1. Exposures to IARC Carcinogenic Agents in Work Settings Not Traditionally Associated with Sinonasal Cancer Risk: The Experience of the Italian National Sinonasal Cancer Registry
- Author
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Alessandra Binazzi, Carolina Mensi, Lucia Miligi, Davide Di Marzio, Jana Zajacova, Paolo Galli, Angela Camagni, Roberto Calisti, Anna Balestri, Stefano Murano, Sara Piro, Angelo d’Errico, Matteo Bonzini, Stefania Massacesi, Denise Sorasio, Alessandro Marinaccio, and on behalf of ReNaTuNS Working group
- Subjects
Occupational cancer ,Health, Toxicology and Mutagenesis ,Population ,Context (language use) ,sinonasal cancer ,occupational exposure ,occupational cancer ,epidemiological surveillance ,Article ,Environmental health ,Occupational Exposure ,Settore MED/44 - Medicina del Lavoro ,Medicine ,Humans ,Registries ,education ,education.field_of_study ,business.industry ,Epidemiological surveillance ,Occupational exposure ,Sinonasal cancer ,Carcinogens ,Dust ,Occupational Diseases ,Paranasal Sinus Neoplasms ,Public Health, Environmental and Occupational Health ,medicine.disease ,Work (electrical) ,Work history ,business - Abstract
The aim of this study is to highlight tasks and jobs not commonly considered at high risk for sinonasal cancer (SNC) identified by Regional Operating Centers currently active in the Italian National Sinonasal Cancer Registry (ReNaTuNS), which retrieve occupational histories through a standardized questionnaire. Data on exposures to IARC carcinogenic agents in work settings unknown to be associated with SNC risk were collected and analyzed. Out of 2,208 SNC cases recorded in the ReNaTuNS database, 216 cases and their worked exposure periods were analyzed. Unsuspected jobs with exposure to wood dust include construction-related tasks, production of resins, agriculture and livestock jobs (straw and sawdust), and heel factory work (cork dust). Other examples are hairdressers, bakers (formaldehyde), dressmakers, technical assistants, wool and artificial fiber spinners, and upholsterers (textile dusts). Moreover, settings with coexposure to different agents (e.g., wood with leather dusts and chromium–nickel compounds) were recognized. The study describes jobs where the existence of carcinogenic agents associated with SNC risk is unexpected or not resulting among primary materials employed. The systematic epidemiological surveillance of all epithelial SNC cases with a detailed collection of their work history, as performed by a dedicated population registry, is essential for detecting all potential occupational cases and should be considered in the context of forensic medicine and the compensation process.
- Published
- 2021