., Dong, X. Charlie, Ain Shams University [ASU], Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University [JGU], Medical University Graz, Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)], Institut Pasteur d'Iran, Leibniz Institute of Plant Biochemistry [IPB], The University of Texas M.D. Anderson Cancer Center [Houston], Institut de pharmacologie moléculaire et cellulaire [IPMC], Lipides - Nutrition - Cancer [Dijon - U1231] [LNC], Centre méditerranéen de médecine moléculaire [C3M], Institut de Biologie Valrose [IBV], Petites Molécules de neuroprotection, neurorégénération et remyélinisation, Signalisation Hormonale, Physiopathologie Endocrinienne et Métabolique, Institut Cochin [IC UM3 (UMR 8104 / U1016)], Institut NeuroMyoGène [INMG], Paris-Centre de Recherche Cardiovasculaire [PARCC (UMR_S 970/ U970)], Marqueurs cardiovasculaires en situation de stress [MASCOT (UMR_S_942 / U942)], Institut de Recherche sur le Cancer et le Vieillissement [IRCAN], Centre de Recherche en Cancérologie de Marseille [CRCM], Centre for Integrative Biology - CBI [Inserm U964 - CNRS UMR7104 - IGBMC], Oncogenesis, Stress, Signaling [OSS], Institut Necker Enfants-Malades [INEM - UM 111 (UMR 8253 / U1151)], Institut de Biologie Intégrative de la Cellule [I2BC], Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte [M2iSH], Centre de Recherches en Cancérologie de Toulouse [CRCT], Physiopathologie et traitement des maladies du foie, Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL], Institut de Génétique et de Biologie Moléculaire et Cellulaire [IGBMC], Laboratoire Bio-PeroxIL. Biochimie du peroxysome, inflammation et métabolisme lipidique [Dijon] [BIO-PEROXIL], Centre de recherche sur l'Inflammation [CRI (UMR_S_1149 / ERL_8252 / U1149)], Unité de génétique et biologie des cancers [U830], Laboratoire d'Optique et Biosciences [LOB], Institut des Maladies Métaboliques et Casdiovasculaires [UPS/Inserm U1297 - I2MC], Différenciation et communication neuronale et neuroendocrine [DC2N], Institut de Recherche en Cancérologie de Montpellier [IRCM - U1194 Inserm - UM], Centre d'Immunologie de Marseille - Luminy [CIML], Physiopathologie et imagerie des troubles neurologiques [PhIND], Laboratory of Fundamental and Applied Bioenergetics = Laboratoire de bioénergétique fondamentale et appliquée [LBFA], Imagine - Institut des maladies génétiques (IHU) [Imagine - U1163], Institut Mondor de Recherche Biomédicale [IMRB], Franco-czech Laboratory for clinical research on obesity, University of Michigan [Ann Arbor], University of Michigan System, Institut de pharmacologie moléculaire et cellulaire (IPMC), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Université Côte d'Azur (UCA), Lipides - Nutrition - Cancer [Dijon - U1231] (LNC), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Centre méditerranéen de médecine moléculaire (C3M), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA), Institut de Biologie Valrose (IBV), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Sud - Paris 11 (UP11), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP), Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Nutrition, Métabolisme, Aquaculture (NuMéA), Université de Pau et des Pays de l'Adour (UPPA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut NeuroMyoGène (INMG), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Paris-Centre de Recherche Cardiovasculaire (PARCC - UMR-S U970), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Institut de Recherche sur le Cancer et le Vieillissement (IRCAN), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre de Recherche en Cancérologie de Marseille (CRCM), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Aix Marseille Université (AMU), Centre for Integrative Biology - CBI (Inserm U964 - CNRS UMR7104 - IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institute of genetics and molecular and cellular biology-Centre National de la Recherche Scientifique (CNRS), Chemistry, Oncogenesis, Stress and Signaling (COSS), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-CRLCC Eugène Marquis (CRLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Necker Enfants-Malades (INEM - UM 111 (UMR 8253 / U1151)), Unité de Nutrition Humaine (UNH), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte (M2iSH), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre de Recherche en Nutrition Humaine d'Auvergne (CRNH d'Auvergne)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Institut des Maladies Neurodégénératives [Bordeaux] (IMN), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Centre International de Recherche en Infectiologie - UMR (CIRI), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherches en Cancérologie de Toulouse (CRCT), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physiologie et Génomique des Poissons (LPGP), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Laboratoire Bio-PeroxIL. Biochimie du peroxysome, inflammation et métabolisme lipidique [Dijon] (BIO-PEROXIL), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre de recherche sur l'Inflammation (CRI (UMR_S_1149 / ERL_8252 / U1149)), Institut Jean-Pierre Bourgin (IJPB), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Unité de génétique et biologie des cancers (U830), Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire d'Optique et Biosciences (LOB), École polytechnique (X)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Différenciation et communication neuronale et neuroendocrine (DC2N), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Physiopathologie et imagerie des troubles neurologiques (PhIND), Université de Caen Normandie (UNICAEN), Laboratory of Fundamental and Applied Bioenergetics = Laboratoire de bioénergétique fondamentale et appliquée (LBFA), Université Grenoble Alpes (UGA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Epithelial biology and disease - Liliane Bettencourt Chair of Developmental Biology (Equipe Inserm U1163), Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Biomécanique cellulaire et respiratoire (BCR), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS), Charles University [Prague]-Institut National de la Santé et de la Recherche Médicale (INSERM), This work was supported by the National Institute of General Medical Sciences [GM131919]., Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM), Marqueurs cardiovasculaires en situation de stress (MASCOT (UMR_S_942 / U942)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Université Sorbonne Paris Nord, Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Physiopathologie des Adaptations Nutritionnelles (PhAN), Université de Nantes (UN)-Institut National de la Recherche Agronomique (INRA), Département Plateforme (PF I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut Gustave Roussy (IGR), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Chinese Academy of Medical Sciences [Suzhou, Chine] (CAMS), Karolinska Institutet [Stockholm], Karolinska University Hospital [Stockholm], Department of Women's and Children's Health [Stockholm, Sweden], Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École polytechnique (X), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, FHU OncoAge - Pathologies liées à l’âge [CHU Nice] (OncoAge), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Institut de Pharmacologie Moléculaire et Cellulaire [UNIV Côte d'Azur] (UPMC), Institut Universitaire du Cancer de Toulouse - Oncopole (IUCT Oncopole - UMR 1037), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM), Life Sciences Institute [Ann Arbor, MI, USA], University of Michigan System-University of Michigan System, European Institute of Oncology IRCCS [Milan, Italy] (EIO), Ain Shams University (ASU), Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University (JGU), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Réseau International des Instituts Pasteur (RIIP), Leibniz Institute of Plant Biochemistry (IPB), Hebrew University of Jerusalem, Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Agro Dijon, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Paris-Centre de Recherche Cardiovasculaire (PARCC (UMR_S 970/ U970)), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Oncogenesis, Stress, Signaling (OSS), Institut des Maladies Métaboliques et Casdiovasculaires (UPS/Inserm U1297 - I2MC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Charles University [Prague] (CU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Klionsky, D. 