1. Automatic staging of cancer tumors using AIM image annotations and ontologies
- Author
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Daniel L. Rubin, Nelson Miranda, Dilvan de Abreu Moreira, and Edson F. Luque
- Subjects
FÍGADO ,Computer science ,Ontology (information science) ,computer.software_genre ,030218 nuclear medicine & medical imaging ,Metastasis ,03 medical and health sciences ,0302 clinical medicine ,Neoplasms ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Data Curation ,Neoplasm Staging ,Cancer staging ,Original Paper ,Radiological and Ultrasound Technology ,business.industry ,Cancer stage ,Second opinion ,Ontology language ,medicine.disease ,Semantics ,Computer Science Applications ,Workflow ,Liver ,Artificial intelligence ,business ,computer ,Classifier (UML) ,030217 neurology & neurosurgery ,Natural language processing - Abstract
A second opinion about cancer stage is crucial when clinicians assess patient treatment progress. Staging is a process that takes into account description, location, characteristics, and possible metastasis of tumors in a patient. It should follow standards, such as the TNM Classification of Malignant Tumors. However, in clinical practice, the implementation of this process can be tedious and error prone. In order to alleviate these problems, we intend to assist radiologists by providing a second opinion in the evaluation of cancer stage. For doing this, we developed a TNM classifier based on semantic annotations, made by radiologists, using the ePAD tool. It transforms the annotations (stored using the AIM format), using axioms and rules, into AIM4-O ontology instances. From then, it automatically calculates the liver TNM cancer stage. The AIM4-O ontology was developed, as part of this work, to represent annotations in the Web Ontology Language (OWL). A dataset of 51 liver radiology reports with staging data, from NCI’s Genomic Data Commons (GDC), were used to evaluate our classifier. When compared with the stages attributed by physicians, the classifier stages had a precision of 85.7% and recall of 81.0%. In addition, 3 radiologists from 2 different institutions manually reviewed a random sample of 4 of the 51 records and agreed with the tool staging. AIM4-O was also evaluated with good results. Our classifier can be integrated into AIM aware imaging tools, such as ePAD, to offer a second opinion about staging as part of the cancer treatment workflow.
- Published
- 2020