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G., Puertollano, R., Puglielli, L., Pulinilkunnil, T., Puri, D., Puri, R., Puyal, J., Qi, X., Qi, Y., Qian, W., Qiang, L., Qiu, Y., Quadrilatero, J., Quarleri, J., Raben, N., Rabinowich, H., Ragona, D., Ragusa, M. J., Rahimi, N., Rahmati, M., Raia, V., Raimundo, N., Rajasekaran, N. -S., Ramachandra Rao, S., Rami, A., Ramirez-Pardo, I., Ramsden, D. B., Randow, F., Rangarajan, P. N., Ranieri, D., Rao, H., Rao, L., Rao, R., Rathore, S., Ratnayaka, J. A., Ratovitski, E. A., Ravanan, P., Ravegnini, G., Ray, S. K., Razani, B., Rebecca, V., Reggiori, F., Regnier-Vigouroux, A., Reichert, A. S., Reigada, D., Reiling, J. H., Rein, T., Reipert, S., Rekha, R. S., Ren, H., Ren, J., Ren, W., Renault, T., Renga, G., Reue, K., Rewitz, K., Ribeiro de Andrade Ramos, B., Riazuddin, S. A., Ribeiro-Rodrigues, T. M., Ricci, J. -E., Ricci, R., Riccio, V., Richardson, D. R., Rikihisa, Y., Risbud, M. V., Risueno, R. M., Ritis, K., Rizza, S., Rizzuto, R., Roberts, H. C., Roberts, L. D., Robinson, K. J., Roccheri, M. C., Rocchi, S., Rodney, G. G., Rodrigues, T., Rodrigues Silva, V. R., Rodriguez, A., Rodriguez-Barrueco, R., Rodriguez-Henche, N., Rodriguez-Rocha, H., Roelofs, J., Rogers, R. S., Rogov, V. V., Rojo, A. I., Rolka, K., Romanello, V., Romani, L., Romano, A., Romano, P. S., Romeo-Guitart, D., Romero, L. C., Romero, M., Roney, J. C., Rongo, C., Roperto, S., Rosenfeldt, M. T., Rosenstiel, P., Rosenwald, A. G., Roth, K. A., Roth, L., Roth, S., Rouschop, K. M. A., Roussel, B. D., Roux, S., Rovere-Querini, P., Roy, A., Rozieres, A., Ruano, D., Rubinsztein, D. C., Rubtsova, M. P., Ruckdeschel, K., Ruckenstuhl, C., Rudolf, E., Rudolf, R., Ruggieri, A., Ruparelia, A. A., Rusmini, P., Russell, R. R., Russo, G. L., Russo, M., Russo, R., Ryabaya, O. O., Ryan, K. M., Ryu, K. -Y., Sabater-Arcis, M., Sachdev, U., Sacher, M., Sachse, C., Sadhu, A., Sadoshima, J., Safren, N., Saftig, P., Sagona, A. 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A., Tencomnao, T., Tenreiro, S., Tepikin, A. V., Testillano, P. S., Tettamanti, G., Tharaux, P. -L., Thedieck, K., Thekkinghat, A. A., Thellung, S., Thinwa, J. W., Thirumalaikumar, V. P., Thomas, S. M., Thomes, P. G., Thorburn, A., Thukral, L., Thum, T., Thumm, M., Tian, L., Tichy, A., Till, A., Timmerman, V., Titorenko, V. I., Todi, S. V., Todorova, K., Toivonen, J. M., Tomaipitinca, L., Tomar, D., Tomas-Zapico, C., Tomic, S., Tong, B. C. -K., Tong, C., Tong, X., Tooze, S. A., Torgersen, M. L., Torii, S., Torres-Lopez, L., Torriglia, A., Towers, C. G., Towns, R., Toyokuni, S., Trajkovic, V., Tramontano, D., Tran, Q. -G., Travassos, L. H., Trelford, C. B., Tremel, S., Trougakos, I. P., Tsao, B. P., Tschan, M. P., Tse, H. -F., Tse, T. F., Tsugawa, H., Tsvetkov, A. S., Tumbarello, D. A., Tumtas, Y., Tunon, M. J., Turcotte, S., Turk, B., Turk, V., Turner, B. J., Tuxworth, R. I., Tyler, J. K., Tyutereva, E. V., Uchiyama, Y., Ugun-Klusek, A., Uhlig, H. H., Ulamek-Koziol, M., Ulasov, I. 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M., Villalobo, A., Villarejo-Zori, B., Villarroya, F., Villarroya, J., Vincent, O., Vindis, C., Viret, C., Viscomi, M. T., Visnjic, D., Vitale, I., Vocadlo, D. J., Voitsekhovskaja, O. V., Volonte, C., Volta, M., Vomero, M., Von Haefen, C., Vooijs, M. A., Voos, W., Vucicevic, L., Wade-Martins, R., Waguri, S., Waite, K. A., Wakatsuki, S., Walker, D. W., Walker, M. J., Walker, S. A., Walter, J., Wandosell, F. G., Wang, B., Wang, C. -Y., Wang, C., Wang, D., Wang, F., Wang, G., Wang, H., Wang, H. -G., Wang, J., Wang, K., Wang, L., Wang, M. H., Wang, M., Wang, N., Wang, P., Wang, Q. J., Wang, Q., Wang, Q. K., Wang, Q. A., Wang, W. -T., Wang, W., Wang, X., Wang, Y., Wang, Y. -Y., Wang, Z., Warnes, G., Warnsmann, V., Watada, H., Watanabe, E., Watchon, M., Wawrzynska, A., Weaver, T. E., Wegrzyn, G., Wehman, A. M., Wei, H., Wei, L., Wei, T., Wei, Y., Weiergraber, O. H., Weihl, C. C., Weindl, G., Weiskirchen, R., Wells, A., Wen, R. H., Wen, X., Werner, A., Weykopf, B., Wheatley, S. P., Whitton, J. L., Whitworth, A. J., Wiktorska, K., Wildenberg, M. E., Wileman, T., Wilkinson, S., Willbold, D., Williams, B., Williams, R. S. B., Williams, R. L., Williamson, P. R., Wilson, R. A., Winner, B., Winsor, N. J., Witkin, S. S., Wodrich, H., Woehlbier, U., Wollert, T., Wong, E., Wong, J. H., Wong, R. W., Wong, V. K. W., Wong, W. W. -L., Wu, A. -G., Wu, C., Wu, J., Wu, K. K., Wu, M., Wu, S. -Y., Wu, S., Wu, W. K. K., Wu, X., Wu, Y. -W., Wu, Y., Xavier, R. J., Xia, H., Xia, L., Xia, Z., Xiang, G., Xiang, J., Xiang, M., Xiang, W., Xiao, B., Xiao, G., Xiao, H., Xiao, H. -T., Xiao, J., Xiao, L., Xiao, S., Xiao, Y., Xie, B., Xie, C. -M., Xie, M., Xie, Y., Xie, Z., Xilouri, M., Xu, C., Xu, E., Xu, H., Xu, J., Xu, L., Xu, W. W., Xu, X., Xue, Y., Yakhine-Diop, S. M. S., Yamaguchi, M., Yamaguchi, O., Yamamoto, A., Yamashina, S., Yan, S., Yan, S. -J., Yan, Z., Yanagi, Y., Yang, C., Yang, D. -S., Yang, H., Yang, H. -T., Yang, J. -M., Yang, J., Yang, L., Yang, M., Yang, P. -M., Yang, Q., Yang, S., Yang, S. -F., Yang, W., Yang, W. Y., Yang, X., Yang, Y., Yao, H., Yao, S., Yao, X., Yao, Y. -G., Yao, Y. -M., Yasui, T., Yazdankhah, M., Yen, P. M., Yi, C., Yin, X. -M., Yin, Y., Yin, Z., Ying, M., Ying, Z., Yip, C. K., Yiu, S. P. T., Yoo, Y. H., Yoshida, K., Yoshii, S. R., Yoshimori, T., Yousefi, B., Yu, B., Yu, H., Yu, J., Yu, L., Yu, M. -L., Yu, S. -W., Yu, V. C., Yu, W. H., Yu, Z., Yuan, J., Yuan, L. -Q., Yuan, S., Yuan, S. -S. F., Yuan, Y., Yuan, Z., Yue, J., Yue, Z., Yun, J., Yung, R. L., Zacks, D. N., Zaffagnini, G., Zambelli, V. O., Zanella, I., Zang, Q. S., Zanivan, S., Zappavigna, S., Zaragoza, P., Zarbalis, K. S., Zarebkohan, A., Zarrouk, A., Zeitlin, S. O., Zeng, J., Zeng, J. -D., Zerovnik, E., Zhan, L., Zhang, B., Zhang, D. D., Zhang, H., Zhang, H. -L., Zhang, J., Zhang, J. -P., Zhang, K. Y. B., Zhang, L. W., Zhang, L., Zhang, M., Zhang, P., Zhang, S., Zhang, W., Zhang, X., Zhang, X. -W., Zhang, X. D., Zhang, Y., Zhang, Y. -D., Zhang, Y. -Y., Zhang, Z., Zhao, H., Zhao, L., Zhao, S., Zhao, T., Zhao, X. -F., Zhao, Y., Zheng, G., Zheng, K., Zheng, L., Zheng, S., Zheng, X. -L., Zheng, Y., Zheng, Z. -G., Zhivotovsky, B., Zhong, Q., Zhou, A., Zhou, B., Zhou, C., Zhou, G., Zhou, H., Zhou, J., Zhou, K., Zhou, R., Zhou, X. -J., Zhou, Y., Zhou, Z. -Y., Zhou, Z., Zhu, B., Zhu, C., Zhu, G. -Q., Zhu, H., Zhu, W. -G., Zhu, Y., Zhuang, H., Zhuang, X., Zientara-Rytter, K., Zimmermann, C. M., Ziviani, E., Zoladek, T., Zong, W. -X., Zorov, D. B., Zorzano, A., Zou, W., Zou, Z., Zuryn, S., Zwerschke, W., Brand-Saberi, B., Dong, X. C., Kenchappa, C. S., Lin, Y., Oshima, S., Rong, Y., Sluimer, J. C., Stallings, C. L., Tong, C. -K., and Centre National de la Recherche Scientifique (CNRS)
Subjects: 0301 basic medicine, Programmed cell death, Settore BIO/06, Autophagosome, Autolysosome, [SDV]Life Sciences [q-bio], lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], Autophagy-Related Proteins, Review, Computational biology, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Biology, Settore MED/04, 03 medical and health sciences, stress, Chaperone-mediated autophagy, ddc:570, Autophagy, LC3, Animals, Humans, cancer, Settore BIO/10, flux, lysosome, macroautophagy, neurodegeneration, phagophore, vacuole, Set (psychology), Molecular Biology, 030102 biochemistry & molecular biology, business.industry, Interpretation (philosophy), Autophagosomes, Cell Biology, Multicellular organism, 030104 developmental biology, Knowledge base, Biological Assay, Lysosomes, business, Biomarkers, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: Contains fulltext : 232759.pdf (Publisher’s version ) (Closed access) In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.
Published: 2021

32. Adjuvant Stereotactic Body Radiotherapy After Marginal Resection for Hepatocellular Carcinoma With Micro-Vascular Invasion: A Randomized Controlled Trial

Author: Binghua Dai, Changying Shi, Cheng-Jun Sui, Weifeng Shen, Jiongjiong Lu, Jiamei Yang, Yong Li, Li Geng, and Mianshun Pan
Subjects: History, medicine.medical_specialty, Randomization, Polymers and Plastics, business.industry, medicine.medical_treatment, Single Center, Industrial and Manufacturing Engineering, law.invention, Radiation therapy, Clinical trial, Randomized controlled trial, law, Resection margin, medicine, Radiology, Business and International Management, Hepatectomy, Adverse effect, business
Abstract: Background: Marginal resection frequently occurred in hepatectomy for hepatocellular carcinoma (HCC), which led to increased local recurrence, especially among patients with microvascular invasion (MVI). Stereotactic body radiotherapy (SBRT) shows effective in tumor controlling, while limited research reported the efficacy of SBRT as adjuvant setting for HCC after surgery. We hypothesized existence of residual tumor cells or foci in unsafe margin parenchyma caused local recurrence in HCC patients with MVI, and SBRT might be a solution to resolve the problem. This study aimed to investigate the efficacy of SBRT targeting on the susceptible area with residue MVI as adjuvant setting for HCC patients. Methods: This was a single center, randomized controlled trial conducted in Eastern Hepatobiliary Surgery Hospital, Shanghai, China. Participants with HCC and MVI receiving marginal resection were randomly assigned to postoperative adjuvant SBRT group or surgery alone (SA) group. SBRT was delivered by the CyberKnife® system (Accuracy Inc., Sunnyvale) with marker tracking devices. Patients in SBRT group received SBRT targeting on the resection marginal parenchyma where MVI most likely occurred one month after surgery. The disease-free survival (DFS) and overall survival (OS) were compared between the groups and the adverse events (AE) in the SBRT group were monitored. This trial was registered with ClinicalTrials.gov, NCT04891874. Findings: A total of 76 participants were enrolled from August 1, 2015 to December 31, 2016, with 38 in each group. The 1-, 3-, and 5-year DFS rates were 92.1%, 65.8%, and 56.1% in the SBRT group, versus 76.3%, 36.8%, and 26.3% in the SA group, respectively (p=0.005). The 1-, 3-, and 5-year OS rates were 100%, 89.5%, and 75.0% in the SBRT group, versus 100.0%, 68.4%, and 53.7% in the SA group, respectively (p=0.053). The total dose of SBRT for each participant was 35Gy and the biological effective dose (BED) is 59.5 Gy. The overall incidence of radiotherapy related AE was 31.6% (12/38), and no grade 3 or higher grade AE developed. Fatigue was the most frequent AE. Interpretation: SBRT on resection marginal parenchyma provides a safe therapeutic modality of adjuvant setting in MVI-positive HCC participants without satisfying resection margin. It prevents local recurrence and improves disease-free survival. Further evidence is necessary to evaluate its long-term survival outcome. Clinical Trial Registration Details: This trial was registered with ClinicalTrials.gov, NCT04891874. Funding Information: This research has received funding from the ‘Clinical science and technology innovation project of Shenkang Hospital Development Center’ (SHDC12020104). Declaration of Interests: The authors disclose no conflicts. Ethics Approval Statement: Detailed information of the clinical protocol was explained to every participants and written informed consent were collected before randomization. This trial was approved by the Institutional Ethics Committee of Shanghai Eastern Hepatobiliary Surgery Hospital. The study protocol conformed to the principles of Declaration of Helsinki (1983).
Published: 2021

33. Position Detection for Electric Vehicle Dwcs Using Vi-Slam Method

Author: Cheng Jun, Long Rong, Liyan Zhang, and Chen Qihong
Subjects: Ground truth, Monocular, business.product_category, Mean squared error, Inertial measurement unit, Position (vector), business.industry, Computer science, Real-time computing, Electric vehicle, Wireless, Simultaneous localization and mapping, business
Abstract: The dynamic wireless charging system (DWCS) is developed to solve the problems of large battery volume and mileage anxiety of electric vehicles. However, the accurate position detection for electric vehicle DWCS is facing challenge. The traditional communication, detection and estimation methods are difficult to accurately obtain the position. To tackle this problem, the visual inertial simultaneous localization and mapping (VI-SLAM) method is applied to the electric vehicles DWCS. Firstly, the graph optimization based tight coupling method is used to integrate the monocular visual and IMU measurements. Secondly, the NVIDIA TX2 and MYNT VI-sensor suite are assembled, which the MTi300-IMU is treated as the ground truth system. Finally, the mobile vehicle is controlled to race on the simulated DWCS pathway. The experimental result shows that the method achieves great performance with the accuracy of centimeter level. In particular, the root mean square error (RMSE) in X, Y, Z directions are 0.086,0.092,0.102, respectively.
Published: 2021

34. 'One-Time Face Recognition System' Drives Changes in Civil Aviation Smart Security Screening Mode

Author: Yu Shi, Luo Daijian, Enpeng Yang, Zhenghao Li, Yong Guo, Xiang-Dong Zhou, Changcheng Zhang, Zhang Lijun, Lu Han, Cheng Jun, and Lijun Wang
Subjects: Engineering, Airport security, business.industry, Civil aviation, ComputerApplications_COMPUTERSINOTHERSYSTEMS, ComputingMilieux_LEGALASPECTSOFCOMPUTING, Chinese academy of sciences, Facial recognition system, International airport, Mode (computer interface), Aeronautics, Obstacle, business, China
Abstract: With the surge of civil aviation airport passenger traffic in recent years, the airport security and screening mode is under great pressure, which has become an obstacle for achieving the target to become a leading civil aviation power. This paper first outlines the progress and trend of civil airport security screening inside China and abroad, then explains in detail the “One-time Face Recognition System”, which is an innovative achievement of the Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences in the intelligentization of civil aviation security. The system integrates various advanced technologies and innovative ideas. With the support of Civil Aviation Administration of China (CAAC) and the support of Hongguang Special Project funded by Chinese Academy of Sciences (CAS), the system has applied to Hohhot Baita International Airport, achieving great success. The system and the operating procedures have been approved by the authorities, authorizing the use of manually assisted computerized verification to replace the original manual verification, which has started a reform of the civil aviation smart security screening mode in China.
Published: 2021

35. Sex difference in clinical outcomes of Chinese patients with atrial fibrillation and coronary stenting according to age

Author: Yi-Da Tang, Tian-Chang Li, Zhi-Min Ma, Yun-Dai Chen, Dong-Tao Li, Jian-Yong Zheng, Yu Chen, and Cheng-Jun Guo
Subjects: Male, medicine.medical_specialty, China, Anemia, Hemorrhage, Disease, Risk Factors, Internal medicine, Diabetes mellitus, Atrial Fibrillation, Medicine, Diseases of the circulatory (Cardiovascular) system, Humans, sex, Aged, Original Investigation, Sex Characteristics, business.industry, Hazard ratio, percutaneous coronary intervention, Atrial fibrillation, Middle Aged, medicine.disease, mortality, Confidence interval, Stroke, age, Heart failure, RC666-701, Female, Stents, Cardiology and Cardiovascular Medicine, business, Kidney disease
Abstract: Objective: Sex differences in the clinical outcomes of patients with atrial fibrillation (AF) and coronary stenting should be assessed according to age. Methods: We analyzed the clinical data of all patients with nonvalvular AF who underwent coronary stenting between January 2010 and June 2015 in 12 hospitals of Beijing, China. Results: A total of 2,146 patients (71.8% men and 28.2% women) were included in the study. The mean age of the patients was 66.6±9.4 years. Women in this study were older and had higher prevalence of hypertension, diabetes, chronic kidney disease (CKD), and anemia. Smoking history was found to be higher in men, and women were less likely to be current smokers. The mean follow-up duration was 39.7 months. Women younger than 65 years had a remarkably higher mortality (11.2% vs. 5.3%, p=0.012) and a significantly lower rate of repeat revascularization (1.6% vs. 6.3%, p=0.034) than men. Female gender remained an independent predictor for all-cause mortality [hazard ratio (HR)=2.03, 95% confidence interval (CI): 1.09–3.79, p=0.025], along with heart failure (HR=3.64, 95% CI: 2.02–6.57, p
Published: 2020

36. Research on Characteristics of True 3D Display System Based on FM Model

Author: Cheng Jun Tian, Ye Tian, Hao Wu, and Yang Yang
Subjects: Computer science, business.industry, Quantization (signal processing), Process (computing), Stereo display, computer.software_genre, Position (vector), Voxel, State space, Point (geometry), Computer vision, Artificial intelligence, business, Realization (systems), computer
Abstract: In the true three-dimensional display system, the brightness and color of each voxel in the imaging space must be controllable, and the relative spatial position relationship between voxels must be truly reflected, which is convenient for people to control the display effect of the system. In order to model the real 3D display system and analyze its performance, a four-dimensional FM model is established to represent the state space of each voxel point in the volume space, and the working process of true 3D display system is further described under this model. The realtime condition of the real-time display system is given, the fixed-point quantization model is introduced, and the conditions of global asymptotic stability, FM model representation method is conducive to system modeling and analysis, software realization of micro-controller. The stability analysis is conducive to system design.
Published: 2020

37. Research on the Dimensions and Influencing Factors of Enterprise Humanism Management — An Empirical Study Based on the Questionnaire of Dongguan Enterprises

Author: Cheng-jun Wang, Han-ming Xu, and Ming-hua Jiang
Subjects: Knowledge management, business.industry, media_common.quotation_subject, Organizational culture, Employee motivation, Humanism, Confirmatory factor analysis, Exploratory factor analysis, Interpersonal relationship, Promotion (rank), Empirical research, business, Psychology, media_common
Abstract: Humanism management is manifested as a multi-dimensional structural system, which embodies the comprehensive attributes of humanism management. Through the development of enterprise humanism management questionnaires, 1,530 corporate survey data in Dongguan were collected. The result of exploratory factor analysis shows that enterprise humanism management is composed of five dimensions: management responsibility, employee motivation, staff promotion, interpersonal relationship and corporate culture. The result of confirmatory factor analysis shows the fitting effect of the five-factor model of humanism management of Dongguan enterprises better. The results of the analysis of variance show that different types of enterprises have different influences on the four dimensions of humanism management: employee motivation, staff promotion, interpersonal relationships and corporate culture. The result of the mean comparison shows that the employee's identity in the enterprise has a differential impact on the various dimensions of humanistic management.
Published: 2020

38. Idiopathic Pulmonary Fibrosis Registry China study (PORTRAY): protocol for a prospective, multicentre registry study

Author: Dingyuan Jiang, Cheng-Jun Ban, Ruie Feng, Shiyao Wang, Chen Wang, Jing Geng, Sa Luo, Bingbing Xie, Qihang Chen, Yanhong Ren, Xuan He, Ling Zhao, Min Liu, and Huaping Dai
Subjects: medicine.medical_specialty, China, thoracic medicine, Lung biopsy, Disease, Idiopathic pulmonary fibrosis, Usual interstitial pneumonia, Internal medicine, Epidemiology, medicine, Humans, Prospective Studies, Registries, Respiratory Medicine, interstitial lung disease, medicine.diagnostic_test, business.industry, Interstitial lung disease, General Medicine, medicine.disease, Institutional review board, Idiopathic Pulmonary Fibrosis, Bronchoalveolar lavage, Medicine, epidemiology, business, Bronchoalveolar Lavage Fluid
Abstract: IntroductionIdiopathic pulmonary fibrosis (IPF) is a progressive and lethal lung disease characterised by a fibrotic histological pattern found in usual interstitial pneumonia. Its causes, pathogenesis, clinical phenotype and molecular mechanisms are poorly defined. Large-scale, multicentre studies are warranted to better understand IPF as a disease in China, its associated risk factors, clinical characteristics, diagnosis, disease progression and treatment.Methods and analysisThe Idiopathic Pulmonary Fibrosis Registry China Study (PORTRAY) is a prospective, multicentre registry study of patients with IPF in China. Eight hundred patients will be enrolled over a 36-month period and followed for at least 3 years to generate a comprehensive database on baseline characteristics and various follow-up parameters including patient-reported outcomes. Biological specimens will also be collected from patients to develop a library of blood, bronchoalveolar lavage fluid and lung biopsy samples, to support future research. As of 15 December 2019, 204 patients from 19 large medical centres with relatively high IPF diagnosis and treatment rates had been enrolled. Patient characteristics will be presented using descriptive statistics. The Kaplan-Meier method will be used for survival analyses. Repeated measures will be used to compare longitudinal changes in lung function, imaging and laboratory tests. Results following analysis have been projected to be available by July 2025.Ethics and disseminationThe study protocol was reviewed and approved by the Institutional Review Board from all the study sites currently recruiting patients. Study results will be published in peer-reviewed journals.Trial registration numberNCT03666234.
Published: 2020

39. 3D Stackable Via RRAM Cells by Cu BEOL Process in FinFET CMOS Technologies

Author: Chrong Jung Lin, Cheng-Jun Lin, Ya-Chin King, and Wang-Yi Lee
Subjects: Non-volatile memory, Materials science, CMOS, business.industry, Electrode, Optoelectronics, Nanometre, Data retention, business, Low voltage, Layer (electronics), Resistive random-access memory
Abstract: In this study, a Vertical Via RRAM fully compatible to cutting-edge FinFET CMOS logic process has been demonstrated. These Vertical Via RRAM devices are formed by the stacked nanometer via and metal in the Cu BEOL CMOS logic process. Between the two Cu electrodes, the TaON-based transition metal oxide (TMO) film functions as the resistive switching layer after a reset forming process. This 3D stackable Vertical Via RRAM features low voltage operation, large read window and enables compact cell size. Excellent data retention and immunity to read disturb are demonstrated as well.
Published: 2020

40. Pulmonary Adventitial Fibroblasts Regulate Macrophage Transcriptional and Metabolic Programs in Pulmonary Hypertension

Author: B. A. McKeon, Min Li, K.C. El Kasmi, Suzette R. Riddle, Joanna M. Poczobutt, Julie A. Reisz, Aya Laux, Sushil Kumar, Hui Zhang, R.D. Brown, Travis Nemkov, Angelo D'Alessandro, Mehdi A. Fini, Kurt R. Stenmark, Maria G. Frid, and Cheng-Jun Hu
Subjects: business.industry, Immunology, Macrophage, Medicine, business, medicine.disease, Pulmonary hypertension
Published: 2020

41. Epigenetic-Targeted Therapies in Pulmonary Hypertension Combined Inhibition of Histone Deacetylases and Bromodomain Proteins Normalizes the Persistent Activation of Pulmonary Vascular Adventitial Fibroblasts In Vitro

Author: Cheng-Jun Hu, A. Laux, Min Li, Nicholas W. Morrell, X. Liu, Kurt R. Stenmark, Amanda Flockton, and Hui Zhang
Subjects: Histone, biology, business.industry, biology.protein, Cancer research, medicine, Epigenetics, medicine.disease, business, Pulmonary hypertension, In vitro, Bromodomain
Published: 2020

42. Oral Supplementation of Sodium Butyrate Attenuates the Progression of Non-Alcoholic Steatohepatitis

Author: Ina Bergheim, Sascha Venturelli, Cheng Jun Jin, Annette Brandt, Anja Baumann, Cathrin Sellmann, Markus Burkard, and Anika Nier
Subjects: 0301 basic medicine, Receptor expression, toll-like receptor 4, Nitric Oxide Synthase Type II, Impaired glucose tolerance, Cholesterol, Dietary, chemistry.chemical_compound, 0302 clinical medicine, Non-alcoholic Fatty Liver Disease, Intestine, Small, Melatonin, Nutrition and Dietetics, Fatty liver, Sodium butyrate, medicine.anatomical_structure, Liver, Disease Progression, 030211 gastroenterology & hepatology, Female, non-alcoholic steatohepatitis, lcsh:Nutrition. Foods and food supply, medicine.medical_specialty, melatonin synthesis, lcsh:TX341-641, Carbohydrate metabolism, Diet, High-Fat, Article, 03 medical and health sciences, Internal medicine, medicine, Animals, sodium butyrate, Inflammation, business.industry, Interleukin-6, Tumor Necrosis Factor-alpha, inducible nitric oxide synthase, medicine.disease, Small intestine, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, Endocrinology, Glucose, chemistry, Dietary Supplements, Butyric Acid, Steatosis, Steatohepatitis, business, Food Science
Abstract: Sodium butyrate (SoB) supplementation has been suggested to attenuate the development of non-alcoholic fatty liver disease (NAFLD). Here, we determined the therapeutic potential of SoB on NAFLD progression and molecular mechanism involved. Eight-week old C57BL/6J mice were pair-fed a fat-, fructose- and cholesterol-rich diet (FFC) or control diet (C). After 8 weeks, some mice received 0.6g SoB/kg bw in their respective diets (C+SoB, FFC+SoB) or were maintained on C or FFC for the next 5 weeks of feeding. Liver damage, markers of glucose metabolism, inflammation, intestinal barrier function and melatonin metabolism were determined. FFC-fed mice progressed from simple steatosis to early non-alcoholic steatohepatitis, along with significantly higher TNF&alpha, and IL-6 protein levels in the liver and impaired glucose tolerance. In FFC+SoB-fed mice, disease was limited to steatosis associated with protection against the induction of Tlr4 mRNA and iNOS protein levels in livers. SoB supplementation had no effect on FFC-induced loss of tight junction proteins in the small intestine but was associated with protection against alterations in melatonin synthesis and receptor expression in the small intestine and livers of FFC-fed animals. Our results suggest that the oral supplementation of SoB may attenuate the progression of simple steatosis to steatohepatitis.
Published: 2020
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43. Antibody responses to SARS-CoV-2 in COVID-19 patients: the perspective application of serological tests in clinical practice

Author: Chunhui Lang, Ni Tang, Xia-mao Liu, Xue-Fei Cai, Li-hua Yu, Zhijie Li, Jianglin Xiang, Li Wang, Zheng Zhou, Wen-Guang Tian, Yin-yin Xu, Fang Gong, Xiao Feng Li, Chang-chun Niu, Pu Liao, Ji-Hua Ren, Ailong Huang, Xiaojun Tang, Deqiang Wang, Yong Zhang, Cheng-jun Xue, Jin-jing Li, De-chun Zhang, Fan Zhang, Qin Li, Qing-jun Yang, Xianxiang Zhang, Bei-zhong Liu, Shao-bo Wu, Yong Lin, Kun Wang, Yuan Hu, Jing Wang, Xiaohe Luo, Liu Ping, Zhan Mo, Xiao-ping Cui, Quanxin Long, Jieli Hu, Haijun Deng, Yao-kai Chen, Xiao-li Zhang, Guicheng Wu, Huawen Liu, Jingfu Qiu, Juan Chen, and Hong-xin Du
Subjects: medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), biology, business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Serology, Titer, Antibody response, Internal medicine, Cohort, medicine, biology.protein, Seroconversion, Antibody, business
Abstract: BackgroundWe aim to investigate the profile of acute antibody response in COVID-19 patients, and provide proposals for the usage of antibody test in clinical practice.MethodsA multi-center cross-section study (285 patients) and a single-center follow-up study (63 patients) were performed to investigate the feature of acute antibody response to SARS-CoV-2. A cohort of 52 COVID-19 suspects and 64 close contacts were enrolled to evaluate the potentiality of the antibody test.ResultsThe positive rate for IgG reached 100% around 20 days after symptoms onset. The median day of seroconversion for both lgG and IgM was 13 days after symptoms onset. Seroconversion of IgM occurred at the same time, or earlier, or later than that of IgG. IgG levels in 100% patients (19/19) entered a platform within 6 days after seroconversion. The criteria of ‘IgG seroconversion’ and ‘> 4-fold increase in the IgG titers in sequential samples’ together diagnosed 82.9% (34/41) of the patients. Antibody test aided to confirm 4 patients with COVID-19 from 52 suspects who failed to be confirmed by RT-PCR and 7 patients from 148 close contacts with negative RT-PCR.ConclusionIgM and IgG should be detected simultaneously at the early phase of infection. The serological diagnosis criterion of seroconversion or the ‘>; 4-fold increase in the IgG titer’ is suitable for a majority of COVID-19 patients. Serologic test is helpful for the diagnosis of SARS-CoV-2 infection in suspects and close contacts.
Published: 2020

44. A giant hepatic cavernous hemangioma with an abdominal wall hemangioma: a case report

Author: Zhang Zhou, Li Li, Cheng-jun Luo, Xue Gu, Yan Liu, and Na Yang
Subjects: body regions, Hemangioma, Abdominal wall, medicine.medical_specialty, medicine.anatomical_structure, business.industry, medicine, cardiovascular diseases, sense organs, Radiology, medicine.disease, business, eye diseases
Abstract: Introdoction: Hepatic cavernous hemangioma is the most common benign tumor of the liver without special treatment，which is very common in clinical work.But some larger cavernous hemangioma has the risk of bleeding, clinical diagnosis and treatment of large hepatic cavernous hemangioma is of great significance.Case presentation: The patient was a 45-year-old middle-aged woman who was admitted to the hospital due to a large lesion of the abdominal wall. At first, she was considered as having a melanoma of the abdominal wall. After imaging and pathological examinations, she was diagnosed as having a giant cavernous hemangioma of the liver. Percutaneous hepatic artery superselective angiography and embolization significantly reduced the lesions.Conclusion: Hepatic cavernous hemangioma is relatively more common clinically, but there are few reports of multiple and huge hemangioma, as reported here, our patient had a large abdominal wall hemangioma. It is speculated that the coexistence of the two is related. In fact,during embryonic development,the fetus and mother are connected by two umbilical arteries and one umbilical vein. An aneurysm-like deformity caused by excessive development or abnormal differentiation of blood vessels during the developmental process may be the cause of the patient's massive abdominal wall and liver hemangiomas.
Published: 2020

45. Comparison of the clinical outcomes of percutaneous vertebroplasty vs. kyphoplasty for the treatment of osteoporotic Kümmell’s disease:a prospective cohort study

Author: Dong-Ping Shu, Ming-Jian Bei, Jian-Zhong Chang, Cheng-Jun Sun, Ji-Bin Chen, and Ya-Ping Xiao
Subjects: Male, medicine.medical_specialty, Percutaneous, Vertebral compression fracture, lcsh:Diseases of the musculoskeletal system, medicine.medical_treatment, Operative Time, Kyphosis, Percutaneous vertebroplasty, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, 030202 anesthesiology, Fractures, Compression, medicine, Humans, Pain Management, Kyphoplasty, Orthopedics and Sports Medicine, Prospective Studies, Aged, Pain Measurement, Aged, 80 and over, Vertebroplasty, Percutaneous kyphoplasty, business.industry, Bone Cements, Middle Aged, medicine.disease, Bone cement, Oswestry Disability Index, Surgery, Vertebra, Treatment Outcome, medicine.anatomical_structure, Orthopedic surgery, Spinal Fractures, Female, Kümmell’s disease, osteoporosis, lcsh:RC925-935, business, Osteoporotic Fractures, 030217 neurology & neurosurgery, Research Article
Abstract: Background Percutaneous vertebroplasty (PVP) and percutaneous kyphoplasty (PKP) are widely used in the treatment of Kümmell’s disease. The purpose of this article is to investigate the clinical efficacy of PVP and PKP for Kümmell’s disease. Methods The clinical data that 56 cases of Kümmell’s disease treated with either PVP (28 cases) or PKP (28 cases) from December 2015 to December 2017 were prospectively analyzed. Gender, age, course of disease, injury segment, bone mineral density (BMD), visual analogue scale (VAS), Oswestry disability index (ODI), imaging measurement indexes before surgery between the two groups showed no significant difference (all P > 0.05). The bone cement leakage rate, bone cement injection amount, operation time, VAS, ODI, the rate of vertebral compression, correction rate of kyphosis and refracture rate of adjacent vertebra in 2 years were compared between the two groups to calculate clinical efficacy. Results The two groups were followed up for 24–48 months. There was no significant difference in the follow-up time, amount of bone cement injected, incidence of bone cement leakage and refracture rate of adjacent vertebrae between the two groups (all P > 0.05). The operation time, intraoperative blood loss and fluoroscopy times of the PVP group were significantly lower than those of the PKP group (all P = 0.000). VAS score and ODI of the two groups were significantly lower at 1 day, 1 year and 2 years after surgery than before surgery (all P P > 0.05). The rate of vertebral compression and kyphosis correction in the two groups were significantly corrected (P P P > 0.05). Conclusion Both PVP and PKP can achieve similar effects in the treatment of Kümmell’s disease. Because the cost, operation time, blood loss, radiation exposure and surgical procedure of PVP are less than those of PKP, PVP has more clinical priority value.
Published: 2020

46. Suppression of HIF2 signaling attenuates the initiation of hypoxia-induced pulmonary hypertension

Author: Maria G. Frid, Steven C. Pugliese, Aya Laux, Amanda Flockton, Min Li, Sushil Kumar, R. Dale Brown, Kurt R. Stenmark, Suzette R. Riddle, Brittany McKeon, Wallace Eli M, Gary Mouradian, Brian B. Graham, Jens M. Poth, Hui Zhang, and Cheng-Jun Hu
Subjects: Male, Pulmonary and Respiratory Medicine, Hypertension, Pulmonary, Myocytes, Smooth Muscle, Inflammation, Pulmonary Artery, Vascular Remodeling, Pharmacology, Muscle, Smooth, Vascular, Article, Rats, Sprague-Dawley, Mice, 03 medical and health sciences, 0302 clinical medicine, Right ventricular hypertrophy, Basic Helix-Loop-Helix Transcription Factors, medicine, Animals, Humans, 030212 general & internal medicine, Hypoxia, Cells, Cultured, Cell Proliferation, Mice, Knockout, Lung, Hypertrophy, Right Ventricular, biology, business.industry, Tenascin C, Endothelial Cells, Hypoxia (medical), medicine.disease, Pulmonary hypertension, Rats, Mice, Inbred C57BL, Respiratory pharmacology, Disease Models, Animal, medicine.anatomical_structure, Gene Expression Regulation, 030228 respiratory system, biology.protein, Female, medicine.symptom, Signal transduction, business, Signal Transduction
Abstract: Most published studies addressing the role of HIFs in hypoxia-induced PH development employ models that may not recapitulate the clinical setting, including the use of animals having pre-existing lung/vascular defects secondary to embryonic HIF ablation or activation. Further, critical questions including how and when HIF-signalling contributes to hypoxia-induced PH remains unanswered.Normal adult rodents in which global HIF1 or 2 was inhibited by inducible gene deletion or pharmacological inhibition (antisense oligonucleotides-ASO and small molecule inhibitors) were exposed to short-term (4 days) or chronic (4–5 weeks) hypoxia. Hemodynamic studies were performed, the animals euthanized and lungs and heart obtained for pathologic and transcriptomic analysis. Cell-type specific HIF signals for PH initiation were determined in normal pulmonary vascular cells in vitro and in mice (using cell-type specific HIF deletion).Global HIF1α deletion in mice did not prevent hypoxia-induced PH at 5 weeks. Mice with global HIF2α deletion did not survive long-term hypoxia. Partial HIF2α gene deletion, or HIF2-ASO (but not HIF1-ASO) reduced vessel muscularization, rises in pulmonary artery pressures and right ventricular hypertrophy in mice exposed to 4–5 week hypoxia. A small molecule HIF2 inhibitor (PT2567) significantly attenuated early events (monocyte recruitment and vascular cell proliferation) in rats exposed to 4-day hypoxia as well as vessel musculization, tenascin C accumulation and PH development in rats exposed to 5 week hypoxia. In vitro, HIF2 induced a distinct set of genes in normal pulmonary vascular EC, mediating inflammation and proliferation of EC and SMC. EC HIF2α knockout prevented hypoxia-induced PH in mice.Inhibition of HIF2, not HIF1 can provide a therapeutic approach to prevent the development of hypoxia-induced PH. Future studies are needed to investigate the role of HIFs in PH progression and reversal.
Published: 2019

47. Comparison of admission serum albumin and hemoglobin as predictors of outcome in children with moderate to severe traumatic brain injury: A retrospective study

Author: Cheng-Jun Liu, Hong-Chun Luo, Cheng-Yan You, Feng Xu, and Yueqiang Fu
Subjects: Male, medicine.medical_specialty, Critical Care, Anemia, Serum albumin, law.invention, 03 medical and health sciences, 0302 clinical medicine, law, Predictive Value of Tests, Internal medicine, Brain Injuries, Traumatic, medicine, Humans, Glasgow Coma Scale, 030212 general & internal medicine, Hypoalbuminemia, Hospital Mortality, Child, Serum Albumin, Retrospective Studies, Glycated Hemoglobin, biology, business.industry, Area under the curve, Retrospective cohort study, General Medicine, Odds ratio, medicine.disease, Intensive care unit, Respiration, Artificial, 030220 oncology & carcinogenesis, Case-Control Studies, Child, Preschool, biology.protein, Female, Erratum, business, Biomarkers
Abstract: Hypoalbuminemia and anemia are frequent among in patients with traumatic brain injury (TBI). We assess whether serum albumin and hemoglobin at admission can predict outcome in children with moderate to severe TBI.This retrospective study was conducted in a tertiary pediatric hospital between May 2012 and Jun 2018 included children with an admission Glasgow Coma Scale of ≤13.A total of 213 patients were included of whom 45 died in hospital. Multivariate logistic regression showed that hypoalbuminemia (serum albumin
Published: 2019

48. Direct medical costs of hospitalized patients with idiopathic pulmonary fibrosis in China

Author: Bingbing Xie, Chen Wang, Yanhong Ren, Min Zhu, Ya-Li Liu, Huaping Dai, Dingyuan Jiang, Zheng X, Jing Geng, Shutian Zhang, and Cheng-Jun Ban
Subjects: medicine.medical_specialty, business.industry, Mortality rate, Incidence (epidemiology), Psychological intervention, respiratory system, medicine.disease, respiratory tract diseases, Idiopathic pulmonary fibrosis, Blood pressure, Respiratory failure, DLCO, Emergency medicine, Medicine, business, Medical costs
Abstract: BackgroundIdiopathic pulmonary fibrosis (IPF) is a chronic, progressive fibrosing interstitial pneumonia of unknown cause. The incidence of IPF is increasing year by year, as well as the mortality rates, which is really a burden both for the family and the society. However few data concerning the economic burden of the patients with IPF is available, especially in China.ObjectiveThis study aimed to examine the direct medical costs of hospitalized patients with IPF and to determine the contributing factors.MethodsThis retrospective analysis used the cost-of-illness framework in order to analyze the direct medical costs of patients with IPF. The study used data from the pneumology department of Beijing Chao-Yang Hospital affiliated to Capital Medical University from year 2012 to 2015. The direct medical costs included drug fee, auxiliary examination fee, treatment fee and other fee. Patients’ characteristics, medical treatment, and the direct medical costs were analyzed by descriptive statistics and multivariable regression.ResultsThere were 219 hospitalized patients meeting the diagnosis of IPF, 91% male. The mean age was 65 years old. For the direct medical costs of hospitalized patients with IPF, the mean(SD) of the total costs per IPF patient per admission was 14882.3 (30975.8)CNY. The largest parts were the examination fee of 6034.5 (15651.2)CNY and the drug fee of 5048.9 (3855.1)CNY. By regression analysis we found that length of stay, emergency treatment, ventilator use and being a Beijing native were significantly (PConclusionThis study showed that IPF has a major impact on the direct medical costs. Thus, appropriate long-term interventions are recommended to lower the economic burden of IPF.Strengths and limitations of this studyIt was the first time in China to discuss the economic burden of diseases and its influencing factors in patients with IPF.The results of this study might be of reference for the establishment of IPF disease-related medical policies in future.The retrospective cross-sectional design does not allow for establishing any causal relationships.It was a a single-center study, resulting a slightly smaller sample size. A large sample of multicenter studies is needed to confirm this.
Published: 2019
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49. Antiviral treatment of mild chronic hepatitis B patients with tuberculosis: A controlled study

Author: Jing-Yi Yang, Cheng-Jun Huang, Shu-Quan Cheng, Fu-Ming Jiang, Jun Lin, Ping-Xiang Liu, and Ya-Zhao Cao
Subjects: medicine.medical_specialty, Tuberculosis, Chronic hepatitis, business.industry, Internal medicine, medicine, Antiviral treatment, medicine.disease, business, Gastroenterology
Published: 2017

50. Clinical significance of expression of TLR3 and TLR4 in liver tissue of patients with chronic hepatitis B

Author: Xiu-Fen Li, Jing-Yi Yang, Shu-Quan Cheng, Cheng-Jun Huang, Jun Lin, Fu-Ming Jiang, and Ya-Zhao Cao
Subjects: Pathology, medicine.medical_specialty, Chronic hepatitis, business.industry, Liver tissue, TLR3, TLR4, Medicine, Clinical significance, business
Published: 2017

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